15 results on '"Álvarez-Lario, Bonifacio"'
Search Results
2. CORRESPONDENCE: Gout treatment: when a tablet is not enough
- Author
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Álvarez-Lario, Bonifacio and Alonso-Valdivielso, José L.
- Published
- 2014
- Full Text
- View/download PDF
3. Giant Cell Arteritis With Spontaneous Remission
- Author
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Álvarez-Lario, Bonifacio, primary, Lorenzo-Martín, José Andrés, additional, Colazo-Burlato, María, additional, Macarrón-Vicente, Jesús Luis, additional, and Alonso-Valdivielso, José Luis, additional
- Published
- 2021
- Full Text
- View/download PDF
4. Carbamazepine-induced systemic lupus erythematosus: A case-based review
- Author
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Álvarez-Lario, Bonifacio, Bártulos-Iglesias, Mónica, Colazo-Burlato, María, and Macarrón-Vicente, Jesús
- Subjects
lcsh:Immunologic diseases. Allergy ,medicine.medical_specialty ,Anti-nuclear antibody ,Constitutional symptoms ,Mucocutaneous zone ,Arthritis ,Serology ,03 medical and health sciences ,Pericarditis ,Epilepsy ,0302 clinical medicine ,systemic lupus erythematosus ,drug-induced systemic lupus erythematosus ,Medicine ,antiepileptic drugs ,skin and connective tissue diseases ,Literature Review ,business.industry ,medicine.disease ,Dermatology ,Discontinuation ,carbamazepine ,030220 oncology & carcinogenesis ,Anticonvulsant drugs ,business ,lcsh:RC581-607 ,030217 neurology & neurosurgery - Abstract
A case of carbamazepine-induced systemic lupus erythematosus (CBZ-DILE) is presented, along with a literature review, with the aim to define the clinical and serological characteristics of this group, and compare them with systemic lupus erythematosus (SLE) triggered by other drugs (DILE). A 31-year-old woman presented with a 6-month history of hand arthritis and nasal ulcers. She had been diagnosed with epilepsy at 12 years of age and had continued treatment with carbamazepine (CBZ) for the past 18 years with excellent clinical control. Laboratory data revealed antinuclear antibodies (ANA) positive to a titer of 1/1280, and positive anti-nucleosome antibodies. The patients' clinical symptoms disappeared after the CBZ discontinuation and did not reappear during the 1-year follow-up period. A search was made in the PubMed/Medline database of the (CBZ-DILE) published cases. A total of 26 cases of CBZ-DILE were found in the search. CBZ-DILE cases are characterized by variable latency periods that often last for years and are not related to the dose of CBZ. Most frequent clinical findings of CBZ-DILE in patients are arthralgia/arthritis, mucocutaneous manifestations, constitutional symptoms, and pleuritis or pericarditis. The renal involvement has not been reported in CBZ-DILE. Antihistone antibodies were observed less frequently, and anti-dsDNA antibodies were observed more frequently than in the "classic" DILE. The ANA remained positive in over 60% of cases during the follow-up after withdrawal. The CBZ-DILE has significant clinical and laboratory manifestations that distinguish it from classic DILE or idiopathic SLE.
- Published
- 2019
5. Giant cell arteritis with spontaneous remission.
- Author
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Álvarez-Lario, Bonifacio, Lorenzo-Martín, José Andrés, Colazo-Burlato, María, Macarrón-Vicente, Jesús Luis, and Alonso-Valdivielso, José Luis
- Subjects
- *
GIANT cell arteritis , *POLYMYALGIA rheumatica , *GENERAL practitioners , *AXILLARY artery , *SYMPTOMS , *TEMPORAL arteries - Published
- 2022
- Full Text
- View/download PDF
6. Uric acid and evolution
- Author
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Álvarez-Lario, Bonifacio and Macarrón-Vicente, Jesús
- Published
- 2010
- Full Text
- View/download PDF
7. Arteritis de células gigantes y Síndrome de Charles Bonnet
- Author
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Álvarez-Lario, Bonifacio, primary and Macarrón-Vicente, Jesús, additional
