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Magnetic flux ropes (MFRs), as the most probable core structure of solar eruptive activity, remain mysterious on their origination, magnetic environment, and erupting mechanisms. Here, we newly identify a large-scale hot channel MFR, named “MFR3”, that connects an anti-Hale active region (AR) 11429 and a normal AR 11430 on 2012 March 7 based on multi-wavelength observations. An oscillation is first detected at the top of MFR3 during 00:10–00:30 UT as triggered by an X5.4 flare-related eruption of an MFR (named “MFR1” here) in AR 11429. Then, after a quiet period of ∼20 minutes at around 00:52 UT, external magnetic reconnection (EMR) occurred above MFR3 manifested by not only bidirectional outflow in extreme ultraviolet images, but also microwave quasi-periodic pulsation in broadband radio spectral observations for the first time. With the occurrence of EMR, the large-scale MFR3 quickly erupted at 01:01 UT and triggered an X1.3 flare, which is related to the eruption of the other MFR (named “MFR2” here) in AR 11429 at 01:05 UT. The erupting MFR3 and MFR2 appeared successively in the same associated halo coronal mass ejection (CME) as two different core structures. The identification of the large-scale MFR3 between two separated ARs and its complex activity may shed new light on our understanding of the initiation mechanism of a CME. Further work should lay emphasis on how a large-scale MFR3 forms in the solar atmosphere. [ABSTRACT FROM AUTHOR]

Current diffusion is an old issue, nevertheless, the relationship between the current diffusion and the efficiency of light emitting diodes (LEDs) needs to be further quantitatively clarified. By incorporating current crowding effect (CCE) into the conventional ABC model, we have theoretically and directly correlated the current diffusion and the internal quantum efficiency (IQE), light extraction efficiency (LEE), and external quantum efficiency (EQE) droop of the lateral LEDs. However, questions still exist for the vertical LEDs (V-LEDs). Here firstly the current diffusion length Ls(I) and Ls(II) have been clarified. Based on this, the influence of CCE on the EQE, IQE, and LEE of V-LEDs were investigated. Specifically to our V-LEDs with moderate series resistivity, Ls(III) was developed by combining Ls(I) and Ls(II), and the CCE effect on the performance of V-LEDs was investigated. The wall-plug efficiency (WPE) of V-LEDs ware investigated finally. Our works provide a deep understanding of the current diffusion status and the correlated efficiency droop in V-LEDs, thus would benefit the V-LEDs' chip design and further efficiency improvement. [ABSTRACT FROM AUTHOR]

In deep X-ray surveys, active galactic nuclei (AGNs) with a broad range of luminosities have been identified. However, cosmologically distant low-luminosity AGN (LLAGN, erg s−1) identification still poses a challenge because of significant contamination from host galaxies. Based on the 7 Ms Chandra Deep Field-South (CDF-S) survey, the longest-timescale (∼17 years) deep X-ray survey to date, we utilize an X-ray variability selection technique to search for LLAGNs that remain unidentified among the CDF-S X-ray sources. We find 13 variable sources from 110 unclassified CDF-S X-ray sources. Except for one source that could be an ultraluminous X-ray source, the variability of the remaining 12 sources is most likely due to accreting supermassive black holes. These 12 AGN candidates have low intrinsic X-ray luminosities, with a median value of 7 × 1040 erg s−1. They are generally not heavily obscured, with an average effective power-law photon index of 1.8. The fraction of variable AGNs in the CDF-S is independent of X-ray luminosity and is only restricted by the total number of observed net counts, confirming previous findings that X-ray variability is a near-ubiquitous property of AGNs over a wide range of luminosities. There is an anticorrelation between X-ray luminosity and variability amplitude for high-luminosity AGNs, but as the luminosity drops to ≲1042 erg s−1, the variability amplitude no longer appears dependent on the luminosity. The entire observed luminosity–variability trend can be roughly reproduced by an empirical AGN variability model based on a broken power-law power spectral density function. [ABSTRACT FROM AUTHOR]

