Search

Your search keyword '"África Muxí"' showing total 10 results
Start Over Author "África Muxí"
10 results on '"África Muxí"'

1. Characterisation of the coexistence between sarcoidosis and Sjögren's syndrome. Analysis of 43 patients

Author

Alejandra Flores-Chavez, Wan-Fai Ng, Alessia Alunno, Nevsun Inanc, Carlos Feijoo-Massó, Raphaele Seror, Gabriela Hernandez-Molina, Valerie Devauchelle-Pensec, Benedikt Hofauer, Sandra G. Pasoto, Angel Robles, Miriam Akasbi, Miguel López-Dupla, Soledad Retamozo, Matilde Bandeira, Vasco C. Romão, Francesco Carubbi, Daniel Loaiza-Cabello, Jóse-Salvador García-Morillo, Mariana Benegas, Marcelo Sánchez, África Muxí, David Fuster, Jacobo Sellarés, Xavier Mariette, Manuel Ramos-Casals, and Pilar Brito-Zéron

Subjects
Sjogren's Syndrome, Sarcoidosis, Rheumatology, Biopsy, Immunology, Humans, Immunology and Allergy, Female, Middle Aged, Salivary Glands, Sialadenitis
Abstract

To characterise the key epidemiological, clinical, immunological, imaging, and pathological features of the coexistence between sarcoidosis and Sjögren's syndrome (SS).All centres included in two large multicentre registries (the Sjögren Syndrome Big Data Consortium and the Sarco-GEAS-SEMI Registry) were contacted searching for potential cases of coexistence between SS and sarcoidosis seen in daily practice. Inclusion criteria were the fulfilment of the current classification criteria both for SS (2016 ACR/EULAR) and sarcoidosis (WASOG). The following features were considered for evaluating a coexisting immunopathological scenario between the two diseases: non-caseating granulomas (NCG), focal lymphocytic sialadenitis (FLS) and positive anti-Ro antibodies.We identified 43 patients who fulfilled the inclusion criteria (38 women, with a mean age of 53 years at diagnosis of SS and of 52 years at diagnosis of sarcoidosis). In 28 (65%) cases, sarcoidosis was diagnosed concomitantly with SS, or during the follow-up of patients with an already diagnosed SS, while in the remaining 15 (35%), SS was diagnosed during the follow-up of an already diagnosed sarcoidosis. Patients in whom sarcoidosis was diagnosed first showed a lower mean age (43.88 vs. 55.67 years, p=0.005) and were less frequently women (73% vs. 96%, p=0.04) in comparison with those in whom sarcoidosis was diagnosed concomitantly with SS, or during the follow-up of an already diagnosed SS. We identified the following immunopathological scenarios: a combination of NCG involving extrasalivary tissues and anti-Ro antibodies in 55% of patients, a coexistence of both pathological scenarios (extrasalivary NCG and FLS in MSGB) in 42% (with positive anti-Ro antibodies in two thirds of cases), and NCG involving salivary glands and anti-Ro antibodies in 3% of cases.We have characterised the largest reported series of patients who fulfilled the current classification criteria for both SS and sarcoidosis. This implies that sarcoidosis (and not just the presence of isolated NCG on salivary gland biopsy) may, like other systemic autoimmune diseases, coexist with SS, and that a sarcoidosis diagnosis does not preclude the development of SS in the future.

Published
2022

2. CO

Author

Isabel, Vilaseca, Francesc, Xavier Avilés-Jurado, Eduardo, Lehrer, Izaskun, Valduvieco, Neus, Baste, Rosa, Delia Ramírez, José, Miguel Costa, Santiago, Medrano-Martorell, África, Muxí, Paola, Castillo, Llúcia, Alós, and Manuel, Bernal-Sprekelsen

Subjects
Glottis, Treatment Outcome, Carcinoma, Squamous Cell, Humans, Laryngectomy, Laser Therapy, Carbon Dioxide, Middle Aged, Laryngeal Neoplasms, Aged, Neoplasm Staging, Retrospective Studies
Abstract

