24 results on '"Çeltİk, Aygül"'
Search Results
2. Screening for the Frequency of Fabry Disease in Patients Followed Up in the Nephrology Outpatient Clinic.
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Saray, Seray, Çeltik, Aygül, Atay, Gökhan, Aşçı, Gülay, Demirci, Meltem Seziş, and Yılmaz, Mümtaz
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ANGIOKERATOMA corporis diffusum , *MEDICAL screening , *WOMEN patients , *ENZYME replacement therapy , *DELAYED diagnosis , *GENETIC counseling , *GENETIC mutation - Abstract
Background: The goal of this study was to determine the prevalence of Fabry disease in the nephrology outpatient clinic population, whose diagnosis is frequently delayed despite the availability of enzyme replacement therapy today. Additionally, it was aimed at identifying patient groups that should be evaluated in terms of Fabry disease diagnosis based on symptoms, making an early diagnosis in some patients through family screening, and starting early treatment in these patients. Methods: The study, which enrolled 950 patients, followed in our outpatient clinic. Questionnaires were used to assess the patients. According to the results of the questionnaire, blood samples were taken from those with the possibility of Fabry disease, and the disease was screened by examining Fabry gene mutations in female patients and alpha-galactosidase A levels in male patients. Results: A female patient with Fabry disease was not included in the study. During the study only one female patient was found to have a genetic mutation. The diagnostic phase of the patient, who had a genetic variant considered as a polymorphism by some authors, could not be completed because the diagnosis of amyloidosis-myeloma was made and the patient died without further examination. Conclusion: Although individuals with the possibility of Fabry disease were selected by a questionnaire study in a specifc patient population, the frequency of the disease was found to be consistent with the literature. [ABSTRACT FROM AUTHOR]
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- 2024
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3. The effect of hypercalcemia on allograft calcification after kidney transplantation
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Çeltik, Aygül, Şen, Sait, Yılmaz, Mümtaz, Demirci, Meltem Seziş, Aşçı, Gülay, Tamer, Abdülkerim Furkan, Sarsık, Banu, Hoşcoşkun, Cüneyt, Töz, Hüseyin, and Ok, Ercan
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- 2016
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4. Is Loss of Residual Renal Function Related to Longitudinal Uric Acid and CRP Levels in Peritoneal Dialysis Patients?
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ÇELTİK, Aygül, primary, ALATAŞ, Zalal, additional, YILMAZ, Mümtaz, additional, SEZİŞ DEMİRCİ, Meltem, additional, AŞÇI, Gülay, additional, TÖZ, Hüseyin, additional, and ÖZKAHYA, Mehmet, additional
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- 2022
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5. Periton Diyalizi Hastalarında, Rezidüel Renal Fonksiyonların Kaybı Boylamsal Ürik Asit ve CRP Düzeyleri ile İlişkili midir?
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Alataş, Zalal, Özkahya, Mehmet, Yılmaz, Mümtaz, Seziş, Meltem, Aşçı, Gülay, Çeltik, Aygül, and Toz, Hüseyin
- Abstract
Amaç: Periton diyalizi yapan hastalarda rezidüel renal fonksiyonların morbidite ve mortalite üzerinde olumlu etkileri vardır. Amacımız, periton diyalizi başlanmadan önceki bazal verilerin ve başlandıktan sonra ilk üç yıldaki boylamsal ürik asit ve C-reaktif protein (CRP) düzeyinin rezidüel renal fonksiyon kaybı üzerindeki etkilerinin araştırılmasıdır. Gereç ve Yöntem: Retrospektif kohort bir çalışmadır. Son dönem böbrek yetmezliği nedeni ile periton diyalizi başlanan 34 hasta çalışmaya dahil edildi. Primer sonlanım noktası rezidüel renal fonksiyon kaybıydı ve rezidüel idrar miktarının 200 mL/24 saatten az olması olarak tanımlandı. Hastalar, periton diyalizi başlandıktan sonra üç yıl boyunca veya RRF kaybı olana kadar takip edildi. Hastaların klinik ve laboratuvar verileri hasta dosyalarından kaydedildi. Bulgular: Takip süresi 32,7 (12,9-36) aydı. Periton diyalizi başlandıktan 22,1±9,8 ay sonra 10 hastada rezidüel renal fonksiyon kaybı oldu. Boylamsal ürik asit düzeyi 6,1±1,2 mg/dL ve boylamsal CRP düzeyi 0,5 (0,3-0,7) mg/dL idi. Rezidüel renal fonksiyon kaybı olan hastalarda, bazal sodyum, trigliserid düzeyleri daha düşük iken parathormon düzeyi