We systematically analyze the X-ray variability of active galactic nuclei (AGNs) in the 7 Ms Chandra Deep Field-South survey. On the longest timescale (≈17 years), we find only a weak (if any) dependence of X-ray variability amplitudes on energy bands or obscuration. We use four different power spectral density (PSD) models to fit the anticorrelation between normalized excess variance () and luminosity, and obtain a best-fit power-law index for the low-frequency part of the AGN PSD. We also divide the whole light curves into four epochs in order to inspect the dependence of on these timescales, finding an overall increasing trend. The analysis of these shorter light curves also infers a β of ∼1.3 that is consistent with the above-derived β, which is larger than the frequently assumed value of . We then investigate the evolution of . No definitive conclusion is reached because of limited source statistics, but if present, the observed trend goes in the direction of decreasing AGN variability at fixed luminosity toward high redshifts. We also search for transient events and find six notable candidate events with our considered criteria. Two of them may be a new type of fast transient events, one of which is reported here for the first time. We therefore estimate a rate of fast outbursts and a tidal disruption event (TDE) rate assuming the other four long outbursts to be TDEs. [ABSTRACT FROM AUTHOR]

We investigate the dependence of black hole accretion rate (BHAR) on host-galaxy star formation rate (SFR) and stellar mass (M*) in the CANDELS/GOODS-South field in the redshift range of . Our sample consists of galaxies, allowing us to probe galaxies with and/or . We use sample-mean BHAR to approximate long-term average BHAR. Our sample-mean BHARs are derived from the Chandra Deep Field-South 7 Ms observations, while the SFRs and M* have been estimated by the CANDELS team through spectral energy distribution fitting. The average BHAR is correlated positively with both SFR and M*, and the BHAR–SFR and BHAR–M* relations can both be described acceptably by linear models with a slope of unity. However, BHAR appears to be correlated more strongly with M* than SFR. This result indicates that M* is the primary host-galaxy property related to supermassive black hole (SMBH) growth, and the apparent BHAR–SFR relation is largely a secondary effect due to the star-forming main sequence. Among our sources, massive galaxies () have significantly higher BHAR/SFR ratios than less massive galaxies, indicating that the former have higher SMBH fueling efficiency and/or higher SMBH occupation fraction than the latter. Our results can naturally explain the observed proportionality between and M* for local giant ellipticals and suggest that their is higher than that of local star-forming galaxies. Among local star-forming galaxies, massive systems might have higher compared to dwarfs. [ABSTRACT FROM AUTHOR]

RXJ 1301.9+2747 is an optically identified very-low-mass AGN candidate with , which shows extremely soft X-ray emission and unusual X-ray variability in the form of short-lived flares. We present an analysis of multiwavelength observations of RXJ 1301.9+2747 in order to study the properties of the active nucleus and its host galaxy. The UV-to-X-ray spectrum in the quiescent state can be well and self-consistently described by a thermal and a Comptonized emission from the accretion disk, with the black body dominating ∼70% of the X-rays in the 0.2–2 keV. The same model can describe the X-ray spectrum in the flare state, but the Comptonized component becomes dominant (∼80%). The best fit implies an Eddington ratio of ∼0.14 and a black-hole mass of M⊙, in agreement with the estimation from the optical data within errors. However, the best-fitting model under predicts the optical flux for the HST point source by a factor of ∼2. The excess of nuclear optical emission could be attributed to a nuclear stellar cluster, which is frequently seen in low-mass AGNs. The X-ray to optical spectral slope () is lower than in most other active galaxies, which may be attributed to intrinsically X-ray weakness due to very little hot and optically thin coronal emission. We performed a pilot search for weak or hidden broad emission lines using optical spectropolarimetry observations, but no polarized broad lines are detected. The host galaxy appears to be a disk galaxy with a boxy pseudobulge or nuclear bar accounting for ∼15% of the total starlight, which is consistent with the general characteristics of the host of low-mass AGNs. [ABSTRACT FROM AUTHOR]

