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This article discusses the management of severe fetal anemia through intrauterine transfusion at a tertiary center in Budapest, Hungary. Severe fetal anemia is a condition that is often underdiagnosed and can lead to adverse outcomes if left untreated. The study summarizes the results of intrauterine transfusion procedures performed between November 2023 and March 2024, with a total of 7 interventions conducted. The majority of cases involved red-blood cell isoimmunization, and the intrahepatic approach was the preferred method due to its lower complication rate. The procedure has shown promising results in improving perinatal outcomes and extending the duration of pregnancy, but further studies are needed to assess its long-term effectiveness. [Extracted from the article]

This article compares the diagnostic accuracy of transvaginal ultrasound (TVS) and magnetic resonance imaging (MRI) in detecting deep myometrial infiltration (DMI) in endometrial cancer. The study found that the prevalence of DMI does not significantly affect the diagnostic accuracy of either imaging method. Both TVS and MRI demonstrated comparable positive predictive values (PPV) and negative predictive values (NPV) across different prevalence groups. However, further studies are needed to validate these findings. [Extracted from the article]

This article discusses the establishment of a Fetal Medicine Task Force at Semmelweis University in Hungary. The task force aims to improve the management of high-risk pregnancies, establish a referral system for patients with fetal abnormalities, and identify candidates for fetal therapy. The article highlights the successful performance of several fetal interventions, such as intrauterine fetal transfusions and relieving cystocentesis. The task force's efforts are seen as a groundbreaking step in the field of Fetal Medicine in Hungary, with the goal of improving perinatal outcomes and reducing mortality and morbidity. [Extracted from the article]

This article discusses the efficacy of letrozole (LE) compared to clomiphene citrate (CC) for ovulation induction in women with polycystic ovary syndrome (PCOS). The study found that women treated with LE had higher rates of ovulation and pregnancy, as well as increased endometrial thickness. Additionally, the resistance index of subendometrial arteries decreased, potentially improving conditions for embryo implantation and development. This information may be useful for library patrons researching PCOS and fertility treatments. [Extracted from the article]

This article, published in the journal Ultrasound in Obstetrics & Gynecology, discusses a study that aimed to investigate the feasibility of visualizing the piriformis muscle (PM) and the sacral nerves using gynecological transvaginal ultrasound (TVS). The study included 305 patients and found that the PM was visualized in 96.4% of cases on the right side and 96.0% on the left side, with median antero-posterior (AP) diameters of 18.3mm and 18.4mm, respectively. The sacral nerves (S1-S3) were visualized in 81.6% of cases on the right side and 81.0% on the left side, with median AP diameters of 4.8mm. The authors suggest that integrating the assessment of these structures into routine pelvic TVS may be beneficial for women with deep endometriosis. [Extracted from the article]

Bladder DE was in 78/98 (80%), ureteral DE in 8 (8%) both ureteric and bladder DE in 12 (12%) patients present. Patients with UTE infiltrating the bladder were undergoing surgical treatment by dissection using a skinning technique or partial cystectomy. To test the accuracy of IDEA criteria for suspected urinary tract endometriosis (UTE) and to determine the distribution, size and consequences of UTE. [Extracted from the article]

The authors studied the changes in subjective symptoms of menopause in 2016 Hungarian women who had been treated with an isopropanol extract of Cimicifuga racemosa (black cohosh). The inclusion criteria were age (40-65 y). Kupperman index (20), and refusal or contraindication for estrogen therapy. The severity of the symptoms was evaluated at the start of the study and at the end of 4, 8, and 12 weeks of treatment. The average decrease in Kupperman index after 12 weeks of therapy was 17.64 points (P<.001). Based on the weighted symptom scores, the most favorable changes were found in hot flashes (-6.31 points), sweating (-2.86 points), insomnia (-2.27 points), and anxiety (-2.00 points) (P<.001 in each case). The isopropanol extract of C racemosa was found to be effective in the alleviation of menopausal symptoms. [ABSTRACT FROM AUTHOR]

