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2. Short- and long-term outcomes of percutaneous left atrial appendage occlusion in cancer patients

Author

Mariana Tinoco, Julio Echarte-Morales, Claudio E. Guerreiro, Erick M. Ávila Gil, Berenice Caneiro-Queija, Manuel Barreiro-Pérez, Rocío González-Ferreiro, Saleta Fernández, Alberto Ortiz-Saez, Víctor Alfonso Jiménez-Díaz, Francisco Calvo-Iglesias, Antonio A. de Miguel-Castro, Carina González-Ríos, Guillermo Bastos-Fernández, José Antonio Baz-Alonso, Rodrigo Estévez-Loureiro, and Andrés Íñiguez-Romo

Subjects
Left atrial appendage occlusion, Atrial fibrillation, Cancer, Stroke, Major bleeding, Mortality, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Introduction and objectives: Percutaneous left atrial appendage occlusion (LAAO) is a viable option to mitigate bleeding and stroke risks in patients with atrial fibrillation (AF) who are not eligible for oral anticoagulation. Its safety and efficacy in cancer patients remain unclear due to their exclusion from trials. This study aimed to compare short- and long-term LAAO outcomes between cancer and non-cancer patients. Methods: Retrospective single centre study of 361 consecutive patients who underwent LAAO between april-2010 and december-2023 were included. Short-term outcomes included periprocedural complications, 30-day hospital readmission and mortality. Long-term outcomes included the composite of stroke, bleeding, and mortality and each component assessed separately. Results: The study included 93 cancer patients (54 % active, 46 % in remission) and 268 non-cancer patients. Baseline characteristics were similar, including ischemic and bleeding risk profiles (CHA2DS2-VASc: 4.5 ± 1.4 vs. 4.4 ± 1.5; HAS-BLED: 3.3 ± 0.9 vs. 3.2 ± 0.9), previous stroke and total bleeding events. Short-term outcomes showed no significant differences in periprocedural complications (7 % vs. 6 %), 30-day readmission (2 % vs. 3 %), or 30-day mortality (0 % vs. 1.5 %). Over 32 months, there was no significant difference regarding the composite endpoint (p = 0.067), stroke (SHR 0.54; p = 0.25) or bleeding events (SHR 1.36; p = 0.35). LAAO was effective in terms of stroke reduction in cancer and non-cancer patients (p = 0.027 and p = 0.006, respectively). All-cause mortality rates were higher in cancer patients (p = 0.002), mainly due to cancer progression and infections. Conclusions: LAAO procedure was safe and effective in both populations. Cancer patients experienced higher rates of all-cause mortality, with no differences in stroke and bleeding outcomes between groups.

Published
2025
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4. Left ventricular outflow tract obstruction after transcatheter mitral valve replacement: a case report with a multifaceted approach

Author

Berenice Caneiro-Queija, Claudio E. Guerreiro, Julio Echarte-Morales, Rodrigo Estévez-Loureiro, Manuel Barreiro-Pérez, Rocío González-Ferreiro, Francisco Estévez-Cid, Juan José Legarra, Jose Antonio Baz, and Andrés Íñiguez-Romo

Subjects
Tendyne, left ventricular outflow tract obstruction, transcatheter mitral valve replacement, mitral annular calcification, alcohol septal ablation (ASA), Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

An 83-year-old woman was admitted to our center because of heart failure. Transthoracic echocardiography revealed severe mitral annular calcification resulting in a double mitral valve lesion. After discussion by the heart team, transcatheter mitral valve replacement with Tendyne (Abbott Structural, Santa Clara, CA, USA) was performed. Despite having a predicted neo-left ventricular outflow tract (LVOT) above the cut-off value, the patient developed clinically significant LVOT obstruction (LVOTO) refractory to medical treatment. This situation is often treated before the intervention, and dealing with LVOTO afterward can be challenging. After taking the patient's anatomy into consideration, we decided to perform alcohol septal ablation. Applying a combined strategy of medical treatment and intervention led to success. In this case report, we discuss this event and the strategies available for preventing and managing the condition.

Published
2024
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5. Short- and long-term outcomes of percutaneous left atrial appendage occlusion in cancer patients

Author

Tinoco, Mariana, Echarte-Morales, Julio, Guerreiro, Claudio E., Ávila Gil, Erick M., Caneiro-Queija, Berenice, Barreiro-Pérez, Manuel, González-Ferreiro, Rocío, Fernández, Saleta, Ortiz-Saez, Alberto, Jiménez-Díaz, Víctor Alfonso, Calvo-Iglesias, Francisco, de Miguel-Castro, Antonio A., González-Ríos, Carina, Bastos-Fernández, Guillermo, Antonio Baz-Alonso, José, Estévez-Loureiro, Rodrigo, and Íñiguez-Romo, Andrés

Published
2025
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9. Diagnostic Challenges in Aortic Stenosis

Author

André González-García, Pablo Pazos-López, Francisco Eugenio Calvo-Iglesias, Tatiana Mallely Matajira-Chía, Raquel Bilbao-Quesada, Elisa Blanco-González, Carina González-Ríos, María Castiñeira-Busto, Manuel Barreiro-Pérez, and Andrés Íñiguez-Romo

