22 results on '"Çakmak, Özgür Öztop"'
Search Results
2. Spinal fusion in facioscapulohumeral dystrophy for hyperlordosis: A case report
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Eren, İlker, Abay, Berk, Günerbüyük, Caner, Çakmak, Özgür Öztop, Şar, Cüneyt, and Demirhan, Mehmet
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- 2020
- Full Text
- View/download PDF
3. Hand pronation-supination movement as a proxy for remotely monitoring gait and posture stability in Parkinson's disease
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Çakmak, Özgür Öztop (ORCID 0000-0003-3413-0332 & YÖK ID 299358); Ertan, Fatoş Sibel (ORCID 0000-0003-1339-243X & YÖK ID 112829); Gürsoy Özdemir, Yasemin (ORCID 0000-0002-0860-8964 & YÖK ID 170592), Çakmak, Yusuf Özgür; Ölçek, Can; Özsoy, Burak; Khwaounjoo, Prashannaa; ;Kızıltan, Güneş; Apaydın, Hülya; Gündüz, Ayşegül; Gökçay, Didem, Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM), School of Medicine, Çakmak, Özgür Öztop (ORCID 0000-0003-3413-0332 & YÖK ID 299358); Ertan, Fatoş Sibel (ORCID 0000-0003-1339-243X & YÖK ID 112829); Gürsoy Özdemir, Yasemin (ORCID 0000-0002-0860-8964 & YÖK ID 170592), Çakmak, Yusuf Özgür; Ölçek, Can; Özsoy, Burak; Khwaounjoo, Prashannaa; ;Kızıltan, Güneş; Apaydın, Hülya; Gündüz, Ayşegül; Gökçay, Didem, Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM), and School of Medicine
- Abstract
The Unified Parkinson’s Disease Rating Scale (UPDRS) is a subjective Parkinson’s Disease (PD) physician scoring/monitoring system. To date, there is no single upper limb wearable/non-contact system that can be used objectively to assess all UPDRS-III motor system subgroups (i.e., tremor (T), rigidity (R), bradykinesia (B), gait and posture (GP), and bulbar anomalies (BA)). We evaluated the use of a non-contact hand motion tracking system for potential extraction of GP information using forearm pronation–supination (P/S) motion parameters (speed, acceleration, and frequency). Twenty-four patients with idiopathic PD participated, and their UPDRS data were recorded bilaterally by physicians. Pearson’s correlation, regression analyses, and Monte Carlo validation was conducted for all combinations of UPDRS subgroups versus motion parameters. In the 262,125 regression models that were trained and tested, the models within 1% of the lowest error showed that the frequency of P/S contributes to approximately one third of all models; while speed and acceleration also contribute significantly to the prediction of GP from the left-hand motion of right handed patients. In short, the P/S better indicated GP when performed with the non-dominant hand. There was also a significant negative correlation (with medium to large effect size, range: 0.3–0.58) between the P/S speed and the single BA score for both forearms and combined UPDRS score for the dominant hand. This study highlights the potential use of wearable or non-contact systems for forearm P/S to remotely monitor and predict the GP information in PD., Koç Holding; Koç University
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- 2022
4. Investigation of Factors Affecting the Side of the Disease Onset in Parkinson's Disease.
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ÖZKAN, Esra, ÇAKMAK, Özgür ÖZTOP, KILIÇ, Emine ŞEKERDAĞ, ŞELTE, Ceren Müşerref, and ERTAN, Sibel
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MATHEMATICAL statistics , *DISEASE progression , *HANDEDNESS , *ACADEMIC medical centers , *PARAMETERS (Statistics) , *CEREBRAL dominance , *POLYPHARMACY , *RETROSPECTIVE studies , *CLINICS , *OCCUPATIONS , *ARM , *RISK assessment , *COMPARATIVE studies , *PHYSICAL activity , *PARKINSON'S disease , *AGE factors in disease , *DESCRIPTIVE statistics , *DISEASE duration , *NEURODEGENERATION , *DISEASE risk factors - Abstract
Introduction: Parkinson's disease (PD) is a progressive neurodegenerative disease that starts unilaterally in almost all cases and tends to emerge on the side of the dominant hand, but what we know about the cause of this lateralization is limited. Frequent use of the extremity and physical activity are argued to be protective from PD in preclinical and clinical studies. This study aimed to evaluate the effect of handedness and working in occupations that require continuous use of upper extremities on the disease onset-side. Methods: We retrospectively collected 84 PD patients who applied to Koç University Neurology outpatient clinic between July 2016-October 2018. We analyzed the parameters of the side and region of disease onset, age of onset, number of drugs used for PD, hand preference, and patients' occupations. Results: The median age of our study group was 61 (53-69). Thirty (36%) of the 84 patients were women. Seventy-nine patients (94%) were right-handed. Eighty-three (99%) had asymmetric onset. The disease started on the dominant hand side in 47 patients (57%) and on the nondominant hand side in 36 (43%) patients. In our group with a median disease duration of four (2-7) years, the side with more severe complaints measured with the Unified Parkinson's Disease Evaluation Scale was consistent with the onset-side of the disease (p<0.001). In addition, the number of drugs used for PD and the scale score were higher in patients with longer disease duration (p=0.039, p=0.005). The number of drugs used for PD was also higher in patients with lower extremity-onset or both upper and lower extremities affected simultaneously than the upper extremity-onset (p=0.005). While the probability of starting on the dominant side was 43% in patients working in occupations requiring continuous use of upper extremities, it was 65% in others (p=0.027). Conclusion: According to this study, the onset of PD tends to be on the dominant hand side. Continuous upper extremity use may reduce the possibility of starting on the dominant side. [ABSTRACT FROM AUTHOR]
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- 2022
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5. Acil serviste hekimler fonksiyonel nörolojik belirti bozukluğu ve somatik belirti bozukluğunu nasıl yönetiyor? Bir vinyet çalışması
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Eser, Hale Yapıcı (ORCID 0000-0003-0318-2770 & YÖK ID 134359); Necef, Işıl; Çakmak, Özgür Öztop (ORCID 0000-0003-3413-0332 & YÖK ID 299358); Aktaş, Can (ORCID 0000-0002-2980-6652 & YÖK ID 24297), Kılıç, Özge; Altunöz, Umut, Koç University Hospital, School of Medicine, Eser, Hale Yapıcı (ORCID 0000-0003-0318-2770 & YÖK ID 134359); Necef, Işıl; Çakmak, Özgür Öztop (ORCID 0000-0003-3413-0332 & YÖK ID 299358); Aktaş, Can (ORCID 0000-0002-2980-6652 & YÖK ID 24297), Kılıç, Özge; Altunöz, Umut, Koç University Hospital, and School of Medicine
