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The penetration level of renewable generation has increased significantly in recent years, which has led to operational concerns associated with the system ramping capability. Here, we propose the flexible ramping capacity (FRC) model, which considers the practical ramping capability of generation resources as well as the uncertainty in net load. The FRC model also incorporates the demand curve of the ramping capacity, which represents the hourly economic value of the ramping capacity. The model is formulated mathematically using ramp constraints, which are incorporated into unit commitment (UC) and economic dispatch (ED) processes. Simulations are carried out using a 10-unit system to compare the FRC model with conventional methods. We show that the FRC method can improve reliability and reduce expected operating costs. The simulation results also show that, by using the FRC model, system reliability can be satisfied at high wind power generation levels while achieving economic efficiency.

To conduct a systematic review and meta‐analysis of longitudinal studies assessing the bi‐directional association between depression and diabetes macrovascular and microvascular complications. Embase, Medline and PsycINFO databases were searched from inception through 27 November 2017. A total of 4592 abstracts were screened for eligibility. Meta‐analyses used multilevel random/mixed‐effects models. Quality was assessed using the Newcastle‐Ottawa scale. Twenty‐two studies were included in the systematic review. Sixteen studies examined the relationship between baseline depression and incident diabetes complications, of which nine studies involving over one million participants were suitable for meta‐analysis. Depression was associated with an increased risk of incident macrovascular (HR = 1.38; 95% CI: 1.30–1.47) and microvascular disease (HR = 1.33; 95% CI: 1.25–1.41). Six studies examined the association between baseline diabetes complications and subsequent depression, of which two studies involving over 230 000 participants were suitable for meta‐analysis. The results showed that diabetes complications increased the risk of incident depressive disorder (HR = 1.14; 95% CI: 1.07–1.21). The quality analysis showed increased risk of bias notably in the representativeness of selected cohorts and ascertainment of exposure and outcome. Depression in people with diabetes is associated with an increased risk of incident macrovascular and microvascular complications. The relationship between depression and diabetes complications appears bi‐directional. However, the risk of developing diabetes complications in depressed people is higher than the risk of developing depression in people with diabetes complications. The underlying mechanisms warrant further research. What's new?: Numerous studies have examined the longitudinal relationship between depression and diabetes complications but comprehensive evidence about the magnitude and direction is unavailable.The current study shows that the relationship between depression and diabetes complications appears bi‐directional with depression being associated with an increased risk of developing incident macrovascular and microvascular complications, and diabetes complications increasing the risk of subsequent depression.The increase in risk of developing diabetes complications in depressed people (by 38 and 33% for macrovascular and microvascular complications, respectively) is higher than the increase in risk of developing depression (by 9 and 24% for macrovascular and microvascular complications, respectively) in people with diabetes complications. [ABSTRACT FROM AUTHOR]

An abstract of the article "Comparison of the fetal fibronectin (Rapid fFN) and placental alpha microglobulin-1 (PartoSure) tests for predicting imminent spontaneous preterm birth," by C. Van Holsbeke and colleagues is presented.

Social interactions affect physiological and pathological processes, yet their direct impact in peripheral tissues remains elusive. Recently we showed that disruption of pair bonds in monogamous Peromyscus californicus promotes lung tumorigenesis, pointing to a direct effect of bonding status in the periphery (Naderi et al., 2021). Here we show that lung transcriptomes of tumor-free Peromyscus are altered in a manner that depends on pair bonding and superseding the impact of genetic relevance between siblings. Pathways affected involve response to hypoxia and heart development. These effects are consistent with the profile of the serum proteome of bonded and bond-disrupted Peromyscus and were extended to lung cancer cells cultured in vitro, with sera from animals that differ in bonding experiences. In this setting, the species' origin of serum (deer mouse vs FBS) is the most potent discriminator of RNA expression profiles, followed by bonding status. By analyzing the transcriptomes of lung cancer cells exposed to deer mouse sera, an expression signature was developed that discriminates cells according to the history of social interactions and possesses prognostic significance when applied to primary human lung cancers. The results suggest that present and past social experiences modulate the expression profile of peripheral tissues such as the lungs, in a manner that impacts physiological processes and may affect disease outcomes. Furthermore, they show that besides the direct effects of the hormones that regulate bonding behavior, physiological changes influencing oxygen metabolism may contribute to the adverse effects of bond disruption. [ABSTRACT FROM AUTHOR]