daha yüksekti. Her iki grup arasında boylamsal ürik asit ve CRP düzeyi açısından fark yoktu. Periton diyalizi başlanmadan önceki parathormon [tehlike oranı (HR), 1.003; %95 güven aralığı (GA) 1.001-1.006; p=0,013], sodyum (HR 0,801; %95 GA 0,665-0,965; p=0,019) ve vücut kitle indeksi (HR 0,817; %95 GA 0,684-0,975; p=0,025) rezidüel renal fonksiyon kaybı için risk faktörüydü. Sonuç: Periton diyalizi hastalarında, bazal sodyum, trigliserid ve vücut kitle indeksi rezidüel renal fonksiyon kaybı için risk faktörü olarak bulunmuştur. Rezidüel renal fonksiyon kaybı ile boylamsal CRP ve ürik asit düzeyi arasında ilişki gösterilememiştir. İdeal ürik asit ve CRP düzeyinin belirlenmesi için prospektif çalışmalara ihtiyaç vardır.
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- 2022
6. Relationship Between Severity of Renal Amyloid Deposition and Clinical Outcomes in Non-AA Amyloidosis.
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Çeltik, Aygül, Şen, Sait, Karadağ, Fatma Keklik, Saydam, Güray, Aşçı, Gülay, Kumbaracı, Banu Sarsık, Özkahya, Mehmet, and Töz, Hüseyin
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AMYLOID , *AMYLOIDOSIS , *STEM cell transplantation , *AMYLOID plaque , *GLOMERULAR filtration rate , *WECHSLER Adult Intelligence Scale - Abstract
Objective: Renal involvement is a common manifestation of systemic amyloidosis. Amyloid load can be predicted by histopathological grading of amyloid deposits in renal biopsy specimens. This study aimed to determine the relationship of renal amyloid deposition grade with clinical manifestations and outcomes in patients with biopsy-proven renal non-AA amyloidosis. Methods: This retrospective cohort study included 74 subjects with renal non-AA amyloidosis (52 light chain amyloidosis and 22 unclassified amyloidosis). Baseline characteristics and follow-up data were recorded. Pattern and quantity of amyloid deposition in glomeruli, interstitium, vessels, and tubulointerstitial changes were scored. Renal Amyloid Prognostic Score was obtained by addition of all scores and divided into 3 grades (Renal Amyloid Prognostic Score grades I, II, III). Results: In light chain amyloidosis group, the median follow-up was 11 (4-45) months. The baseline estimated glomerular filtration rate was significantly lower among patients with Renal Amyloid Prognostic Score grade III. Death-censored Renal survival was significantly lower among patients with Renal Amyloid Prognostic Score grade III. Renal Amyloid Prognostic Score grade III was a significant predictor of lower renal survival. Patient survival was not significantly different according to Renal Amyloid Prognostic Score grade. Receiving autologous stem cell transplantation treatment was associated with better patient survival. The type of amyloid could not be determined in 22 patients. In this group, baseline estimated glomerular filtration rate was significantly lower in patients with Renal Amyloid Prognostic Score grade III. Conclusions: In patients with light chain amyloidosis, baseline renal function is associated with Renal Amyloid Prognostic Score grade. Renal survival is significantly lower in patients with the highest Renal Amyloid Prognostic Score grade. However, patient survival is not significantly different according to Renal Amyloid Prognostic Score grade. [ABSTRACT FROM AUTHOR]
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- 2022
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7. Genetic characterization of Toxoplasma gondiistrains isolated from humans living in İzmir, Türkiye
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Karakavuk, Muhammet, Can, Hüseyin, Çeltik, Aygül, Karakavuk, Tuğba, Gül, Ceren, Erdem, Hüseyin Aytaç, Pullukçu, Hüsnü, Taşbakan, Meltem, Taşbakan, Mehmet Sezai, Gürüz, Adnan Yüksel, Döşkaya, Mert, and Değirmenci Döşkaya, Aysu
- Abstract
Toxoplasma gondiiis an obligate intracellular zoonotic parasite that can infect all warm-blooded animals, including humans. Currently, clinical findings of toxoplasmosis are being related to T. gondiistrains such as Type I genotype may cause high pathogenicity and Type II genotype causes a milder clinical presentation. We have showed in our previous that Type II genotype is the most frequent strain detected in stray cats and wild birds living in natural life of İzmir. The aim of this study was to assess toxoplasmosis seroprevalence in immunocompromised patients, investigate the presence of T. gondiiDNA in their blood samples, and genotype the PCR positive ones.