We perform long-term (≈15 years, observed-frame) X-ray variability analyses of the 68 brightest radio-quiet active galactic nuclei (AGNs) in the 6 Ms Chandra Deep Field-South survey; the majority are in the redshift range of 0.6–3.1, providing access to penetrating rest-frame X-rays up to ≈10–30 keV. Of the 68 sources, 24 are optical spectral type I AGNs, and the rest (44) are type II AGNs. The timescales probed in this work are among the longest for X-ray variability studies of distant AGNs. Photometric analyses reveal widespread photon flux variability: 90% of AGNs are variable above a 95% confidence level, including many X-ray obscured AGNs and several optically classified type II quasars. We characterize the intrinsic X-ray luminosity () and absorption () variability via spectral fitting. Most (74%) sources show variability; the variability amplitudes are generally smaller for quasars. A Compton-thick candidate AGN shows variability of its high-energy X-ray flux, indicating the size of reflecting material to be ≲0.3 pc. variability is also detected in a broad absorption line quasar. The variability amplitude for our sample appears to rise as time separation increases. About 16% of sources show variability. One source transitions from an X-ray unobscured to obscured state, while its optical classification remains type I; this behavior indicates the X-ray eclipsing material is not large enough to obscure the whole broad-line region. [ABSTRACT FROM AUTHOR]

We present measurements of the evolution of normal-galaxy X-ray emission from 0–7 using local galaxies and galaxy samples in the ≈6 Ms Chandra Deep Field-South (CDF-S) survey. The majority of the CDF-S galaxies are observed at rest-frame energies above 2 keV, where the emission is expected to be dominated by X-ray binary (XRB) populations; however, hot gas is expected to provide small contributions to the observed-frame ≲1 keV emission at z ≲ 1. We show that a single scaling relation between X-ray luminosity () and star-formation rate (SFR) literature, is insufficient for characterizing the average X-ray emission at all redshifts. We establish that scaling relations involving not only SFR, but also stellar mass () and redshift, provide significantly improved characterizations of the average X-ray emission from normal galaxy populations at 0–7. We further provide the first empirical constraints on the redshift evolution of X-ray emission from both low-mass XRB (LMXB) and high-mass XRB (HMXB) populations and their scalings with and SFR, respectively. We find (LMXB)/ and (HMXB)/SFR , and show that these relations are consistent with XRB population-synthesis model predictions, which attribute the increase in LMXB and HMXB scaling relations with redshift as being due to declining host galaxy stellar ages and metallicities, respectively. We discuss how emission from XRBs could provide an important source of heating to the intergalactic medium in the early universe, exceeding that of active galactic nuclei. [ABSTRACT FROM AUTHOR]

The ubiquitousness of the solar inter-network horizontal magnetic field has been revealed by space-borne observations with high spatial resolution and polarization sensitivity. However, no consensus has been achieved on the origin of the horizontal field among solar physicists. For a better understanding, in this study, we analyze the cyclic variation of the inter-network horizontal field by using the spectro-polarimeter observations provided by the Solar Optical Telescope on board Hinode, covering the interval from 2008 April to 2015 February. The method of wavelength integration is adopted to achieve a high signal-to-noise ratio. It is found that from 2008 to 2015 the inter-network horizontal field does not vary when solar activity increases, and the average flux density of the inter-network horizontal field is 87 ± 1 G, In addition, the imbalance between horizontal and vertical fields also keeps invariant within the scope of deviation, i.e., 8.7 ± 0.5, from the solar minimum to maximum of solar cycle 24. This result confirms that the inter-network horizontal field is independent of the sunspot cycle. The revelation favors the idea that a local dynamo is creating and maintaining the solar inter-network horizontal field. [ABSTRACT FROM AUTHOR]