COTo evaluate the complications and the oncologic and functional outcomes of CORetrospective analysis of 1244 consecutive laryngeal carcinomas treated with COThe mean age was 64.2 ± 11.1 years (20-96). Four hundred and sixteen patients were older than 70 years and 104 older than 80 years. The main location was the glottis (912), followed by the supraglottis (332). There were no differences in pT classification between the age groups. No differences were observed in voice outcomes. A higher rate of signs of aspiration at the glottic location was observed for those older than 70 years (2.1 % vs 5 %, p = 0.027). The need for definitive gastrostomy in supraglottic tumours was higher in those older than 70 years (0 % vs 6.5 %, p: 0.001). In the glottis, no differences in tracheostomy or gastrostomy rates were observed. Five-year overall survival was lower in the older than 70 years. No differences in disease-specific survival were observed in early stages for both locations, but a lower survival was observed in stage III glottic cancer for the older than 70 years.CO

Published
2022

5. Colaboradores

Author

Abalovich, Marcos S., Adamo, Bárbara, García-Navarro, Alvar Agustí, García-Navarro, Carlos Agustí, Alcalá Hernández, Luis, Alcaraz Asensio, Antonio, Alcázar Arroyo, Roberto, Alegre de Miquel, Víctor, Almirante Gragera, Benito, Alonso Fernández, Pedro Luis, Alonso Pérez, Manuel, Alonso Tarrés, Carles, Alsina Gibert, Mercè, Alsina Manrique de Lara, Laia, José Álvarez Martínez, Miriam, Luis Álvarez-Sala Walther, José, Álvarez Twose, Iván, Ambrosioni Czyrko, Juan, Ancochea Bermúdez, Julio, Andrade Bellido, Raúl J., Antón López, Jordi, Antón Nieto, Esperanza, Aran Perramon, Josep Maria, Arance Fernández, Ana, Arboleya Rodríguez, Luis, Arias Gómez, Manuel, Ariza Cardenal, Xavier, Armengol Dulcet, Lluís, Aróstegui Gorospe, Juan Ignacio, Arranz Amo, José Antonio, Arrese, Marco, Arribas López, José Ramón, Audí Parera, Laura, Aulinas Masó, Anna, Azpiroz Vidaur, Fernando, Ramon Badia Jobal, Joan, Badimon Maestro, Lina, Baena Caparrós, Jacinto, Martínez de Irujo, Jaume Baldirà, Barbé Illa, Ferran, Barberà Mir, Joan Albert, Barberán López, José, Barile Fabrís, Leonor, Bartra Tomás, Joan, Bassas Arnau, Lluís, Bassat, Quique, Bataller Alberola, Luis, Bataller Alberola, Ramon, Bayés Colomer, Mónica, Berdasco Menéndez, María, Bernabeu Morón, Ignacio, Bernardo Arroyo, Miquel, Berraondo López, Pedro, Berzigotti, Annalisa, Bielsa Marsol, Isabel, Bladé Creixenti, Joan, Blanco Arévalo, José Luis, Blanco García, Francisco Javier, Blanco Vich, Isabel, Blasco Pelicano, Miquel, Blesa González, Rafael, Bodegas Cañas, Andrés Ignacio, Bodro Marimont, Marta, Boronat Guerrero, Susana, Borràs Andrés, Josep Maria, Borrego Rabasco, Francisco, Bosch Genover, Xavier, Bosch Mestres, Jordi, Botey Puig, Albert, Bouza Santiago, Emilio, Brugada Terradellas, Josep, Brugada Terradellas, Ramon, Bruix Tudó, Jordi, Bruna Escuer, Jordi, Buján Rivas, Segundo, Fernández de Piérola, Luis Bujanda, Burgos Rincón, Felip, Buti Ferret, María, Caballería Rovira, Joan, Cabellos Mínguez, Carmen, Cahn, Pedro, Calvet Calvo, Xavier, Campins Martí, Magda, Campistol Plana, Josep M.