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John Wayne Cancer Institute, Santa Monica, California, researchers have uncovered a piece of the cancer puzzle that helps explain how tumors are able to resist chemotherapy. The result of this [...]

In two separate studies, a team of Japanese scientists investigated the links between expression of specific oncogenes and patients' responses to chemotherapy. The findings of both studies were published in [...]

According to the authors' abstract of an article published in Cancer Letters, 'Utilizing a microplate ATP bioluminescence assay, two human breast carcinoma cell lines, MCF-7 and MDA-MB-231, were tested against [...]

According to an abstract submitted by the author to the New York Academy of Sciences conference Bone Marrow Transplantation in the 90's: Into the 21st Century, held March 15-18, 1995, [...]

According to an abstract presented by the authors to Southern or Western Regional meetings of the American Federation for Clinical Research, held February 2-4, 1995, and February 8-11, 1995, in [...]

CellPro Inc., Bothell, Washington, announced that the company's Ceprate SC Stem Cell Selection System is being used to purify CD34 antigen-expressing stem and blood progenitor cells from the bone marrow [...]

Research suggests that patient age affects the contribution of the thymus to the regeneration of CD4(+) T-lymphocytes. Crystal L. Mackall et al., from the U.S. National Institutes of Health, suggest [...]

Chronic Lymphatic Leukemia High expression of P-glycoprotein (P-gp) is only partially responsible for defective drug accumulation in chronic lymphatic leukemia of the B-cell type (B-CLL), according to a report from [...]

AUTHORS: D. Crowther. Christie Hospital, Manchester, England. According to the author's abstract of an oral presentation to the 32nd annual meeting of the British Association for Cancer Research, held in [...]

SOURCE: Cancer Research, September 15, 1990; 50:5720-5726. Cyclophosphamide treatment appears to be able to modulate hepatic P-450 activities through multiple mechanisms and in a manner than may alter P-450 metabolism [...]

University of California Illudin S, a derivative of the mushroom Omphalotus illudens, appears to have highly specific toxicity for several types of cancer cells that possess an energy-dependent transport mechanism, [...]

Researchers at Ligand Pharmaceuticals and SmithKline Beecham have discovered the first non-peptide small molecule that mimics the biological activity of Granulocyte-Colony Stimulating Factor (G-CSF). The discovery could lead to an [...]

Guo, Y.S.; Jin, G.F.; Houston, C.W.; Thompson, J.C.; Townsend, C.M. 'Insulin-like Growth Factor-I Promotes Multidrug Resistance in MCLM Colon Cancer Cells.' Journal of Cellular Physiology, May 1998;175(2):141-148. According to the [...]

Drugs that successfully carve away at cancers of the lung, brain, breast, and other organs could be acting as double-edged swords, according to a new study by Massachusetts General Hospital [...]

Zhang, W.; Law, R.E.; hinton, D.R.; Couldwell, W.T. 'Inhibition of Human Malignant Glioma Cell Motility and Invasion in vitro by Hypericin, a Potent Protein Kinase C Inhibitor.' Cancer Letters, November [...]

Nagpal, S.; Cai, J.; Zheng, T.; Patel, S.; Masood, R.; Lin, G.Y.; Friant, S.; Johnson, A.; Smith, D.L.; Chandraratna, R.A.S.; Gill, P.S. 'Retinoid Antagonism of NF-IL6: Insight into the Mechanism [...]

Tsuruta, T.; Muraishi, O.; Katsuyama, Y.; Murata, Y.; Ichino, M.; Ogawa, A. 'Liposome Encapsulated Doxorubicin Transfer to the Pelvic Lymph Nodes by Endoscopic Administration into the Bladder Wall: A Preliminary [...]

Zlotta, A.R.; Drowart, A.; Vanvooren, J.P.; Decock, M.; Pirson, M.; Palfliet, K.; Jurion, F.; Vanonckelen, A.; Simon, J.; Schulman, C.C.; Huygen, K. 'Evolution and Clinical Significance of the T Cell [...]