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Introduction: we aimed to explore how physicians from different specialties approach the management of functional neurological symptom (conversion) and somatic symptom disorders in the emergency department compared with pulmonary embolism and how physicians’ professional and personal characteristics influence their diagnostic preferences. Methods: using a vignette methodology, and cross-sectional design, three emergency department case vignettes of possible functional neurological symptom, somatic symptom disorder, and pulmonary embolism were presented to physicians from internal medicine, emergency medicine, and psychiatry. A structured survey including questions on diagnosis and management of these cases, and physicians’ professional and personal characteristics (childhood trauma, attachment style) was conducted. Results: physicians from internal medicine and emergency medicine tended to consider functional neurological symptom disorder as ‘malingering’ while psychiatrists tended to diagnose the pulmonary embolism case as a psychiatric condition. Emergency medicine physicians preferred to manage functional neurological symptom disorder themselves, while other doctors endorsed recommending a psychiatric consultation. In the univariable model, being a physician from psychiatry, emergency medicine, or internal medicine; being a specialist, history of childhood sexual abuse, dismissive, and fearful attachment styles of doctors were significant predictors of diagnosing functional neurological symptom disorder as malingering. Being a psychiatrist stayed as the only significant predictor in the multivariable model. Conclusion: objectively-aberrant functional neurological symptoms and subjective somatic symptoms may be creating different reactions in physicians. In the emergency department, physicians’ diagnostic and treatment preferences of conversion disorder may be influenced by lack of training in conversion disorder, rather than their personal characteristics. / Amaç, NA
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- 2021
6. Neuropsychiatric symptoms of COVID-19 explained by SARS-CoV-2 proteins' mimicry of human protein interactions
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Eser, Hale Yapıcı (ORCID 0000-0003-0318-2770 & YÖK ID 134359); Keskin Özkaya, Zehra Özlem (ORCID 0000-0002-4202-4049 & YÖK ID 26605); Gürsoy, Attila (ORCID 0000-0002-2297-2113 & YÖK ID 8745); Köroğlu, Yunus Emre;Çakmak, Özgür Öztop (ORCID 0000-0003-3413-0332 & YÖK ID 299358); Gürsoy Özdemir, Yasemin (ORCID 0000-0002-0860-8964 & YÖK ID 170592) (ORCID 0000-0002-0860-8964 & YÖK ID 170592), Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM), School of Medicine; College of Engineering; Graduate School of Sciences and Engineering, Department of Chemical and Biological Engineering; Department of Computational Sciences and Engineering, Eser, Hale Yapıcı (ORCID 0000-0003-0318-2770 & YÖK ID 134359); Keskin Özkaya, Zehra Özlem (ORCID 0000-0002-4202-4049 & YÖK ID 26605); Gürsoy, Attila (ORCID 0000-0002-2297-2113 & YÖK ID 8745); Köroğlu, Yunus Emre;Çakmak, Özgür Öztop (ORCID 0000-0003-3413-0332 & YÖK ID 299358); Gürsoy Özdemir, Yasemin (ORCID 0000-0002-0860-8964 & YÖK ID 170592) (ORCID 0000-0002-0860-8964 & YÖK ID 170592), Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM), School of Medicine; College of Engineering; Graduate School of Sciences and Engineering, and Department of Chemical and Biological Engineering; Department of Computational Sciences and Engineering
- Abstract
The first clinical symptoms focused on the presentation of coronavirus disease 2019 (COVID-19) have been respiratory failure, however, accumulating evidence also points to its presentation with neuropsychiatric symptoms, the exact mechanisms of which are not well known. By using a computational methodology, we aimed to explain the molecular paths of COVID-19 associated neuropsychiatric symptoms, based on the mimicry of the human protein interactions with SARS-CoV-2 proteins. Methods: available 11 of the 29 SARS-CoV-2 proteins’ structures have been extracted from Protein Data Bank. HMI-PRED (Host-Microbe Interaction PREDiction), a recently developed web server for structural PREDiction of protein-protein interactions (PPIs) between host and any microbial species, was used to find the “interface mimicry” through which the microbial proteins hijack host binding surfaces. Classification of the found interactions was conducted using the PANTHER Classification System. Results: predicted Human-SARS-CoV-2 protein interactions have been extensively compared with the literature. Based on the analysis of the molecular functions, cellular localizations and pathways related to human proteins, SARS-CoV-2 proteins are found to possibly interact with human proteins linked to synaptic vesicle trafficking, endocytosis, axonal transport, neurotransmission, growth factors, mitochondrial and blood-brain barrier elements, in addition to its peripheral interactions with proteins linked to thrombosis, inflammation and metabolic control. Conclusion: SARS-CoV-2-human protein interactions may lead to the development of delirium, psychosis, seizures, encephalitis, stroke, sensory impairments, peripheral nerve diseases, and autoimmune disorders. Our findings are also supported by the previous in vivo and in vitro studies from other viruses. Further in vivo and in vitro studies using the proteins that are pointed here, could pave new targets both for avoiding and reversing neuropsychiatric prese, Science Academy's Young Scientists' Award Program (BAGEP)
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- 2021
7. Intrinsic auricular muscle zone stimulation improves walking parameters of Parkinson's patients faster than levodopa in the motion capture analysis: a pilot study
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Özsoy, Burak; Ertan, Fatoş Sibel; Çakmak, Özgür Öztop (ORCID 0000-0003-3413-0332 & YÖK ID 299358); Özyaprak, Ecem; Gürsoy Özdemir, Yasemin (ORCID 0000-0002-0860-8964 & YÖK ID 170592) (ORCID 0000-0002-0860-8964 & YÖK ID 170592); Eser, Hale Yapıcı (ORCID 0000-0003-0318-2770 & YÖK ID 134359); Ölçer, Selim; Ürey, Hakan (ORCID 0000-0002-2031-7967 & YÖK ID 8579) (ORCID 0000-0002-2031-7967 & YÖK ID 8579), Çakmak, Yusuf O.; Kızıltan, Güneş, Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM), School of Medicine; Graduate School of Health Sciences; College of Engineering, Department of Electrical and Electronics Engineering, Özsoy, Burak; Ertan, Fatoş Sibel; Çakmak, Özgür Öztop (ORCID 0000-0003-3413-0332 & YÖK ID 299358); Özyaprak, Ecem; Gürsoy Özdemir, Yasemin (ORCID 0000-0002-0860-8964 & YÖK ID 170592) (ORCID 0000-0002-0860-8964 & YÖK ID 170592); Eser, Hale Yapıcı (ORCID 0000-0003-0318-2770 & YÖK ID 134359); Ölçer, Selim; Ürey, Hakan (ORCID 0000-0002-2031-7967 & YÖK ID 8579) (ORCID 0000-0002-2031-7967 & YÖK ID 8579), Çakmak, Yusuf O.; Kızıltan, Güneş, Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM), School of Medicine; Graduate School of Health Sciences; College of Engineering, and Department of Electrical and Electronics Engineering
- Abstract
