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Ninety-four smokers completed the delay discounting procedure for either hypothetical amounts of money, $10 (money) and $1000 (money) or hypothetical amounts of cigarettes ($10 and $1000 worth of cigarettes). We investigated how variables previously found to be related to rates of delay discounting accounted for the observed results. These variables included the following: demographic information, smoking characteristics, executive function abilities, impulsivity, time perception, and the Utility Measure of Cigarette Reinforcing Efficacy (UMCE). Education level and UMCE were each significantly correlated with 3 out of 4 of the discounting measures. Moreover, the largest effect sizes observed were between these two measures and the four discounting measures. All potential discounting predictors were also investigated using step-wise linear regression with Bayesian Information Criterion (BIC) analysis—these BIC models revealed that education level and UMCE accounted for large portions of the variance. We conclude that education level and UMCE were the most consistent predictors of discounting. This data is discussed within the framework of a widely accepted neuroeconomic model that suggests that two brain systems separately assess two separate facets of decision-making, and the interplay between these two systems determines self-control in smokers. We hypothesize that education level and UMCE may serve as surrogate measures of the functionality of these two systems and that discounting may be a sentinel measure of self-control., (Copyright © 2015 Elsevier Ltd. All rights reserved.)

Objective: Previous studies suggest that many patients with diabetes do not receive an annual dilated eye examination because of a lack of referrals from primary care physicians (PCPs). This study aims to determine the depth of knowledge of PCPs regarding diabetic eye disease., Design: Cross-sectional assessment., Participants: Ninety-seven PCPs., Methods: An 8-question, multiple-choice assessment was administered over a 3-month period to 208 PCPs in attendance at continuing medical education conferences., Results: Ninety-seven PCPs completed the assessment. Participants had a mean total score of 5.9 of 8 possible (73.8%). Questions regarding screening, clinical findings, and prevention were answered correctly by ≥ 81% of the respondents. However, questions regarding risk factors and complications were answered correctly by less than 35% of the respondents. No difference in scores was found based on the type of residency training received or the number of years in practice., Conclusions: Although PCPs may require greater education in the complications and risk factors of diabetic eye disease, study participants demonstrated a good overall depth of knowledge regarding diabetic eye disease. Thus, previous reports of only 35% to 55% of patients with diabetes receiving an annual dilated fundus examination are likely not due to a lack of physician education., (Copyright © 2015. Published by Elsevier Inc.)

Objectives: To investigate associations between age, sex, education, and birth cohort and global cognitive decline among a population that would most likely not progress to dementia., Methods: A total of 1538 dementia-free subjects aged 60 to 80years in 1992 were followed up through 2011 without dementia occurrence. We assessed cognitive function using the Cognitive Ability Screening Instrument (CASI). Using stepwise-like model selection procedure, we built mixed-effects models for initial cognition and longitudinal cognition., Results: Initial CASI scores for younger age and more years of formal education were higher than those for older and less education. Sex did not show a significant effect. In the longitudinal analysis, cognitive decline became more rapid with increasing age. Sex and education did not modify the degree of deterioration with age. CASI scores were higher for younger cohorts and men due to differences in education levels., Conclusion: Among dementia-free subjects, age is an important predictor of cognitive function level and cognitive decline. Education level affects cognitive function level, but did not affect cognitive decline. The results have implications not only for elucidation of the aging process, but also for reference in dementia screening., (Copyright © 2015 Elsevier B.V. All rights reserved.)

Repetitive transcranial magnetic stimulation (rTMS) is a new frontier in the examination of addictive behaviors and perhaps the development of new interventions. This study examined differences in recruitment, eligibility, and retention among smokers and nonsmokers in an rTMS study. We modeled participant eligibility and study completion among eligible participants accounting for demographic differences between smokers and nonsmokers. Nonsmokers were more likely than smokers to remain eligible for the study after the in-person screen (84.2% versus 57.4%; OR 4.0 CI: 1.0, 15.4, p=0.05) and to complete the study (87.5% versus 59.3%; OR=43.9 CI: 2.8, 687.2, p=0.007). The preliminary findings suggest that careful screening for drugs of abuse and brain abnormalities among smokers prior to administering rTMS is warranted. More research is needed concerning the prevalence of brain abnormalities in smokers. Smokers might need to be informed about a higher risk of incidental MRI findings.