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351. A High Energy Resolution X-ray Spectrometer using SDD

Author

Chen Er Lei, Liu Shu bin, Ye Chun feng, and Feng Chang qing

Subjects
Physics, Thermoelectric cooling, Spectrometer, Analogue electronics, Silicon drift detector, Physics::Instrumentation and Detectors, business.industry, Dynamic range, Detector, Resolution (electron density), Analytical chemistry, Full width at half maximum, Optics, business
Abstract

A high energy resolution X-ray spectrometer based on Silicon Drift Detector is described in this paper. The spectrometer consists of the SDD detector module, the analog electronics for shaping and filtering and the digital electronics for peak detection and data transfer. The system can working at room temperature as a thermo electric cooler (Peltier Element) is integrated into the SDD chip. The dynamic range is about 1 keV to 10 keV. Test results indicated high energy resolution Full Width at Ha lf Maximum (FWHM), which is better than 160 eV @ 5.9 keV with the incoming photon of radioisotopes ( 55 Fe).

Published
2015
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352. High Gain Lateral Semi-Insulating GaAs Photoconductive Switch Triggered by 1064 nm Laser Pulses

Author

Li Qi, Chen Er-Zhu, Zhao Wei, Shi Wei, and Zhang Xian-Bin

Subjects
Materials science, business.industry, General Physics and Astronomy, Condensed Matter::Mesoscopic Systems and Quantum Hall Effect, Laser, law.invention, Wavelength, Absorption edge, law, Electrode, Optoelectronics, business, Absorption (electromagnetic radiation), Energy (signal processing), Pulse-width modulation, Voltage
Abstract

We report on the experimental results of a lateral semi-insulating GaAs photoconductive switch, with a gap of 8 mm between two electrodes, triggered by 1064 nm laser pulses at a wavelength beyond the GaAs absorption edge. Both the linear and nonlinear modes of the switch were observed when it was triggered by light pulses with an energy of 1.9 mJ and a pulse width of 60 ns, and operated at high voltages of 3 and 5 kV. The results show that when the semi-insulating GaAs photoconductive switch operates under an electrical field of 4.37 kV/cm, it will enter into the linear mode first, and then the switch will undergo the nonlinear mode (lock-on) after a delay of about 20-100 ns. It is worth noticing that the delay time under high light energy is longer than that in the low optical energy. The non-intrinsic absorption mechanism is discussed. EL2 deep level defects and double-photon absorption in GaAs may play a key part in the absorption process.

Published
2002
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353. OsABT, a Rice WD40 Domain-Containing Protein, Is Involved in Abiotic Stress Tolerance

Author

Chen Eryong and Shen Bo

Subjects
abscisic acid, Arabidopsis, drought stress, rice, salt stress, WD40 domain-containing protein, Plant culture, SB1-1110
Abstract

Plant growth and crop productivity are severely affected by abiotic stress on a global scale. WD40 repeat-containing proteins play a significant role in the development and environmental adaptation of eukaryotes. In this study, OsABT, a stress response gene, was cloned from rice (Oryza sativa L. cv. Nipponbare). OsABT encodes a protein containing seven WD40 domains. Expression analysis revealed that the OsABT gene was first up-regulated and then down-regulated following treatment with abscisic acid (ABA) and NaCl, but was down-regulated when treated with PEG8000. Subcellular localization results showed that OsABT was located in the cytoplasm and nucleus of Arabidopsis roots. OsABT transgenic Arabidopsis showed significantly increased tolerance to ABA and salt stress during plant seedling development. However, the transgenic lines were more sensitive to drought stress. Moreover, OsABT can interact with OsABI2, a component of ABA signaling pathway. These results showed that OsABT plays a positive regulatory role in response to salt stress and a negative role in response to drought stress in Arabidopsis.

Published
2022
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354. A Cost-Effectiveness Analysis of Clopidogrel for Patients with Non-ST-Segment Elevation Acute Coronary Syndrome in China.

