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3 results on '"Ève-Marie Roy"'

1. Effects of the loss of estrogen on the heart’s hypertrophic response to chronic left ventricle volume overload in rats

Author

Elisabeth Walsh-Wilkinson, Catherine Beaumont, Marie-Claude Drolet, Ève-Marie Roy, Charlie Le Houillier, Jonathan Beaudoin, Marie Arsenault, and Jacques Couet

Subjects
Cardiac hypertrophy, Estrogens, Left ventricle, Aortic valve regurgitation, Rat, Ovariectomy, Medicine, Biology (General), QH301-705.5
Abstract

Aortic valve regurgitation (AR) can result in heart failure from chronic overloading of the left ventricle (LV). Little is known of the role of estrogens in the LV responses to this condition. The aim of the study was to compare LV remodeling in female rats with severe AR in absence of estrogens by ovariectomy (Ovx). In a first study, we investigated over 6 months the development of hypertrophy in four groups of female Wistar rats: AR or sham-operated (sham) and Ovx or not. Ovx reduced normal heart growth. As expected, volume overload (VO) from AR resulted in significant LV dilation (42% and 32% increase LV end-diastolic diameter in intact and Ovx groups vs. their respective sham group; p

Published
2019
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2. Sex differences in the response to angiotensin II receptor blockade in a rat model of eccentric cardiac hypertrophy

Author

Élisabeth Walsh-Wilkinson, Marie-Claude Drolet, Charlie Le Houillier, Ève-Marie Roy, Marie Arsenault, and Jacques Couet

Subjects
Cardiac hypertrophy, Sex differences, Angiotensin receptor blockade, Aortic valve regurgitation, Rat, Volume overload, Medicine, Biology (General), QH301-705.5
Abstract

Background. Men and women differ in their susceptibility to cardiovascular disease, though the underlying mechanism has remained elusive. Heart disease symptoms, evolution and response to treatment are often sex-specific. This has been studied in animal models of hypertension or myocardial infarction in the past but has received less attention in the context of heart valve regurgitation. The aim of the study was to evaluate the development of cardiac hypertrophy (CH) in response to left ventricle (LV) volume overload (VO) caused by chronic aortic valve regurgitation (AR) in male and female rats treated or not with angiotensin II receptor blocker (ARB), valsartan. We studied eight groups of Wistar rats: male or female, AR or sham-operated (sham) and treated or not with valsartan (30 mg/kg/day) for 9 weeks starting one week before AR surgical induction. Results. As expected, VO from AR resulted for both male and female rats in significant LV dilation (39% vs. 40% end-diastolic LV diameter increase, respectively; p

Published
2019
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3. Effects of the loss of estrogen on the heart’s hypertrophic response to chronic left ventricle volume overload in rats

Author

Charlie Le Houillier, Catherine Beaumont, Marie-Claude Drolet, Elisabeth Walsh-Wilkinson, Jacques Couet, Ève-Marie Roy, Marie Arsenault, and Jonathan Beaudoin

Subjects
Cardiac function curve, medicine.medical_specialty, Cardiac output, endocrine system, Sex dimorphism, Ovariectomy, Volume overload, Cardiology, lcsh:Medicine, 030204 cardiovascular system & hematology, General Biochemistry, Genetics and Molecular Biology, Muscle hypertrophy, 03 medical and health sciences, 0302 clinical medicine, Atrial natriuretic peptide, Internal medicine, medicine, polycyclic compounds, Aortic valve regurgitation, 030304 developmental biology, 0303 health sciences, business.industry, General Neuroscience, lcsh:R, Estrogens, General Medicine, Left ventricle, medicine.disease, Brain natriuretic peptide, Diabetes and Endocrinology, Cardiac hypertrophy, medicine.anatomical_structure, Endocrinology, surgical procedures, operative, Ventricle, Heart failure, Rat, General Agricultural and Biological Sciences, business, hormones, hormone substitutes, and hormone antagonists
Abstract

Aortic valve regurgitation (AR) can result in heart failure from chronic overloading of the left ventricle (LV). Little is known of the role of estrogens in the LV responses to this condition. The aim of the study was to compare LV remodeling in female rats with severe AR in absence of estrogens by ovariectomy (Ovx). In a first study, we investigated over 6 months the development of hypertrophy in four groups of female Wistar rats: AR or sham-operated (sham) and Ovx or not. Ovx reduced normal heart growth. As expected, volume overload (VO) from AR resulted in significant LV dilation (42% and 32% increase LV end-diastolic diameter in intact and Ovx groups vs. their respective sham group; p Nppa) gene expression was reduced by Ovx in sham-operated females whereas brain natriuretic peptide (Nppb) expression was increased. Alpha (Myh6) and beta (Myh7) myosin heavy chain genes were also significantly modulated by Ovx in sham females. In AR rats, LV expression of both Nppa and Nppb genes were increased as expected. Ovx further increased it of AR rats for Nppa and did the opposite for Nppb. Interestingly, AR in Ovx rats had only minimal effects on Myh6 and Myh7 genes whereas they were modulated as expected for intact AR animals. In summary, loss of estrogens by Ovx in AR rats was not accompanied by a worsening of hypertrophy or cardiac function. Normal cardiac growth was reduced by Ovx in sham females but not the hypertrophic response to AR. On the other hand, Ovx had important effects on LV gene expression both in sham and AR female rats.

Published
2019

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