351. Prenatal allergen and diesel exhaust exposure and their effects on allergy in adult offspring mice
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Rachel L. Miller, Gabriele Grunig, Chunli Quan, Frederica P. Perera, Manisha Ballaney, Ximei Jin, Huaijie Zhu, Lung Chi Chen, and Lin Corson
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lcsh:Immunologic diseases. Allergy ,Pulmonary and Respiratory Medicine ,Allergy ,Offspring ,medicine.disease_cause ,Immunoglobulin E ,complex mixtures ,Aspergillus fumigatus ,03 medical and health sciences ,0302 clinical medicine ,Allergen ,Medicine ,Eosinophilia ,Immunology and Allergy ,skin and connective tissue diseases ,Sensitization ,030304 developmental biology ,0303 health sciences ,Pregnancy ,biology ,business.industry ,Research ,General Medicine ,respiratory system ,biology.organism_classification ,medicine.disease ,respiratory tract diseases ,medicine.anatomical_structure ,030228 respiratory system ,13. Climate action ,Immunology ,biology.protein ,medicine.symptom ,lcsh:RC581-607 ,business ,human activities - Abstract
BackgroundMultiple studies have suggested that prenatal exposure to either allergens or air pollution may increase the risk for the development of allergic immune responses in young offspring. However, the effects of prenatal environmental exposures on adult offspring have not been well-studied. We hypothesized that combined prenatal exposure to Aspergillus fumigatus (A. fumigatus) allergen and diesel exhaust particles will be associated with altered IgE production, airway inflammation, airway hyperreactivity (AHR), and airway remodeling of adult offspring.MethodsFollowing sensitization via the airway route toA. fumigatusand mating, pregnant BALB/c mice were exposed to additionalA. fumigatusand/or diesel exhaust particles. At age 9-10 weeks, their offspring were sensitized and challenged withA. fumigatus.ResultsWe found that adult offspring from mice that were exposed toA. fumigatusor diesel exhaust particles during pregnancy experienced decreases in IgE production. Adult offspring of mice that were exposed to bothA. fumigatusand diesel exhaust particles during pregnancy experienced decreases in airway eosinophilia.ConclusionThese results suggest that, in this model, allergen and/or diesel administration during pregnancy may be associated with protection from developing systemic and airway allergic immune responses in the adult offspring.
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