Short-Term Changes In Plasma HIV RNA Following Chemotherapy for Lymphoma.' D.R. Churchill, S.A. Galpin, J. Harvey and J.N. Weber. Imperial College School of Medicine at St. Mary's, London, United Kingdom. [...]

Therapy Raymond, E.; Haon, C.; Boaziz, C.; Coste, M. 'Logistic Regression Model of Fotemustine Toxicity Combining Independent Phase II Studies.' Cancer, November 1, 1996;78(9):1980-1987. According to the authors' abstract of [...]

According to the authors' abstract of an article published in International Journal of Oncology, 'The role of bcl-2 in protection against apoptosis is well established in a great variety of [...]

According to the authors' abstract of an article published in Cancer Research, 'The goal of this study was to demonstrate that glutathione S-transferase (GST)-pi is directly involved in the intrinsic [...]

According to an abstract submitted by the authors to the 37th Annual Meeting of the American Society of Hematology, held December 1-5, 1995, in Seattle, Washington, 'Thirteen cases of AML [...]

U.S. BIOSCIENCE ACQUIRES RIGHTS TO COMPOUND THAT REDUCES SIDE EFFECTS OF CANCER DRUGS BLUE BELL, Pa., Oct. 22 /PRNewswire/ -- U.S. Bioscience, a subsidiary of U.S. Healthcare Inc. (NASDAQ: USHC), [...]

Dr. Grant MacLean, Medical Oncologist and principal investigator for Biomira's clinical study at the Cross Cancer Institute in Edmonton, Alberta, Canada, presented results of Biomira's Phase II clinical trials of [...]

According to the authors' abstract of an article published in International Journal of Cancer, 'Local administration of high-dose r-TNF alpha with IFN gamma in the limbs of melanoma patients has [...]

According to the authors' abstract of an article published in Anti - Cancer Drugs, 'There is increasing attention directed to the hypothesis that apoptosis plays a role in the response [...]

According to the authors' abstract of an article published in Cancer Chemotherapy and Pharmacology, 'A previous study has shown that lipophilic prodrugs can be delivered efficiently to normal lung endothelium [...]

According to the authors' abstract of an article published in Cancer Research, 'The efficacy of tamoxifen and ovariectomy in the management of breast cancer is limited by the resistance of [...]

SOURCE: Trends in Biotechnology, December 1993;11(12):511-516. According to the authors' abstract of an article published in Trends in Biotechnology, 'Tumour cells can be resistant to a variety of chemotherapeutic drugs [...]

AUTHORS: J.A. Tavek and R.T. Chlebowski. UCLA Medical Center, Torrance, California. According to the abstract of a poster presentation to the meeting of the Western Society for Clinical Investigation, held [...]

AUTHORS: O.A. Oredipe, S.L. White, B.L. Gause and K. Olden. Howard University Cancer Center, Washington, D.C. According to the authors' abstract of a poster presentation to the 83rd annual meeting [...]

AUTHORS: F.J. Adshead, J.L. Millar, B.C. Millar, D.C. Talbot, M.B. Matson, C.J.M. Davies and I.E. Smith. Institute of Cancer Research and Royal Marsden Hospital, Sutton, Surrey, England According to the [...]

SOURCE: International Journal of Cancer, November, 1990; 46: 808-812. Chromosomal aberrations related to treatment with the chemotherapeutic agent etoposide are not random, but instead appear to be specific mutagenesis occurring [...]

AUTHORS: J. Gerain, D. Heumann, T. Calandra, J.D. Baumgartner and M.P. Glausser. CHUV, Lausanne, Switzerland. According to the authors' abstract of a presentation to the 30th Interscience Conference on Antimicrobial [...]

University of Wisconsin Previous studies have shown that L1210/0 cells incubated with cisplatin are arrested in the G2 phase of the cell cycle, then either die or resume the cycle. [...]