Author

Cui, Ming, Tu, Chen, Chen, Er, Wang, Xiao, Tan, Seng, Chen, Can, Tu, Chen Chen, Chen, Er Zhen, Wang, Xiao Li, and Tan, Seng Chuen

Subjects
ASPIRIN, COMBINATION drug therapy, COMPARATIVE studies, COST effectiveness, RESEARCH methodology, MEDICAL care costs, MEDICAL cooperation, PROBABILITY theory, RESEARCH, EVALUATION research, TICLOPIDINE, RANDOMIZED controlled trials, QUALITY-adjusted life years, PLATELET aggregation inhibitors, ACUTE coronary syndrome, ECONOMICS, DIAGNOSIS, THERAPEUTICS
Abstract

Introduction: There are a number of economic evaluation studies of clopidogrel for patients with non-ST-segment elevation acute coronary syndrome (NSTEACS) published from the perspective of multiple countries in recent years. However, relevant research is quite limited in China. We aimed to estimate the long-term cost effectiveness for up to 1-year treatment with clopidogrel plus acetylsalicylic acid (ASA) versus ASA alone for NSTEACS from the public payer perspective in China.Methods: This analysis used a Markov model to simulate a cohort of patients for quality-adjusted life years (QALYs) gained and incremental cost for lifetime horizon. Based on the primary event rates, adherence rate, and mortality derived from the CURE trial, hazard functions obtained from published literature were used to extrapolate the overall survival to lifetime horizon. Resource utilization, hospitalization, medication costs, and utility values were estimated from official reports, published literature, and analysis of the patient-level insurance data in China. To assess the impact of parameters' uncertainty on cost-effectiveness results, one-way sensitivity analyses were undertaken for key parameters, and probabilistic sensitivity analysis (PSA) was conducted using the Monte Carlo simulation.Results: The therapy of clopidogrel plus ASA is a cost-effective option in comparison with ASA alone for the treatment of NSTEACS in China, leading to 0.0548 life years (LYs) and 0.0518 QALYs gained per patient. From the public payer perspective in China, clopidogrel plus ASA is associated with an incremental cost of 43,340 China Yuan (CNY) per QALY gained and 41,030 CNY per LY gained (discounting at 3.5% per year). PSA results demonstrated that 88% of simulations were lower than the cost-effectiveness threshold of 150,721 CYN per QALY gained. Based on the one-way sensitivity analysis, results are most sensitive to price of clopidogrel, but remain well below this threshold.Conclusion: This analysis suggests that treatment with clopidogrel plus ASA for up to 1 year for patients with NSTEACS is cost effective in the local context of China from a public payers' perspective.Funding: Sanofi China. [ABSTRACT FROM AUTHOR]

Published
2016
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356. Prostate-derived ETS factor improves prognosis and represses proliferation and invasion in hepatocellular carcinoma

Author

Chen, Er-Bao, primary, Zhou, Shao-Lai, additional, Pang, Xu-Guang, additional, Yin, Dan, additional, Miao, Pei-Zhen, additional, Yang, Yi, additional, Chen, Qing, additional, Zhu, Kai, additional, Gao, Dong-Mei, additional, Liu, Tian-Shu, additional, Wang, Xiao-Yi, additional, Shi, Ying-Hong, additional, Wu, Wei-Zhong, additional, Zhou, Jian, additional, Zhou, Zheng-Jun, additional, and Dai, Zhi, additional

Published
2017
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367. Value of Kidney Disease Improving Global Outcomes Urine Output Criteria in Critically Ill Patients

Author

Qin, Jun-Ping, primary, Yu, Xiang-You, additional, Qian, Chuan-Yun, additional, Li, Shu-Sheng, additional, Qin, Tie-He, additional, Chen, Er-Zhen, additional, Lin, Jian-Dong, additional, Ai, Yu-Hang, additional, Wu, Da-Wei, additional, Liu, De-Xin, additional, Sun, Ren-Hua, additional, Hu, Zhen-Jie, additional, Cao, Xiang-Yuan, additional, Zhou, Fa-Chun, additional, He, Zhen-Yang, additional, Zhou, Li-Hua, additional, An, You-Zhong, additional, Kang, Yan, additional, Ma, Xiao-Chun, additional, Zhao, Ming-Yan, additional, Jiang, Li, additional, Xu, Yuan, additional, and Du, Bin, additional