Hydrothermally synthesized ZnO nanotube arrays were used to fabricate the gas sensor for detection of the toxic gas NO2. The ZnO nanotube gas sensor exhibited sensitive response to NO2 down to 500 ppb at low temperature 30 degC. Abnormal temperature-dependent and concentration-dependent N-P transition behaviors were observed. The excellent sensing ability of the sensor and their anomalous conductivity behaviors may be attributed to the unique surface conductivity related to the hollow nanostructure feature. These sensing behaviors may help to comprehensively understand the sensing mechanism of 1D ZnO nanostructures and improve the selectivity of the ZnO gas sensor. [ABSTRACT FROM AUTHOR]

Injector-like zinc oxide (ZnO) nanostructures have been synthesized on Si substrate by the vapour phase transport method. Samples with different areal densities were obtained by controlling the temperature. The field emission properties of the injector-like ZnO nanostructures showed a clear dependence on the areal density of the nanostructures, which is due to the screening effect. The samples with a needle length of 850 nm and an areal density of 1 × 108cm?2showed the lowest field emission turn-on field of 1.85 V µm?1at a current density of 10 µA cm?2, and the current density reaches 1 mA cm?2at an applied field of 4.7 V µm?1. [ABSTRACT FROM AUTHOR]

The ZnO microrafts with diamond-shaped cross sections have been prepared by the vapour transport method in air using a copper catalyst. Our results showed that the backbone of these microstructures had a quadrate cross section growing along the direction, while its diamond-shaped branches were growing along the [0001] direction. The copper-doped structures exhibited modified Raman and photoluminescence spectra and were ferromagnetic at room temperature. The possible growth process of these microstructures is discussed. [ABSTRACT FROM AUTHOR]

Background: In order to study the anticancer effects and cellular apoptosis pathways induced by daidzein. Materials and methods: We used the human MCF-7 breast cancer cell line as a model and examined the apoptosis by Hoechst–propidium iodide staining fluorescence imaging and flow cytometry. Results: Our data indicated that daidzein induces antiproliferative effects in a concentration- and time-dependent manner. We demonstrated that daidzein-induced apoptosis in MCF-7 cells was initiated by the generation of reactive oxygen species (ROS). Furthermore, we showed that this daidzein-induced ROS generation was accompanied by disruption of mitochondrial transmembrane potential, down-regulation of bcl-2, and up-regulation of bax, which led to the release of cytochrome C from the mitochondria into the cytosol, which, in turn, resulted in the activation of caspase-9 and caspase-7, and ultimately in cell death. The induction of the mitochondrial caspase-dependent pathway was confirmed by pretreatment with pan-caspase inhibitor z-VAD-fmk and antioxidant N-acetyl-L-cysteine. Conclusion: Accordingly, daidzein could induce breast cancer cell apoptosis through the mitochondrial caspasedependent cell death pathway. [ABSTRACT FROM AUTHOR]

The cellular endosomal sorting complex required for transport (ESCRT) system comprises five distinct components and is involved in many different physiological processes. Recent studies have shown that different viruses rely upon the host ESCRT system for viral infection. However, whether this system is involved in white spot syndrome virus (WSSV) infection remains unclear. Here, we identified 24 homologs of ESCRT subunits in kuruma shrimp, Marsupenaeus japonicus , and found that some key components were strongly upregulated in shrimp after WSSV infection. Knockdown of key components of the ESCRT system using RNA interference inhibited virus replication, suggesting that the ESCRT system is beneficial for WSSV infection. We further focused on TSG101, a crucial member of the ESCRT-I family that plays a central role in recognizing cargo and activating the ESCRT-II and ESCRT-III complexes. TSG101 colocalized with WSSV in hemocytes. The addition of N16 (a TSG101 inhibitor) markedly decreased WSSV replication. TSG101 and ALIX of the ESCRT system interact with WSSV envelope proteins. The host proteins TSG101, RAB5, and RAB7, the viral protein VP28, and DNA were detected in endosomes isolated from hemocytes of WSSV-infected shrimp. Knockdown of Rab5 and Rab7 expression reduced viral replication. Taken together, these results suggest that the ESCRT system is hijacked by WSSV for transport through the early to late endosome pathway. Our work identified a novel requirement for the intracellular trafficking and infection of WSSV, and provided novel therapeutic targets for the prevention and control of WSSV in shrimp aquaculture., Importance: Viruses utilize the ESCRT machinery in a variety of strategies for their replication and infection. This study revealed that the interaction of ESCRT complexes with WSSV envelope proteins plays a crucial role in WSSV infection in shrimp. The ESCRT system is conserved in the shrimp Marsupenaeus japonicus , and 24 homologs of the ESCRT system were identified in the shrimp. WSSV exploits the ESCRT system for transport and propagation via the interaction of envelope proteins with host TSG101 and ALIX in an endosome pathway-dependent manner. Understanding the underlying mechanisms of WSSV infection is important for disease control and breeding in shrimp aquaculture., Competing Interests: The authors declare no conflict of interest.

