Search

Background and aim: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for the current pandemic, can have multi-organ impact. Recent studies show that liver injury could be a manifestation of the disease, and that liver disease could also be related to a worse prognosis. Our aim was to compare the characteristics of patients with severe coronavirus disease 2019 (COVID-19) due to SARS-CoV-2 who required intubation versus stable hospitalized patients to identify the early biochemical predictive factors of a severe course of COVID-19 and subsequent requirement for intubation, specifically in Mexican. Methods: This was an observational case-control study nested in a cohort study. Complete medical records of patients admitted for confirmed COVID-19 at a tertiary level center in Mexico City were reviewed. Clinical and biochemical data were collected, and the characteristics of patients who required invasive mechanical ventilation (IMV) (cases) were compared with stable hospitalized patients without ventilation (controls). Results: We evaluated 166 patients with COVID-19 due to SARS-CoV-2 infection; 114 (68.7%) were men, the mean age was 50.6 ± 13.3 years, and 27 (16.3%) required IMV. The comparative analysis between cases and controls showed (respectively) significantly lower blood oxygen saturation (SpO2) (73.5 ± 12.0% vs. 83.0 ± 6.8%, P

Backgrounds/aims The bile duct injuries are the most severe complications that occur after the surgical manipulation of the bile duct. The hepaticojejunostomy remained as the best treatment. Several factors identified that affect the result. This study aimed to analyze and identify risk factors that affected the evolution of these patients. Methods A retrospective, observational study was conducted from February 1998 to June 2017. We included all patients with bile duct injuries who required surgical treatment. Results We found 79 patients. The majority had a Bismuth type III in 35.4% (n=28). The morbidity of the Hepaticojejunostomy was 19% (n=15). In short-term follow-up, the main complications were cholangitis 11.4% (n=9) and bile leak 10% (n=8). In the long-term follow-up, in 2.5% (n=2) stricture was presented. On the comparison between postoperative and preoperative parameters, biliary peritonitis after a cholecystectomy (p=0.02) was an independent predictor of postoperative morbidity (p Conclusions In the treatment of bile duct injuries, different factors affect their outcomes. Our results show that infectious complications continue to affect the results of the treatment of bile duct lesions.

Introduction: Some patients with SARSCov-2 infection develop severe disease (SARS); however, the factors associated with severity are not yet fully understood. Some reports indicate that liver injury may be a poor prognostic factor. Aim: To identify the biochemical factors related to the development of SARS with mechanical ventilation (MV) requirement in patients with SARSCov-2 and COVID-19. Methods Type of study: Observational. Cohort study. Procedure: Data from COVID-19 patients were collected at admission time to a tertiary care center. Differential factors were identified between seriously ill SARS+MV patients versus stable patients without MV. Transformation to the natural logarithm of significant variables was performed and multiple linear regression was applied, then a predictive model of severity called AAD (Age-AST-D dimer) was constructed. Results: 166 patients were included, 114(68.7%) men, mean age 50.6±13.3 years-old, 27(16.3%) developed SARS+MV. In the comparative analysis between those with SARS+MV versus stable patients without MV we found significant raises of ALT (225.4±341.2 vs. 41.3±41.1; P=0.003), AST 325.3±382.4 vs. 52.8±47.1; P=0.001), LDH (764.6±401.9 vs. 461.0±185.6; P=0.001), D dimer (7765±9109 vs. 1871±4146; P=0.003), age (58.6±12.7 vs. 49.1±12.8; P=0-001). The results of the regression are shown in the Table, where model 3 was the one that best explained the development of SARS+MV; with these variables was constructed the model called AAD, where: [AAD= 3.896 + ln(age)x-0.218 + ln(AST)x-0.185 + ln(DD)x0.070], where a value ≤ 2.75 had sensitivity=0.797 and 1-specificity= 0.391, AUROC=0.74 (95%CI: 0.62-0.86; P

