362 results on '"Huc, P."'
Search Results
352. Epilepsy in Cambodia-treatment aspects and policy implications: a population-based representative survey.
- Author
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Bhalla D, Chea K, Hun C, Chan V, Huc P, Chan S, Sebbag R, Gérard D, Dumas M, Oum S, Druet-Cabanac M, and Preux PM
- Subjects
- Adolescent, Adult, Anticonvulsants economics, Anticonvulsants therapeutic use, Cambodia epidemiology, Child, Community Health Centers, Epilepsy economics, Epilepsy mortality, Female, Follow-Up Studies, Health Care Costs, Health Policy, Health Services Accessibility organization & administration, House Calls, Humans, Male, Medication Adherence, Patient Satisfaction, Prognosis, Seizures, Surveys and Questionnaires, Treatment Outcome, Workforce, Young Adult, Epilepsy epidemiology, Epilepsy therapy
- Abstract
Introduction: We tested two treatment strategies to determine: treatment (a) prognosis (seizure frequency, mortality, suicide, and complications), (b) safety and adherence of treatment, (c) self-reported satisfaction with treatment and self-reported productivity, and policy aspects (a) number of required tablets for universal treatment (NRT), (b) cost of management, (c) manpower-gap and requirements for scaling-up of epilepsy care., Methods: We performed a random-cluster survey (N = 16510) and identified 96 cases (≥1 year of age) in 24 villages. They were screened by using a validated instrument and diagnosed by the neurologists. International guidelines were used for defining and classifying epilepsy. All were given phenobarbital or valproate (cost-free) in two manners patient's door-steps (March 2009-March 2010, primary-treatment-period, PTP) and treatment through health-centers (March 2010-June 2011, treatment-continuation-period, TCP). The emphasis was to start on a minimum dosage and regime, without any polytherapy, according to the age of the recipients. No titration was done. Seizure-frequency was monthly and self-reported., Results: The number of seizures reduced from 12.6 (pre-treatment) to 1.2 (end of PTP), following which there was an increase to 3.4 (end of TCP). Between start of PTP and end of TCP, >60.0% became and remained seizure-free. During TCP, ∼26.0% went to health centers to collect their treatment. Complications reduced from 12.5% to 4.2% between start and end of PTP and increased to 17.2% between start and end of TCP. Adverse events reduced from 46.8% to 16.6% between start and end of PTP. Nearly 33 million phenobarbital 100 mg tablets are needed in Cambodia., Conclusions: Epilepsy responded sufficiently well to the conventional treatment, even when taken at a minimal dosage and a simple daily regimen, without any polytherapy. This is yet another confirmation that it is possible to substantially reduce direct burden of epilepsy through means that are currently available to us.
- Published
- 2013
- Full Text
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353. Comprehensive evaluation of the psychosocial parameters of epilepsy: a representative population-based study in Prey Veng (Cambodia).
- Author
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Bhalla D, Chea K, Chamroeun H, Vichea C, Huc P, Samleng C, Sebbag R, Gérard D, Dumas M, Oum S, Druet-Cabanac M, and Preux PM
- Subjects
- Adolescent, Adult, Aged, Cambodia epidemiology, Child, Child, Preschool, Cohort Studies, Community Health Planning, Epilepsy complications, Fear psychology, Female, Humans, Male, Middle Aged, Reproducibility of Results, Social Support, Stereotyping, Stress, Psychological, Surveys and Questionnaires, Young Adult, Adaptation, Psychological, Epilepsy epidemiology, Epilepsy psychology, Health Knowledge, Attitudes, Practice, Quality of Life psychology, Self Concept
- Abstract
Purpose: We conducted a population-based study of epilepsy in Prey Veng (Cambodia) to explore self-esteem, fear, discrimination, knowledge-attitude-practice (KAP), social-support, stigma, coping strategies, seizure-provoking factors, and patient-derived factors associated with quality of life (QOL)., Methods: The results are based on a cohort of 96 cases and matched controls (n = 192), randomly selected from the same source population. Various questionnaires were developed and validated for internal consistency (by split-half, Spearman-Brown prophecy, Kuder-Richardson 20), content clarity and soundness. Summary, descriptive statistics, classical tests of hypothesis were conducted. Uncorrected chi-square was used. Group comparison was done to determine statistically significant factors, for each domain, by conducting logistic regression; 95% confidence interval (CI) with 5% (two-sided) statistical significance was used., Key Findings: All questionnaires had high internal consistency. Stress was relevant in 14.0% cases, concealment in 6.2%, denial in 8.3%, negative feelings in public in 3.0%. Mean self-esteem was 7.5, range 0-8, related to seizure frequency. Mean discrimination was least during social interactions. Coping strategies were positive (e.g. look for treatment). Postictal headache, anger, no nearby health facility, etc. were associated with QOL., Significance: The reliability of our questionnaires was high. A positive social environment was noted with many infrequent social and personal prejudices. Not all populations should (by default) be considered as stigmatized or equipped with poor KAP. We addressed themes that have been incompletely evaluated, and our approach could therefore become a model for other projects., (Wiley Periodicals, Inc. © 2013 International League Against Epilepsy.)