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- 2024
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8. Evaluation of nephrotoxicity and prognosis in patients treated with colistin due to hospital-acquired pneumonia Hastane kökenli pnömoni nedeniyle kolistin ile tedavi edilen olgularda nefrotoksisite ve prognozun değerlendirilmesi
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KORKMAZ EKREN, PERVİN, Toreyin, Zehra Nur, Ergan, Begum, Yalcin, Aslihan, Salturk, Cuneyt, Ergun, Recai, Guven, Pinar, Ulubay, Gaye, Gurun Kaya, Aslihan, ULUER, HATİCE, Bacakoglu, Feza, Berk Takir, Huriye, Kalamanoglu Balci, Merih, Gaygisiz, ÜMMÜGÜLSÜM, AYDOĞDU, MÜGE, GÜRSEL, GÜL, SAYINER, ABDULLAH, and ÇELTİK, AYGÜL
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© 2018, Ankara University. All rights reserved.Introduction: Colistimethate sodium (CMS) is frequently used in the treatment of nosocomial multidrug-resistant gram-negative infections. Nephrotoxicity is the most important side effect. The aim of this study is to evaluate the effect of colistin on nephrotoxicity and to assess prognosis in patients treated with CMS due to hospital-acquired pneumonia (HAP). Materials and Methods: Patients treated with CMS for HAP due to multidrug-resistant Pseudomonas aeruginosa or Acinetobacter baumannii were included in this cohort study. Results: We evaluated 281 patients treated with two different brands of CMS whose administration dose is different: imported (n= 58, low dose/kg) and domestic (n= 223, high dose/kg). Nephrotoxicity developed in 175 patients (62.3%). The median age (73 vs. 66 years, p= 0.004) and mortality rates were higher (66.9% vs. 52.8%, p= 0.022) in patients having nephrotoxicity. The patients receiving high dose/kg had higher nephrotoxicity rate (67.7% vs. 41.4%, p< 0.001). The clinical, bacteriological response and mortality rates of the whole group were 52.0%, 61.0%, 61.6%, respectively. The clinical and bacteriological response rates were similar in the different dose groups. Multivariate analysis showed that nephrotoxicity was associated with domestic brand depending on use of high dose (OR= 3.97), advanced age (β= 0.29, p= 0.008), male gender (OR= 2.60), hypertension (OR= 2.50), red blood cells transfusion (OR= 2.54), absence of acute kidney injury (OR= 10.19), risk stage of RIFLE (OR= 11.9). Conclusion: Nephrotoxicity is associated with the use of high dose colistin, age, gender, hypertension, red blood cells replacement and RIFLE stage. The mortality rate is higher in patients developing nephrotoxicity.