Subjects
aortic stenosis, multimodality cardiac imaging, continuity equation, low-flow aortic stenosis, discordant aortic stenosis, planimetry, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Aortic stenosis (AS) is the most prevalent degenerative valvular disease in western countries. Transthoracic echocardiography (TTE) is considered, nowadays, to be the main imaging technique for the work-up of AS due to high availability, safety, low cost, and excellent capacity to evaluate aortic valve (AV) morphology and function. Despite the diagnosis of AS being considered straightforward for a very long time, based on high gradients and reduced aortic valve area (AVA), many patients with AS represent a real dilemma for cardiologist. On the one hand, the acoustic window may be inadequate and the TTE limited in some cases. On the other hand, a growing body of evidence shows that patients with low gradients (due to systolic dysfunction, concentric hypertrophy or coexistence of another valve disease such as mitral stenosis or regurgitation) may develop severe AS (low-flow low-gradient severe AS) with a similar or even worse prognosis. The use of complementary imaging techniques such as transesophageal echocardiography (TEE), multidetector computed tomography (MDTC), or cardiac magnetic resonance (CMR) plays a key role in such scenarios. The aim of this review is to summarize the diagnostic challenges associated with patients with AS and the advantages of a comprehensive multimodality cardiac imaging (MCI) approach to reach a precise grading of the disease, a crucial factor to warrant an adequate management of patients.

Published
2024
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11. Self-administered intranasal etripamil using a symptom-prompted, repeat-dose regimen for atrioventricular-nodal-dependent supraventricular tachycardia (RAPID): a multicentre, randomised trial

Author

Ip, James E, Jones, Alonzo, Sr, Stambler, Bruce S, Schleinkofer, David E, Winters, Stephen, Lam, Wilson, Goldstein, Robert, Dor, Isaac Dor, Talwar, Sandeep, O'Neill, Padraig G, Koren, Michael J, Beinart, Sean C, Ambati, Srivani, Mazer, Sean P, Kinn, Robert M, Roy, Karine, Manshadi, Ramin, Kuk, Richard, Verma, Aditya, Phelan, Timothy, Stoian, Alexandru A, Ellenbogen, Kenneth, Jayachandran, J Vijay, Connelly, Terence P, Daccarett, Marcos, Gandhi, Gaurang, Mittal, Suneet, Abdel-Wahab, Amir, Augostini, Ralph, Ip, John H, Sorrentino, Denise, Roux, Jean-Francois, Brar, Ramandeep, Khoo, Clarence, Bennett, Matthew, Lo, Eric, Coutu, Benoit, Sterns, Laurence, Greer, Gerald S, Gujja, Pradeep, Gianfagna, Robert A, Swarup, Vijendra, Sogade, Felix, Wilton, Stephen, Ruisi, Christopher, Barbera, Saverio, Banchs, Javier E., Korley, Victoria, Schulze, Christopher, Damle, Roger, Healey, Jeffrey Sean, Pandey, A Shekhar, Anderson, Jeffrey L, Venkatachalam, K L, Noseworthy, Peter, Mondésert, Blandine, Verma, Atul, Friars, Douglas G, Kambur, Thomas R, Lockwood, Evan, Meininger, Glenn, Olsovsky, Greg, Jones Sr, Alonzo, Greer, Gerald, Mehta, Rohit, Akbar, Saleem, Salman, Malik, Rama, Bhola, Arora, Ramesh, Shah, Dhirenkumar, Shah, Rakesh, Cammarata, Michael, Owens, Andrew, Ludington, Katherine, Wharton, Marcus, Bagheri, Michael, Khan, Mohammed, Carr, Kenneth Warren, Siddique, Sultan, Parvathaneni, Sunthosh, Devabhaktuni, Subodh, Mouhaffel, Assad, Mark, George, Di Biase, Luigi, Rangappa, Sunil, Morton, Jared, Yarmohammadi, Hirad, Karim, Amin, Martinez Fleites, Aldo, Nero, Thomas, Shafiq, Qaiser, Pandey, Shekhar, Khaykin, Yaariv, Joza, Jacqueline, Gosselin, Gilbert, Skanes, Allen, Vyselaar, John, Savard, Daniel, Heidbuchel, Hein, Xhaet, Olivier, Catez, Emmanuel, Vijgen, Johan, Godart, Pascal, Casado, Ruben, Mairesse, Georges, Rossenbacker, Tom, Haemers, Peter, Hoffer, Etienne, Hausman, Pierre, Vertes, Andras, Duray, Gabor, Szolnoki, Erzsebet, Csanadi, Zoltan, Lakatos, Ferenc, Alings, Marco, Dorman, Reinhart, Tuininga, Y S, Jansen, W, Velthuis, Sebastiaan, van Bemmel, B, Bech, Gerhard Jan Willem, Pisters, Ron, Valk, Suzanne, Romer, Tjeerd, Luermans, Justin, Beelen, Driek, van Eck, Martijn, Houtgraaf, Jaco, Vet, Thijs, Shellings, Dirk, Oosterhof, T, Miekus, Pawel, Bebenek, Waldemar, Bielecka-Dabrowa, Agata, Gniot, Jacek, Zmuda, Witold, Kasprzak, Michal, Balak, Wojciech, Ptaszynski, Pawel, Nowak, Jacek, Prokopczuk, Janusz, Przybylski, Andrzej, Wozniak-Skowerska, Iwona, Derejko, Pawel, Czarnecka, Danuta, Janas, Adam, Merino Llorens, Jose Luis, Tercedor, Luis, Iniguez Romo, Andres, Ruiz Granell, Ricardo, Gonzalez Juanatey, Jose Ramon, Pascual-Figal, Domingo, Martinez-Selles, Manuel, Anguera Camos, Ignacio, Ibanez Criado, Alicia, Matrinez Basterra, Javier, Izquierdo, Alvaro, Rivas Gandara, Nuria, Alegret Colome, Josep M, Perez Diez, Diego, Martínez Hervás, Miguel Ángel, Medina, Maria, Segura Saint-Gerons, Jose María, Pedrote Leal, Alonso, Fernandez Lozano, Ignacio, Quesada, Aurelio, Guerra Ramos, Jose, Sarrias, Axel, Ramos Maqueda, Javier, Mansourati, Jacques, Defaye, Pascal, Guedon-Moreau, Laurence, Milhem, Antoine, De Guillebon, Maxime, Chevalier, Philippe, Badoz, Marc, Kriatselis, Charalampos, Simonis, Gregor, Lewalter, Thorsten, Zarse, Markus, Wilke, Andreas, Kraemer, Fabian, Al-Zoebi, Ayham, Camm, A John, Dorian, Paul, Kowey, Peter R, Merino, Jose L, Piccini, Jonathan P, Pokorney, Sean D, Sager, Philip T, Wharton, J Marcus, Bharucha, David B, Plat, Francis, Shardonofsky, Silvia, and Chen, Michael