- Published
- 2019
- Full Text
- View/download PDF
8. Carbamazepine-induced systemic lupus erythematosus: A case-based review.
- Author
-
Álvarez-Lario, Bonifacio, Bártulos-Iglesias, Mónica, Colazo-Burlato, María, and Macarrón-Vicente, Jesús
- Abstract
A case of carbamazepine-induced systemic lupus erythematosus (CBZ-DILE) is presented, along with a literature review, with the aim to define the clinical and serological characteristics of this group, and compare them with systemic lupus erythematosus (SLE) triggered by other drugs (DILE). A 31-year-old woman presented with a 6-month history of hand arthritis and nasal ulcers. She had been diagnosed with epilepsy at 12 years of age and had continued treatment with carbamazepine (CBZ) for the past 18 years with excellent clinical control. Laboratory data revealed antinuclear antibodies (ANA) positive to a titer of 1/1280, and positive anti-nucleosome antibodies. The patients' clinical symptoms disappeared after the CBZ discontinuation and did not reappear during the 1-year follow-up period. A search was made in the PubMed/Medline database of the (CBZ-DILE) published cases. A total of 26 cases of CBZ-DILE were found in the search. CBZ-DILE cases are characterized by variable latency periods that often last for years and are not related to the dose of CBZ. Most frequent clinical findings of CBZ-DILE in patients are arthralgia/arthritis, mucocutaneous manifestations, constitutional symptoms, and pleuritis or pericarditis. The renal involvement has not been reported in CBZ-DILE. Antihistone antibodies were observed less frequently, and anti-dsDNA antibodies were observed more frequently than in the "classic" DILE. The ANA remained positive in over 60% of cases during the follow-up after withdrawal. The CBZ-DILE has significant clinical and laboratory manifestations that distinguish it from classic DILE or idiopathic SLE. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
9. Hiperuricemia y gota: el papel de la dieta
- Author
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Álvarez-Lario, Bonifacio and Alonso-Valdivielso, J. L.
- Subjects
Ácido úrico ,Gout ,Dieta ,Hyperuricemia ,Gota ,Uric acid ,Hiperuricemia ,Comorbilidades ,Diet ,Comorbidities - Abstract
Desde la antigüedad se ha relacionado a la gota con los excesos en el comer y en el beber; sin embargo, ha sido en la última década cuando se ha llegado a un mayor conocimiento sobre los factores dietéticos asociados con el desarrollo de hiperuricemia y gota. La obesidad, el abuso en la ingesta de carnes y las bebidas alcohólicas ya eran vistos como culpables desde la antigüedad. Las legumbres y las verduras ricas en purinas han sido exculpadas tras los estudios. Se han descrito nuevos factores de riesgo, no reconocidos anteriormente, como la fructosa y las bebidas edulcoradas. Finalmente, también se han descrito factores protectores, como los lácteos desnatados. La gota se caracteriza no sólo por el aumento del ácido úrico, eventuales episodios de artritis y el daño crónico articular, sino también por su asociación con diversas comorbilidades y con el aumento del riesgo cardiovascular. La adopción de hábitos dietéticos más sanos puede contribuir a un mejor control de la uricemia y también a una reducción de las enfermedades asociadas. Se recogen las recomendaciones prácticas más habituales según los conocimientos actuales y siguiendo los consejos de las principales guías de tratamiento. Son necesarios más estudios sobre la eficacia real en la práctica clínica de la adopción de unas y otras medidas dietéticas en el tratamiento y evolución de los pacientes con hiperuricemia y gota. From ancient times, gout has been related with excessive eating and drinking; however, it has not been until the last decade that a broader knowledge on dietary factors associated with hyperuricemia and gout has been achieved. Obesity, excessive intake of red meats and alcoholic beverages were already recognized as causal factors from Antiquity. Legumes and purine rich vegetables have been exculpated after the studies. New risk factors, not previously recognized, have been described such as fructose and sweetened beverages. Finally, protective factors have also been described, such as skimmed dairy products. Gout is characterized not only by an increase in uric acid, eventual episodes of arthritis, and chronic joint damage, but also by association with several comorbidities and increased cardiovascular risk. The adoption of more healthier dietary habits may contribute to better management of uricemia and also to a reduction of associated diseases. The most common practice recommendations according to current knowledge and the main treatment guidelines are reviewed. Additional studies are needed on the actual efficacy in clinical practice of the adoption of specific dietary measures on the management and clinical course of patients with hyperuricemia and gout.