ª, Campo Güerri, Elías, Campuzano Larrea, Óscar, Campuzano Uceda, Victoria, Cardellach López, Francesc, Carmena Rodríguez, Rafael, Carmona Herrera, Francisco, Carracedo Álvarez, Ángel, Carracedo Pérez, Arkaitz, Carreres Molas, Anna, Casabona i Barbarà, Jordi, Casademont Pou, Jordi, Casanueva Freijo, Felipe F., Cases Amenós, Aleix, Castells Garangou, Antoni, Castelo-Branco, Camil, Castón Osorio, Juan José, Castro Fornieles, Josefina, Castro Rebollo, Pedro, Catalán Eraso, Beatriz, Caylà Buqueras, Joan A., Cervantes Requena, Francisco, Cervera Álvarez, Carlos, Cervera Segura, Ricard, Chamorro Sánchez, Ángel, Cid Xutglà, María Cinta, Cinca Cuscullola, Juan María, Coll Daroca, Joaquim, José Coll Rosell, M.ª, Colmenero Arroyo, Jordi, Compta Hirnyi, Yaroslau, Conesa Bertrán, Gerardo, Corell Almuzara, Alfredo, Crespo Casal, Manuel, Crespo Conde, Gonzalo, Crespo García, Javier, Cristòfol Allué, Ramon, Cigudosa García, Juan Cruz, Cubiella Fernández, Joaquín, Cuenca Estrella, Manuel, Cuevas Esteban, Jorge, Dalmau Obrador, Josep, Davant Llauradó, Ester, Iserte, Alejandro de la Sierra, Pascual, Enrique de Madaria, Rabassó, Joan de Pablo, Galván, Eduardo de Teresa, Casanelles, Miguel del Campo, Bueno, Ana del Río, Delgado González, Julio, Diekmann, Fritz, Domínguez Benítez, José Antonio, Domínguez García, Ángela, Domínguez Luengo, Carmen, Ángeles Domínguez Luzón, M.ª, Jesús Domínguez Tordable, M.ª, Dopazo Blázquez, Joaquín, Dueñas Laita, Antonio, Durán Rebolledo, Carlos Eduardo, Duró Pujol, Joan Carles, Echevarría Mayo, Juan Emilio, Eiros Bouza, José M.ª, Ignaci Elizalde Frez, J., Embid López, Cristina, Engel Rocamora, Pablo, de Salamanca Lorente, Rafael Enríquez, Escorsell Mañosa, Àngels, España Alonso, Agustín, Esteban Mur, Rafael, Esteller Badosa, Manel, Esteve Comas, María, Esteve Pardo, María, Esteve Reyner, Jordi, Estruch Riba, Ramón, Fainboim, Leonardo, Feliu Frasnedo, Evarist, Fernández Bañares, Fernando, Fernández Fernández, Óscar, Fernández Gómez, Javier, Fernández Llama, Patricia, Ferrándiz Foraster, Carlos, Ferrer Monreal, Miguel, Figuerola Pino, Daniel, Fillat Fonts, Cristina, Fonollosa Pla, Vicent, Fontanellas Romá, Antonio, Forcada Vega, Carme, Forner González, Alejandro, Forns Bernhardt, Xavier, Fortuny Guasch, Claudia, Franco de Castro, Agustín, Fresno Escudero, Manuel, Fullana Rivas, Miquel A., Gaba García, Lydia, Gaig Ventura, Carles, Galarza Delgado, Dionicio Ángel, Galicia Paredes, Miguel, Gállego Culleré, Montserrat, García de Vinuesa, Pastora Gallego, Garcia-Esteve, Lluïsa, García Lareo, Manuel, García-Moncó, Juan Carlos, García Nieto, Víctor, García-Pagán, Juan Carlos, García Sánchez, José Elías, Garrido Marín, Eduardo, Gascón Brustenga, Joaquim, Gatell Artigas, Josep M.ª, Gaztambide Sáenz, Sonia, Genescà Ferrer, Joan, Giavina-Bianchi, Pedro, Gil de Extremera, Blas, Giménez Pérez, Montserrat, Giné Soca, Eva, Ginès Gibert, Pere, Goday Arnó, Albert, Gómez-Batiste Alentorn, Xavier, Gómez Dantés, Héctor, Gómez Gil, Esther, Gomollón García, Fernando, Xavier González Argenté, F., González Juanatey, José Ramón, González Macías, Jesús, González Martín, Julià, González Tugas, Matías, Gracia Guillén, Diego, Grande i Fullana, Iria, Grau de Castro, Juan José, Grau Junyent, Josep M.