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Fresh data on proinsulin are presented in the report 'Insulin analogues and cancer risk: cause for concern or cause celebre.' According to a study from Montreal, Canada, 'People with diabetes, [...]

Research findings, 'Pharmacological properties of thalidomide and its analogues,' are discussed in a new report. 'Thalidomide and its immunomodulatory imide drugs (IMiDs) analogues CC-5013 (Revlimid, Lenalidomide) and CC-4047 (Actimid, Pomalidomide) [...]

New investigation results, 'In vitro studies of the activity of newly sinthesized nociceptin / orphanin FQ receptor ligand analogues,' are detailed in a study published in Protein and Peptide Letters. [...]

According to a study from Singapore, Singapore, 'There is evidence to indicate that the Asp residue in the third transmembrane helix (TMH) of opioid receptors forms a salt bridge with [...]

'Electrically conductive paper was prepared via in-situ chemical oxidative polymerization of pyrrole by using ferric chloride as an oxidant and p-toluenesulfonic acid (PTSA) as a dopant. The deposition of polypyrrole [...]

According to a study from Adelaide, Australia, '1. Butyrate is a well known product of starch fermentation by colonic bacteria and is of interest owing to its ability to induce [...]

Researchers detail in 'Chemoenzymatic synthesis of Amaryllidaceae constituents and biological evaluation of their C-1 analogues. The next generation synthesis of 7-deoxypancratistatin and trans-dihydrolycoricidine,' new data in organic chemicals. According to [...]

Fresh data on epithelial cells are presented in the report 'Do GnRH analogues directly affect human endometrial epithelial cell gene expression.' 'We examined whether Gonadotrophin-releasing hormone (GnRH) analogues [leuprolide acetate [...]

A report, 'Structural requirements of penetratin absorption enhancement efficiency for insulin delivery,' is newly published data in Journal of Controlled Release. According to recent research published in the Journal of [...]

A report, 'Kidney protection during peptide receptor radionuclide therapy with somatostatin analogues,' is newly published data in European Journal of Nuclear Medicine and Molecular Imaging. 'This review focuses on the [...]

Research findings, 'Assessment of peripheral blood and bone marrow cells apoptosis caused by purine analogues in patients with chronic lymphocytic leukemia in correlation with parameters of disease progression,' are discussed [...]

'In this study fragment-based drug design is combined with molecular docking simulation technique, to design databases of virtual sialic acid (SA) analogues with new substitutions at C2, C5 and C6 [...]

A new study, 'Structure-activity relationship of (N)-Methanocarba phosphonate analogues of 5'-AMP as cardioprotective agents acting through a cardiac P2X receptor,' is now available. 'P2X receptor activation protects in heart failure [...]

Investigators publish new data in the report 'Antiproliferative activity of purine nucleoside phosphorylase multisubstrate analogue inhibitors containing difluoromethylene phosphonic acid against leukaemia and lymphoma cells.' 'Potent inhibitors of purine nucleoside [...]

Investigators publish new data in the report 'Four generations of transition-state analogues for human purine nucleoside phosphorylase.' According to a study from the United States, 'Inhibition of human purine nucleoside [...]

Fresh data on piperazine therapy are presented in the report 'Quantification of piperazine phosphate in human plasma by high-performance liquid chromatography-electrospray ionization tandem mass spectrometry employing precolumn derivatization with dansyl [...]

Current study results from the report, 'Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for smoking cessation,' have been published. According to recent research from the United States, [...]

A report, 'Tautomerism and isotopic multiplets in the 13C NMR spectra of partially deuterated 3-arylpyrimido[4,5-c]pyridazine-5,7(6H,8H)-diones and their sulfur analogs--evidence for elucidation of the structure backbone and tautomeric forms,' is newly [...]

New investigation results, 'Structure-function relationships of epoxide hydrolases and their potential use in biocatalysis,' are detailed in a study published in Biochimica Et Biophysica Acta. 'Chiral epoxides and diols are [...]

'Tc-99m-BnAO is one of the nonnitroimidazole hypoxia markers with the highest citation and could be potentially useful in both oncology and other clinical applications. However, it appears inferior in vitro [...]

'The occurrence of furan in some food products has already been known for a few decades, and it has been reconfirmed in more recent investigations that furan is present in [...]

Fresh data on phenazine are presented in the report 'The Pseudomonas aeruginosa oxidative stress regulator OxyR influences production of pyocyanin and rhamnolipids: protective role of pyocyanin.' 'The LysR-type transcriptional regulator [...]

Data detailed in 'RNA looping by PTB: Evidence using FRET and NMR spectroscopy for a role in splicing repression' have been presented. 'Alternative splicing plays an important role in generating [...]

Current study results from the report, 'Synthesis and anti-hepatitis C virus activity of 2'(beta)-hydroxyethyl and 4'(alpha)-hydroxymethyl carbodine analogues,' have been published. According to a study from Korea, '2'(beta)-Hydroxyethylated adenosine is [...]

Data detailed in 'Synthesis and in vitro activity evaluation of 2',3'-C-dimethyl carbocyclic nucleoside analogues as potential anti-HCV agents' have been presented. 'The first synthetic route of novel 2'(beta),3'(beta)-C-dimethyl carbodine analogues [...]

Investigators publish new data in the report 'Synthesis and anti-HCV evaluation of 4'(alpha)-ethyl and 2'(beta)-methyl-carbodine analogues.' According to a study from Korea, 'Novel 4'(alpha)-ethyl-2'(beta)-methyl carbocyclic nucleoside analogues have been prepared [...]