It has been demonstrated that intrinsic auricular muscles zone stimulation (IAMZS) can improve the motor symptoms of Parkinson's disease (PD) patients who are examined with the Unified Parkinson's Disease Rating Scale (UPDRS) motor scores. In the present pilot study, using motion capture technology, we aimed to investigate the efficacy of IAMZS compared to medication alone or in combination with medication. Ten PD patients (mean age: 54.8 ± 10.1 years) were enrolled. Each participant participated in three different sessions: sole medication, sole stimulation-20 min of IAMZS, and combined IAMZS (20 min) and medication. Each session was performed on different days but at the same time to be aligned with patients' drug intake. Motion capture recording sessions took place at baseline, 20, 40, and 60 min. Statistical analysis was conducted using one-way repeated measures ANOVA. Bonferroni correction was implemented for pairwise comparisons. The sole medication was ineffective to improve gait-related parameters of stride length, stride velocity, stance, swing, and turning speed. In the sole-stimulation group, pace-related gait parameters were significantly increased at 20 and 40 min. These improvements were observed in stride length at 20 (p = 0.0498) and 40 (p = 0.03) min, and also in the normalized stride velocity at 40 min (p-value = 0.02). Stride velocity also tended to be significant at 20 min (p = 0.06) in the sole-stimulation group. Combined IAMZS and medication demonstrated significant improvements in all the time segments for pace-related gait parameters [stride length: 20 min (p = 0.04), 40 min (p = 0.01), and 60 min (p < 0.01); stride velocity: 20 min (p < 0.01), 40 min (p = 0.01), and 60 min (p < 0.01)]. These findings demonstrated the fast action of the IAMZS on PD motor symptoms. Moreover, following the termination of IAMZS, a prolonged improvement in symptoms was observed at 40 min. The combined use of IAMZS with medication showed the most profound improvem, Koç Holding; Koç University
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- 2020
8. Spinal fusion in facioscapulohumeral dystrophy for hyperlordosis: a case report
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Eren, İlker (ORCID 0000-0003-2965-7690 & YÖK ID 168021); Çakmak, Özgür Öztop; Günerbüyük, Caner; Demirhan, Mehmet Selahattin (ORCID 0000-0001-8411-7596 & YÖK ID 9882); Abay, Berk, Sar, Cüneyt, School of Medicine; Graduate School of Health Sciences, Eren, İlker (ORCID 0000-0003-2965-7690 & YÖK ID 168021); Çakmak, Özgür Öztop; Günerbüyük, Caner; Demirhan, Mehmet Selahattin (ORCID 0000-0001-8411-7596 & YÖK ID 9882); Abay, Berk, Sar, Cüneyt, and School of Medicine; Graduate School of Health Sciences
- Abstract
Rationale: facioscapulohumeral muscular dystrophy (FSHD) is the third most common muscular dystrophy, which is associated with facial, shoulder girdle, and paraspinal muscle atrophy. Most of the patients develop hypokyphosis and hyperlordosis in the course of the disease, to preserve standing posture. Corrective fusion is contraindicated in these patients as the surgery results with loss of compensatory hyperlordosis and leads to loss of trunk balance while standing. Although spinal fusion in neuromuscular scoliosis is a known treatment option, there are no studies in the literature on the spinal fusion of this specific patient group. Patient concerns: in this case report we have presented a 66-year-old woman, who was admitted with back and abdominal pain, inability to sit straight, abdominal discomfort, and numbness in the lower extremities after prolonged sitting. Diagnoses: the patient developed severe hyperlordosis causing intra-abdominal disorders, radicular symptoms, and sitting discomfort due to FSHD. Interventions: the patient underwent T2-S1 fusion and successful fusion was achieved. Outcomes:Individualized Neuromuscular Quality of Life Questionnaire (INQoL) was used to assess preoperative and 3 years postoperative functional outcomes. All domains and total score improved at the end of the follow-up period and successful fusion was verified radiologically. Lessons: this case suggests that spinal fusion may provide functional improvement in carefully selected patient groups. Patient stratification considering spinal disability is required for further studies in this specific indication., NA
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- 2020
9. Un nouveau système d’évaluation du handicap de l’épaule après l’arthrodèse scapulo-thoracique chez les patients souffrant de dystrophie facio-scapulo-humérale
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Eren, İlker, primary, Birsel, Olgar, additional, Çakmak, Özgür Öztop, additional, Aslanger, Ayça, additional, Özdemir, Yasemin Gürsoy, additional, Eraslan, Serpil, additional, Kayserili, Hülya, additional, Oflazer, Piraye, additional, and Demirhan, Mehmet, additional
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- 2020
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10. The role of pericytes in the pathophysiology multiple of sclerosis
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Şekerdağ, Emine; Atak, Dila; Yılmaz, Aysu; Zeybel, Müjdat (ORCID 0000-0002-1542-117X & YÖK ID 214694); Çakmak, Özgür Öztop (ORCID & YÖK ID); Gürsoy- Özdemir, Yasemin (ORCID 0000-0002-0860-8964 & YÖK ID 170592); Vural, Atay (ORCID 0000-0003-3222-874X & YÖK ID 182369), Tüzün, Erdem; Ulusoy, Canan; Küçükali, Cem, Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM), School of Medicine, Department of Gastroenterology and Hepatology; Department of Neurology, Şekerdağ, Emine; Atak, Dila; Yılmaz, Aysu; Zeybel, Müjdat (ORCID 0000-0002-1542-117X & YÖK ID 214694); Çakmak, Özgür Öztop (ORCID & YÖK ID); Gürsoy- Özdemir, Yasemin (ORCID 0000-0002-0860-8964 & YÖK ID 170592); Vural, Atay (ORCID 0000-0003-3222-874X & YÖK ID 182369), Tüzün, Erdem; Ulusoy, Canan; Küçükali, Cem, Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM), School of Medicine, and Department of Gastroenterology and Hepatology; Department of Neurology
- Abstract
NA
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- 2019
11. A facioscapulohumeralis muscularis dystrophia kezelésének multidiszciplináris megközelítése
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Çakmak, Özgür Öztop, primary, Eren, İlker, additional, Aslanger, Ayça, additional, Günerbüyük, Caner, additional, Kayserili, Hülya, additional, Oflazer, Piraye, additional, Şar, Cüneyt, additional, Demirhan, Mehmet, additional, and Özdemir, Yasemin Gürsoy, additional
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- 2018
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12. Rare case of glioblastoma multiforme located in posterior corpus callosum presenting with depressive symptoms and visual memory deficits
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Eser, Hale Yapıcı (ORCID 0000-0003-0318-2770 & YÖK ID 134359); Onay, Aslıhan; Çakmak, Özgür Öztop; Egemen, Emrah; Vanlı-Yavuz, Ebru Nur; Solaroğlu, İhsan (ORCID 0000-0002-9472-1735 & YÖK ID 102059), Koç University Hospital, School of Medicine, Department of Psychiatry; Department of Radiology; Department of Neurology; Department of Neurosurgery, Eser, Hale Yapıcı (ORCID 0000-0003-0318-2770 & YÖK ID 134359); Onay, Aslıhan; Çakmak, Özgür Öztop; Egemen, Emrah; Vanlı-Yavuz, Ebru Nur; Solaroğlu, İhsan (ORCID 0000-0002-9472-1735 & YÖK ID 102059), Koç University Hospital, School of Medicine, and Department of Psychiatry; Department of Radiology; Department of Neurology; Department of Neurosurgery
- Abstract
Most of the primary brain tumours are located in the supratentorial region, and it is uncommon to see tumour growth on deep brain structures such as posterior corpus callosum (PCC). In addition, lesions in PCC are also difficult to recognise, because construction apraxia, visuospatial perception and attentional capacity impairment may be the only presenting symptoms. Here, we represent a rare case of gliobastoma multiforme located in PCC, which solely presents with depressive symptoms and visual memory deficits. Initial manifestations of primary brain tumours with psychiatric symptoms and memory disturbances, in addition to headaches and seizures, should be kept in mind., NA
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- 2016
13. A MULTIDISCIPLINARY CLINICAL APPROACH TO FACIOSCAPULOHUMERAL MUSCULAR DYSTROPHY: ORTHOPEDIC SURGERY IN FACIOSCAPULOHUMERAL DYSTROPHY.