- Published
- 2014
10. Gout treatment: when a tablet is not enough
- Author
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Álvarez-Lario, Bonifacio, primary and Alonso-Valdivielso, José L., additional
- Published
- 2014
- Full Text
- View/download PDF
11. Artritis reactiva por Mycoplasma pneumoniae
- Author
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Álvarez Lario, Bonifacio, primary, Alonso Valdivielso, José Luis, additional, and Ceballos Barón, Isabel, additional
- Published
- 2002
- Full Text
- View/download PDF
12. El libro de la artritis reumatoide
- Author
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Alvarez Lario, Bonifacio and Alvarez Lario, Bonifacio
- Abstract
Este libro, escrito por un médico reumatólogo, está pensado para los pacientes, e intenta dar respuestas a sus preocupaciones y a los temas que les interesan. Este no es un libro para diagnosticar la artritis reumatoide; el diagnostico de la enfermedad corresponde al médico. De ninguna manera es un libro para automedicarse: el tratamiento de su enfermedad corresponde igualmente a su médico. Es un libro dirigido a mejorar la información al paciente sobre su enfermedad, no para proporcionar cuidados médicos. El libro aparece dividido en dos partes. En la primera se ofrece información general sobre la enfermedad. La segunda parte está dedicada fundamentalmente a los cuidados personales, consejosy autoayuda del paciente con artritis reumatoide. No es una novela para leerlade un tirón. Si la primera se le hace pesada, puede pasar a la segunda parteque es más práctica y amena. Ya irá leyendo poco a poco la información sobre la enfermedad. Para los que se les haga pesadas la lectura de todo el texto y para reforzar las ideas generales, al final de cada capítulo aparece un recuadro con las recomendaciones generales o puntos clave más importantes y prácticospara el paciente.INDICE Introducción. La artritis reumatoide. El diagnóstico. Las causas. Los síntomas. Evolución y pronóstico. Tratamiento de la artritis reumatoide. Complicaciones que conviene vigilar. Otras informaciones de interés. Relación médico-enfermo. Métodos para alivio del dolor. Ejercicio y artritis reumatoide. Medidas generales de protección articular. Cansancio. Alimentación. Terapias alternativas. Actividad sexual. Terapia psicosocial. Decálogo para enfrentarse con éxito a la artritis reumatoide. Bibliografía.
- Published
- 2003
13. Long-Term Survival of Subcutaneous Biosimilar Tumor Necrosis Factor Inhibitors Compared to Originators: Results From a Multicenter Prospective Registry.