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- 2017
9. Frequency and Outcomes of Pregnancy on Nocturnal Home Haemodialysis
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Demirci, Cenk, Demirci, Meltem Seziş, Aşçı, Gülay, Çeltik, Aygül, Seymen, Pınar, Çolak, Taşkın, Ok, Ercan, and Ege Üniversitesi
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Cerrahi - Abstract
AMAÇ: Diyaliz tedavisi alan doğurgan çağdaki kadınlarda gebelik nadir gözlenmektedir ve kötü sonuçlar ile birliktedir. 1990'lı yıllarda yayınlanan çeşitli çalışmalarda gebelik oranları 0,3-0,5/100 hasta-yılı olarak saptanmış ve bu gebeliklerde canlı doğum oranları düşük kalmıştır. Daha yeni çalışmalar, intensif hemodiyalizin fertiliteyi ve canlı doğum oranını artırdığını göstermektedir. Amacımız evde haftada üç gün nokturnal hemodiyaliz (NHD) tedavisinin klinik ve biyokimyasal parametrelerdeki değişiklikler ile birlikte başarılı gebelik sonuçları ve canlı doğum oranlarına katkısının olup olmadığını değerlendirmektir. GEREÇ ve YÖNTEMLER: Mevcut tanımlayıcı kohort çalışmasında, Ağustos 2010 ve Ocak 2015 arasında evde NHD tedavisine başlayan üreme çağındaki 60 kadında (14-44 yaş) gebelik sonuçları analiz edildi. BULGULAR: Ortalama 20±11 aylık izlem süresinde evde NHD ile dört gebelik saptandı (4/ 100 hastayılı). Bu dört hastanın, ortalama yaşı gebelik başlangıcında 37,3±4,8 yıl ve ev HD'nde geçirdikleri süre 19±12 ay idi. Haftalık hemodiyaliz seansı gebelik başlangıcında ortalama 23,8±1,8 iken, termde 36,6±0,5 saate çıkarıldı; serum üre düzeyi 50 mg/dl altında ve yüksek eritropoetin dozları ile hemoglobin düzeyi 10 g/dl üzerinde tutuldu. Kan basıncı antihipertansif ilaç kullanılmadan normal sınırlarda seyretti. Üç gebe hasta 38, 35 ve 38. haftalarda herhangi bir maternal ve fetal komplikasyon olmadan sezeryanseksiyo ile üç sağlıklı bebek doğurdu. Doğum ağırlıkları sırayla 2.750, 2.550 ve 3.100 g. idi. Dördüncü hasta (sekonder amiloidoz ve multipl spontan abortus öyküsü olan) 25. haftada erken doğum yaptı ve bebek neonatal ikinci günde exitus oldu. SONUÇ: Çalışmamızda üreme çağındaki kadınlarda evde nokturnal hemodiyaliz tedavisinin yüksek konsepsiyon ve canlı doğum oranları ile birlikte olduğunu gözlemledik., OBJeCTIVe: Pregnancy in women of reproductive age on dialysis is rare and has a poor outcome. Several studies published in the 1990s revealed pregnancy rates of 0.3 to 0.5 per 100 patient-years, but not all pregnancies resulted in live births. More recent studies suggest that intensive haemodialysis increases fertility and successful pregnancies with live births. duration 19±12 months at the beginning of pregnancy. Duration of the weekly haemodialysis session was increased from 23.8±1.8 at baseline to 36.6±0.5 hours at term; serum urea was maintained below 50 mg/dl, and haemoglobin over 10 g/dl with an increase in erythropoietin doses. Blood pressure was within the normal ranges and there was no need for antihypertensive drugs.Three women underwent a caesarean section at 38,35,38 weeks, delivering three healthy newborns without any maternal or fetal complications. Birth weights were 2.750, 2.550 and 3.100 g, respectively. the fourth patient (with a history of secondary amyloidosis and multiple spontaneous abortions) delivered at the 25th week, resulting in neonatal death on the second day.CONCLUSION: We observed that women of reproductive age on NHHD had high rates of conception and live birth.