Published
2023
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15. Cierre de orejuela izquierda frente a ACOD en pacientes mayores: análisis con emparejamiento por puntuación de propensión

Author

Berenice Caneiro-Queija, Rodrigo Estévez-Loureiro, Sergio Raposeiras-Roubín, Emad Abu-Assi, Rocío González-Ferreiro, Ignacio Cruz-González, Alejandro Diego-Nieto, Antonio A. de Miguel-Castro, Guillermo Bastos-Fernández, José Antonio Baz-Alonso, Guilles O'Hara, Josep Rodés-Cabau, and Andrés Íñiguez-Romo

Subjects
Fibrilación auricular, Cierre de orejuela izquierda, Anticoagulantes orales directos, Riesgo embólico, Riesgo hemorrágico, Internal medicine, RC31-1245
Abstract

RESUMEN Introducción y objetivos: Existe poca información comparativa entre el cierre de la orejuela izquierda (COI) y los anticoagulantes orales de acción directa (ACOD). Nuestro objetivo fue comparar los resultados clínicos entre el COI y los ACOD en una población de pacientes mayores de 80 años. Métodos: Se analizaron 1.144 pacientes octogenarios con fibrilación auricular provenientes de 3 hospitales terciarios. De ellos, 970 recibían ACOD y 174 fueron sometidos a COI. Ambos grupos presentaban similares factores de riesgo cardiovascular. El grupo de COI tenía mayor porcentaje de antecedentes de hemorragia, anemia y cáncer previo. Se llevó a cabo un análisis emparejado y se obtuvieron 2 grupos de 58 pacientes con similares factores de riesgo, comorbilidad y escalas de riesgo que fueron sometidos a COI o recibían tratamiento con ACOD. Los resultados de acuerdo con la estrategia terapéutica se obtuvieron mediante regresión de Cox. Resultados: Durante una mediana de seguimiento de 2 años [rango: 0,9-3,5] no hubo diferencias en cuanto al evento combinado primario de muerte, hemorragia mayor o ictus (HR = 1,05; IC95%, 0,15-7,51). Las hemorragias fueron similares en ambos grupos, sin diferencias estadísticamente significativas (HR = 1,79; IC95%, 0,73-4,41). La mortalidad fue mayor en los pacientes con ACOD (31,8%) frente a aquellos con COI (26,4%), sin diferencias significativas (HR = 0,70; IC95%, 0,33-1,47). Conclusiones: En comparación con los ACOD, el COI no ha mostrado diferencias en cuanto a eventos embólicos, hemorragias y mortalidad en una población de pacientes de edad avanzada. En nuestra cohorte, el COI es una alternativa que puede considerarse para los pacientes mayores de 80 años.