ª, García-Milà, Isabel Graupera, Graus Ribas, Francesc, Gual Solé, Antoni, Guañabens Gay, Nuria, Gurguí Ferrer, Mercè, Ponce de León, Fernando Gutiérrez, Halperin Rabinovich, Irene, Alexandra Hanzu, Felicia, Hawkins Carranza, Federico G., Hernández García, Miguel Teodoro, Hernández Gea, Virginia, Hernández Rodríguez, José, Herrero Santos, José Ignacio, Ibáñez Toda, Lourdes, Illa Sendra, Isabel, Iranzo de Riquer, Alejandro, Pérez de Guzmán, Dolores Jaraquemada, Jiménez Castro, David, Juan Otero, Manuel, Juanola Roura, Xavier, Kalil, Jorge, Khamashta, Munther A., Labarca Labarca, Jaime, Laborde, Amalia, Lanas Arbeloa, Ángel, Landete Rodríguez, Pedro, Larrosa Escartín, Nieves, Lens García, Sabela, Carlota Londoño, Maria, Bernaldo de Quirós, Juan Carlos López, López de Sá, Esteban, López Guillermo, Armando, López-Sendón, José, López-Vélez Pérez, Rogelio, Lozano Sánchez, Francisco S., Lozano Soto, Francisco, Lumbreras Bermejo, Carlos, Mallolas Masferrer, Josep, Manzanera López, Rafael, Mañá Rey, Juan, Marco Reverté, Francesc, Ángeles Marcos Maeso, M.ª, Marimón Ortiz de Zarate, José María, Mariño Méndez, Zoe, Maroñas Amigo, Olalla, Marrades Sicart, Ramon M.ª, Marrugat de la Iglesia, Jaume, Martí Domènech, María Josep, Martí Mestre, Francesc Xavier, Martí Ripoll, Mercè, Cristina Martín Sierra, M.ª, Martínez Díaz-Guerra, Guillermo, Martínez-Lavín, Manuel, Martínez Martínez, José Antonio, Martínez Valle, Fernando, Martínez Vea, Alberto, Martínez Yoldi, Miguel Julián, Martorell Pons, Jaume, Mas Capó, Jordi, Masana Marín, Lluís, Masana Montejo, Guillem, Mascaró Galy, José Manuel, Matas Andreu, Lurdes, Maurel Santasusana, Joan, Melero Bermejo, Ignacio, Melero Maseda, Marcelo José, Mellado González, Begoña, Mensa Pueyo, José, Mercé Klein, Jorge, Mestres Alomar, Gaspar, Milà Recasens, Montserrat, Milone, Jorge H., Miralles Basseda, Ramón, Miralles Hernández, Manuel, Miró Meda, José María, Mòdol Deltell, Josep M.ª, Molero Richard, Xavier, Molina Infante, Javier, Molina Molina, María, Molins López-Rodó, Laureano, Mont Girbau, Lluís, Montoro Huguet, Miguel Ángel, Montserrat Canal, Josep Maria, Mora Casterá, Elvira, Mora Porta, Mireia, Morales-Olivas, Francisco, Morales Romero, Blai, Morán Chorro, Indalecio, Morata Ruiz, Laura, Asunción Moreno Camacho, M.ª, Moreno Carriles, Rosa María, Muga Bustamante, Roberto, Muñoz Almagro, Carmen, Muñoz Bermúdez, Rosana, Muñoz García, José Esteban, García-Paredes, Patricia Muñoz, Muñoz Gutiérrez, José, Muñoz Mateu, Montserrat, Muñoz Villegas, Álvaro, África Muxí Pradas, María, Navarro Acebes, Xavier, Navasa Anadón, Miquel, Nicolás Arfelis, José María, Nolla Solé, Joan Miquel, Norman, Francesca F., Obach Baurier, Víctor, Obrador Vera, Gregorio Tomás, Oliva Dámaso, Elena, Olivé Marqués, Alejandro, Oriola Ambròs, Josep, Ortiz Arduan, Alberto, de Lejarazu Leonardo, Raúl Ortiz, Oteo Revuelta, José Antonio, Palau Martínez, Francesc, Pallarés Giner, Román, Palou Rivera, Eduardo, Panés Díaz, Julián, Parés Darnaculleta, Albert, Pascal Capdevila, Mariona, Pascual Gómez, Eliseo, Pascual Gómez, Julio, Pascual Mateos, Juan Carlos, Pedro-Botet Montoya, Juan, Luisa Pedro-Botet Montoya, M.ª, Pereira Saavedra, Arturo, Pérez Gisbert, Javier, Pérez-Jurado, Luis Alberto, Pérez Sáenz, José Luis, Picado de Puig, Albert, Picado Valles, César, Picó Alfonso, Antonio, Pigrau Serrallach, Carlos, Jesús Pinazo Delgado, M.