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- 2017
10. Evaluation of nephrotoxicity and prognosis in patients treated with colistin due to hospital-acquired pneumonia
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Korkmaz Ekren, Pervin, primary, Töreyin, Zehra Nur, additional, Berk Takır, Huriye, additional, Kalamanoğlu Balcı, Merih, additional, Gaygısız, Ümmügülsüm, additional, Gürsel, Gül, additional, Ergan, Begüm, additional, Yalçın, Aslıhan, additional, Saltürk, Cüneyt, additional, Aydoğdu, Müge, additional, Ergün, Recai, additional, Güven, Pınar, additional, Ulubay, Gaye, additional, Gürün Kaya, Aslıhan, additional, Çeltik, Aygül, additional, Uluer, Hatice, additional, Bacakoğlu, Feza, additional, and Sayıner, Abdullah, additional
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- 2017
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11. Frequency and Outcomes of Pregnancy on Nocturnal Home Haemodialysis
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Demirci, Cenk, primary, Seziş Demirci, Meltem, additional, Aşçı, Gülay, additional, Çeltik, Aygül, additional, Seymen, Pınar, additional, Kırçelli, Fatih, additional, Çolak, Taşkın, additional, and Ok, Ercan, additional
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- 2017
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12. Renal amiloidoz tanısı konan olguların klinikopatolojik olarak değerlendirilmesi
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Çeltik, Aygül, Töz, Hüseyin, and İç Hastalıkları Anabilim Dalı
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Amyloid ,Nefroloji ,Kidney diseases ,Survival ,Nephrology ,Amyloidosis ,Kidney - Abstract
Amiloidoz, protein katlanmasındaki bozukluğa sekonder, birçok organda, ekstraselüler alanda fibriller yapıda proteinlerin birikmesi ile karakterize sistemik hastalıklar grubudur. Amiloidozda en önemli morbidite ve mortalite nedenlerinden biri böbrek tutulumudur.Amacımız, merkezimizde renal amiloidoz tanısı konulan hastaların histolojik ve klinik olarak değerlendirilmesi ve diğer merkezlerle karşılaştırılmasıdır. Çalışmada Ocak 2005 ile Aralık 2012 arasında Ege Üniversitesi' nde renal amiloidoz tanısı konan 122 hasta retrospektif olarak değerlendirildi. Hastaların klinik ve laboratuvar verileri, renal replasman tedavileri ve sağkalımları ile ilgili bilgileri hastane kayıtlarından elde edildi. En sık amiloidoz tipi AA amiloidozdu. Hastaların % 13.9' unda tiplendirme yapılamadı. Tiplendirilemeyen amiloidozu olan hastalarda serum kreatinin düzeyi anlamlı olarak yüksekti. Mediyan takip süresi 24 ay olan çalışmada, renal replasman tedavisi ihtiyacı olan hasta oranı yaklaşık %40 idi. Hasta sağkalımı, AA amiloidoz grubunda AL ve tiplendirilemeyen gruba göre ve böbrek sağkalımı ise AA ve AL amiloidoz grubunda tiplendirilemeyen amiloidoz grubuna göre daha iyiydi. Renal amiloidoz prognostik skorunun artması ile renal sağkalımın azaldığı gösterildi.Sonuç olarak, renal amiloidoz nadir görülen bir hastalık olsa da morbiditesi ve mortalitesi yüksektir. AA amiloidoz ülkemizde en sık amiloidoz tipidir. Hastaların bir kısmında tiplendirme yapılamaması nedeniyle amiloidoz tiplerinin doğru saptanması için yeni yöntemler gerekmektedir. Skorlama sistemleri ile amiloidozun derecelendirilmesi, böbrek ve hasta sağkalımı ve tedaviye yanıtın değerlendirilmesi açısından önemli olabilir Amyloidosis is a group of systemic diseases which are characterised by accumulation of extracellular fibrils resulting from abnormal folding of proteins in organs. Renal involvement is one of the important consequences that are associated with mortality and morbidity.The aim of the study is to evaluate the histologic and clinical findings of the patients with renal amyloidosis. The study included 122 patients who were diagnosed renal amyloidosis between January 2005 and December 2012. The demographic and clinical features at the time of the diagnosis and follow-up data were retrospectively collected from the patient's records. The most common type of amyloidosis was AA amyloidosis. In 13.6 % of patients, the type of the amyloid protein was undetermined. The serum creatinine level of the patients with undetermined amyloidosis was significantly higher. The median duration of follow-up was 24 months. Nearly 40 % of the patients underwent renal replacement treatment. Patient survival was significantly higher among patients with AA amyloidosis when compared with AL and undetermined amyloidosis and renal survival was significantly higher among patients with AA and AL amyloidosis when compared with undetermined amyloidosis. Renal survival decreased with increase in renal amyloidosis prognostic score. In conclusion, renal amyloidosis is a rare disease with high morbidity and mortality. In our study, AA amyloidosis is the most common type. New diagnostic tools are needed to determine the type of the amyloid proteins as it is impossible to determine the type of the amyloid protein accuretly in some patients. The scoring systems may be useful to predict the renal and patient survival and the efficacy of the treatment. 57
- Published
- 2014
13. Mean Platelet Volume in Women with Gestational Diabetes
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Çeltik, Aygül, primary, Akıncı, Barış, additional, and Demir, Tevfik, additional
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- 2016
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14. Recurrent lupus nephritis after transplantation: Clinicopathological evaluation with protocol biopsies
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Çeltİk, Aygül, primary, Şen, Saİt, additional, Tamer, Abdülkerİm Furkan, additional, Yılmaz, Mümtaz, additional, Sarsık, Banu, additional, Özkahya, Mehmet, additional, Başçı, Alı, additional, and Töz, Hüseyİn, additional
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- 2016
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15. A Case of Chickenpox Developing 11 Years after Renal Transplantation.