Published
2022
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16. Left atrial appendage closure versus DOAC in elderly patients: a propensity score matching study

Author

Berenice Caneiro-Queija, Rodrigo Estévez-Loureiro, Sergio Raposeiras-Roubín, Emad Abu-Assi, Rocío González-Ferreiro, Ignacio Cruz-González, Alejandro Diego-Nieto, Antonio A. de Miguel-Castro, Guillermo Bastos-Fernández, José Antonio Baz-Alonso, Guilles O'Hara, Josep Rodés-Cabau, and Andrés Íñiguez-Romo

Subjects
Atrial fibrillation, Left atrial appendage closure, Direct oral anticoagulants, Embolic risk, Bleeding risk, Medicine
Abstract

ABSTRACT Introduction and objectives: Information comparing left atrial appendage closure (LAAC) to direct oral anticoagulation (DOAC) therapy is scarce. Our aim is to compare the clinical outcomes between LAAC and DOACs on an elderly population (> 80 years of age). Methods: We retrospectively collected 1144 octogenarian patients with atrial fibrillation from 3 different tertiary hospitals. A total of 970 patients received DOACs and 174 patients were treated with LAAC. At baseline, both groups had similar cardiovascular risk factors. The LAAC group had more history of bleeding, anemia or previous cancer. We conducted a propensity score matching study and obtained 2 different paired groups of 58 patients with similar baseline risk factors, comorbidities, and risk scores who received DOACs or were treated with LAAC. The outcomes of the therapeutic strategy used (DOACs or LAAC) were assessed using the Cox regression analysis. Results: During a median follow-up of 2.0 years [range 0.9-3.5] no differences regarding the primary endpoint (a composite of death, major bleeding, and stroke) were found (HR, 1.05; 95%CI, 0.15-7.51). Bleeding events were similar in both groups with no statistically significant differences being reported (HR, 1.79; 95%CI, 0.73-4.41). Mortality rate was numerically higher in patients on DOACs (31.8%) vs LAAC (26.4%). However, this finding did not reach statistical significance (HR, 0.70; 95%CI, 0.33-1.47; P = .343). Conclusions: Compared to DOACs, LAAC has not shown any differences regarding embolic events, bleeding, and mortality in a population of elderly patients > 80 years of age. In our population, LAAC is a strategy as safe and effective as DOACs, and is an alternative to be taken into consideration in real-world patients > 80 years.

Published
2022
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17. Technological advances in the management of cardiovascular diseases: perspective of physicians and administrators

Author

Pablo Lázaro, Manel Sabaté, Juan Sanchis, Enrique Puras Mallagray, Andrés Íñiguez Romo, and Carlos Macaya Miguel

Subjects
Medicine
Abstract

To the Editor, New technologies have improved the effectiveness of treatments for cardiovascular diseases, yet these technologies pose poorly explored challenges. Therefore, a study was conducted in Spain to find out about the perspective of doctors and administrators on the implications of technology in the management of coronary artery disease and peripheral arterial disease. The insights and perspectives of doctors and administrators were obtained using the Delphi method following the RAND/UCLA Appropriateness Method (RUAM).1 A scientific committee including 6 cardiologists, 1 vascular surgeon, and 1 interventional radiologist selected the panel of doctors (16 cardiologists, 3 endocrinologists, 3 vascular surgeons, 1 internist, and 1 surgeon specialized in diabetic foot disease), and administrators (12 administrators from both the public and private sectors) (annex 1 of the supplementary data). The doctors’ questionnaire had 112 items and the administrators’ one 79 (74 items were common to both panels). The panellists scored the relevance of each item on a scale from 1 (irrelevant) to 9 (maximum relevance). «Agreement» was defined as less than a third of the panelists giving scores from 1 to 3 to a given item, and less than a third gave scores from 7 to 9. «Low relevance» items were those whose median scores...

Published
2022
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18. Avances tecnológicos en el tratamiento de las enfermedades cardiovasculares: perspectiva de médicos y administradores

Author

Pablo Lázaro, Manel Sabaté, Juan Sanchis, Enrique Puras Mallagray, Andrés Íñiguez Romo, and Carlos Macaya Miguel

Subjects
Internal medicine, RC31-1245
Abstract

Sr. Editor: Las nuevas tecnologías han mejorado la efectividad de los tratamientos de las enfermedades cardiovasculares, pero plantean retos insuficientemente explorados. Por esta razón, se llevó a cabo un estudio para conocer las percepciones de médicos y administradores sobre las implicaciones de la tecnología en la atención de la arteriopatía coronaria y periférica en España. Se obtuvieron las percepciones de médicos y administradores utilizando el método Delphi según el RAND/UCLA Appropriateness Method (RUAM)1. Un comité científico, compuesto por 6 cardiólogos, 1 cirujano vascular y 1 radiólogo intervencionista, seleccionó el panel de médicos (16 cardiólogos, 3 endocrinólogos, 3 cirujanos vasculares, 1 internista y 1 cirujano especializado en pie diabético) y de administradores (12 administradores de los sectores público y privado) (anexo 1 del material adicional). El cuestionario de médicos tenía 112 ítems y el de administradores tenía 79 ítems (74 eran comunes para ambos paneles). Los panelistas puntuaron la relevancia de cada ítem en una escala de 1 (irrelevante) a 9 (máxima relevancia). Se definió «acuerdo» cuando menos de un tercio de los panelistas puntuó el ítem en el rango 1-3 y menos de un tercio lo puntuó en el rango 7-9. Se clasificaron como de «relevancia baja» aquellos ítems cuya mediana de...