'Curcumin (diferuloylmethane) is an orange-yellow compound from turmeric (Curcuma longa), a spice found in curry powder. Traditionally known for its anti-inflammatory effects, curcumin has established itself in the last two [...]

Research findings, 'CD154 expression triggered by purine analogues in vitro: Correlation with treatment response and autoimmune events in chronic lymphocytic leukemia,' are discussed in a new report. According to recent [...]

New research, 'Conformational analyses and MO studies of f152A1 and its analogues as potent protein kinase inhibitors,' is the subject of a report. 'f152A1 was isolated from a fermentation broth [...]

Scientists discuss in 'Synthesis of tropolone derivatives and evaluation of their in vitro neuroprotective activity' new findings in life sciences. 'beta-Thujaplicin (hinokitiol or 2-hydroxy-4-isopropyl-2,4,6-cycloheptatrien-1-one), a natural tropolone, shows numerous activities [...]

A report, '[Ru(bpy)2dppz]2+ electrochemiluminescence switch and its applications for DNA interaction study and label-free ATP aptasensor,' is newly published data in Analytical Chemistry. According to recent research from Changchun, People's [...]

Investigators publish new data in the report 'Oxovanadium(IV) complexes of phenanthroline bases: the dipyridophenazine complex as a near-IR photocytotoxic agent.' 'Oxovanadium(iv) complexes [VOCl(B)(2)]Cl (1-3) of phenanthroline bases (B), viz. 1,10-phenanthroline [...]

New investigation results, 'Preliminary studies of 99mTc-BnAO and its analogues: synthesis, radiolabeling and in vitro cell uptake,' are detailed in a study published in Nuclear Medicine and Biology. '(99m)Tc-BnAO is [...]

New research, 'Inhibition of monoamine oxidase by 8-benzyloxycaffeine analogues,' is the subject of a report. 'Based on recent reports that several (E)-8-styrylcaffeinyl analogues are potent reversible inhibitors of monoamine oxidase [...]

Fresh data on chymotrypsin are presented in the report 'Selection of peptomeric inhibitors of bovine alpha-chymotrypsin and cathepsin G based on trypsin inhibitor SFTI-1 using a combinatorial chemistry approach.' According [...]

According to a study from Montreal, Canada, 'In an effort to improve the bioavailability of the non-selective, cyclic enkephalin analogues H-Dmt-c[d-Cys-Gly-Phe-d(or L)-Cys]NH2 (Dmt = 2',6'-dimethyltyrosine), analogues N-methylated at the Phe4 [...]

New research, 'Matrix metalloproteinase 2 inhibition: combined quantum mechanics and molecular mechanics studies of the inhibition mechanism of (4-phenoxyphenylsulfonyl)methylthiirane and its oxirane analogue,' is the subject of a report. 'The [...]

Investigators publish new data in the report 'Design and preliminary structure-activity relationship of redox-silent semisynthetic tocotrienol analogues as inhibitors for breast cancer proliferation and invasion.' 'Vitamin E (VE) is a [...]

Investigators publish new data in the report 'Molecular modeling study of 4-phenylpiperazine and 4-phenyl-1,2,3,6-tetrahydropyridine derivatives: a new step towards the design of high-affinity 5-HT1A ligands.' According to a study from [...]

Fresh data on life sciences are presented in the report 'Substitution-controlled ultrafast excited-state processes in Ru-dppz-derivatives.' According to recent research from Jena, Germany, "Ru-dppz (dppz=dipyrido[3,2-a:2',3,3'-c]phenazine) complexes play an important role [...]

Current study results from the report, 'Study on steady-state kinetics of nucleotide analogues incorporation by non-gel CE,' have been published. 'A method for studying steady-state kinetics of nucleotide analogues incorporation [...]

A new study, 'Facile and rapid access to linear and truncated microcystin analogues for the implementation of immunoassays,' is now available. According to a study from Mont-Saint-Aignan, France, "A series [...]

A report, 'Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1A partial agonists,' is newly published data in Bioorganic & Medicinal [...]

Fresh data on carcinoid tumor are presented in the report 'Review article: somatostatin analogues in the treatment of gastroenteropancreatic neuroendocrine (carcinoid) tumours.' 'The discovery of somatostatin (SST) and the synthesis [...]

According to a study from Bari, Italy, 'sigma(2)-Agonist 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (7, PB 28), which proved to revert doxorubicin resistance in breast cancer cells, was taken as a template to prepare new [...]

Current study results from the report, 'Anticancer activity of heteroleptic diimine complexes of dirhodium: a study of intercalating properties, hydrophobicity and in cellulo activity,' have been published. 'The series of [...]

According to a study from Naples, Italy, 'A series of 4-substituted piperazine derivatives bearing a norbornene nucleus have been prepared and their affinity for serotonin 5-HT1A, 5-HT2A and 5-HT2C receptors [...]

According to a study from Budapest, Hungary, "Despite the clinical outcomes of ovarian stimulation with either GnRH-agonist or GnRH-antagonist analogues for in vitro fertilization (IVF) being well analysed, the effect [...]

'The inhibition mechanism of matrix metalloproteinase 2 (MMP2) by the selective inhibitor (4-phenoxyphenylsulfonyl)methylthiirane (SB-3CT) and its oxirane analogue is investigated computationally. The inhibition mechanism involves C-H deprotonation with concomitant opening [...]

"This report describes the synthesis of analogues of 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2naphthyl)ethynyl]benzoic acid(1),commonly known as bexarotene, and their analysis in acting as retinoid X receptor (RXR)-specific agonists. Compound 1 has FDA approval to [...]