ª, Pintado García, Vicente, Pintos Morell, Guillem, Piñeiro Ibáñez, Daniel José, Piqueras Carrasco, Josep, López de Briñas, Esteban Poch, Pons-Estel, Bernardo A., Pons-Estel, Guillermo J., Pons Lladó, Guillem, Porcel Pérez, José Manuel, Portela Hernández, Margarita, Praga Terente, Manuel, Prat Aparicio, Aleix, Puig Domingo, Manuel, Pujol-Borrell, Ricardo, Pulido Mestre, Marta, Pumarola Suñé, Tomàs, Puras Mallagray, Enrique, Quintana Porras, Luis F., Quintero Carrión, Enrique, Adrián Rabinovich, Gabriel, Rabionet Janssen, Raquel, Ramos Casals, Manuel, Raya Sánchez, José María, Rego Castro, Maria José, Reguart Aransay, Noemí, Reverter Calatayud, Joan Carles, Reverter Calatayud, Jorge Luis, Reyes Moreno, José, Riambau Alonso, Vicente, Ribera Casado, José Manuel, Ribera Santasusana, Josep M.ª, Ribes Rubió, Antonia, Robert Boter, Neus, Roca Lecumberri, Alba, Roca Torrent, Josep, Roche Rebollo, Enric, Gonzalo de Liria, Carlos Rodrigo, Rodríguez Baño, Jesús, Rodríguez de Castro, Felipe, Rodríguez Panadero, Francisco, Rodríguez Pérez, José Carlos, Rodríguez-Roisin, Roberto, Rodríguez Valero, Natalia, Roig Minguell, Eulàlia, Rojas García, Ricardo, Roman Broto, Antonio, Romero Gómez, Manuel, Ros Cerro, Cristina, Rovira Cañellas, Àlex, Rozman, Ciril, Rozman Jurado, María, Ruiz-Argüelles, Guillermo José, Ruiz Granell, Ricardo, Ruiz Manzano, Juan, Ruiz Moreno, Javier, Sabaté Tenas, Manel, Saiz Hinajeros, Albert, Sala Sanjaume, Joan, Salgado García, Emilio, Salinas Vert, Isabel, San Miguel Izquierdo, Jesús F., Sánchez del Valle Díaz, Raquel, Sánchez González, Marcelo, Sánchez Rodríguez, Ángel, Sanmartí Sala, Raimon, Ángel Sanz Alonso, Miguel, Sanz Santillana, Guillermo F., Saperas Franch, Esteban, Saurí Nadal, Tamara, Schwarzstein, Diego, Segura Egea, Antònia, Segura Porta, Ferrán, Sellarés Torres, Jacobo, Selva O’Callaghan, Albert, Serra Majem, Lluís, Serrano Gimaré, Mercedes, Sibila Vidal, Oriol, Sierra Gil, Jorge, Sierra Romero, Gustavo Adolfo, Sitges Carreño, Marta, Solà Vergés, Elsa, Solana Lara, Rafael, Solans Laqué, Roser, Gloria Soldevila Melgarejo, M.ª, Soler Porcar, Néstor, Sopena Galindo, Nieves, Soriano Viladomiu, Álex, Soy Muner, Dolors, Suárez Fernández, Ricardo, Suela Rubio, Javier, Targarona Soler, Eduardo M.ª, Tejedor Jorge, Alberto, Tolosa Sarró, Eduardo, Tornero Molina, Jesús, Tornos Mas, Pilar, Torra Balcells, Roser, Torregrosa Prats, José Vicente, Torres Hortal, Montserrat, Torres Martí, Antoni, Torres Ramírez, Armando, Torrico, Faustino, Trilla García, Antoni, Tuca Rodríguez, Albert, Tudela Hita, Pere, Urbano Ispizua, Álvaro, Urrutia de Diego, Agustín, Valero Santiago, Antonio Luis, Valle Velasco, Laura, Eugenia Valls Lolla, M.ª, Valls Solé, Josep, Vaquero Raya, Eva C., Varsavsky, Mariela, Vázquez Martínez, Clotilde, San Miguel, Federico Vázquez, Vázquez Zaragoza, Miguel Ángel, Vicente García, Vicente, Vidal Bermúdez, José Ernesto, Vidal Losada, Maria, Vidal-Puig, Antonio, Vieta Pascual, Eduard, Vila Estapé, Jordi, Vilardell Tarrés, Miquel, Vilaseca González, Isabel, Vilella i Morató, Anna, Villà i Freixa, Salvador, Villabona Artero, Carles, Villamor Casas, Neus, Vinuesa Aumedes, Teresa, Viñolas Segarra, Nuria, Vives Corrons, Joan Lluís, Volberg Vincent, Veronica Inés, Vollmer Torrubiano, Ivan, Webb Youdale, Susan M., Yagüe Ribes, Jordi, Yugueros Castellnou, Xavier, and Zarranz Imirizaldu, Juan José