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Akyol, Deniz, Pullukçu, Hüsnü, Çeltik, Aygül, Mermut, Gülşen, and Işıkgöz, Meltem Taşbakan
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WOMEN patients ,HEMODIALYSIS patients ,KIDNEY transplantation ,CENTRAL nervous system infections ,CHICKENPOX ,CHICKENPOX vaccines ,CHRONIC kidney failure - Abstract
In solid organ transplant recipients, it is recommended that the necessary vaccinations be completed at least 4 weeks before transplant. Chickenpox infection in adulthood can lead to serious clinical conditions such as pneumonia, hepatitis, and central nervous system infections. Herein, the case of chickenpox in a 36-year-old female patient with renal transplantation for end-stage renal disease due to vesicoureteral reflux 11 years previously and without a history of chickenpox or its vaccination before and after transplantation is reported. In this case, because of the development of thrombocytopenia associated with intravenous acyclovir, treatment was successfully concluded with oral valacyclovir. [ABSTRACT FROM AUTHOR]
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- 2020
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16. A rare cause of soft tissue infections: Pseudallescheria boydii
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Taşbakan, Meltem, primary, Önal, Uğur, additional, Metin, Dilek, additional, Pullukçu, Hüsnü, additional, Yamazhan, Tansu, additional, Çeltik, Aygül, additional, Hilmioğlu-Polat, Süleyha, additional, Argın, Mehmet, additional, and Ulusoy, Sercan, additional
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- 2015
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17. Gestasyonel diabetes mellitus öyküsü olan kadınlarda adiposit yağ asidi bağlayıcı protein düzeyi ve metabolik sendrom ile ilişkisinin değerlendirilmesi
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Çeltik, Aygül, Yeşil, Sena, and İç Hastalıkları Ana Bilim Dalı
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Diabetes mellitus ,Glucose ,Carrier proteins ,Endocrinology and Metabolic Diseases ,Diabetes-gestational ,Endokrinoloji ve Metabolizma Hastalıkları ,Carotid intima media ,Adipose tissue ,Metabolic syndrome - Abstract
Gestasyonel diabetes mellitus (GDM) ilk defa gebelikte ortaya çıkan veya saptanan anormal glukoz intoleransıdır. GDM' nin patogenezinde önemli rol oynayan insülin direnci, birçok kadında doğumdan sonra devam etmektedir. Bu nedenle GDM öyküsü olan kadınlar, metabolik sendrom (MS) ve kardiyovasküler hastalıklar açısından risklidir.Adiposit yağ asidi bağlayıcı protein (A-FABP) yağ doku ve makrofalarda bulunan, hücre içi yağ asidi taşınmasında görevli proteindir. Dolaşımdaki A-FABP düzeyinin, MS, DM ve ateroskleroz ile ilişkili olduğu gösterilmiştir.Bu çalışmamızda GDM öyküsü olan kadınlarda MS ve kardiyovasküler hastalıklarla ilişkili risk faktörlerini, subklinik aterosklerozu ve bunların serum A-FABP düzeyi ile ilişkisini inceledik.