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ÇAKMAK, Özgür Öztop, EREN, İlker, ASLANGER, Ayça, GÜNERBÜYÜK, Caner, KAYSERILI, Hülya, OFLAZER, Piraye, ŞAR, Cüneyt, DEMIRHAN, Mehmet, and ÖZDEMIR, Yasemin Gürsoy
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FACIOSCAPULOHUMERAL muscular dystrophy ,MAGNETIC resonance imaging ,ARTHRODESIS ,ELECTROCARDIOGRAPHY ,MUSCULAR dystrophy - Abstract
Copyright of Clinical Neuroscience / Ideggyógyászati Szemle is the property of LifeTime Media Kft. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2018
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14. On the Severity of Carpal Tunnel Syndrome: Diabetes or Metabolic Syndrome
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Yurdakul, Fatma Gül, primary, Bodur, Hatice, additional, Çakmak, Özgür Öztop, additional, Ateş, Can, additional, Sivas, Filiz, additional, Eser, Filiz, additional, and Taşdelen, Özlem Yılmaz, additional
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- 2015
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15. Embracing Monogenic Parkinson's Disease: The MJFF Global Genetic PD Cohort
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Vollstedt, Eva-Juliane, Schaake, Susen, Lohmann, Katja, Padmanabhan, Shalini, Brice, Alexis, Lesage, Suzanne, Tesson, Christelle, Vidailhet, Marie, Wurster, Isabel, Hentati, Faycel, Mirelman, Anat, Giladi, Nir, Marder, Karen, Waters, Cheryl, Fahn, Stanley, Kasten, Meike, Brüggemann, Norbert, Borsche, Max, Foroud, Tatiana, Tolosa, Eduardo, Garrido, Alicia, Annesi, Grazia, Gagliardi, Monica, Bozi, Maria, Stefanis, Leonidas, Ferreira, Joaquim J, Correia Guedes, Leonor, Avenali, Micol, Petrucci, Simona, Clark, Lorraine, Fedotova, Ekaterina Y, Abramycheva, Natalya Y, Alvarez, Victoria, Menéndez-González, Manuel, Jesús Maestre, Silvia, Gómez-Garre, Pilar, Mir, Pablo, Belin, Andrea Carmine, Ran, Caroline, Lin, Chin-Hsien, Kuo, Ming-Che, Crosiers, David, Wszolek, Zbigniew K, Ross, Owen A, Jankovic, Joseph, Nishioka, Kenya, Funayama, Manabu, Clarimon, Jordi, Williams-Gray, Caroline H, Camacho, Marta, Cornejo-Olivas, Mario, Torres-Ramirez, Luis, Wu, Yih-Ru, Lee-Chen, Guey-Jen, Morgadinho, Ana, Pulkes, Teeratorn, Termsarasab, Pichet, Berg, Daniela, Kuhlenbäumer, Gregor, Kühn, Andrea A, Borngräber, Friederike, De Michele, Giuseppe, De Rosa, Anna, Zimprich, Alexander, Puschmann, Andreas, Mellick, George D, Dorszewska, Jolanta, Carr, Jonathan, Ferese, Rosangela, Gambardella, Stefano, Chase, Bruce, Markopoulou, Katerina, Satake, Wataru, Toda, Tatsushi, Rossi, Malco, Merello, Marcelo, Lynch, Timothy, Olszewska, Diana A, Lim, Shen-Yang, Ahmad-Annuar, Azlina, Tan, Ai Huey, Al-Mubarak, Bashayer, Hanagasi, Hasmet, Koziorowski, Dariusz, Ertan, Sibel, Genç, Gençer, De Carvalho Aguiar, Patricia, Barkhuizen, Melinda, Pimentel, Marcia MG, Saunders-Pullman, Rachel, Van De Warrenburg, Bart, Bressman, Susan, Toft, Mathias, Appel-Cresswell, Silke, Lang, Anthony E, Skorvanek, Matej, Boon, Agnita JW, Krüger, Rejko, Sammler, Esther M, Tumas, Vitor, Zhang, Bao-Rong, Garraux, Gaetan, Chung, Sun Ju, Kim, Yun Joong, Winkelmann, Juliane, Sue, Carolyn M, Tan, Eng-King, Damásio, Joana, Klivényi, Péter, Kostic, Vladimir S, Arkadir, David, Martikainen, Mika, Borges, Vanderci, Hertz, Jens Michael, Brighina, Laura, Spitz, Mariana, Suchowersky, Oksana, Riess, Olaf, Das, Parimal, Mollenhauer, Brit, Gatto, Emilia M, Petersen, Maria Skaalum, Hattori, Nobutaka, Wu, Ruey-Meei, Illarioshkin, Sergey N, Valente, Enza Maria, Aasly, Jan O, Aasly, Anna, Alcalay, Roy N, Thaler, Avner, Farrer, Matthew J, Brockmann, Kathrin, Corvol, Jean-Christophe, Klein, Christine, MJFF Global Genetic Parkinson's Disease Study Group, Vollstedt, Ej, Schaake, S, Lohmann, K, Padmanabhan, S, Brice, A, Lesage, S, Tesson, C, Vidailhet, M, Wurster, I, Hentati, F, Mirelman, A, Giladi, N, Marder, K, Waters, C, Fahn, S, Kasten, M, Brüggemann, N, Borsche, M, Foroud, T, Tolosa, E, Garrido, A, Annesi, G, Gagliardi, M, Bozi, M, Stefanis, L, Ferreira, Jj, Correia Guedes, L, Avenali, M, Petrucci, S, Clark, L, Fedotova, Ey, Abramycheva, Ny, Alvarez, V, Menéndez-González, M, Jesús Maestre, S, Gómez-Garre, P, Mir, P, Belin, Ac, Ran, C, Lin, Ch, Kuo, Mc, Crosiers, D, Wszolek, Zk, Ross, Oa, Jankovic, J, Nishioka, K, Funayama, M, Clarimon, J, Williams-Gray, Ch, Camacho, M, Cornejo-Olivas, M, Torres-Ramirez, L, Wu, Yr, Lee-Chen, Gj, Morgadinho, A, Pulkes, T, Termsarasab, P, Berg, D, Kuhlenbäumer, G, Kühn, Aa, Borngräber, F, de Michele, G, De Rosa, A, Zimprich, A, Puschmann, A, Mellick, Gd, Dorszewska, J, Carr, J, Ferese, R, Gambardella, S, Chase, B, Markopoulou, K, Satake, W, Toda, T, Rossi, M, Merello, M, Lynch, T, Olszewska, Da, Lim, Sy, Ahmad-Annuar, A, Tan, Ah, Al-Mubarak, B, Hanagasi, H, Koziorowski, D, Ertan, S, Genç, G, de Carvalho Aguiar, P, Barkhuizen, M, Pimentel, Mmg, Saunders-Pullman, R, van de Warrenburg, B, Bressman, S, Toft, M, Appel-Cresswell, S, Lang, Ae, Skorvanek, M, Boon, Ajw, Krüger, R, Sammler, Em, Tu, Repositório da Universidade de Lisboa, Clinical Genetics, Neurology, Internal Medicine, Aasly, Anna, Aasly, Jan O, Abramycheva, Natalya Y, Ahmad-Annuar, Azlina, Albanese, Alberto, Alcalay, Roy N, Aldakheel, Amaal, Alkhairallah, Thamer, Al-Mubarak, Bashayer, Al-Tassan, Nada, Alvarez, Victoria, Amami, Paolo, Annesi, Grazia, Appel-Cresswell, Silke, Leite, Marco Antonio Araujo, Arkadir, David, Avenali, Micol, Ferraz, Henrique Ballalai, Bardien, Soraya, Barkhuizen, Melinda, Barrett, Matthew J, Başak, A Nazlı, Berg, Daniela, Bilgic, Basar, Bloem, Bastiaan R, Bonifati, Vincenzo, Boon, Agnita J W, Borges, Vanderci, Borngräber, Friederike, Borsche, Max, Bozi, Maria, Bressman, Susan, Brice, Alexis, Brighina, Laura, Brockmann, Kathrin, Brüggemann, Norbert, Camacho, Marta, Belin, Andrea Carmine, Carr, Jonathan, Cesarini, Martin Emiliano, Cornejo-Olivas, Mario, Chase, Bruce, Chung, Sun Ju, Guedes, Leonor Correia, Clarimon, Jordi, Clark, Lorraine, Corvol, Jean-Christophe, Crosiers, David, Das, Parimal, de Carvalho Aguiar, Patricia, Damásio, Joana, de Michele, Giuseppe, De Rosa, Anna, Dieguez, Elena, Dorszewska, Jolanta, Ertan, Sibel, Fahn, Stanley, Farrer, Matthew J, Fedotova, Ekaterina Y, Ferese, Rosangela, Ferreira, Joaquim J, Foroud, Tatiana, Funayama, Manabu, Fung, Victor S C, Gagliardi, Monica, Gambardella, Stefano, Garraux, Gaetan, Garrido, Alicia, Gatto, Emilia M, Genç, Gençer, Giladi, Nir, Gómez-Garre, Pilar, Hanagasi, Hasmet, Hattori, Nobutaka, Hentati, Faycel, Hertz, Jens Michael, Illarioshkin, Sergey N, Jankovic, Joseph, Januario, Cristina, Maestre, Silvia Jesús, Kaasinen, Valtteri, Kasten, Meike, Kataoka, Hiroshi, Kievit, Anneke A, Kim, Yun Joong, Klein, Christine, Klivényi, Péter, Kostic, Vladimir S, Koziorowski, Dariusz, Krüger, Rejko, Kühn, Andrea, Kuhlenbäumer, Gregor, Kuo, Ming-Che, Lang, Anthony E, Lee-Chen, Guey-Jen, Lesage, Suzanne, Lim, Jia Lun, Lim, Shen-Yang, Lin, Chin-Hsien, Lohmann, Katja, Lynch, Timothy, Marder, Karen, Markopoulou, Katerina, Martikainen, Mika, May, Patrick, McCarthy, Allan, Mellick, George