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353. Accelerating Seismic Imaging on GPUs

Author

Souza, P., primary, Teixeira, T., additional, Panetta, J., additional, Cunha, C., additional, Romanelli, A., additional, Roxo, F., additional, Pedrosa, I., additional, Sinedino, S., additional, Monnerat, L., additional, Carneiro, L., additional, and Albrecht, C., additional

Published
2011
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362. Lung permeability, antioxidant status and NO2 inhalation: a selenium supplementation study in rats

Author

Congrès AIRNET et NERAM (Network for environmental risk assessment and management) :Strategies for clean air and health (5-7 novembre 2003: Rome), de Burbure, Claire, Heilier, Jean François, Neve, Jean, Becker, A., Albrecht, C., Borm, Paul, Grodmazinzska, J., Wasowicz, Wojciech, Rydzynski, Konrad, Bernard, Anne-Marie, Congrès AIRNET et NERAM (Network for environmental risk assessment and management) :Strategies for clean air and health (5-7 novembre 2003: Rome), de Burbure, Claire, Heilier, Jean François, Neve, Jean, Becker, A., Albrecht, C., Borm, Paul, Grodmazinzska, J., Wasowicz, Wojciech, Rydzynski, Konrad, and Bernard, Anne-Marie

Abstract

info:eu-repo/semantics/nonPublished

Published
2003

378. Quantum phase transitions in NbFe2 and Ca3Ru2O7

Author

Duncan, W. J., primary, Welzel, O. P., additional, Moroni‐Klementowicz, D., additional, Albrecht, C., additional, Niklowitz, P. G., additional, Grüner, D., additional, Brando, M., additional, Neubauer, A., additional, Pfleiderer, C., additional, Kikugawa, N., additional, Mackenzie, A. P., additional, and Grosche, F. M., additional

Published
2010
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381. Functional analysis of candidate ABC transporter proteins for sitosterol transport

Author

Albrecht, C, Elliott, J I, Sardini, A, Litman, Thomas, Stieger, B, Meier, P J, Higgins, C F, Albrecht, C, Elliott, J I, Sardini, A, Litman, Thomas, Stieger, B, Meier, P J, and Higgins, C F

Abstract

Two ATP-binding cassette (ABC) proteins, ABCG5 and ABCG8, have recently been associated with the accumulation of dietary cholesterol in the sterol storage disease sitosterolemia. These two 'half-transporters' are assumed to dimerize to form the complete sitosterol transporter which reduces the absorption of sitosterol and related molecules in the intestine by pumping them back into the lumen. Although mutations altering ABCG5 and ABCG8 are found in affected patients, no functional demonstration of sitosterol transport has been achieved. In this study, we investigated whether other ABC transporters implicated in lipid movement and expressed in tissues with a role in sterol synthesis and absorption, might also be involved in sitosterol transport. Transport by the multidrug resistance P-glycoprotein (P-gp; Abcb1), the multidrug resistance-associated protein (Mrp1; Abcc1), the breast cancer resistance protein (Bcrp; Abcg2) and the bile salt export pump (Bsep; Abcb11) was assessed using several assays. Unexpectedly, none of the candidate proteins mediated significant sitosterol transport. This has implications for the pathology of sitosterolemia. In addition, the data suggest that otherwise broad-specific ABC transporters have acquired specificity to exclude sitosterol and related sterols like cholesterol presumably because the abundance of cholesterol in the membrane would interfere with their action; in consequence, specific transporters have evolved to handle these sterols.

Published
2002

383. Left ventricular assist with an axial flow pump (Hemopump): clinical application

Author

Willem Daenen, Belhan Akpinar, Patrick Wouters, Roland Demeyere, Paul Sergeant, Peter Lauwers, Willem Flameng, Albrecht C. Wiebalck, and F R Waldenberger

Subjects
Pulmonary and Respiratory Medicine, Adult, Graft Rejection, Male, medicine.medical_specialty, Heart disease, Central Venous Pressure, medicine.medical_treatment, Cardiac Output, Low, Myocardial Infarction, Shock, Cardiogenic, Blood Pressure, Hemolysis, Ventricular Function, Left, Atheromatosis, Internal medicine, medicine, Humans, Myocardial infarction, Cardiac Output, Aged, Heart transplantation, business.industry, Central venous pressure, Equipment Design, Middle Aged, medicine.disease, Surgery, Transplantation, Survival Rate, medicine.anatomical_structure, Treatment Outcome, Ventricle, Cardiology, Heart Transplantation, Equipment Failure, Female, Heart-Assist Devices, Cardiology and Cardiovascular Medicine, business, Hemopump
Abstract

Eighteen patients suffering from acute left heart failure were selected as candidates for Hemopump support. In 6 patients, peripheral atheromatosis prevented insertion of the device. Of the remaining 12 patients, 9 had postcardiotomy shock, 2 had acute rejection after orthotopic heart transplantation, and 1 had acute myocardial infarction complicated by a large postinfarction ventricular septal defect. During Hemopump support, hemodynamics recovered in all patients. Major complications were related to mechanical pump failure, such as fracture of the drive cable and expulsion of the cannula out of the ventricle, or to hemolysis of variable degree. Seven patients (58%) survived and were discharged from the hospital: the 2 patients bridged to heart transplantation and 5 of the 9 postcardiotomy patients, including 1 who could not be weaned but later underwent successful transplantation. The patient with the postinfarction vetricular septal defect died after removal of the device because of hemolysis. These results indicate that the Hemopump is a relatively noninvasive and efficacious left ventricular system of moderate power.

Published
1993

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