Published
2020
Full Text
View/download PDF

6. Transoral laser microsurgery for locally advanced (T3-T4a) supraglottic squamous cell carcinoma: Sixteen years of experience

Author

Isabel, Vilaseca, José Luis, Blanch, Joan, Berenguer, Juan José, Grau, Eugenia, Verger, África, Muxí, and Manuel, Bernal-Sprekelsen

Subjects
Male, Natural Orifice Endoscopic Surgery, Glottis, Microsurgery, Databases, Factual, Laryngectomy, Kaplan-Meier Estimate, Risk Assessment, Disease-Free Survival, Humans, Neoplasm Invasiveness, Laryngeal Neoplasms, Aged, Neoplasm Staging, Retrospective Studies, Aged, 80 and over, Chi-Square Distribution, Squamous Cell Carcinoma of Head and Neck, Middle Aged, Prognosis, Survival Analysis, Logistic Models, Treatment Outcome, Head and Neck Neoplasms, Carcinoma, Squamous Cell, Female, Laser Therapy, Neoplasm Recurrence, Local
Abstract

Controversy exists regarding treatment of advanced laryngeal cancer. The purpose of this study was to evaluate the oncologic and functional outcomes of T3 to T4a supraglottic squamous carcinomas treated with transoral laser microsurgery (TLM).We conducted a retrospective analysis from an SPSS database. Primary outcomes were: locoregional control, overall survival (OS), disease-specific survival (DSS), laryngectomy-free survival, and function-preservation rates. Secondary objectives were: rate of tracheostomies and gastrostomies according to age. Risk factors for local control and larynx preservation were also evaluated.One hundred fifty-four consecutive patients were chosen for this study. Median follow-up was 40.7 + /- 32.8 months. Five and 10-year OS, DSS, and laryngectomy-free survival were 55.6% and 47%, 67.6% and 58.6%, and 75.2% and 59.5%, respectively. Paraglottic involvement was an independent factor for larynx preservation. Six patients (3.9%) needed a definitive tracheostomy, a gastrostomy, or both. The gastrostomy rate was higher in the group of patients above 65 years of age (p = .03). Five-year laryngectomy-free survival with preserved function was 74.5%.TLM constitutes a true alternative for organ preservation in locally advanced supraglottic carcinomas with good oncologic and functional outcomes. © 2016 Wiley Periodicals, Inc. Head Neck 38: 1050-1057, 2016.