D, Menéndez-González, Manuel, Merello, Marcelo, Mir, Pablo, Mirelman, Anat, Mollenhauer, Brit, Briceno, Hugo Morales, Morgadinho, Ana, Morris, Huw, Mosejova, Alexandra, Nishioka, Kenya, Çakmak, Özgür Öztop, Olszewska, Diana A, Orr-Urtreger, Avi, Pachchek, Sinthuja, Padmanabhan, Shalini, Periñán, Maria Teresa, Petrucci, Simona, Pimentel, Marcia M G, Procopio, Radha, Pulkes, Teeratorn, Puschmann, Andreas, Ran, Caroline, Riess, Olaf, Ross, Owen A, Rossi, Malco, Ruiz-Martinez, Javier, Sammler, Esther M, Pereira, João Santos, Satake, Wataru, Saunders-Pullman, Rachel, Schaake, Susen, Petersen, Maria Skaalum, Skorvanek, Matej, Stefanis, Leonidas, Soto-Beasley, Alexandra I, Sousa, Mário, Spitz, Mariana, Suchowersky, Oksana, Sue, Carolyn M, Tan, Ai Huey, Tan, Eng-King, Thaler, Avner, Tepgeç, Fatih, Termsarasab, Pichet, Tesson, Christelle, Toda, Tatsushi, Toft, Mathias, Tolosa, Eduardo, Torres-Ramirez, Luis, Tumas, Vitor, Uyguner, Oya, Valente, Enza Maria, van de Warrenburg, Bart, Vidailhet, Marie, Vollstedt, Eva-Juliane, Walton, Ronald L, Waters, Cheryl, Williams-Gray, Caroline H, Winkelmann, Juliane, Wu, Yih-Ru, Wurster, Isabel, Wszolek, Zbigniew K, Wu, Ruey-Meei, Zhang, Bao-Rong, Zimprich, Alexander, Vollstedt, Eva-Juliane [0000-0002-6898-9201], Lohmann, Katja [0000-0002-5121-1460], Mirelman, Anat [0000-0002-1520-2292], Brüggemann, Norbert [0000-0001-5969-6899], Borsche, Max [0000-0002-9651-5986], Tolosa, Eduardo [0000-0002-3781-0854], Ferreira, Joaquim J [0000-0003-3950-5113], Alvarez, Victoria [0000-0002-1916-2523], Mir, Pablo [0000-0003-1656-302X], Kuo, Ming-Che [0000-0003-3688-0225], Ross, Owen A [0000-0003-4813-756X], Nishioka, Kenya [0000-0001-8607-9757], Williams-Gray, Caroline H [0000-0002-2648-9743], Camacho, Marta [0000-0002-1490-5703], Cornejo-Olivas, Mario [0000-0001-6313-5680], Wu, Yih-Ru [0000-0003-1191-2542], Termsarasab, Pichet [0000-0002-3260-3119], Borngräber, Friederike [0000-0001-9650-6820], Zimprich, Alexander [0000-0002-1668-5177], Gambardella, Stefano [0000-0002-3727-4502], Chase, Bruce [0000-0001-5491-7242], Olszewska, Diana A [0000-0002-1814-8834], Tan, Ai Huey [0000-0002-2979-3839], Barkhuizen, Melinda [0000-0002-9952-7085], Appel-Cresswell, Silke [0000-0002-5986-1468], Skorvanek, Matej [0000-0001-5497-8715], Sammler, Esther M [0000-0003-3218-7116], Zhang, Bao-Rong [0000-0002-8099-7407], Chung, Sun Ju [0000-0003-4118-8233], Apollo - University of Cambridge Repository, and MJFF Global Genetic Parkinson's Disease Study Group
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parkinson's disease ,monogenic pd ,monogenic PD ,Parkinson's disease ,Monogenic PD ,Parkinson Disease ,Disorders of movement Donders Center for Medical Neuroscience [Radboudumc 3] ,ddc ,Neurology ,genetics [Parkinson Disease] ,Mutation ,Humans ,Human medicine ,ddc:610 ,Neurology (clinical) ,Research Article ,Research Articles - Abstract
© 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited., Background: As gene-targeted therapies are increasingly being developed for Parkinson's disease (PD), identifying and characterizing carriers of specific genetic pathogenic variants is imperative. Only a small fraction of the estimated number of subjects with monogenic PD worldwide are currently represented in the literature and availability of clinical data and clinical trial-ready cohorts is limited. Objective: The objectives are to (1) establish an international cohort of affected and unaffected individuals with PD-linked variants; (2) provide harmonized and quality-controlled clinical characterization data for each included individual; and (3) further promote collaboration of researchers in the field of monogenic PD. Methods: We conducted a worldwide, systematic online survey to collect individual-level data on individuals with PD-linked variants in SNCA, LRRK2, VPS35, PRKN, PINK1, DJ-1, as well as selected pathogenic and risk variants in GBA and corresponding demographic, clinical, and genetic data. All registered cases underwent thorough quality checks, and pathogenicity scoring of the variants and genotype-phenotype relationships were analyzed. Results: We collected 3888 variant carriers for our analyses, reported by 92 centers (42 countries) worldwide. Of the included individuals, 3185 had a diagnosis of PD (ie, 1306 LRRK2, 115 SNCA, 23 VPS35, 429 PRKN, 75 PINK1, 13 DJ-1, and 1224 GBA) and 703 were unaffected (ie, 328 LRRK2, 32 SNCA, 3 VPS35, 1 PRKN, 1 PINK1, and 338 GBA). In total, we identified 269 different pathogenic variants; 1322 individuals in our cohort (34%) were indicated as not previously published. Conclusions: Within the MJFF Global Genetic PD Study Group, we (1) established the largest international cohort of affected and unaffected individuals carrying PD-linked variants; (2) provide harmonized and quality-controlled clinical and genetic data for each included individual; (3) promote collaboration in the field of genetic PD with a view toward clinical and genetic stratification of patients for gene-targeted clinical trials. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society., Michael J. Fox Foundation for Parkinson's Research. Grant Number: ID 15015.02. NIHR Cambridge Biomedical Research Centre. Grant Number: BRC-1215-20014
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- 2023
16. Hand Pronation-Supination Movement as a Proxy for Remotely Monitoring Gait and Posture Stability in Parkinson's Disease
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Yusuf Ozgur Cakmak, Can Olcek, Burak Ozsoy, Prashanna Khwaounjoo, Gunes Kiziltan, Hulya Apaydin, Aysegul Günduz, Ozgur Oztop Cakmak, Sibel Ertan, Yasemin Gursoy-Ozdemir, Didem Gokcay, Çakmak, Özgür Öztop (ORCID 0000-0003-3413-0332 & YÖK ID 299358), Ertan, Fatoş Sibel (ORCID 0000-0003-1339-243X & YÖK ID 112829), Özdemir, Yasemin Gürsoy, Çakmak, Yusuf Özgür, Ölçek, Can, Özsoy, Burak, Khwaounjoo, Prashannaa, Kızıltan, Güneş, Apaydın, Hülya, Gündüz, Ayşegül, Gökçay, Didem, Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM), and School of Medicine
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Posture ,Parkinson Disease ,Analytical chemistry ,Electrical and electronic engineering ,Instruments and instrumentation ,Biochemistry ,Supination ,Atomic and Molecular Physics, and Optics ,Analytical Chemistry ,Upper Extremity ,Humans ,gait ,posture ,Parkinson’s disease ,pronation ,supination ,bulbar anomalies ,Pronation ,Gait ,Parkinson's disease ,Bulbar anomalies ,Electrical and Electronic Engineering ,Gait Analysis ,Instrumentation - Abstract
