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3 results on '"Çilingir S"'

1. Identity and integration among Turkish sunni muslims in Britain

Author

Çilingir, S.

Abstract

This article attempts to analyze various aspects of ethnic and religious identity configurations among the Turkish Sunni Muslims in Britain and to explore how such social processes influence their socio-political integration. It tries to situate the Turkish community in the context of British Muslim identity politics. Findings in this article are based on in-depth interviews on perceptions and attitudes the Turkish Sunni Muslims have and their implications in the planning of collective activities, especially in the field of education. This study reveals that although the current level of integration among the Turkish Sunni Muslims in Britain is less than expected, neither living in a non-Muslim country nor claiming to have a British identity are perceived as incompatible with Turkish and Islamic values. This paper concludes that educating Turkish youths in ethnic and religious values is a priority, as it is seen as a means to protect against assimilation, while allowing for successful integration.

Published
2010

2. Numerical Investigation on MHD Flow and Heat Transfer over an Exponentially Stretching Sheet with Viscous Dissipation and Radiation Effects

Author

Çilingir Süngü İnci

Subjects
Information technology, T58.5-58.64
Abstract

This study is to examine the steady two dimensional laminar flow of a viscous incompressible electrically conducting fluid over a continuous surface. In this study DTM-Padé method is used to solve which is a combination of differential transform method (DTM) and Padé approximant. Comparisons between the solutions obtained by DTM and DTM-Padé and are shown that DTM-Padé is the completely powerful method then DTM for solving the problems in which boundary conditions at infinity. Also in this study the effect of Magnetic and Radiation parameters, Prandtl number and Eckert number for velocity and temperature distributions are investigated.

Published
2017
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3. Phenotype screens of murine pancreatic cancer identify a Tgf-α-Ccl2-paxillin axis driving human-like neural invasion.

Author

Wang X, Istvanffy R, Ye L, Teller S, Laschinger M, Diakopoulos KN, Görgülü K, Li Q, Ren L, Jäger C, Steiger K, Muckenhuber A, Vilne B, Çifcibaşı K, Reyes CM, Yurteri Ü, Kießler M, Gürçınar IH, Sugden M, Yıldızhan SE, Sezerman OU, Çilingir S, Süyen G, Reichert M, Schmid RM, Bärthel S, Oellinger R, Krüger A, Rad R, Saur D, Algül H, Friess H, Lesina M, Ceyhan GO, and Demir IE

Subjects
Humans, Animals, Mice, Transforming Growth Factor alpha genetics, Transforming Growth Factor alpha metabolism, Paxillin genetics, Paxillin metabolism, Phenotype, Cell Line, Tumor, Pancreatic Neoplasms pathology, Carcinoma, Pancreatic Ductal metabolism
Abstract

Solid cancers like pancreatic ductal adenocarcinoma (PDAC), a type of pancreatic cancer, frequently exploit nerves for rapid dissemination. This neural invasion (NI) is an independent prognostic factor in PDAC, but insufficiently modeled in genetically engineered mouse models (GEMM) of PDAC. Here, we systematically screened for human-like NI in Europe's largest repository of GEMM of PDAC, comprising 295 different genotypes. This phenotype screen uncovered 2 GEMMs of PDAC with human-like NI, which are both characterized by pancreas-specific overexpression of transforming growth factor α (TGF-α) and conditional depletion of p53. Mechanistically, cancer-cell-derived TGF-α upregulated CCL2 secretion from sensory neurons, which induced hyperphosphorylation of the cytoskeletal protein paxillin via CCR4 on cancer cells. This activated the cancer migration machinery and filopodia formation toward neurons. Disrupting CCR4 or paxillin activity limited NI and dampened tumor size and tumor innervation. In human PDAC, phospho-paxillin and TGF-α-expression constituted strong prognostic factors. Therefore, we believe that the TGF-α-CCL2-CCR4-p-paxillin axis is a clinically actionable target for constraining NI and tumor progression in PDAC.

Published
2023
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