Published
2022
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20. Transcatheter Tricuspid Valve Replacement With a Dedicated Device in a Patient With 2 Endocardial Leads

Author

Rodrigo Estevez-Loureiro, MD, PhD, Manuel Barreiro-Pérez, MD, PhD, Miguel Piñon, MD, PhD, Rocío González, MD, PhD, David Dobarro, MD, PhD, Thomas Modine, MD, PhD, Anson Cheung, MD, PhD, Jose A. Baz-Alonso, MD, Berenice Caneiro-Queija, MD, and Andrés Íñiguez-Romo, MD, PhD

Subjects
endocardial leads, transcatheter tricuspid valve replacement, tricuspid regurgitation, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

A 79-year-old woman with a history of dilated cardiomyopathy who required a permanent peacemaker, recently upgraded to implantable cardioverter-defibrillator cardiac resynchronization therapy, was admitted for right heart failure. On echocardiography, torrential tricuspid regurgitation was noted, with 2 leads across the valve. After multidisciplinary evaluation, a dedicated transcatheter valve replacement was successfully implanted. (Level of Difficulty: Intermediate.)

Published
2023
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25. Outcomes of transcatheter aortic valve implantation in Spain through the Activity Registry of Specialized Health Care

Author

Andrés Íñiguez-Romo, José Javier Zueco-Gil, Mercedes Álvarez-Bartolomé, José Antonio Baz Alonso, Víctor Alfonso Jiménez Díaz, Rodrigo Estévez Loureiro, Gabriela Veiga Fernández, Dae-Hyun Lee Hwang, Belén Martí-Sánchez, and Jesús Cuervo

Subjects
Aortic Stenosis, surgical aortic valve replacement, valvular heart disease, Activity Registry of Specialized Health Care, transcatheter aortic valve implantation, TAVI, Medicine
Abstract

ABSTRACT Introduction and objectives: Transcatheter aortic valve implantation (TAVI) has become the treatment of choice for the management of symptomatic severe aortic stenosis. As it happens with all procedures, the safety and effectiveness of TAVI must be monitored. To this end, we assessed the data available from the Spanish National Health Service from 2014 through 2017. Methods: The study included patients aged > 50 years treated with TAVI and registered in the Activity Registry of Specialized Health Care from 2014 through 2017 from public and private hospitals in compliance with the National Health System. Multivariate logistic regression analyses were performed to identify factors associated with mortality and complications, and negative binomial models for the mean hospital length of stay (LoS). Standardized rates were used to discriminate both the effectiveness and safety among regions with higher and lower levels of implementation of the technique using the national median as the threshold, (37 implants x 105 habitants) in the 4-year period. Results: A total of 5454 TAVIs were analyzed. The in-hospital mortality rate dropped from 4.89% in 2014 to 2.7% in 2017. The LoS decreased from 13.1 days in 2014 to 11.3 days in 2017. No differences in mortality were observed among the regions. However, the LoS of regions with a high volume of implants was significantly lower (OR, 0.88; 95%CI, 0.86-0.91; P < .01), as well as the risk of infections (OR, 0.54; 95%CI, 0.32-0.9; P = .02), and pacemaker implantation (OR, 0.77; 95%CI, 0.65-0.91; P < .01). Conclusions: The use of TAVI in Spain is safe and has grown progressively with improved outcomes regarding morbidity and mortality. Differences among regions have been highlighted regarding patient access to TAVI. This heterogeneity was not associated with mortality but with differences in the morbidity rates.

Published
2022
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26. Resultados del implante percutáneo de válvula aórtica en España mediante el Registro de Actividad de Atención Especializada

Author

Andrés Íñiguez-Romo, José Javier Zueco-Gil, Mercedes Álvarez-Bartolomé, José Antonio Baz Alonso, Víctor Alfonso Jiménez Díaz, Rodrigo Estévez Loureiro, Gabriela Veiga Fernández, Dae-Hyun Lee Hwang, Belén Martí-Sánchez, and Jesús Cuervo

Subjects
Estenosis aórtica, Reemplazo de la válvula aórtica, Registro de Actividad de Atención Especializada, Enfermedad de las válvulas cardiacas, Implante percutáneo de válvula aórtica, TAVI, Internal medicine, RC31-1245
Abstract

RESUMEN Introducción y objetivos: El implante percutáneo de válvula aórtica (TAVI) se ha consolidado como tratamiento de la estenosis aórtica grave. Como toda intervención, su seguridad y su efectividad deben monitorizarse en condiciones de práctica real. Para ello, se han analizado los datos del Sistema Nacional de Salud disponibles entre los años 2014 y 2017. Métodos: Se evaluaron todos los pacientes mayores de 50 años con TAVI por vía transfemoral incluidos en el Registro de Actividad de Atención Especializada entre 2014 y 2017 procedentes de centros públicos o concertados. Se hicieron análisis de regresión logísticos para evaluar los factores asociados con la mortalidad y las complicaciones, y modelos binomiales negativos para la estancia media hospitalaria. Se usaron tasas estandarizadas para ajustar diferencias en las variables de efectividad y seguridad entre las diferentes comunidades autónomas, de acuerdo con el alto y bajo volumen de implantación de la técnica, considerando como referencia la mediana nacional (37 implantes por 105 habitantes) durante el periodo de tiempo analizado. Resultados: En total se analizaron 5.454 casos de TAVI. La mortalidad intrahospitalaria pasó del 4,89% en 2014 al 2,7% en 2017. La estancia media hospitalaria descendió de 13,1 días en 2014 a 11,3 en 2017. A pesar de no observar diferencias en la mortalidad entre comunidades autónomas, aquellas con mayor volumen de implantes tuvieron una menor estancia media hospitalaria (OR = 0,88; IC95%, 0,86-0,91; p < 0,01), menor riesgo de infecciones (OR = 0,54; IC95%, 0,32-0,9; p = 0,02) y menor necesidad de marcapasos permanente (OR = 0,77; IC95%, 0,65-0,91; p < 0,01). Conclusiones: El uso de TAVI crece progresivamente en España con resultados cada vez mejores respecto al éxito del implante y la morbimortalidad perioperatoria. La variabilidad interregional en las tasas de implante no se relaciona con la mortalidad observada, pero sí con la morbilidad y la estancia hospitalaria.