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- 2013
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- View/download PDF
354. Population-based study of epilepsy in Cambodia associated factors, measures of impact, stigma, quality of life, knowledge-attitude-practice, and treatment gap.
- Author
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Bhalla D, Chea K, Hun C, Vannareth M, Huc P, Chan S, Sebbag R, Gérard D, Dumas M, Oum S, Druet-Cabanac M, and Preux PM
- Subjects
- Cambodia epidemiology, Epilepsy physiopathology, Epilepsy psychology, Epilepsy therapy, Female, Humans, Male, Surveys and Questionnaires, Epilepsy epidemiology, Health Knowledge, Attitudes, Practice, Quality of Life, Stereotyping
- Abstract
Purpose: Identify epilepsy-associated factors and calculate measures of impact, stigma, quality of life (QOL), knowledge-attitude-practice (KAP) and treatment gap in Prey Veng, Cambodia., Methods: This first Cambodian population-based case-control study had 96 epileptologist-confirmed epilepsy cases and 192 randomly selected matched healthy controls. Standard questionnaires, which have been used in similar settings, were used for collecting data on various parameters. Univariate and multivariate regression was done to determine odds ratios. Jacoby stigma, 31-item QOL, KAP etc were determined and so were the factors associated with them using STATA software. Treatment gap was measured using direct method., Key Findings: Multivariate analyses yielded family history of epilepsy, difficult or long delivery, other problems beside seizures (mainly mental retardation, hyperthermia), and eventful pregnancy of the subject's mother as factors associated with epilepsy. There was high frequency of seizure precipitants esp. those related to sleep. Population attributable risk (%) was: family history (15.0), eventful pregnancy of subject's mother (14.5), long/difficult birth (6.5), and other problem beside seizures (20.0). Mean stigma (1.9±1.1, on a scale of 3) was mainly related to treatment efficacy. Mean QOL (5.0±1.4 on a scale of 10) was mainly related to treatment regularity. Cause or risk factor could be determined in 56% of cases. Treatment gap was 65.8%., Significance: Factors in pre- and perinatal period were found to be most crucial for epilepsy risk in Cambodia which inturn provides major prevention opportunities. A global action plan for treatment, stigma reduction and improvement of QOL should be set-up in this country.
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- 2012
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355. First-ever, door-to-door cross-sectional representative study in Prey Veng province (Cambodia).
- Author
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Preux PM, Chea K, Chamroeun H, Bhalla D, Vannareth M, Huc P, Samleng C, Cayreyre M, Gérard D, Dumas M, and Oum S
- Subjects
- Adolescent, Adult, Age Distribution, Age of Onset, Aged, Cambodia epidemiology, Child, Cross-Sectional Studies methods, Cross-Sectional Studies statistics & numerical data, Data Collection, Epilepsy diagnosis, Female, Health Surveys methods, Humans, Male, Mass Screening methods, Middle Aged, Prevalence, Epilepsy epidemiology, Surveys and Questionnaires
- Abstract
Purpose: To estimate the lifetime prevalence of epilepsy in Prey Veng province (Cambodia)., Methods: Door-to-door screening was performed using a random cluster survey whereby all people >1 year of age were screened for epilepsy by using a validated and standardized questionnaire for epilepsy in tropical countries. Suspected epilepsy patients identified by the questionnaire were revisited and examined by epileptologists. The confirmation of epilepsy was based on an in-depth clinical examination. Electroencephalograms were recorded at the community dispensary., Key Findings: Five hundred three potential epilepsy cases were identified from 16,510 screened subjects, and 96 were diagnosed to have epilepsy. An overall prevalence of 5.8 per 1,000 [95% confidence interval (CI) 4.6-7.0 per 1,000] was obtained. Generalized epilepsy (76%) was more common than partial epilepsy (12.5%). Three cases were of generalized myoclonic epilepsy (3.1%) and one case each (1.0%) were of absence and olfactory partial epilepsy. Six cases (5.2%) had more than one seizure type [one case with absence + generalized tonic-clonic (GTC), one case each with GTC + partial seizures with secondary generalization and absence + generalized myoclonic seizures and absence + simple partial seizures, and two cases with GTC + complex partial seizures]. Electroencephalography (EEG) studies revealed spike and wave discharges in 43.8%, focal spikes in 21.0%, generalized slow waves in 19.2%, and generalized slowing of background in 15.7%., Significance: This is the first population-based study in Cambodia that had epilepsy as a primary objective, and compared to Western and neighboring countries it shows a lower prevalence., (Wiley Periodicals, Inc. © 2011 International League Against Epilepsy.)
