351. Comparative effectiveness of two lipid emulsions in preventing retinopathy of prematurity in preterm infants requiring parenteral nutrition.
- Author
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Cabañas Poy MJ, Montoro Ronsano JB, Castillo Salinas F, Martín-Begué N, Clemente Bautista S, and Gorgas Torner MQ
- Subjects
- Humans, Retrospective Studies, Infant, Newborn, Male, Female, Soybean Oil therapeutic use, Soybean Oil administration & dosage, Phospholipids therapeutic use, Phospholipids administration & dosage, Gestational Age, Incidence, Treatment Outcome, Olive Oil, Fish Oils, Plant Oils, Triglycerides, Retinopathy of Prematurity prevention & control, Parenteral Nutrition, Fat Emulsions, Intravenous therapeutic use, Infant, Premature, Weight Gain
- Abstract
Objectives: The main aim was to compare the effects of two parenteral lipid emulsions on retinopathy of prematurity (ROP) incidence, severity, and need for treatment. Secondary aim was to compare the effect on weight gain in the first 6 weeks of life., Methods: Single-center, observational, retrospective study analyzing preterm infants with a gestational age < 31 weeks and a birth weight < 1,251 g, born between April 2015 and December 2018. The infants' medical records were reviewed to collect clinical data. Parenteral nutrition details were obtained from the hospital pharmacy database., Results: In total, 180 patients were included: 90 received ClinOleic® and 90 received SMOFlipid®. No significant differences were observed for the incidence of ROP (40% in ClinOleic® group and 41% in SMOFlipid® group, p=0.88) or ROP requiring treatment (4% and 10% respectively, p=0.152). Weekly weight gain was similar in the two groups., Conclusions: This study showed no difference between the two groups regarding ROP, ROP requiring treatment or weekly weight gain in the first 6 weeks of life., (Copyright © 2023 Sociedad Española de Farmacia Hospitalaria (S.E.F.H). Publicado por Elsevier España, S.L.U. All rights reserved.)
- Published
- 2024
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