Published
2022
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27. Ischemic-hemorrhagic balance in diabetic and non-diabetic patients after acute coronary syndrome

Author

Domínguez-Rodríguez, Luis Manuel, Raposeiras-Roubín, Sergio, Abu-Assi, Emad, Cespón-Fernández, María, Melendo-Viu, María, D’Ascenzo, Fabrizio, Kinnaird, Tim, Ariza-Solé, Albert, Manzano-Fernández, Sergio, Templin, Christian, Velicki, Lazar, Xanthopoulou, Ioanna, Cerrato, Enrico, Quadri, Giorgio, Rognoni, Andrea, Boccuzzi, Giacome, Montabone, Andrea, Taha, Salma, Durante, Alessandro, Gili, Sebastiano, Magnani, Giulia, Autelli, Michele, Grosso, Alberto, Flores-Blanco, Pedro, Garay, Alberto, Varbella, Ferdinando, Tommassini, Francesco, Gallo, Diego, Morbiducci, Umberto, Domínguez-Rodríguez, Alberto, Valdés, Mariano, Cequier, Ángel, Gaita, Fiorenzo, Alexopoulos, Dimitrios, and Íñiguez-Romo, Andrés

Published
2022
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34. Diagnostic Challenges in Aortic Stenosis

Author

González-García, André, primary, Pazos-López, Pablo, additional, Calvo-Iglesias, Francisco Eugenio, additional, Matajira-Chía, Tatiana Mallely, additional, Bilbao-Quesada, Raquel, additional, Blanco-González, Elisa, additional, González-Ríos, Carina, additional, Castiñeira-Busto, María, additional, Barreiro-Pérez, Manuel, additional, and Íñiguez-Romo, Andrés, additional

Published
2024
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38. Prognostic Impact of Nutritional Status After Transcatheter Edge‐to‐Edge Mitral Valve Repair: The MIVNUT Registry

Author

Berenice Caneiro‐Queija, Sergio Raposeiras‐Roubin, Marianna Adamo, Xavier Freixa, Dabit Arzamendi, Tomas Benito‐González, Antonio Montefusco, Isaac Pascual, Luis Nombela‐Franco, Josep Rodes‐Cabau, Mony Shuvy, Antonio Portolés‐Hernández, Cosmo Godino, Dan Haberman, Laura Lupi, Ander Regueiro, Chin Hion Li, Felipe Fernández‐Vázquez, Simone Frea, Pablo Avanzas, Gabriela Tirado‐Conte, Jean‐Michel Paradis, Alona Peretz, Vanessa Moñivas, Jose A. Baz, Michele Galasso, Luca Branca, Laura Sanchís, Lluís Asmarats, Carmen Garrote‐Coloma, Filippo Angelini, Victor León, José A. de Agustín, Alberto Alperi, Ronen Beeri, Gloria Maccagni, Manel Sabaté, Estefanía Fernández‐Peregrina, Javier Gualis, Pier Paolo Bocchino, Salvatore Curello, Andrés Íñiguez‐Romo, and Rodrigo Estévez‐Loureiro

Subjects
CONUT, heart failure, malnutrition, mortality, transcatheter edge‐to‐edge repair, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Background Malnutrition is associated with poor prognosis in several cardiovascular diseases. However, its prognostic impact in patients undergoing transcatheter edge‐to‐edge mitral valve repair (TEER) is not well known. This study sought to assess the prevalence, clinical associations, and prognostic consequences of malnutrition in patients undergoing TEER. Methods and Results A total of 892 patients undergoing TEER from the international MIVNUT (Mitral Valve Repair and Nutritional Status) registry were studied. Malnutrition status was assessed with the Controlling Nutritional Status score. The association of nutritional status with mortality was analyzed with multivariable Cox regression models, whereas the association with heart failure admission was assessed by Fine‐Gray models, with death as a competing risk. According to the Controlling Nutritional Status score, 74.4% of patients with TEER had any degree of malnutrition at the time of TEER (75.1% in patients with body mass index

Published
2022
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39. Percutaneous mitral valve repair in patients developing severe mitral regurgitation early after an acute myocardial infarction: A review

Author

Rodrigo Estévez-Loureiro, Marta Tavares Da Silva, José Antonio Baz-Alonso, Berenice Caneiro-Queija, Manuel Barreiro-Pérez, Francisco Calvo-Iglesias, Rocio González-Ferreiro, Luis Puga, Miguel Piñón, and Andrés Íñiguez-Romo