Published
2016
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380. Comparison of hospital length of stay, costs, and readmissions of alteplase versus catheter replacement among patients with occluded central venous catheters

Author

Ernst, Frank R, Chen, Er, Lipkin, Craig, Tayama, Darren, and Amin, Alpesh N

Subjects
Adult, Male, Venous Thrombosis, Catheterization, Central Venous, Adolescent, Length of Stay, Middle Aged, Patient Readmission, Young Adult, Fibrinolytic Agents, Tissue Plasminogen Activator, Costs and Cost Analysis, North Carolina, Central Venous Catheters, Humans, Equipment Failure, Female, Hospital Costs, Device Removal, Original Research, Aged, Retrospective Studies
Abstract

Background Central venous catheter (CVC) occlusion is common, affecting 30% of all CVCs. Objective To compare length of stay (LOS), costs, and readmissions associated with the use of alteplase to clear catheter blockage to outcomes associated with catheter replacement. Design Retrospective observational study utilizing a large hospital database. Participants Hospitalized patients treated for catheter occlusion from January 2006 to December 2011. Main Measures Univariate analyses of patient characteristics and treatment patterns and multivariable regression analyses of postocclusion hospital costs, LOS, and 30- and 90-day readmissions were conducted. Key Results We included 34,579 patients treated for a CVC occlusion by replacement (N = 1028) or by alteplase (2 mg) administration (N = 33,551). Patients receiving alteplase were somewhat younger than those having catheter replacement (60 ± 19 vs 62 ± 20 years old, P = 0.0002). After adjusting for patient and hospital factors via regression modeling, average daily postocclusion costs were $317 lower for alteplase recipients than for catheter replacement patients (95% confidence interval [CI]: 238.22–392.24; P 0.05). Odds of readmission were not significantly different at 30 or 90 days. Conclusions Among patients treated for an occluded CVC, alteplase-treated patients had lower daily and total postocclusion costs than patients receiving catheter replacement. Cost differences were mainly driven by lower operating room/surgery, radiology, and supplier costs. Journal of Hospital Medicine 2014;9:490–496. © 2014 The Authors Journal of Hospital Medicine published by Wiley Periodicals, Inc. on behalf of Society of Hospital Medicine

Published
2014
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383. Genome-wide analysis of GRAS transcription factor gene family in Gossypium hirsutum L.

Author

Bin Zhang, Liu, J., Yang, Zhao E., Chen, Er Y., Zhang, Chao J., Zhang, Xue Y., and Li, Fu G.

Abstract

Background: Cotton is a major fiber and oil crop worldwide. Cotton production, however, is often threatened by abiotic environmental stresses. GRAS family proteins are among the most abundant transcription factors in plants and play important roles in regulating root and shoot development, which can improve plant resistance to abiotic stresses. However, few studies on the GRAS family have been conducted in cotton. Recently, the G. hirsutum genome sequences have been released, which provide us an opportunity to analyze the GRAS family in G. hirsutum. Results: In total, 150 GRAS proteins from G. hirsutum were identified. Phylogenetic analysis showed that these GRAS protins could be classified into 14 subfamilies including SCR, DLT, OS19, LAS, SCL4/7, OS4, OS43, DELLA, PAT1, SHR, HAM, SCL3, LISCL and G_GRAS. The gene structure and motif distribution analysis of the GRAS members in G. hirsutum revealed that many genes of the SHR subfamily have more than one intron, which maybe a kind of form in the evolution of plant by obtaining or losing introns. Chromosomal location and duplication analysis revealed that segment and tandem duplication maybe the reasons of the expension of the GRAS family in cotton. Gene expression analysis confirmed the expression level of GRAS members were up-regulated under different abiotic stresses, suggesting that their possible roles in response to stresses. What’s more, higher expression level in root, stem, leaf and pistil also indicated these genes may have effect on the development and breeding of cotton. Conclusions: This study firstly shows the comprehensive analysis of GRAS members in G. hirsutum. Our results provide important information about GRAS family and a framework for stress-resistant breeding in G. hirsutum. [ABSTRACT FROM AUTHOR]