- Author
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Martínez-Vidal MP, Fernández-Carballido C, Otero-Varela L, Manero Ruiz FJ, Pérez-Vera Y, Manrique Arija S, Campos Fernández C, Jovaní V, Expósito L, Álvarez Lario B, García-González J, Sánchez-Alonso F, and Castrejón I
- Abstract
Objective: To analyze the long-term survival of subcutaneous biosimilar tumor necrosis factor inhibitors compared to the originator molecules in patients with rheumatic diseases, as well as the factors associated with drug discontinuation., Methods: Retrospective analysis of BIOBADASER, the Spanish multicenter prospective registry of patients with rheumatic disease receiving biologic and targeted disease-modifying antirheumatic drugs. Patients who started etanercept (ETN) or adalimumab (ADA) from January 2016 to October 2023 were included. The survival probabilities of biosimilars and originators were compared using Kaplan-Meier estimating curves. To identify factors associated with differences in the retention rates, hazard ratios (HR) were estimated using Cox regression models for all and specific causes (inefficacy or adverse events [AEs]) of discontinuation., Results: A total of 4162 patients received 4723 treatment courses (2991 courses of ADA and 1732 courses of ETN), of which 722 (15.29%) were with originator molecules and 4001 (84.71%) were with biosimilars. The originators were more frequently discontinued than biosimilars (53.32% vs 33.37%, respectively). The main reason for discontinuation was inefficacy (60.35% of the treatments). The risk of overall discontinuation was lower for biosimilars (adjusted HR 0.84, 95% CI 0.75-0.95). Female sex, obesity, and second or later treatment lines increased the risk of discontinuation, whereas disease duration and the use of concomitant methotrexate were associated with a greater survival. When assessing cause-specific reasons of discontinuation, excluding nonmedical switching, the results from the crude and adjusted analyses showed no significant differences in the retention rate between biosimilars and originators., Conclusion: No significant differences were found between treatments in long-term survival due to inefficacy or AEs.
- Published
- 2024
- Full Text
- View/download PDF
14. [Giant Cell Arteritis and Charles Bonnet Syndrome. The Case of Saint Martin of Leon]
- Author
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Álvarez-Lario B and Macarrón-Vicente J
- Subjects
- Charles Bonnet Syndrome diagnosis, Giant Cell Arteritis diagnosis, History, Medieval, Humans, Charles Bonnet Syndrome history, Giant Cell Arteritis history
- Abstract
Saint Martin of Leon was a monk who lived in the 12th century. The details of his life are known because they were described by his contemporary, Lucas de Tuy, in the Liber de Miraculis Sancti Isidori. Saint Martin of Leon was a venerable old man who suffered from severe headaches, considerable difficulties in raising or maintaining his arms raised, asthenia, and anorexia. In addition, he is represented in his codex Concordia with an unusual hyperpigmentation of the temples suggesting a therapeutic intervention on temporal arteries. These data lead us to think that this could be the first described case of giant cell arteritis with some clinical information. Moreover, he experienced a singular and curious appearance of Saint Isidore of Seville, who made him swallow a booklet, which might correspond to a complex visual hallucination or associated Charles Bonnet syndrome. Historical data on the disease are reviewed and discussed, as well as its evolution and treatment before giving steroids.
- Published
- 2019
- Full Text
- View/download PDF
15. [Hyperuricemia and gout; the role of diet].
- Author
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Álvarez-Lario B and Alonso-Valdivielso JL
- Subjects
- Humans, Diet, Gout diet therapy, Gout etiology, Hyperuricemia complications, Hyperuricemia diet therapy
- Abstract
From ancient times, gout has been related with excessive eating and drinking; however, it has not been until the last decade that a broader knowledge on dietary factors associated with hyperuricemia and gout has been achieved. Obesity, excessive intake of red meats and alcoholic beverages were already recognized as causal factors from Antiquity. Legumes and purine rich vegetables have been exculpated after the studies. New risk factors, not previously recognized, have been described such as fructose and sweetened beverages. Finally, protective factors have also been described, such as skimmed dairy products. Gout is characterized not only by an increase in uric acid, eventual episodes of arthritis, and chronic joint damage, but also by association with several comorbidities and increased cardiovascular risk. The adoption of more healthier dietary habits may contribute to better management of uricemia and also to a reduction of associated diseases. The most common practice recommendations according to current knowledge and the main treatment guidelines are reviewed. Additional studies are needed on the actual efficacy in clinical practice of the adoption of specific dietary measures on the management and clinical course of patients with hyperuricemia and gout., (Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights reserved.)
- Published
- 2014
- Full Text
- View/download PDF
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