The Unified Parkinson’s Disease Rating Scale (UPDRS) is a subjective Parkinson’s Disease (PD) physician scoring/monitoring system. To date, there is no single upper limb wearable/non-contact system that can be used objectively to assess all UPDRS-III motor system subgroups (i.e., tremor (T), rigidity (R), bradykinesia (B), gait and posture (GP), and bulbar anomalies (BA)). We evaluated the use of a non-contact hand motion tracking system for potential extraction of GP information using forearm pronation–supination (P/S) motion parameters (speed, acceleration, and frequency). Twenty-four patients with idiopathic PD participated, and their UPDRS data were recorded bilaterally by physicians. Pearson’s correlation, regression analyses, and Monte Carlo validation was conducted for all combinations of UPDRS subgroups versus motion parameters. In the 262,125 regression models that were trained and tested, the models within 1% of the lowest error showed that the frequency of P/S contributes to approximately one third of all models; while speed and acceleration also contribute significantly to the prediction of GP from the left-hand motion of right handed patients. In short, the P/S better indicated GP when performed with the non-dominant hand. There was also a significant negative correlation (with medium to large effect size, range: 0.3–0.58) between the P/S speed and the single BA score for both forearms and combined UPDRS score for the dominant hand. This study highlights the potential use of wearable or non-contact systems for forearm P/S to remotely monitor and predict the GP information in PD., Koç Holding; Koç University
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- 2021
17. Neuropsychiatric Symptoms of COVID-19 Explained by SARS-CoV-2 Proteins’ Mimicry of Human Protein Interactions
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Hale Yapici-Eser, Yunus Emre Koroglu, Ozgur Oztop-Cakmak, Ozlem Keskin, Attila Gursoy, Yasemin Gursoy-Ozdemir, Eser, Hale Yapıcı (ORCID 0000-0003-0318-2770 & YÖK ID 134359), Keskin Özkaya, Zehra Özlem (ORCID 0000-0002-4202-4049 & YÖK ID 26605), Gürsoy, Attila (ORCID 0000-0002-2297-2113 & YÖK ID 8745), Köroğlu, Yunus Emre, Çakmak, Özgür Öztop (ORCID 0000-0003-3413-0332 & YÖK ID 299358), Özdemir, Yasemin Gürsoy (ORCID 0000-0002-0860-8964 & YÖK ID 170592), Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM), School of Medicine, College of Engineering, Graduate School of Sciences and Engineering, Department of Chemical and Biological Engineering, and Department of Computational Sciences and Engineering
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Psychosis ,Inflammation ,Biology ,Endocytosis ,Synaptic vesicle ,lcsh:RC321-571 ,Protein–protein interaction ,03 medical and health sciences ,Behavioral Neuroscience ,delirium ,0302 clinical medicine ,Hypothesis and Theory ,medicine ,Autoimmune ,COVID-19 ,Delirium ,Mimicry ,Neuropsychiatric ,SARS-CoV-2 ,lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry ,Biological Psychiatry ,030304 developmental biology ,0303 health sciences ,Neurosciences ,Psychology ,autoimmune ,computer.file_format ,Protein Data Bank ,medicine.disease ,In vitro ,Psychiatry and Mental health ,Neuropsychology and Physiological Psychology ,Neurology ,neuropsychiatric ,Axoplasmic transport ,medicine.symptom ,computer ,Neuroscience ,mimicry ,030217 neurology & neurosurgery - Abstract
The first clinical symptoms focused on the presentation of coronavirus disease 2019 (COVID-19) have been respiratory failure, however, accumulating evidence also points to its presentation with neuropsychiatric symptoms, the exact mechanisms of which are not well known. By using a computational methodology, we aimed to explain the molecular paths of COVID-19 associated neuropsychiatric symptoms, based on the mimicry of the human protein interactions with SARS-CoV-2 proteins. Methods: available 11 of the 29 SARS-CoV-2 proteins’ structures have been extracted from Protein Data Bank. HMI-PRED (Host-Microbe Interaction PREDiction), a recently developed web server for structural PREDiction of protein-protein interactions (PPIs) between host and any microbial species, was used to find the “interface mimicry” through which the microbial proteins hijack host binding surfaces. Classification of the found interactions was conducted using the PANTHER Classification System. Results: predicted Human-SARS-CoV-2 protein interactions have been extensively compared with the literature. Based on the analysis of the molecular functions, cellular localizations and pathways related to human proteins, SARS-CoV-2 proteins are found to possibly interact with human proteins linked to synaptic vesicle trafficking, endocytosis, axonal transport, neurotransmission, growth factors, mitochondrial and blood-brain barrier elements, in addition to its peripheral interactions with proteins linked to thrombosis, inflammation and metabolic control. Conclusion: SARS-CoV-2-human protein interactions may lead to the development of delirium, psychosis, seizures, encephalitis, stroke, sensory impairments, peripheral nerve diseases, and autoimmune disorders. Our findings are also supported by the previous in vivo and in vitro studies from other viruses. Further in vivo and in vitro studies using the proteins that are pointed here, could pave new targets both for avoiding and reversing neuropsychiatric presentations., Science Academy's Young Scientists' Award Program (BAGEP)
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- 2021
18. How do physicians manage functional neurological symptom disorder and somatic symptom disorder in the emergency department? A vignette study
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Eser, Hale Yapıcı (ORCID 0000-0003-0318-2770 & YÖK ID 134359), Necef, Işıl, Çakmak, Özgür Öztop (ORCID 0000-0003-3413-0332 & YÖK ID 299358), Aktaş, Can (ORCID 0000-0002-2980-6652 & YÖK ID 24297), Kılıç, Özge, Altunöz, Umut, Koç University Hospital, and School of Medicine
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Neurosciences and neurology ,Healthcare professional ,Physician ,Functional neurological symptom ,Somatic symptom ,Conversion disorder ,Attachment - Abstract
Introduction: we aimed to explore how physicians from different specialties approach the management of functional neurological symptom (conversion) and somatic symptom disorders in the emergency department compared with pulmonary embolism and how physicians’ professional and personal characteristics influence their diagnostic preferences. Methods: using a vignette methodology, and cross-sectional design, three emergency department case vignettes of possible functional neurological symptom, somatic symptom disorder, and pulmonary embolism were presented to physicians from internal medicine, emergency medicine, and psychiatry. A structured survey including questions on diagnosis and management of these cases, and physicians’ professional and personal characteristics (childhood trauma, attachment style) was conducted. Results: physicians from internal medicine and emergency medicine tended to consider functional neurological symptom disorder as ‘malingering’ while psychiatrists tended to diagnose the pulmonary embolism case as a psychiatric condition. Emergency medicine physicians preferred to manage functional neurological