Published
2018
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384. 密度泛函理论下的分子电负性——Ⅱ.基团电负性及基团中原子电荷分布的直接计算

Author

Chen Er-Zhong Yang Zhong-Zhi

Subjects
Building and Construction
Abstract

依据密度泛函理论和电负性均衡原理,由分子中原子有效电负性更为精密的表达式,提出和建立了计算基团电负性及基团中原子电荷分布的新方案,并给出了一些常见原子的电负性和硬度的各类价态参数。通过对100多个基团进行的计算、分析和比较,表明该方案的结果是合理的和可以推广应用的。

Published
1995
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385. Detection of antibodies to surface antigens ofAngiostrongylus cantonensisby ELISA

Author

Wang Lc, Chen Er, Chung Ly, Soi-Moi Chye, Jui-Hsien Chang, Chuan-Min Yen, and Wang Jj

Subjects
030231 tropical medicine, Antibodies, Helminth, Enzyme-Linked Immunosorbent Assay, 03 medical and health sciences, 0302 clinical medicine, Antigen, 030225 pediatrics, medicine, Animals, Humans, Rats, Wistar, Larva migrans, Strongylida Infections, biology, Angiostrongylus cantonensis, Elisa assay, medicine.disease, biology.organism_classification, Virology, Rats, Infectious Diseases, Antigens, Helminth, Antigens, Surface, biology.protein, Angiostrongyliasis, Parasitology, Antibody
Published
1995
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386. 密度泛函理论下的分子电负性——Ⅰ.由电负性均衡原理直接计算分子中的原子电荷

Author

Yang Zhong-Zhi Chen Er-Zhong

Subjects
Building and Construction
Abstract

以密度泛函理论表述的电负性及其均衡原理为基础,以组成原子电负性的调和平均为分子电负性参考取值,提出和设计了直接计算分子中原子电荷分布的新方案,避免了原算法中的多元回归和参数的多重选择,给出了分子环境下原子电负性和硬度的价态标度.本方案能更简便广泛的应用于大分子中原子电荷分布的计算,结果与ab initio STO-3G的结果符合相当好.

Published
1995
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387. High efficiency luminescent liquid crystal: aggregation-induced emission strategy and biaxially oriented mesomorphic structure

Author

Yuan, Wang Zhang, Yu, Zhen-Qiang, Lu, Ping, Deng, Chunmei, Lam, Jacky W. Y., Wang, Zhiming, Chen, Er-Qiang, Ma, Yuguang, and Tang, Ben Zhong

Abstract

Rational combination of aggregation-induced emission active luminogens and mesogens generates high solid-state efficiency luminescent liquid crystals, thus resolving the problem of aggregation-caused quenching normally occurs in the fabrication of luminescent mesomorphic films.

Published
2012

388. BI6727, a polo-like kinase 1 inhibitor with promising efficacy on Burkitt lymphoma cells

Author

Chen, Er and Pei, Renzhi

Abstract

Objective BI6727, an ATP-competitive PLK1 inhibitor, has been shown to cause cell death in multi-tumors. This study aimed to investigate the anti-tumor effect and potential molecular mechanism of BI6727 in human Burkitt lymphoma (BL) cell lines.Methods We assessed polo-like kinase 1 (PLK1) expression in BL patient tissues and cells, also investigated the cytotoxic effect using CCK8 assay and flow cytometry. In addition, western blotting and real-time polymerase chain reaction (RT-PCR) assays were used to explore the molecular mechanisms of BI6727 in human BL cell lines.Results PLK1 was overexpressed in BL cells compared with normal cells. The PLK1 inhibitor BI6727 reduced activated PLK1 expression and caused mitotic arrest in BL cells. Additionally, BI6727 suppressed cellular proliferation and induced apoptosis in BL cell lines. BI6727 treatment also decreased C-MYC protein and mRNA expression, blocked the PI3K/AKT/mTOR signaling pathway, and stabilized the FBXW7 protein.Conclusions Our findings explained a potential molecular mechanism of BI6727 in BL cells and suggested that BI6727 might be a new therapeutic agent for BL in the future.