Background: Minimizing the duration of mechanical ventilation is one of the most important therapeutic goals during the care of preterm infants at neonatal intensive care units (NICUs). The rate of extubation failure among preterm infants is between 16% and 40% worldwide. Numerous studies have been conducted on the assessment of extubation suitability, the optimal choice of respiratory support around extubation, and the effectiveness of medical interventions. Since the Caffeine Therapy for Apnea of Prematurity (CAP) trial, caffeine has become one of the essential drugs at NICUs. However, the optimal dosage and timing for adequate effectiveness still need to be more conclusive. Previous studies suggest that higher doses of caffeine treatment increase the success rate of extubation. Therefore, we aim to determine whether using a single additional loading dose of caffeine citrate one hour prior to extubation impacts the success rate of extubation., Methods: The study is an open-label, multicenter randomized clinical trial testing the effectiveness and safety of pre-extubational loading dose of caffeine citrate. Inclusion criteria will be infants born before the 32nd gestational week, before the first extubation attempt after at least 48 hours of mechanical ventilation, and a signed parental informed consent. A total of 226 patients will be randomly allocated to either the experimental or control group. The randomization will be stratified by gestational age and antenatal steroid prophylaxis. Preterm infants in the experimental group will receive an additional intravenous (IV) loading dose (20 mg/kg) of caffeine citrate one hour before the first planned extubation, in addition to the standard dosing regimen (20 mg/kg caffeine citrate IV on the first day of life and 5 to 10 mg/kg IV or orally caffeine citrate each consecutive day). Preterm infants in the control group will receive the standard dosing regimen. The primary outcome will be reintubation within 48 hours., Discussion: A pre-extubational loading dose of caffeine citrate can reduce extubation failure. Obtaining evidence on this feature has the potential to contribute to finding the optimal dosing regimen., Trial Registration Number: The study protocol was approved by the Hungarian Ethics Committee for Clinical Pharmacology of the Medical Research Council and National Institute of Pharmacy and Nutrition (OGYÉI/6838-11/2023). ClinicalTrials.gov identifier NCT06401083 Registered 06. May 2024.; EudraCT number: 2022-003202-77., Competing Interests: The authors have declared that no competing interests exist., (Copyright: © 2025 Kovács et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)

Background/objectives: Both hyperandrogenism (HA) and vitamin D deficiency (VDD) can separately lead to impaired vascular reactivity and ovulatory dysfunction in fertile females. The aim was to examine the early interactions of these states in a rat model of PCOS., Methods: Four-week-old adolescent female rats were divided into four groups: vitamin D (VD)-supplemented ( n = 12); VD-supplemented and testosterone-treated ( n = 12); VDD- ( n = 11) and VDD-and-testosterone-treated ( n = 11). Animals underwent transdermal testosterone treatment for 8 weeks. Target VD levels were achieved with oral VD supplementation and a VD-free diet. Estrous cycles were followed by vaginal smear, and quantitative histomorphometric measurements of the ovaries were also taken. In the 8th week, testosterone- and estrogen-induced relaxation of coronary arterioles was examined with pressure angiography. Estrogen receptor (ER) density and oxidative and nitrative stress parameters (Poly-(ADP-Ribose)-Polymerase and 3-nitrotyrosine) in the vessel wall were investigated with immunohistochemistry., Results: VDD caused impaired estrous cycles, and testosterone caused anovulatory cycles (the cycles were stopped at the diestrous phase). VDD combined with testosterone treatment resulted in reduced testosterone and estrogen vasorelaxation, lower ER density, and higher oxidative and nitrative stress in the vessel wall., Conclusions: PCOS with vitamin D deficiency may be associated with increased oxidative-nitrative stress in coronary arterioles. This oxidative and nitrative stress, potentially caused by hyperandrogenism and/or vitamin D deficiency, could impair estrogen-induced relaxation of the coronary arterioles, possibly by decreasing NO bioavailability and disrupting the estrogen-induced relaxation pathway.