Aim. Coronavirus disease (COVID-19) ranges from mild clinical phenotypes to life-threatening conditions like severe acute respiratory syndrome (SARS). It has been suggested that early liver injury in these patients could be a risk factor for poor outcome. We aimed to identify early biochemical predictive factors related to severe disease development with intensive care requirements in patients with COVID-19. Methods. Data from COVID-19 patients were collected at admission time to our hospital. Differential biochemical factors were identified between seriously ill patients requiring intensive care unit (ICU) admission (ICU patients) versus stable patients without the need for ICU admission (non-ICU patients). Multiple linear regression was applied, then a predictive model of severity called Age-AST-D dimer (AAD) was constructed ( n = 166 ) and validated ( n = 170 ). Results. Derivation cohort: from 166 patients included, there were 27 (16.3%) ICU patients that showed higher levels of liver injury markers ( P < 0.01 ) compared with non-ICU patients: alanine aminotrasnferase (ALT) 225.4 ± 341.2 vs. 41.3 ± 41.1 , aspartate aminotransferase (AST) 325.3 ± 382.4 vs. 52.8 ± 47.1 , lactic dehydrogenase (LDH) 764.6 ± 401.9 vs. 461.0 ± 185.6 , D-dimer (DD) 7765 ± 9109 vs. 1871 ± 4146 , and age 58.6 ± 12.7 vs. 49.1 ± 12.8 . With these finding, a model called Age-AST-DD (AAD), with a cut-point of sensitivity = 0.797 and specificity = 0.391 , c − statistic = 0.74 ; 95%IC: 0.62-0.86, P < 0.001 ), to predict the risk of need admission to ICU ( OR = 5.8 ; 95% CI: 2.2-15.4, P = 0.001 ), was constructed. Validation cohort: in 170 different patients, the AAD model < 2.75 ( c − statistic = 0.80 (95% CI: 0.70-0.91, P < 0.001 ) adequately predicted the risk ( OR = 8.8 , 95% CI: 3.4-22.6, P < 0.001 ) to be admitted in the ICU (27 patients, 15.95%). Conclusions. The elevation of AST (a possible marker of early liver injury) along with DD and age efficiently predict early (at admission time) probability of ICU admission during the clinical course of COVID-19. The AAD model can improve the comprehensive management of COVID-19 patients, and it could be useful as a triage tool to early classify patients with a high risk of developing a severe clinical course of the disease.

Introduction Solid pseudopapillary neoplasm of the pancreas is a rare form of cancer with low malignant potential, accounting for 0.17–2.7% of all pancreatic tumours. Case report 1 A 17-year-old female patient who presented with symptoms six months after a Caesarean section. She was referred to our institution for a 10 cm × 10 cm tumour in the upper right quadrant. Abdominal computed tomography showed a mixed mass at the head of the pancreas compatible with Frantz's tumour. Underwent surgery, in which the classic Whipple procedure was performed. Case report 2 A 17-year-old female patient with a history of blunt abdominal trauma days before admission. Abdominal computed tomography showed a 10.6 cm × 10 cm heterogeneous and septate tumour at the head of the pancreas; preoperative diagnosis of solid pseudopapillary neoplasm. Underwent surgery, in which the pylorus-preserving Whipple procedure was performed. Conclusion Solid pseudopapillary neoplasm of the pancreas is a rare tumour of unknown origin and with good prognosis after surgical resection.

