1. Escherichia coli: an old friend with new tidings
- Author
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Vila, J., Saez-Lopez, E., Johnson, J. R., Romling, U., Dobrindt, U., Canton, R., Giske, C. G., Naas, T., Carattoli, A., Martinez-Medina, M., Bosch, J., Retamar, P., Rodriguez-Bano, J., Baquero, F., Soto, S. M., [Vila, J.] Hosp Clin Univ Barcelona, Barcelona Ctr Int Hlth Res CRESIB, ISGlobal, Barcelona 08036, Spain, [Saez-Lopez, E.] Hosp Clin Univ Barcelona, Barcelona Ctr Int Hlth Res CRESIB, ISGlobal, Barcelona 08036, Spain, [Bosch, J.] Hosp Clin Univ Barcelona, Barcelona Ctr Int Hlth Res CRESIB, ISGlobal, Barcelona 08036, Spain, [Soto, S. M.] Hosp Clin Univ Barcelona, Barcelona Ctr Int Hlth Res CRESIB, ISGlobal, Barcelona 08036, Spain, [Vila, J.] Univ Barcelona, Hosp Clin, Dept Clin Microbiol, E-08036 Barcelona, Spain, [Bosch, J.] Univ Barcelona, Hosp Clin, Dept Clin Microbiol, E-08036 Barcelona, Spain, [Vila, J.] Inst Salud Carlos III, Spanish Network Res Infect Dis REIPI, Madrid 28220, Spain, [Canton, R.] Inst Salud Carlos III, Spanish Network Res Infect Dis REIPI, Madrid 28220, Spain, [Rodriguez-Bano, J.] Inst Salud Carlos III, Spanish Network Res Infect Dis REIPI, Madrid 28220, Spain, [Johnson, J. R.] VA Med Ctr, Minneapolis, MN USA, [Johnson, J. R.] Univ Minnesota, Minneapolis, MN 55417 USA, [Romling, U.] Karolinska Inst, S-17177 Stockholm, Sweden, [Giske, C. G.] Karolinska Inst, S-17177 Stockholm, Sweden, [Dobrindt, U.] Univ Munster, Inst Hyg, D-48149 Munster, Germany, [Canton, R.] Hosp Univ Ramon y Cajal, Microbiol Serv, E-28034 Madrid, Spain, [Baquero, F.] Hosp Univ Ramon y Cajal, Microbiol Serv, E-28034 Madrid, Spain, [Canton, R.] Inst Invest Sanitaria IRYCIS, E-28034 Madrid, Spain, [Baquero, F.] Inst Invest Sanitaria IRYCIS, E-28034 Madrid, Spain, [Naas, T.] Univ Paris 11, Hop Bicetre, F-94270 Le Kremlin Bicetre, France, [Carattoli, A.] Ist Super Sanita, Dept Infect Parasit & Immune Mediated Dis, I-00161 Rome, Italy, [Martinez-Medina, M.] Univ Girona, Dept Biol, Lab Mol Microbiol, Girona 17004, Spain, [Retamar, P.] Univ Seville, Dept Med, Hosp Univ Virgen Macarena & Virgen del Rocio, Unidad Clin Enfermedades Infecciosas Microbiol &, Seville 41071, Spain, [Rodriguez-Bano, J.] Univ Seville, Dept Med, Hosp Univ Virgen Macarena & Virgen del Rocio, Unidad Clin Enfermedades Infecciosas Microbiol &, Seville 41071, Spain, 'Instituto de Salud Carlos III' of Spain - European Development Regional Fund, Ministerio de Economia y Competitividad, Spanish Network for the Research in Infectious Diseases, Karolinska Institutet's 'Elitforskartjanst' in Molecular Microbiology, German Federal Ministry for Education and Research, and Veterans Affairs
- Subjects
Cyclic-di-gmp ,Onset neonatal sepsis ,pathogenesis ,Klebsiella-pneumoniae ,Invasive e. coli ,clinical ,Gram-negative organisms ,In-vitro activity ,Carbapenemase-producing enterobacteriaceae ,Spectrum-beta-lactamase ,evolution ,Escherichia coli ,epidemiology ,antimicrobial resistance ,Blood-stream infections ,Comparative genomic analysis - Abstract
Escherichia coli is one of the most-studied microorganisms worldwide but its characteristics are continually changing. Extraintestinal E. coli infections, such as urinary tract infections and neonatal sepsis, represent a huge public health problem. They are caused mainly by specialized extraintestinal pathogenic E. coli (ExPEC) strains that can innocuously colonize human hosts but can also cause disease upon entering a normally sterile body site. The virulence capability of such strains is determined by a combination of distinctive accessory traits, called virulence factors, in conjunction with their distinctive phylogenetic background. It is conceivable that by developing interventions against the most successful ExPEC lineages or their key virulence/colonization factors the associated burden of disease and health care costs could foreseeably be reduced in the future. On the other hand, one important problem worldwide is the increase of antimicrobial resistance shown by bacteria. As underscored in the last WHO global report, within a wide range of infectious agents including E. coli, antimicrobial resistance has reached an extremely worrisome situation that 'threatens the achievements of modern medicine'. In the present review, an update of the knowledge about the pathogenicity, antimicrobial resistance and clinical aspects of this 'old friend' was presented.New knowledgements about pathogenesis, antimicrobial resistance and clinical aspects of Escherichia coli.New knowledgements about pathogenesis, antimicrobial resistance and clinical aspects of Escherichia coli.
- Published
- 2016