1. DEPTOR in Skeletal Development and Diseases
- Author
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Perez-Tejeiro, Jose Miguel, Csukasi, Fabiana, [Perez-Tejeiro,JM, Csukasi,F] Department of Cell Biology, Genetics and Physiology, Faculty of Sciences, IBIMA, University of Málaga, Málaga, Spain. [Perez-Tejeiro,JM, Csukasi,F] Biomaterials and Nanomedicine (CIBER-BBN), Andalusian Centre for Nanomedicine and Biotechnology-BIONAND, Networking Biomedical Research Center in Bioengineering, Málaga, Spain., Junta de Andalucia: CV20-81404, UMA18-FEDERJA-177. CIBER Actions, the Instituto de Salud Carlos III, Regional Government of Andalusia (PAIDI group BIO-217), and and University of Malaga (Plan Propio).
- Subjects
Anatomy::Musculoskeletal System::Skeleton::Bone and Bones [Medical Subject Headings] ,Disciplines and Occupations::Natural Science Disciplines::Biological Science Disciplines::Biology [Medical Subject Headings] ,DEPTOR ,Cartílago ,Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Biochemical Processes::Signal Transduction [Medical Subject Headings] ,Esqueleto ,Proteína reguladora asociada a mTOR ,Diana mecanicista del complejo 1 de la rapamicina ,Chemicals and Drugs::Organic Chemicals::Lactones::Macrolides::Sirolimus [Medical Subject Headings] ,Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Molecular Structure::Molecular Conformation::Protein Conformation::Protein Structure, Tertiary::Protein Interaction Domains and Motifs::PDZ Domains [Medical Subject Headings] ,Cartilage ,Anatomy::Cells::Cellular Structures::Chromosomes::Chromosomes, Mammalian::Chromosomes, Human::Chromosomes, Human, 6-12 and X::Chromosomes, Human, Pair 8 [Medical Subject Headings] ,mTOR ,Organisms::Eukaryota::Animals [Medical Subject Headings] ,Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::Phosphotransferases::Phosphotransferases (Alcohol Group Acceptor)::Protein Kinases::Protein-Serine-Threonine Kinases::TOR Serine-Threonine Kinases [Medical Subject Headings] ,Bone ,Huesos ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Clinical Laboratory Techniques::Cytological Techniques [Medical Subject Headings] ,Phenomena and Processes::Physiological Phenomena::Physiological Processes::Homeostasis [Medical Subject Headings] ,Skeleton ,Anatomy::Cells::Cellular Structures::Cell Membrane [Medical Subject Headings] - Abstract
Discovered in 2009, the DEP-domain containing mTOR-interacting protein, DEPTOR, is a known regulator of the mechanistic target of rapamycin (mTOR), an evolutionarily conserved kinase that regulates diverse cellular processes in response to environmental stimuli. DEPTOR was originally identified as a negative regulator of mTOR complexes 1 (mTORC1) and 2 (mTORC2). However, recent discoveries have started to unravel the roles of DEPTOR in mTOR-independent responses. In the past few years, mTOR emerged as an important regulator of skeletal development, growth, and homeostasis; the dysregulation of its activity contributes to the development of several skeletal diseases, both chronic and genetic. Even more recently, several groups have reported on the relevance of DEPTOR in skeletal biology through its action on mTORdependent and mTOR-independent pathways. In this review, we summarize the current understanding of DEPTOR in skeletal development and disease. Yes
- Published
- 2021