Çalışmaya 120 GDM öyküsü olan kadın ile 53 sağlıklı ve GDM öyküsü olmayan kadın alındı. GDM öyküsü olan kadınların % 37.50' sinde bozulmuş açlık glukozu ve bozulmuş glukoz toleransı, % 16.66' sında DM ve % 35.83' ünde MS saptandı. GDM öyküsü olan kadınların daha obez ve insülin dirençlerinin daha fazla olduğu görüdü. MS ve DM gelişimi için prediktif değeri olan serum A-FABP düzeyinin GDM öyküsü olan kadınlarda ve özellikle MS saptanan alt grupta daha yüksek olduğu gösterildi. Serum A-FABP düzeyinin MS kriterlerinden bel çevresi ile bağımsız bir ilişkisi olduğu saptandı. GDM öyküsü olan kadınlardan glukoz tolerans bozukluğu olanlarda düzeylerinin daha yüksek olduğu gösterildi. Ayrıca GDM öyküsü olan kadınlarda erken sayılabilecek bir dönemde karotis intima media kalınlığının arttığı ve serum A-FABP düzeylerinin karotis İMK ile ilişkili olduğu bulundu.Sonuç olarak, GDM öyküsü olan kadınlarda serum A-FABP düzeyi yüksek saptanmıştır. Serum A-FABP düzeyi, GDM öyküsü olan kadınlarda erken dönemde metabolik bozuklukların değerlendirilmesi için kullanılabilir. Gestational diabetes mellitus (GDM) is defined as carbohydrate intolerance diagnosed for the first time during pregnancy. Insulin resistance which plays an important role in the pathogenesis of GDM may continue after delivery. Because of this, women with previous GDM (pGDM) have increased risk of metabolic syndrome and cardiovascular diseases.Adipocyte fatty acid binding protein (A-FABP) is a cytoplasmic protein which is involved in fatty acid transport in adipocytes and macrophages. Circulating A-FABP has been reported to be associated with MS, DM and atherosclerosis.In this study, we aimed to determine the risk factors associated with MS and cardiovascular diseases, the development of subclinical atherosclerosis and to evaluate the relationship of metabolic risk factors and subclinical atherosclerosis with serum A-FABP in women with pGDM.One hundred and twenty women with pGDM and 53 healthy women with no history of pGDM were enrolled. The prevalence of impaired fasting glucose/impaired glucose tolerance, DM and MS were 37.50 %, 16.66 % and 35.83 % among women with pGDM, respectively. Women with pGDM were detected to be more insulin resistant and obese. Serum A-FABP, which is associated with development of MS and DM, was higher among women with pGDM and especially among the subclass with MS. Serum A-FABP was independently associated with waist circumference but not with the other contributers of MS. Serum A-FABP was higher in women with pGDM who had glucoce intolerance. Carotis intima meida thickness (CIMT) was higher in women with pGDM and serum A-FABP was associated with CIMT.In conclusion, serum A-FABP is higher in women with pGDM. Serum A-FABP level can be used as an early indicator of metabolic disturbances in women with pGDM. 59
- Published
- 2010
18. NEW ONSET DIABETES IN RENAL TRANSPLANT RECIPIENTS: SINGLE CENTER EXPERIENCE
- Author
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BORA, SEYMEN, TOSUN TAŞAR, PINAR, ATİLA, KORAY, ÇAVDAR, CANER, Sağlam Eyiler, Funda, ÇELİK, ALİ, ÇAMSARI, TANER, GÜLAY, HÜSEYİN, ÇELTİK, AYGÜL, and SİFİL, AHMET AYKUT
- Published
- 2007
19. CMV DISEASE IN RENAL TRANSPLANT RECIPIENTS: SINGLE CENTER EXPERIENCE
- Author
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ATİLA, KORAY, ÇELİK, ALİ, BORA, SEYMEN, ÇAMSARI, TANER, GÜLAY, HÜSEYİN, TOSUN TAŞAR, PINAR, ÇAVDAR, CANER, ÇELTİK, AYGÜL, Sağlam Eyiler, Funda, and SİFİL, AHMET AYKUT
