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26 results on '"Ångström, Tord"'

5. f laser

Author

Kjellberg, Lennart, Wadell, Göran, Bergman, Frank, Isaksson, Monica, Ångström, Tord, and Dillner, Joakim

Published
2000
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11. A population-based prospective study ofChlamydia trachomatisinfection and cervical carcinoma

Author

Wallin, Keng-Ling, primary, Wiklund, Fredrik, additional, Luostarinen, Tapio, additional, Ångström, Tord, additional, Anttila, Tarja, additional, Bergman, Frank, additional, Hallmans, Göran, additional, Ikäheimo, Irma, additional, Koskela, Pentti, additional, Lehtinen, Matti, additional, Stendahl, Ulf, additional, Paavonen, Jorma, additional, and Dillner, Joakim, additional

Published
2002
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12. Amplification of thetelomerase reverse transcriptase(hTERT) gene in cervical carcinomas

Author

Zhang, Anju, primary, Zheng, Chengyun, additional, Hou, Mi, additional, Lindvall, Charlotta, additional, Wallin, Keng-Ling, additional, Ångström, Tord, additional, Yang, Xiaoyan, additional, Hellström, Ann-Cathrin, additional, Blennow, Elisabeth, additional, Björkholm, Magnus, additional, Zetterberg, Anders, additional, Gruber, Astrid, additional, and Xu, Dawei, additional

Published
2002
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17. A prospective study on the risk of cervical intra-epithelial neoplasia among healthy subjects with serum antibodies to HPV compared with HPV DNA in cervical smears

Author

Chua, Keng-Ling, primary, Wiklund, Fredrik, additional, Lenner, Per, additional, Ångström, Tord, additional, Hallmans, Göran, additional, Bergman, Frank, additional, Sapp, Martin, additional, Schiller, John, additional, Wadell, Göran, additional, Hjerpe, Anders, additional, and Dillner, Joakim, additional

Published
1996
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18. p16INK4a and laminin-5γ2 chain expression during the progression of cervical neoplasia.

Author

Wang, Jian-Liu, Andersson, Sonia, Li, Xidan, Hellström, Ann-Cathrin, Auer, Gert, Ångström, Tord, Lindström, Mikael S., and Keng-Ling Wallin

Subjects
CERVICAL cancer, TISSUES, BIOLOGICAL membranes, EPITHELIUM, CANCER
Abstract

p16INK4a, laminin-5γ2 chain, and PCNA were investigated to compare the expression levels in relation to histological diagnosis and time for progression. The material consisted of 37 normal cervical tissues, 35 with different grades of CIN, and 11 invasive cervical cancers. Our results showed a reduction of basement membrane staining for laminin-5γ2 chain from 78.4% in normal squamous epithelium to 27.8% in CIN3 (p < 0.001). The intracytoplasmic staining for laminin-5γ2 chain increases with severity of lesion. The same trend was observed with p16INK4a and PCNA expression (p < 0.001). Co-expression of p16INK4a and PCNA was seen in 85.7% of samples. Cases that were laminin-5γ2 chain BM - /p16INK4a+/PCNA+ have the shortest interval time (average: 46.8±36.3 months) for progression, while cases with laminin-5γ2 chain BM + /p16INK4a-/PCNAPCNA- have the longest time interval (average: 110.2±52.7 months) (p < 0.05). Thus co-expression of p16INK4a, laminin-5γ2 chain and PCNA may be valuable for the prediction progression of cervical neoplasia. [ABSTRACT FROM AUTHOR]

Published
2006
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22. A population-based prospective study of <TOGGLE>Chlamydia trachomatis</TOGGLE> infection and cervical carcinoma

Author

Wallin, Keng-Ling, Wiklund, Fredrik, Luostarinen, Tapio, Ångström, Tord, Anttila, Tarja, Bergman, Frank, Hallmans, Göran, Ikäheimo, Irma, Koskela, Pentti, Lehtinen, Matti, Stendahl, Ulf, and Paavonen, Jorma

Abstract

Persistent human papillomavirus (HPV) infection is an established cause of cervical cancer, but the role of other sexually transmitted agents, most notably Chlamydia trachomatis, has not been well defined. The women participating in the population-based cervical cancer screening program in Västerbotten county of Northern Sweden were followed up for up to 26 years to identify 118 women who developed cervical cancer after having had a normal Pap smear (on average 5.6 years later; range 0.5 months–26 years). As controls, we selected another 118 women who were matched by birth cohort, time-point of sampling of the baseline normal smear and who had a normal smear at the time when the corresponding case was diagnosed with cancer. The Pap smears and cervical cancer biopsies were analyzed by PCR for C. trachomatis DNA and for HPV DNA. At baseline, C. trachomatis DNA was present in 8% of cases but not among any one of the controls. The relative risk for cervical cancer associated with past C. trachomatis infection, adjusted for concomitant HPV DNA positivity, was 17.1 (95% CI 2.6–∞).The presence of C. trachomatis and of HPV were not interrelated. Whereas C. trachomatis was primarily found in specimens taken many years before cancer diagnosis, HPV DNA was associated with a short lag time before cancer diagnosis. Whereas most women who were HPV DNA-positive in the prediagnostic smear were also positive for the same virus in the cervical cancer biopsy, none of the women were positive for C. trachomatis in both the prediagnostic smear and in the subsequent cervical cancer. In conclusion, a prior cervical C. trachomatis infection was associated with an increased risk for development of invasive cervical cancer. © 2002 Wiley-Liss, Inc.

Published
2002
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