Published
2015

7. Base de datos de normalidad de la SPECT de perfusión miocárdica en la población española

Author

Gemma Cuberas-Borrós, Guillermo Romero-Farina, María Boronat-de Ferrater, Jaume Candell-Riera, Joan Castell-Conesa, Santiago Aguadé-Bruix, David Garcia-Dorado, María África Muxí-Pradas, and Verónica Aliaga

Subjects
business.industry, Medicine, Cardiology and Cardiovascular Medicine, business, Humanities
Abstract

Resumen Introduccion y objetivos El objetivo de este estudio ha sido crear una base de datos espanola (BDE) de normalidad de la SPECT (single photon emission computed tomography) de perfusion miocardica y compararla con una base de datos de normalidad de poblacion norteamericana. Metodos Se selecciono a 104 voluntarios sanos (45 mujeres, media de edad, 42 ± 14 anos) a los que se practico una SPECT de estres y reposo, procesandose los estudios en el programa comercial 4DM-SPECT. La BDE de normalidad generada para varones y mujeres se comparo con la base de datos de la poblacion norteamericana (70 varones y 60 mujeres) que proporciona el programa 4DM-SPECT. Resultados En la BDE el mayor porcentaje de captacion correspondio a la region lateral-medial, y el menor, a la region septal-basal, tanto en estres como en reposo. En las mujeres el porcentaje de captacion de la region anterior-medial fue significativamente mas bajo que en los varones, mientras que en estos se observo una menor captacion en las regiones inferiores, septal medial y apical con respecto a las mujeres. Los valores de la BDE fueron significativamente mas bajos que los de la 4DMSPECT en la mayoria de las regiones. Conclusiones Se ha creado una base de datos de normalidad espanola para mujeres y varones por separado de la SPECT de perfusion miocardica, y se ha observado que hay diferencias significativas con una base de datos comercial de origen norteamericano que suele utilizarse en estudios semicuantitativos.

Published
2010

8. Randomized trial comparing monthly ibandronate and weekly alendronate for osteoporosis in patients with primary biliary cirrhosis

Author

Núria, Guañabens, Anna, Monegal, Dacia, Cerdá, África, Muxí, Laia, Gifre, Pilar, Peris, and Albert, Parés

Subjects
Alendronate, Diphosphonates, Liver Cirrhosis, Biliary, Administration, Oral, Middle Aged, Drug Administration Schedule, Article, Fractures, Bone, Treatment Outcome, Bone Density, Humans, Patient Compliance, Female, Ibandronic Acid, Osteoporosis, Postmenopausal, Aged
Abstract

Osteoporosis resulting in bone fractures is a complication in patients with primary biliary cirrhosis (PBC). Once-weekly alendronate improves bone mass and is well tolerated in these patients, but there is a concern because of poor compliance. Therefore, the efficacy, adherence, and safety of monthly ibandronate (150 mg) with weekly alendronate (70 mg) were compared in a randomized, 2-year study in 42 postmenopausal women with PBC and osteoporosis. Bone mineral density (BMD) of the lumbar spine and proximal femur (by DXA), liver function, and bone markers were measured at entry and every 6 months over 2 years. Adherence to therapy was assessed by the Morisky-Green score. At enrollment, the two groups were similar with respect to age, BMD, severity of cholestasis, previous fractures, and bone markers. Thirty-three patients, 14 in the ibandronate group and 19 in the alendronate group, completed the trial. At 2 years both treatments resulted in a significant increase in BMD at the lumbar spine (from 0.875 ± 0.025 to 0.913 ± 0.026 g/cm(2), P0.001 with alendronate, and from 0.898 ± 0.024 to 0.949 ± 0.027 g/cm(2), P0.001 with ibandronate). The mean percentage change was 4.5% and 5.7%, respectively (P = not significant). BMD increased at the total hip by 2.0% and 1.2%, respectively. Changes in bone markers were similar in both groups and one patient with alendronate developed a new vertebral fracture. Adherence to therapy was higher with ibandronate (P = 0.009). Neither treatment impaired liver function or cholestasis.Both regimens, weekly alendronate and monthly ibandronate, improve bone mass and are comparable in safety for osteoporosis therapy in patients with PBC, although adherence is higher with the monthly regimen. Further larger studies are needed to assess fracture prevention.