Subjects
mitral regurgitation, myocardial infarction, transcatheter mitral valve (MV) repair, cardiogenic shock (CS), MitraClip®, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Acute mitral regurgitation (MR) may develop in the setting of an acute myocardial infarction (AMI) because of papillary muscle dysfunction or rupture. Severe acute MR in this scenario is a life-threatening complication associated with hemodynamic instability and pulmonary edema, and has been linked to a worse prognosis even after reperfusion. Patients treated solely with medical therapy have the highest mortality rates. Surgery has been the only treatment strategy until recently, but the results of the technique are hindered by high rates of morbidity and mortality. Therefore, the development of less invasive interventions for correcting MR would be ideal. We aimed to review the current role of transcatheter interventions in this clinical setting.

Published
2022
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40. Machine learning-based prediction of adverse events following an acute coronary syndrome (PRAISE): a modelling study of pooled datasets

Author

Piroli, Francesco, Saglietto, Andrea, Conrotto, Federico, Omedé, Pierluigi, Montefusco, Antonio, Pennone, Mauro, Bruno, Francesco, Bocchino, Pier Paolo, Boccuzzi, Giacomo, Cerrato, Enrico, Varbella, Ferdinando, Sperti, Michela, Wilton, Stephen B., Velicki, Lazar, Xanthopoulou, Ioanna, Cequier, Angel, Iniguez-Romo, Andres, Munoz Pousa, Isabel, Cespon Fernandez, Maria, Caneiro Queija, Berenice, Cobas-Paz, Rafael, Lopez-Cuenca, Angel, Garay, Alberto, Blanco, Pedro Flores, Rognoni, Andrea, Biondi Zoccai, Giuseppe, Biscaglia, Simone, Nunez-Gil, Ivan, Fujii, Toshiharu, Durante, Alessandro, Song, Xiantao, Kawaji, Tetsuma, Alexopoulos, Dimitrios, Huczek, Zenon, Gonzalez Juanatey, Jose Ramon, Nie, Shao-Ping, Kawashiri, Masa-aki, Colonnelli, Iacopo, Cantalupo, Barbara, Esposito, Roberto, Leonardi, Sergio, Grosso Marra, Walter, Chieffo, Alaide, Michelucci, Umberto, Piga, Dario, Malavolta, Marta, Gili, Sebastiano, Mennuni, Marco, Montalto, Claudio, Oltrona Visconti, Luigi, Arfat, Yasir, D'Ascenzo, Fabrizio, De Filippo, Ovidio, Gallone, Guglielmo, Mittone, Gianluca, Deriu, Marco Agostino, Iannaccone, Mario, Ariza-Solé, Albert, Liebetrau, Christoph, Manzano-Fernández, Sergio, Quadri, Giorgio, Kinnaird, Tim, Campo, Gianluca, Simao Henriques, Jose Paulo, Hughes, James M, Dominguez-Rodriguez, Alberto, Aldinucci, Marco, Morbiducci, Umberto, Patti, Giuseppe, Raposeiras-Roubin, Sergio, Abu-Assi, Emad, and De Ferrari, Gaetano Maria

Published
2021
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42. Impact of anticoagulation in patients with dementia and atrial fibrillation. Results of the CardioCHUVI-FA registry

Author

Cobas Paz, Rafael, Raposeiras Roubín, Sergio, Abu Assi, Emad, Barreiro Pardal, Cristina, García Comesaña, Julio, González-Carrero López, Alberto, Caneiro Queija, Berenice, Cespón Fernández, María, Muñoz Pousa, Isabel, Domínguez Erquicia, Pablo, Domínguez Rodríguez, Luis Manuel, Carpintero Vara, Alberto, García Campo, Enrique, Rodríguez Pascual, Carlos, and Íñiguez Romo, Andrés

Published
2020
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43. Impacto de la anticoagulación en los pacientes con demencia y fibrilación auricular. Resultados del registro CardioCHUVI-FA

Author

Cobas Paz, Rafael, Raposeiras Roubín, Sergio, Abu Assi, Emad, Barreiro Pardal, Cristina, García Comesaña, Julio, González-Carrero López, Alberto, Caneiro Queija, Berenice, Cespón Fernández, María, Muñoz Pousa, Isabel, Domínguez Erquicia, Pablo, Domínguez Rodríguez, Luis Manuel, Carpintero Vara, Alberto, García Campo, Enrique, Rodríguez Pascual, Carlos, and Íñiguez Romo, Andrés

Published
2020
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47. Vitamin K Antagonists and Direct Oral Anticoagulants in Nonagenarian Patients With Atrial Fibrillation

Author

Raposeiras-Roubín, Sergio, Alonso Rodríguez, David, Camacho Freire, Santiago Jesús, Abu-Assi, Emad, Cobas-Paz, Rafael, Rodríguez Pascual, Carlos, García Comesaña, Julio, González-Carrero López, Alberto, Cubelos Fernández, Naiara, López-Masjuán Ríos, Álvaro, Cespón-Fernández, María, Muñoz-Pousa, Isabel, Caneiro-Queija, Berenice, Rodríguez Albarrán, Adrián, Castañera, Sara Álvarez, Guillén, Julia Verísimo, Carpintero Vara, Alberto, Barreiro Pardal, Cristina, Domínguez-Erquicia, Pablo, Domínguez-Rodríguez, Luis Manuel, Díaz Fernández, José Francisco, Fernández Vázquez, Felipe, and Iñíguez-Romo, Andrés

