1. Potential biomarkers for heart failure.
- Author
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Wang, Che, Yang, Honghui, and Gao, Chuanyu
- Subjects
- *
BIOLOGICAL tags , *HEART failure treatment , *GENE expression , *PROTEIN-protein interactions , *INTERFERON regulatory factors , *CCL5 (Chemokine) - Abstract
In this study, we identified candidate biomarkers for heart failure (HF). The gene expression profile GSE57338, containing 117 ischemic cardiomyopathic HF and 136 control samples, was downloaded and analyzed using various bioinformatics approaches. In total, 376 differentially expressed genes (DEGs) were identified, and four modules were explored in protein–protein interaction networks. DEGs (including ankyrin repeat and SOCS box‐containing 14 [ASB14]) in the modules were mainly categorized by the function. Several relationships including interferon regulatory factor 1 (IRF1)‐C‐C motif chemokine ligand 5 (CCL5) were revealed in the transcription factor microRNA target gene regulatory network. Gene–drug analysis revealed 11 DEGs (such as the cluster of differentiation 163 [CD163]) for the target drugs. Data verification analysis identified 118 overlapping DEGs including ASB14, CD163, and CCL5. ASB14 may be involved in HF progression via protein ubiquitination and CCL5 may be involved in HF via the IRF1‐CCL5 interaction. Genes including CD163 are potential biomarkers for HF. 1.ASB14 might take part in the progression of HF via protein ubiquitination. 2.CCL5 might play a vital role in HF via IRF1‐CCL5 interaction. 3.CD163 might be novel biomarkers for HF. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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