- Published
- 2011
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356. [Use of HIV rapid tests in free and anonymous screening consultations in the French West Indies].
- Author
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Cabié A, Bissuel F, Abel S, Huc P, Paturel L, and Pierre-François S
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- False Negative Reactions, False Positive Reactions, HIV Infections prevention & control, HIV-1 isolation & purification, HIV-2 isolation & purification, Hospitals, University, Humans, Infectious Disease Transmission, Vertical prevention & control, Martinique, Mass Screening methods, Mass Screening statistics & numerical data, Predictive Value of Tests, Prospective Studies, Risk Factors, Substance Abuse, Intravenous, Time Factors, Anonymous Testing methods, HIV Infections diagnosis
- Abstract
Objective: Late screening for HIV is frequent in people living in the French West Indies. Rapid tests (RT) create new opportunities to improve screening for HIV. We evaluated the feasibility and acceptability of RT among users of free and anonymous screening consultations in Fort-de-France and Saint-Martin., Methods: After confirming its reliability on more than 20,000 samples, a RT (Determine HIV-1+2 was offered on site to all testers in addition to the classic tests., Results: From October 2007 to May 2008, 373 RT were performed, four were confirmed positive. Results of RT were returned to 99.4% of testers versus 89.4% of persons who underwent additional classic tests. The rate for unclaimed classic tests results was higher for the latter than for persons who had only RT: 22.2% versus 10.6%., Conclusions: Results show that RT improves the proportion of people who are informed of their results. Nevertheless, efforts must be made to persuade patients to come back for results of the standard tests to be informed of a potential sexually transmitted infection or an acute HIV infection.
- Published
- 2009
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357. The challenge of epilepsy control in deprived settings: low compliance and high fatality rates during a community-based phenobarbital program in rural Laos.
- Author
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Tran DS, Zen J, Strobel M, Odermatt P, Preux PM, Huc P, Delneuville L, and Barennes H
- Subjects
- Adult, Community Mental Health Services economics, Community Mental Health Services statistics & numerical data, Epilepsy, Generalized epidemiology, Epilepsy, Generalized mortality, Female, Follow-Up Studies, Health Care Costs, Humans, Laos epidemiology, Male, Medically Underserved Area, Mortality, Patient Compliance, Patient Dropouts, Prevalence, Treatment Outcome, Anticonvulsants therapeutic use, Community Mental Health Services methods, Epilepsy, Generalized drug therapy, Phenobarbital therapeutic use
- Published
- 2008
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358. Risk factors for epilepsy in rural Lao PDR: a case-control study.
- Author
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Tran DS, Odermatt P, Le Oanh T, Huc P, Phoumindr N, Ito A, Druet-Cabanac M, Preux PM, and Strobel M
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- Adolescent, Adult, Case-Control Studies, Cysticercosis blood, Epilepsy epidemiology, Female, Humans, Laos epidemiology, Male, Risk Factors, Epilepsy etiology, Rural Population
- Abstract
The objective of this study was to assess the major etiologic categories of epilepsy in a rural district of the Lao PDR. Thirty-one newly identified patients with confirmed active epilepsy were compared with 124 controls, matched for gender, age and village residence. Risk factors for epilepsy were investigated with particular focus on cysticercosis serology. A history of head trauma (OR=4.7, p=0.05), family history of epilepsy (OR=12.8, p=0.03), and the use of human feces to fertilize domestic vegetable gardens (OR=4.9, p=0.04) were significantly associated with epilepsy. The study did not confirm any direct relation between epilepsy and cysticercosis serology. The cysticercosis seroprevalence was nil in the epilepsy group. This is the first study in the Lao PDR on epilepsy risk factors representing important data for the subregion. Parasitic, environmental, and behavioral factors of this traditional population deserve further studies to explain the missing link between epilepsy and cysticercosis.
