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A benzylation procedure for 4‐hydroxycoumarin is developed for the synthesis of substituted analogues of warfarin (XII) using Bi(OTf)3as inexpensive catalyst.

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.

Pictet‐Spengler cyclocondensation of the cis‐2‐arylcyclohexanamines (I) with formaldehyde (II) leads to the formation of the title compounds (IV) via the postulated intermediates (III).

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

Condensation of the racemic 2‐arylcyclohexanones (I) with (R)‐(+)‐ or (S)‐(‐)‐1‐phenylethylamine (II) as chiral auxiliary produces a mixture of the imine isomers (III) which are hydrogenated in the presence of Raney‐Ni to form the secondary amine hydrochlorides (IV).

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

Eight ventilator-dependent infants with clinical and radiographic BPD (birth weight 924 ± 118 grams; age 22 ± 7 days) were treated with IV dexamethasone (Dex), 0.5 mg/kg/day, for 7 days. Dex was then tapered over 2 weeks and discontinued. These infants were compared to 8 controls (birth weight 986 ± 138 grams) with improving lung disease. At study entry, treated infants had significantly increased ventilator requirements compared to controls at 14 days. Controls were extubated at age 13.3 ± 14 days. FiO2, rate, peak inspiratory pressure (PIP), and alveolar arterial oxygen differences (AaDO2) were compared before and after 7 days of Dex and to controls at age 28 days, using two-tailed Student-t test.All infants were extubated 6.1 ± 2 days after Dex treatment. Compared to 28 day controls, treated infants had higher AaDO2(P <0.05). FiO2, ventilator requirements, and infection rates were similar in both groups. At one year of age, all Dex treated infants were alive, well, living at home, receiving neither oxygen nor diuretic therapy.Conclusion: Early Dex therapy significantly reduces ventilator dependence and may improve prognosis in developing BPD.