Published
2013

9. Normal myocardial perfusion SPECT database for the Spanish population

Author

Gemma Cuberas-Borrós, Guillermo Romero-Farina, María Boronat-de Ferrater, María África Muxí-Pradas, David Garcia-Dorado, Jaume Candell-Riera, Joan Castell-Conesa, Santiago Aguadé-Bruix, and Verónica Aliaga

Subjects
Adult, Male, Tomography, Emission-Computed, Single-Photon, medicine.diagnostic_test, Database, Databases, Factual, business.industry, Mean age, General Medicine, Scintigraphy, computer.software_genre, United States, Spanish population, Reference Values, Spain, Coronary Circulation, North american population, Healthy volunteers, Medicine, Humans, Female, business, Perfusion, computer, Emission computed tomography
Abstract

Introduction and objectives The aims of this study were to create a Spanish database of normal myocardial perfusion SPECT (single-photon emission computed tomography) data, termed the normal Spanish database, and to compare it with a database of normal data from the North American population. Methods We selected 104 healthy volunteers (45 female, mean age 42±14 years) who underwent SPECT during stress and at rest. The findings were analyzed using the 4DM-SPECT commercial software package. The resulting normal Spanish database for males and females was compared with the North American population database (from 70 men and 60 women) provided with the 4DM-SPECT software. Results In the Spanish database, the highest percentage uptake during both stress and rest was observed in the medial–lateral region and the lowest, in the basal–septal region. The percentage uptake in the anterior–medial region was significantly lower in women than men, while uptake in the inferior, medial–septal and apical regions was lower in men than women. Data values in the Spanish database were significantly lower for the majority of heart regions than those in the database with the 4DM-SPECT software. Conclusions A Spanish database of normal myocardial perfusion SPECT data was created and included separate data for men and women. Significant differences were observed between this database and a commercial North American database that is commonly used in semiquantitative studies.

Published
2010

10. Vertebral fracture risk in glucocorticoid-induced osteoporosis: the role of hypogonadism and corticosteroid boluses

Author

José A Gómez-Puerta, Núria Guañabens, Maria Cid, Gerard Espinosa, Sergio Prieto-González, José Hernández-Rodríguez, Helena Florez, Josep Lluis Carrasco, Africa Muxi, Xavier Filella, Silvia Ruiz-Gaspà, Ana Monegal, and Pilar Peris

Subjects
Medicine
Abstract

Objective The aim of this study was to identify the risk factors associated with fragility fracture (FF) development in glucocorticoid (GC)-treated patients.Methods 127 patients (aged 62±18 years, 63% women) on GC-treatment (mean dose 14.5±14.1 mg/day and duration 47.7±69 months) were included. The clinical data collected included bone metabolism study (including gonadal axis), GC-treatment, disease activity, dual-energy X-ray absorptiometry analysis (evaluating densitometric osteoporosis (OP) and trabecular bone score (TBS) degraded microarchitecture values (DMA)), X-ray (assessing vertebral fractures (VF)), FRAX risk (GC-adjusted) and previous FF.Results 17% of the patients had VF, 28% FF (VF and/or non-VF), 29% OP and 52% DMA. Patients with VF received more GC boluses (57.1% vs 29.5%, p=0.03), were older (68±13 vs 60±19 years, p=0.02), postmenopausal (100% vs 67%, p=0.02), had low testosterone levels (57% vs 11%, p=0.02), lower TBS values (1.119±0.03 vs 1.237±0.013, p100, p=0.01) and having received GC boluses (OR 3.45; 95% CI 1.04 to 12.15, p=0.01) were the main factors related to VF. Hypogonadism (OR 7.03; 95% CI 1.47 to 38.37, p=0.01) and FRAX >20 (OR 7.08; 95% CI 1.28 to 53.71, p=0.02) were factors related to FF.Conclusion Hypogonadism is the principal risk factor for developing fractures in GC-treated men and women, whereas receiving GC boluses is a major factor for VF. These results indicate the importance of evaluating the gonadal axis in these patients.

Published
2020
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results