- Published
- 2007
359. Prevalence of epilepsy in a rural district of central Lao PDR.
- Author
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Tran DS, Odermatt P, Le TO, Huc P, Druet-Cabanac M, Barennes H, Strobel M, and Preux PM
- Subjects
- Adolescent, Adult, Aged, Child, Child, Preschool, Cross-Sectional Studies, Electroencephalography, Epilepsies, Partial diagnosis, Epilepsies, Partial epidemiology, Epilepsy diagnosis, Epilepsy, Generalized diagnosis, Epilepsy, Generalized epidemiology, Health Surveys, Humans, Incidence, Infant, Infant, Newborn, Laos, Middle Aged, Neurologic Examination, Risk Factors, Surveys and Questionnaires, Developing Countries, Epilepsy epidemiology, Rural Population statistics & numerical data
- Abstract
Purpose: To assess the prevalence of epilepsy in a rural district of Lao PDR and to describe the clinical and epidemiological profile of the disease., Methods: Door-to-door screening was performed on the entire population of 8 randomly selected villages in the Hinheub district, using an internationally validated and standardized questionnaire. Additional passive case detection was performed through village key informants. Suspected epilepsy patients identified by the questionnaire were revisited and examined by an experienced neurologist on two follow-up visits. The confirmation of epilepsy was based only on an in-depth clinical examination. Electroencephalograms were performed at the district health care center., Results: In the 8 villages, 277 suspected cases of epilepsy were identified among 4,310 interviewed subjects; 194 of whom (70%) underwent a clinical examination by a neurologist during the first visit while 65 of 83 remaining suspected cases were seen on the second confirmation visit. Twenty-seven persons with epilepsy were identified. Six additional patients were diagnosed in 219 self-referred subjects. An overall prevalence of 7.7 cases of epilepsy per thousand inhabitants was calculated (95% CI 5.3-10.7). Generalized epilepsy (21 cases, 63.6%) was commoner than partial epilepsy (9 cases, 27.3%). The remaining 3 cases (9.1%) were not-classifiable as either generalized or partial. EEG abnormal findings were found in 12 of the 24 patients (50.0%) who had an EEG registration., Conclusions: This is the first study in Lao PDR to estimate the prevalence of epilepsy. Compared to Western countries it shows a pattern towards a higher prevalence., (Copyright 2006 S. Karger AG, Basel.)
- Published
- 2006
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360. [Granisetron (per os) compared with ondansetron (per os) in the prevention of nausea and vomiting induced by mildly emetogenic chemotherapies. Groupe de Recherches en Cancerologie du Nord].
- Author
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Huc P, Block S, Carlier D, Darloy F, Bonneterre ME, Bleuse JP, Fournier C, and Bonneterre J
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- Adult, Bleomycin adverse effects, Cross-Over Studies, Cyclophosphamide adverse effects, Doxorubicin adverse effects, Female, Humans, Male, Methotrexate adverse effects, Nausea chemically induced, Prednisone adverse effects, Vindesine adverse effects, Vomiting chemically induced, Antiemetics therapeutic use, Antineoplastic Combined Chemotherapy Protocols adverse effects, Granisetron therapeutic use, Nausea prevention & control, Ondansetron therapeutic use, Vomiting prevention & control
- Abstract
It is a randomised cross-over multicenter study comparing the efficacy and the tolerance of granisetron (Gra) 1 mg and ondansetron (Ond) 8 mg, oral, given during two consecutive cycles to 188 naive patients scheduled to receive a moderately emetogenic chemotherapy. The antiemetic treatment is given one day per course, 1 hour before chemotherapy and the second administration from 8 to 12 hours after the beginning, during each of the two cycles; alternatively according to the randomisation. Five criteria are assessed; nausea (ordinal and visual analogic scales), emeric episodes (vomiting orland retching), complete response (minor or no nausea, no emetic episode and no rescue treatment), patient preference and tolerance. The intent to treat analysis showed no significant difference at cycle 1 between Gra and Ond; at cycle 2, there is no significant difference in the number of emetic episodes; for the prevention of nausea, the ordinal scale shows a significant difference (p = 0.028 in favour of Gra at day 1 (D1) but not from D2 to D5. Gra induced more complete response than Ond at D1 (p = 0.028), but not from D2 to D5. The cross-over study did not show any period or order effect, whereas a treatment effect on Ond was significant in favour of Gra (p = 0.01). There is no significant patients preference in favour of Gra or Ond. In conclusion, Gra was more efficient in preventing nausea and obtaining complete response on the first day of treatment, significantly at the second cycle. Both Gra and Ond had a good antiemetic activity for moderately emetogenic chemotherapy with complete response rates always over 50% on day 1; delayed emesis remain less weli controlled.
- Published
- 1998
361. [Phenotypic expression of heterozygous beta-thalassemia].
- Author
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Font Ferré L, Contreras Barbeta E, and Miret Huc P
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- Heterozygote, Humans, Phenotype, beta-Thalassemia genetics
- Published
- 1994
362. [MUSIC AND MUSCULAR TONUS].
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DELMAS-MARSALET P and HUC P
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- Humans, Electromyography, Muscle Tonus, Music
- Published
- 1963
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