symptom disorder themselves, while other doctors endorsed recommending a psychiatric consultation. In the univariable model, being a physician from psychiatry, emergency medicine, or internal medicine; being a specialist, history of childhood sexual abuse, dismissive, and fearful attachment styles of doctors were significant predictors of diagnosing functional neurological symptom disorder as malingering. Being a psychiatrist stayed as the only significant predictor in the multivariable model. Conclusion: objectively-aberrant functional neurological symptoms and subjective somatic symptoms may be creating different reactions in physicians. In the emergency department, physicians’ diagnostic and treatment preferences of conversion disorder may be influenced by lack of training in conversion disorder, rather than their personal characteristics. / Amaç: farklı uzmanlık dallarından hekimlerin acil serviste fonksiyonel nörolojik (konversiyon) belirti bozukluğu ve bedensel belirti bozukluğunu yönetimini, pulmoner embolinin yönetimi ile karşılaştırarak incelemeyi ve hekimlerin mesleki ve kişisel özelliklerinin tanı tercihlerini nasıl etkilediğini araştırmayı amaçladık. Yöntem: vinyet yöntemi ve kesitsel tasarım kullanıldı. Olası fonksiyonel nörolojik belirti bozukluğu, bedensel belirti bozukluğu ve pulmoner emboli tanısı ile acil servise başvuran üç olgu, iç hastalıkları, acil tıp ve psikiyatri hekimlerine sunuldu. Bu olguların tanı ve tedavisine, ve hekimlerin mesleki ve kişisel özellikleri (çocukluk çağı travması, bağlanma biçimi) ne yönelik sorular içeren yapılandırılmış anket uygulandı. Bulgular: dahiliye ve acil tıp hekimleri, fonksiyonel nörolojik belirti bozukluğunu “temaruz” olarak görme eğilimindeyken, psikiyatristler pulmoner emboli vakasını psikiyatrik bir durum olarak görme eğilimindeydiler. Acil tıp hekimleri, fonksiyonel nörolojik belirti bozukluğunu kendileri yönetmeyi tercih ederken, diğer doktorlar psikiyatri konsültasyonu önerdi. Tek değişkenli modelde psikiyatri, acil tıp veya dahiliye hekimi olmak; uzman olmak, çocukluk çağı cinsel istismarı, kayıtsız ve korkulu bağlanma biçimleri, fonksiyonel nörolojik belirti bozukluğunu temaruz olarak tanımlamayı yordamaktaydı. Çok değişkenli modelde tek anlamlı yordayıcı psikiyatri uzmanlık dalıydı. Sonuç: nesnel olarak gözlenen anormal fonksiyonel nörolojik belirtiler ve öznel bedensel belirtiler hekimlerde farklı tepkilere yol açıyor olabilir. Acil serviste hekimlerin konversiyon bozukluğu tanı ve tedavi tercihleri, kişisel özelliklerinden ziyade konversiyon bozukluğu konusundaki eğitim eksikliğinden etkileniyor olabilir., NA
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- 2021
19. Intrinsic Auricular Muscle Zone Stimulation Improves Walking Parameters of Parkinson's Patients Faster Than Levodopa in the Motion Capture Analysis: A Pilot Study
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Yusuf O. Cakmak, Burak Ozsoy, Sibel Ertan, Ozgur O. Cakmak, Gunes Kiziltan, Hale Yapici-Eser, Ecem Ozyaprak, Selim Olcer, Hakan Urey, Yasemin Gursoy-Ozdemir, Özsoy, Burak, Ertan, Fatoş Sibel, Çakmak, Özgür Öztop (ORCID 0000-0003-3413-0332 & YÖK ID 299358), Özyaprak, Ecem, Özdemir, Yasemin Gürsoy (ORCID 0000-0002-0860-8964 & YÖK ID 170592), Eser, Hale Yapıcı (ORCID 0000-0003-0318-2770 & YÖK ID 134359), Ölçer, Selim, Ürey, Hakan (ORCID 0000-0002-2031-7967 & YÖK ID 8579), Çakmak, Yusuf O., Kızıltan, Güneş, Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM), School of Medicine, Graduate School of Health Sciences, College of Engineering, Department of Electrical and Electronics Engineering, and İÜC, Cerrahpaşa Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
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auricular muscle ,030506 rehabilitation ,Levodopa ,Parkinson's disease ,Medicine ,Neurosciences and neurology ,Clinical neurology ,STRIDE ,Stimulation ,Motor symptoms ,lcsh:RC346-429 ,03 medical and health sciences ,walking ,0302 clinical medicine ,medicine ,motion capture ,lcsh:Neurology. Diseases of the nervous system ,Auricular muscle ,Electrostimulation ,Motion capture ,Walking ,business.industry ,Repeated measures design ,electrostimulation ,motor symptoms ,medicine.disease ,Gait ,Clinical Trial ,Intrinsic auricular muscle ,Neurology ,Anesthesia ,Neurology (clinical) ,0305 other medical science ,business ,030217 neurology & neurosurgery ,medicine.drug - Abstract
It has been demonstrated that intrinsic auricular muscles zone stimulation (IAMZS) can improve the motor symptoms of Parkinson's disease (PD) patients who are examined with the Unified Parkinson's Disease Rating Scale (UPDRS) motor scores. In the present pilot study, using motion capture technology, we aimed to investigate the efficacy of IAMZS compared to medication alone or in combination with medication. Ten PD patients (mean age: 54.8 ± 10.1 years) were enrolled. Each participant participated in three different sessions: sole medication, sole stimulation-20 min of IAMZS, and combined IAMZS (20 min) and medication. Each session was performed on different days but at the same time to be aligned with patients' drug intake. Motion capture recording sessions took place at baseline, 20, 40, and 60 min. Statistical analysis was conducted using one-way repeated measures ANOVA. Bonferroni correction was implemented for pairwise comparisons. The sole medication was ineffective to improve gait-related parameters of stride length, stride velocity, stance, swing, and turning speed. In the sole-stimulation group, pace-related gait parameters were significantly increased at 20 and 40 min. These improvements were observed in stride length at 20 (p = 0.0498) and 40 (p = 0.03) min, and also in the normalized stride velocity at 40 min (p-value = 0.02). Stride velocity also tended to be significant at 20 min (p = 0.06) in the sole-stimulation group. Combined IAMZS and medication demonstrated significant improvements in all the time segments for pace-related gait parameters [stride length: 20 min (p = 0.04), 40 min (p = 0.01), and 60 min (p < 0.01); stride velocity: 20 min (p < 0.01), 40 min (p = 0.01), and 60 min (p < 0.01)]. These findings demonstrated the fast action of the IAMZS on PD motor symptoms. Moreover, following the termination of IAMZS, a prolonged improvement in symptoms was observed at 40 min. The combined use of IAMZS with medication showed the most profound improvements. The IAMZS may be particularly useful during medication off periods and may also postpone the long-term side effects of high-dose levodopa. A large scale multicentric trial is required to validate the results obtained from this pilot study., Koç Holding; Koç University
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- 2020
20. Spinal fusion in facioscapulohumeral dystrophy for hyperlordosis: a case report