- Published
- 2007
20. Evde Nokturnal Hemodiyaliz ile Gebelik Sıklığı ve Sonuçları.
- Author
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DEMİRCİ, Cenk, SEZIŞ DEMİRCİ, Meltem, AŞÇİ, Gülay, ÇELTİK, Aygül, SEYMEN, Pınar, KIRÇELLİ, Fatih, ÇOLAK, Taşkın, and OK, Ercan
- Abstract
Copyright of Turkish Nephrology, Dialysis & Transplantation Journal is the property of Turkish Society of Nephrology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2017
21. Rare cause of weight loss in a kidney transplant recipient: iron overload
- Author
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Yaprak, Mustafa, primary, Çeltik, Aygül, additional, Turan, İlker, additional, Nart, Deniz, additional, Turan, Mehmet N., additional, Sezer, Taylan Ö., additional, Hoşçoşkun, Cüneyt, additional, and Töz, Hüseyin, additional
- Published
- 2013
- Full Text
- View/download PDF
22. A rare cause of soft tissue infections: Pseudallescheria boydii.
- Author
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IşıkgözTaşbakan, Meltem, Önal, Uğur, Metin, Dilek Yeşim, Pullukçu, Hüsnü, Yamazhan, Tansu, Çeltik, Aygül, Hilmioğlu-Polat, Süleyha, Argın, Mehmet, and Ulusoy, Sercan
- Subjects
SOFT tissue infections ,KIDNEY transplantation ,HYPHAENE - Abstract
Copyright of Journal of Microbiology & Infectious Diseases is the property of Journal of Microbiology & Infectious Diseases and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2015
- Full Text
- View/download PDF
23. Kanser ve uyku bozuklukları.
- Author
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YAVUZŞEN, Tuğba, ALACACIOĞLU, Ahmet, ÇELTİK, Aygül, and YILMAZ, Uğur
- Abstract
Copyright of Turkish Journal of Oncology / Türk Onkoloji Dergisi is the property of KARE Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2014
- Full Text
- View/download PDF
24. Rare cause of weight loss in a kidney transplant recipient: iron overload.
- Author
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Yaprak, Mustafa, Çeltik, Aygül, Turan, İlker, Nart, Deniz, Turan, Mehmet N., Sezer, Taylan Ö., Hoşçoşkun, Cüneyt, and Töz, Hüseyin
- Subjects
- *
WEIGHT loss , *KIDNEY transplantation , *PHYSIOLOGICAL effects of iron , *HEMODIALYSIS , *HEART auscultation , *INTRAVENOUS therapy , *HOSPITAL care - Abstract
Various reasons such as malignancies and chronic infections may cause weight loss in kidney transplant patients. In this report, iron overload as a rare cause of weight loss in a kidney transplant patient is presented. Forty-seven-year-old male patient who transplanted from a deceased donor 5 years ago was hospitalized because of 20 kg of weight loss. In medical history, he had history of hemodialysis for 89 months and received 100-300 mg of intravenous iron therapy per week before transplantation and transfused eight units of blood. In physical examination, weight and height were 45 kg and 185 cm, respectively. Respiratory and cardiac auscultation was normal. Laboratory results revealed as follow: glucose 76 mg/dL, urea 60 mg/dL, creatinine 1.35 mg/dL, aspartate aminotransferase 74 U/L, alanine aminotransferase 77 U/L, C-reactive protein 2.59 mg/dL, albumin 3.3 g/dL, globulin 3.4 g/dL, white blood cells 3200/mm3, hemoglobin 13.1 g/dL and platelets 190,000/mm3. Chest and abdominal tomography didn't reveal any pathology. Portal Doppler ultrasound showed signs of early cirrhosis. Viral and autoimmune hepatitis markers were negative. Ferritin was 5300 ng/mL and transferrin saturation was 82%. In liver biopsy, hemosiderosis was diagnosed and heterozygous H63D gene mutation was detected. Totally, 19 units of phlebotomy were performed. Liver function tests and serum ferritin decreased gradually. At outpatient follow-up in 6 months, he returned to former weight. In conclusion, there can be several causes of weight loss in kidney transplant patients. Iron overload can come across as a rare cause of weight loss. In these patients, ferritin levels should be checked and diagnosis should be clarified by liver biopsy and gene mutation analysis. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
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