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Sensory processing disorder, characterized by over- or under-responsivity to non-noxious environmental stimuli, is a common but poorly understood disorder. We examined the role of prenatal alcohol exposure, serotonin transporter gene polymorphic region variation (rh5-HTTLPR), and striatal dopamine (DA) function on behavioral measures of sensory responsivity to repeated non-noxious sensory stimuli in macaque monkeys. Results indicated that early gestation alcohol exposure induced behavioral under-responsivity to environmental stimuli in monkeys carrying the short (s) rh5-HTTLPR allele compared to both early-exposed monkeys homozygous for the long (l) allele and monkeys from middle-to-late exposed pregnancies and controls, regardless of genotype. Moreover, prenatal timing of alcohol exposure altered the relationship between sensory scores and DA D(2)R availability. In early-exposed monkeys, a positive relationship was shown between sensory scores and DA D(2)R availability, with low or blunted DA function associated with under-responsive sensory function. The opposite pattern was found for the middle-to-late gestation alcohol-exposed group. These findings raise questions about how the timing of prenatal perturbation and genotype contributes to effects on neural processing and possibly alters neural connections.

Background: Although depression is a chronic illness with high morbidity and personal and economic losses, little is known about depression in immigrants with an Arab or Chaldean ethnic background., Objectives: Our primary objective was to determine the overall and ethnicity-specific prevalence of self-reported depression in Arab Americans, Chaldean Americans, and African Americans in the Midwest. The secondary objective was to evaluate the associations between potential risk and protective factors and the presence of self-reported depression., Method: A total of 3543 adults were recruited from the Arab and Chaldean communities in Metropolitan Detroit. The sample in this study was restricted to those of Arab, Chaldean, and African ethnic backgrounds, resulting in 81.2% of the original sample (n=2878). A health assessment survey questionnaire was administered., Results: The overall rate of self-reported depression was 18.2%. The highest rate of depression was found in Arab American participants (23.2%), followed by African Americans (15%) and Chaldeans (13.3%). Self-reported prevalence of depression by country of origin differed significantly., Conclusions: Our results show the need to provide culturally competent mental health services for Arab Americans and other minority American subgroups. Research is needed to identify risk factors, preferably modifiable factors, and to ascertain which factors are similar and non-similar to the general American population.

Evaluation of sensory processing function serves as a critical component of treatment planning and implementation of intervention in pediatric occupational therapy practice. We developed a Sensory Processing Scale for Monkeys (SPS-M), based on human tests, that measures behavioral responses to a series of tactile stimuli. This assessment has been used to assess sensory processing in adult rhesus monkeys exposed to prenatal alcohol, stress, or postnatal lead. Control monkeys from undisturbed pregnancies showed a habituation pattern, prenatally stressed monkeys showed sensitization, and prenatal alcohol-exposed monkeys showed relatively high responsiveness without habituation across trials. Lead-exposed monkeys showed sensitization compared to nonlead-exposed controls, and chelation reduced the sensitization in lead-exposed animals. Aversive responsiveness was associated with up-regulated striatal dopamine receptor binding measured with positron emission tomography.

The Gulf War in 1991 resulted in an influx of refugees from Iraq to the United States and to other regions of the world. The purpose of this study was to describe the self-reported medical complaints of Iraqi American refugees who were seeking mental health services in southeastern Michigan. We anticipated that the frequency and pattern of medical symptoms would differ from that reported in the literature on United States Gulf War veterans or other Arab Americans who immigrated to the U.S. in the 1990s. Potential reasons for such differences include indirect effects, such as neglect of general health prior to and during the war, or direct effects, such as the impact of environmental changes from the war itself. As part of a larger study on the health of refugees from Iraq, self-reported medical conditions and symptoms were analyzed in a sample of 116 adult Iraqi immigrants (46 male, 70 female) who were seeking or already receiving outpatient mental health services (n = 87) or treatment in a partial hospitalization program (n = 29). Measures were translated into Arabic and administered in an interview format by one of two bilingual mental health workers. The results were consistent with other studies on refugees in which the number of medical complaints reported was relatively high. Discussion centers on the importance of addressing the specific medical needs of refugees in general, and of the Iraqi refugees in particular, and on how they may be better served within our primary health care systems.

When two masked targets (T1 and T2), both requiring attention, are presented within half a second of each other, report of the second target is poor, demonstrating an attentional blink (AB). Potter, Chun, Banks, and Muckenhoupt (1998) argued that all previous demonstrations of an AB occurring when one or more targets were presented outside the visual modality did not represent true AB but were, instead, artifactual, resulting from switching of task set. In the present experiments, T1 and T2 modalities were independent and varied randomly from trial to trial, allowing no useful preparatory task-set switching from T1 to T2. However, reliable ABs were observed when both targets were visual, when both targets were auditory, and cross-modally when T2s were visual. Furthermore, the ABs observed for cross-modality visual T2s showed the characteristic U-shaped pattern often found in AB experiments in which two visual targets are used--a pattern that should not be observed under task-set switching conditions. These results provide evidence that cross-modality AB can be found under conditions that do not allow useful preparatory task-set switching.

The purpose of this study was to clarify the mental health needs of Iraqi immigrants who arrived in the United States in the 1990s after the Persian Gulf War. The records of 375 clients were examined at a clinic that serves Arab Americans. More posttraumatic stress disorder and health problems were found in Iraqi refugees than in other clients. Results suggest the need for further research on immigrants with traumatic histories to facilitate effective treatments.

Objective: The objectives of this study were to test the dose and strength proportionalities of beclomethasone dipropionate (BDP) delivered from two strengths of a pressurized extrafine solution formulation., Methods: Thirty adults with mild, stable asthma, aged between 18 years and 70 years, completed the study; written informed consent was obtained from all patients. Each patient received, according to a randomized four-period crossover design, 100 microg BDP as two inhalations from 50-microg/actuation strength, 100 microg BDP as one inhalation from 100-microg/actuation strength, 400 microg BDP as eight inhalations from the 50-microg/actuation strength, and 400 microg BDP as four inhalations from the 100-microg/actuation strength. Patients self-administered all inhalations at the same time of day during the study. Blood samples were collected for 12 h during each period to assay for the presence of BDP and metabolites. The log-transformed pharmacokinetic data were compared for proportionality equivalence using a confidence-interval approach., Results: Almost all the BDP-derived material in the plasma was the active metabolite beclomethasone 17-monopropionate (17-BMP). Due to low levels, neither elimination half-life ( t(1/2)) nor the area under the plasma concentration-time curve (AUC) for 17-BMP could be calculated for the 100-microg BDP doses. Dose proportionality of the 100-microg and 400-microg BDP doses, using 17-BMP maximum plasma concentration (C(max)) was demonstrated for each strength. Strength proportionality of the 50-microg and 100-microg/actuation strengths was observed for C(max) at both dose levels and for AUC at the higher dose level. The t(1/2) of 17-BMP was found to be approximately 2.8 h., Conclusion: This study demonstrated both the strength and dose proportionalities of the BDP extrafine aerosol. This important information will allow physicians maximum flexibility in prescribing this aerosol product.