Published
2020
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48. Comparative external validation of the PRECISE-DAPT and PARIS risk scores in 4424 acute coronary syndrome patients treated with prasugrel or ticagrelor

Author

Bianco, Matteo, D'ascenzo, Fabrizio, Raposeiras Roubin, Sergio, Kinnaird, Tim, Peyracchia, Mattia, Ariza-Solé, Albert, Cerrato, Enrico, Manzano-Fernández, Sergio, Gravinese, Carol, Templin, Christian, Destefanis, Paola, Velicki, Lazar, Luciano, Alessia, Xanthopoulou, Ioanna, Rinaldi, Mauro, Rognoni, Andrea, Varbella, Ferdinando, Boccuzzi, Giacomo, Omedè, Pierluigi, Montabone, Andrea, Bernardi, Alessandro, Taha, Salma, Rossini, Roberta, Durante, Alessandro, Gili, Sebastiano, Magnani, Giulia, Autelli, Michele, Grosso, Alberto, Blanco, Pedro Flores, Giustetto, Carla, Garay, Alberto, Quadri, Giorgio, Queija, Berenice Caneiro, Srdanovic, Ilija, Paz, Rafael Cobas, Fernández, María Cespón, Pousa, Isabel Muñoz, Gallo, Diego, Morbiducci, Umberto, Dominguez-Rodriguez, Alberto, Lopez-Cuenca, Ángel, Cequier, Angel, Alexopoulos, Dimitrios, Iñiguez-Romo, Andres, Pozzi, Roberto, Assi, Emad Abu, and Valgimigli, Marco

Published
2020
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49. Impact of renin-angiotensin system blockade on the prognosis of acute coronary syndrome based on left ventricular ejection fraction

Author

Raposeiras-Roubín, Sergio, Abu-Assi, Emad, Cespón-Fernández, María, Ibáñez, Borja, García-Ruiz, José Manuel, D’Ascenzo, Fabrizio, Simao Henriques, Jose Paulo, Saucedo, Jorge, Caneiro-Queija, Berenice, Cobas-Paz, Rafael, Muñoz-Pousa, Isabel, Wilton, Stephen B., González Juanatey, José Ramón, Kikkert, Wouter J., Núñez-Gil, Iván, Ariza-Solé, Albert, Song, Xiantao, Alexopoulos, Dimitrios, Liebetrau, Christoph, Kawaji, Tetsuma, Gaita, Fiorenzo, Huczek, Zenon, Nie, Shao-Ping, Yan, Yan, Fujii, Toshiharu, Correia, Luis, Kawashiri, Masa-aki, Kedev, Sasko, Southern, Danielle, Alfonso, Emilio, Terol, Belén, Garay, Alberto, Zhang, Dongfeng, Chen, Yalei, Xanthopoulou, Ioanna, Osman, Neriman, Möllmann, Helge, Shiomi, Hiroki, Giordana, Francesca, Kowara, Michal, Filipiak, Krzysztof, Wang, Xiao, Fan, Jing-Yao, Ikari, Yuji, Nakahayshi, Takuya, Sakata, Kenji, Yamagishi, Masakazu, Kalpak, Oliver, and Íñiguez-Romo, Andrés

Published
2020
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50. Impacto del bloqueo del sistema renina-angiotensina en el pronóstico del síndrome coronario agudo en función de la fracción de eyección

Author

Raposeiras-Roubín, Sergio, Abu-Assi, Emad, Cespón-Fernández, María, Ibáñez, Borja, García-Ruiz, José Manuel, D’Ascenzo, Fabrizio, Simao Henriques, Jose Paulo, Saucedo, Jorge, Caneiro-Queija, Berenice, Cobas-Paz, Rafael, Muñoz-Pousa, Isabel, Wilton, Stephen B., González Juanatey, José Ramón, Kikkert, Wouter J., Núñez-Gil, Iván, Ariza-Solé, Albert, Song, Xiantao, Alexopoulos, Dimitrios, Liebetrau, Christoph, Kawaji, Tetsuma, Gaita, Fiorenzo, Huczek, Zenon, Nie, Shao-Ping, Yan, Yan, Fujii, Toshiharu, Correia, Luis, Kawashiri, Masa-aki, Kedev, Sasko, Southern, Danielle, Alfonso, Emilio, Terol, Belén, Garay, Alberto, Zhang, Dongfeng, Chen, Yalei, Xanthopoulou, Ioanna, Osman, Neriman, Möllmann, Helge, Shiomi, Hiroki, Giordana, Francesca, Kowara, Michal, Filipiak, Krzysztof, Wang, Xiao, Fan, Jing-Yao, Ikari, Yuji, Nakahayshi, Takuya, Sakata, Kenji, Yamagishi, Masakazu, Kalpak, Oliver, and Íñiguez-Romo, Andrés

Published
2020
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