Published
2024
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389. Monopole Charge Domain in High-Gain Gallium Arsenide Photoconductive Switches

Author

Li Qi, Shi Wei, Chen Er-Zhu, and Zhang Xian-Bin

Subjects
Physics, Field (physics), business.industry, Magnetic monopole, Phase (waves), General Physics and Astronomy, Charge (physics), Electron, Ray, Computational physics, Gallium arsenide, Impact ionization, chemistry.chemical_compound, Optics, chemistry, business
Abstract

Considering that semi-insulating gallium arsenide photoconductive switches can be triggered into the high gain mode and no reliable theories can account for the observed transient characteristics, we propose the monopole charge domain model to explain the peculiar switching phenomena occurring in the high gain mode and we discuss the requirements for the lock-on switching. During operation on this mode, the applied field across the switch and the lock-on field are all larger than the Gunn threshold field. Our developed monopole charge domain is based on the transferred-electron effect, but the domain is only composed of large numbers of electrons piled up due to the negative differential mobility. Using the model and taking the physical mechanism of the avalanche impact ionization and recombination radiation into consideration, we interpret the typical phenomena of the lock-on effect, such as the time delay between the beginning of optical illumination and turning-on of the switch, and the conduction mechanism of the sustaining phase. Under different conditions of bias field intensity and incident light energy, the time delay of the switching is calculated. The results show that the physical mechanisms of impact ionization and recombination radiation occurring in the monopole charge domain are responsible for the lock-on switching.

Published
2002
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397. 西南交通大学授予卞学鐄博士名誉教授仪式: 西南交通大学授予陈耳博士顾问教授仪式. Bicycle ride : 乐山to峨嵋.

Author

Pian, Theodore H. H. , 1919-2009, 陈耳., 西南交通大学(中國), Chen, Er., Xi nan jiao tong da xue (China), Pian, Theodore H. H. , 1919-2009, 陈耳., 西南交通大学(中國), Chen, Er., and Xi nan jiao tong da xue (China)

Abstract

1. 西南交通大学授予卞学鐄博士名誉教授仪式, 西南交通大学授予陈耳博士顾问教授仪式 -- 2. Bicycle ride : 乐山to峨嵋., Detailed contents in vernacular field only., Date and venue: June 14 '83, 西南交通大学 (content 1) ; 6/15/83, 四川省 (content 2)., Title from video content (content 1)., Live recording., Electronic reproduction from Rulan Chao Pian VHS collection., Spoken in Chinese., Date and venue: June 14 '83, Xi nan jiao tong da xue (content 1) ; 6/15/83, Sichuan Sheng (content 2).

Published
2015

399. Notice of Retraction: Numerical simulations of the interaction between the shock waves and moving interfaces

Author

Ma Dawei, Chen Er-yun, and Wang kai

Subjects
Physics::Fluid Dynamics, Shock wave, Physics, Level set method, Computer simulation, Position (vector), Bubble, Multiphase flow, Mechanics, Moving shock, Finite element method
Abstract

It is a crucial problem in the studies of the fluid on numerical simulations of the interfaces movement in multi-component fluids. Fluid dynamic characteristics are studied during shock waves pass helium bubble in this paper. These methods are used including high resolution discontinuous finite method for Fluid dynamic equations, Level set method for capturing moving interfaces and ghost fluid method with Isobaric fix for disposing the interfaces, which obtains profiles of the helium bubble, density contours and the curves of density and pressure with center axial direction. It is in good agreement for the general bubble shape and position compared with those in other numerical schemes.

Published
2010
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400. Patient-Centered Decision Support in Acute Ischemic Stroke

Author

Decker, Carole, primary, Chhatriwalla, Emily, additional, Gialde, Elizabeth, additional, Garavalia, Brian, additional, Summers, Debbie, additional, Quinlan, Miriam E., additional, Cheng, Eric, additional, Rymer, Marilyn, additional, Saver, Jeffrey L., additional, Chen, Er, additional, Kent, David M., additional, and Spertus, John A., additional

Published
2015
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