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Cuneyt Sar, Mehmet Demirhan, Caner Günerbüyük, Berk Abay, Ilker Eren, Özgür Öztop Çakmak, Eren, İlker (ORCID 0000-0003-2965-7690 & YÖK ID 168021), Çakmak, Özgür Öztop, Günerbüyük, Caner, Demirhan, Mehmet Selahattin (ORCID 0000-0001-8411-7596 & YÖK ID 9882), Abay, Berk, Sar, Cüneyt, School of Medicine, and Graduate School of Health Sciences
- Subjects
medicine.medical_specialty ,Abdominal pain ,Medicine, general and internal ,business.industry ,medicine.medical_treatment ,Hyperlordosis ,General Medicine ,Sitting ,medicine.disease ,Trunk ,Facioscapulohumeral muscular dystrophy ,Muscular dystrophy ,Quality of life ,Spinal fusion ,03 medical and health sciences ,0302 clinical medicine ,Atrophy ,030220 oncology & carcinogenesis ,medicine ,Physical therapy ,030212 general & internal medicine ,medicine.symptom ,business - Abstract
Rationale: facioscapulohumeral muscular dystrophy (FSHD) is the third most common muscular dystrophy, which is associated with facial, shoulder girdle, and paraspinal muscle atrophy. Most of the patients develop hypokyphosis and hyperlordosis in the course of the disease, to preserve standing posture. Corrective fusion is contraindicated in these patients as the surgery results with loss of compensatory hyperlordosis and leads to loss of trunk balance while standing. Although spinal fusion in neuromuscular scoliosis is a known treatment option, there are no studies in the literature on the spinal fusion of this specific patient group. Patient concerns: in this case report we have presented a 66-year-old woman, who was admitted with back and abdominal pain, inability to sit straight, abdominal discomfort, and numbness in the lower extremities after prolonged sitting. Diagnoses: the patient developed severe hyperlordosis causing intra-abdominal disorders, radicular symptoms, and sitting discomfort due to FSHD. Interventions: the patient underwent T2-S1 fusion and successful fusion was achieved. Outcomes:Individualized Neuromuscular Quality of Life Questionnaire (INQoL) was used to assess preoperative and 3 years postoperative functional outcomes. All domains and total score improved at the end of the follow-up period and successful fusion was verified radiologically. Lessons: this case suggests that spinal fusion may provide functional improvement in carefully selected patient groups. Patient stratification considering spinal disability is required for further studies in this specific indication., NA
- Published
- 2020
21. Rare case of glioblastoma multiforme located in posterior corpus callosum presenting with depressive symptoms and visual memory deficits
- Author
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Ihsan Solaroglu, Hale Yapici-Eser, Ebru Nur Vanlı-Yavuz, Emrah Egemen, Ozgur Oztop-Cakmak, Aslihan Onay, Eser, Hale Yapıcı (ORCID 0000-0003-0318-2770 & YÖK ID 134359), Onay, Aslıhan, Çakmak, Özgür Öztop, Egemen, Emrah, Vanlı-Yavuz, Ebru Nur, Solaroğlu, İhsan (ORCID 0000-0002-9472-1735 & YÖK ID 102059), Koç University Hospital, School of Medicine, Department of Psychiatry, Department of Radiology, Department of Neurology, and Department of Neurosurgery
- Subjects
medicine.medical_specialty ,Supratentorial region ,Audiology ,Corpus callosum ,Apraxia ,Article ,Corpus Callosum ,03 medical and health sciences ,0302 clinical medicine ,Visual memory ,Rare case ,medicine ,Humans ,Memory Disorders ,medicine.diagnostic_test ,business.industry ,Brain Neoplasms ,Depression ,Antidepressant agent ,Choline ,Creatine ,Gadolinium ,N Acetylaspartic Acid ,Brain ,Brain neoplasms ,Female ,Glioblastoma ,Magnetic resonance imaging ,Memory disorders ,Middle aged ,General Medicine ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,030227 psychiatry ,medicine.anatomical_structure ,Visuospatial perception ,Medicine ,Headaches ,medicine.symptom ,business ,030217 neurology & neurosurgery - Abstract
Most of the primary brain tumours are located in the supratentorial region, and it is uncommon to see tumour growth on deep brain structures such as posterior corpus callosum (PCC). In addition, lesions in PCC are also difficult to recognise, because construction apraxia, visuospatial perception and attentional capacity impairment may be the only presenting symptoms. Here, we represent a rare case of gliobastoma multiforme located in PCC, which solely presents with depressive symptoms and visual memory deficits. Initial manifestations of primary brain tumours with psychiatric symptoms and memory disturbances, in addition to headaches and seizures, should be kept in mind., NA
- Published
- 2016
22. How do Physicians Manage Functional Neurological Symptom Disorder and Somatic Symptom Disorder in the Emergency Department? A Vignette Study.
- Author
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Kiliç Ö, Eser HY, Necef I, Altunöz U, Çakmak ÖÖ, and Aktaş C
- Abstract
Introduction: We aimed to explore how physicians from different specialties approach the management of functional neurological symptom (conversion) and somatic symptom disorders in the emergency department compared with pulmonary embolism and how physicians' professional and personal characteristics influence their diagnostic preferences., Methods: Using a vignette methodology, and cross-sectional design, three emergency department case vignettes of possible functional neurological symptom, somatic symptom disorder, and pulmonary embolism were presented to physicians from internal medicine, emergency medicine, and psychiatry. A structured survey including questions on diagnosis and management of these cases, and physicians' professional and personal characteristics (childhood trauma, attachment style) was conducted., Results: Physicians from internal medicine and emergency medicine tended to consider functional neurological symptom disorder as 'malingering' while psychiatrists tended to diagnose the pulmonary embolism case as a psychiatric condition. Emergency medicine physicians preferred to manage functional neurological symptom disorder themselves, while other doctors endorsed recommending a psychiatric consultation. In the univariable model, being a physician from psychiatry, emergency medicine, or internal medicine; being a specialist, history of childhood sexual abuse, dismissive, and fearful attachment styles of doctors were significant predictors of diagnosing functional neurological symptom disorder as malingering. Being a psychiatrist stayed as the only significant predictor in the multivariable model., Conclusion: Objectively-aberrant functional neurological symptoms and subjective somatic symptoms may be creating different reactions in physicians. In the emergency department, physicians' diagnostic and treatment preferences of conversion disorder may be influenced by lack of training in conversion disorder, rather than their personal characteristics., Competing Interests: Conflict of Interest: The authors have no competing interest to report., (Copyright: © 2021 Turkish Neuropsychiatric Society.)
- Published
- 2021
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