Introduction and aims: At the Upper Gastrointestinal Tract Clinic of the Hospital General de Mexico, achalasia treatment has been standarized through strictly graduated cardiomyotomy. This procedure guarantees a complete myotomy for the satisfactory resolution of dysphagia, a characteristic symptom of achalasia. To ensure the inclusion of the entire lower esophageal sphincter, an 8 cm Penrose drain is placed at the surgical site 6 cm above the gastroesophageal junction and 2 cm in a caudal direction, for accurate laparoscopic measuring. The aim of our study was to evaluate the results of this technique. Materials and methods: A descriptive, retrospective, longitudinal, and observational study was conducted on a cohort of patients diagnosed with achalasia at the Upper Gastrointestinal Tract Clinic of the Hospital General de México “Dr. Eduardo Liceaga”. Results: The study included 48 patients, 40 of whom had no prior surgical treatment and 8 that presented with recurrence. Forty-seven patients (97.9%) underwent a laparoscopic procedure and conversion to open surgery was required in 2 of them (4.25% conversion rate). Postoperative progression was satisfactory in all cases, with mean oral diet commencement at 52 h and mean hospital stay of 5.7 days. No recurrence was registered during the mean follow-up period of 35.75 months and there were no deaths. Conclusions: Laparoscopic graduated (strictly measured) cardiomyotomy with anterior fundoplication is a reproducible, efficacious, and safe option for the surgical treatment of achalasia. Resumen: Introducción y objetivos: En la Clínica de Tracto Digestivo Superior del Hospital General de México, el tratamiento de la acalasia se ha estandarizado mediante la realización de una cardiomiotomía estrictamente graduada que permite garantizar una miotomía completa para resolver de forma satisfactoria la disfagia característica de esta enfermedad. Un penrose de 8 cm, se coloca sobre el lecho quirúrgico, para garantizar la inclusión de todo el EEI, 6 cm por arriba de la UGE y 2 cm en sentido caudal, para asegurar la medición laparoscópica. El objetivo del estudio fue evaluar los resultados obtenidos con esta técnica. Material y métodos: Estudio descriptivo, retrospectivo, longitudinal, observacional, en una cohorte de pacientes con diagnóstico de acalasia, en la Clínica de Tracto Digestivo Superior, del Hospital General de México «Dr. Eduardo Liceaga». Resultados: Se incluyeron 48 pacientes; 40 sin tratamiento quirúrgico previo y 8 con recurrencia. En 47 casos el abordaje fue laparoscópico (97.9%); se requirió conversión a procedimiento abierto en 2 casos (tasa conversión 4.25%). La evolución postoperatoria fue satisfactoria en todos los casos, con inicio de la vía oral a las 52 h en promedio y una estancia intrahospitalaria promedio de 5.7 días. Durante el seguimiento de 35.75 meses en promedio no se han registrado recurrencias. No se presentó mortalidad. Conclusiones: La cardiomiotomía graduada (estrictamente medida) con funduplicatura anterior mediante abordaje laparoscópico es una opción reproducible, eficaz y segura para el tratamiento quirúrgico de la acalasia. Keywords: Achalasia, Cardiomyotomy, Laparoscopy, Anterior fundoplication, Palabras clave: Acalasia, Cardiomiotomía, Laparoscopía, Funduplicatura anterior

Resumen: Introducción y objetivos: En la Clínica de Tracto Digestivo Superior del Hospital General de México, el tratamiento de la acalasia se ha estandarizado mediante la realización de una cardiomiotomía estrictamente graduada que permite garantizar una miotomía completa para resolver de forma satisfactoria la disfagia característica de esta enfermedad. Un penrose de 8 cm, se coloca sobre el lecho quirúrgico, para garantizar la inclusión de todo el EEI, 6 cm por arriba de la UGE y 2 cm en sentido caudal, para asegurar la medición laparoscópica. El objetivo del estudio fue evaluar los resultados obtenidos con esta técnica. Material y métodos: Estudio descriptivo, retrospectivo, longitudinal, observacional, en una cohorte de pacientes con diagnóstico de acalasia, en la Clínica de Tracto Digestivo Superior, del Hospital General de México «Dr. Eduardo Liceaga». Resultados: Se incluyeron 48 pacientes; 40 sin tratamiento quirúrgico previo y 8 con recurrencia. En 47 casos el abordaje fue laparoscópico (97.9%); se requirió conversión a procedimiento abierto en 2 casos (tasa conversión 4.25%). La evolución postoperatoria fue satisfactoria en todos los casos, con inicio de la vía oral a las 52 h en promedio y una estancia intrahospitalaria promedio de 5.7 días. Durante el seguimiento de 35.75 meses en promedio no se han registrado recurrencias. No se presentó mortalidad. Conclusiones: La cardiomiotomía graduada (estrictamente medida) con funduplicatura anterior mediante abordaje laparoscópico es una opción reproducible, eficaz y segura para el tratamiento quirúrgico de la acalasia. Abstract: Introduction and aims: At the Upper Gastrointestinal Tract Clinic of the Hospital General de Mexico, achalasia treatment has been standarized through strictly graduated cardiomyotomy. This procedure guarantees a complete myotomy for the satisfactory resolution of dysphagia, a characteristic symptom of achalasia. To ensure the inclusion of the entire lower esophageal sphincter, an 8 cm Penrose drain is placed at the surgical site 6 cm above the gastroesophageal junction and 2 cm in a caudal direction, for accurate laparoscopic measuring. The aim of our study was to evaluate the results of this technique. Materials and methods: A descriptive, retrospective, longitudinal, and observational study was conducted on a cohort of patients diagnosed with achalasia at the Upper Gastrointestinal Tract Clinic of the Hospital General de México “Dr. Eduardo Liceaga”. Results: The study included 48 patients, 40 of whom had no prior surgical treatment and 8 that presented with recurrence. Forty-seven patients (97.9%) underwent a laparoscopic procedure and conversion to open surgery was required in 2 of them (4.25% conversion rate). Postoperative progression was satisfactory in all cases, with mean oral diet commencement at 52 h and mean hospital stay of 5.7 days. No recurrence was registered during the mean follow-up period of 35.75 months and there were no deaths. Conclusions: Laparoscopic graduated (strictly measured) cardiomyotomy with anterior fundoplication is a reproducible, efficacious, and safe option for the surgical treatment of achalasia. Palabras clave: Acalasia, Cardiomiotomía, Laparoscopía, Funduplicatura anterior, Keywords: Achalasia, Cardiomyotomy, Laparoscopy, Anterior fundoplication