Interleukin 18 (IL-18), as a member of IL-1 superfamily, is an important pleiotropic cytokine that modulates Th1 immune responses. In this report, we cloned and identified a homolog of IL-18 in giant panda (Ailuropoda melanoleuca) (designated as AmIL-18) from peripheral blood mononuclear cells stimulated with lipopolysaccharide. The open readin g frame of AmIL-18 cDNA is 579 bp encoding a deduced protein of 192 amino acids. AmIL-18 gDNA fragments contained 5 exons and 4 introns. The amino acid sequence of AmIL-18 shared 23.9 to 87.0% identity with other species. To evaluate the effects of AmIL-18 on the immune response, we expressed the recombinant AmIL-18 in Escherichia coli BL21 (DE3). The fusion protein PET-AmIL-18 was purified by nickel affinity column chromatography and verified by sodium dodecyl sulfate polyacrylamide gel electrophoresis and Western blot analysis. The biological function of purified PET-AmIL-18 was determined on mouse splenocytes by quantitative real-time polymerase chain reaction. INF-γ and other cytokines were increased when stimulated by PET-AmIL-18, particularly when combined with recombinant human interleukin 12, while a Th2-type cytokine, interleukin-4, was strikingly suppressed. These results will provide information for the potential use of recombinant proteins to manipulate the immune response in giant pandas and facilitate the study to protect this treasured species.

Recently, synthetic curcumin analogs are reported as potential active compounds against Mycobacterium tuberculosis (MTB). During the process of MTB infection, macrophages show increased apoptosis. The candidate virulence factors such as 19-kDa lipoprotein secreted by the MTB (P19) strongly influences macrophages by activation of Toll-like receptor 2 (TLR2) and mitogen-activated protein kinases (MAPKs). It has been reported that curcumin could affect the apoptosis of tumor cells via regulation of MAPKs. However, its effect on the P19-induced apoptosis of macrophages is unclear. This study investigates the effect of curcumin on the MAPKs signaling and apoptosis in human macrophages. The results showed that curcumin and P19 induced macrophage apoptosis in a time- and dose-dependent manner Low doses of curcumin (10 and 20 μM) protected macrophages from P19 induced apoptosis, accompanied by decreased production of cytokines and reduced activation of the c-Jun amino-terminal kinase (JNK) and p38 MAPK. The protective effect of curcumin on P19 induced apoptosis of macrophages were enhanced by treatment with the JNK-specific inhibitors, whereas SB203580, the inhibitor of p38 MAPK had no effect. Curcumin had no effect on the activity of extracellular signal-regulated protein kinase (ERK). Taken together, our data show that the JNK pathway, but not the p38 or ERK pathway, plays an important role in the protective effect of curcumin against P19 induced macrophage apoptosis, and regulation of the JNK pathway may partially elucidate the anti-tuberculosis activity of curcumin., (Copyright © 2014 Elsevier Inc. All rights reserved.)