There are only a few reports regarding the quality of life of patients who underwent a complicated cholecystectomy with an iatrogenic bile duct injury (IBDI); the results have been heterogeneous and realized with unspecific measures. The objective was to determine whether the quality of life of the subjects with a history of IBDI repaired with bilioenteric derivation is modified in the long term with respect to a control group, for which a group of patients with a history of IBDI (group A) was compared with a group of patients with a history of uncomplicated cholecystectomy (group B). Two different measures were used: on the one hand, the SF-12 questionnaire and on the other hand, a questionnaire was implemented where the patient could determine by himself which variables define his quality of life. A total of 46 patients were included in group A and 51 in group B. The analysis of the SF-12 questionnaire showed a statistical significant reduction in 4 of 8 of the evaluated parameters (general health, physical functioning, physical role and social functioning) in group A in comparison with group B. If a more specific questionnaire is used, the results are similar, with a statistically significant reduction in the quality of life within the group A (0.03). We conclude that the quality of life of patients with a history of bilioenteric derivation due to an IBDI decreases significantly compared to patients with uncomplicated cholecystectomy.

Resumen Paciente de 55 anos de edad con cuadro de dolor en flanco izquierdo irradiado a region lumbar de 4 meses de evolucion, con tomografia axial computarizada que reporta tumoracion quistica en region retroperitoneal que comprime ureter y sistema pielocaliceal izquierdo en contacto con cuerpo y cola de pancreas. Es intervenida quirurgicamente y se encuentra en reporte patologico definitivo fibrosis retroperitoneal nodular asociada a IgG4; con Ki67 positivo en centros germinales (5%) e IgG4 positivo (40 celulas plasmaticas en 3 campos de 40x) por inmunohistoquimica. La fibrosis retroperitoneal nodular es una enfermedad poco frecuente, de evolucion paulatina con excelente respuesta al manejo con esteroides. El tratamiento quirurgico se reserva para casos que comprometen estructuras adyacentes, por lo que el identificarlo al estudiar una tumoracion retroperitoneal conlleva un mejor pronostico y sobrevida.

Background Several guidelines have put forward recommendations about the perioperative process of cholecystectomy. Despite the recommendations, controversy remains concerning several topics, especially in low- and middle-income countries. The aim of this study was to develop uniform recommendations for perioperative practices in cholecystectomy in Mexico to standardize this process and save public health system resources. Methods A modified Delphi method was used. An expert panel of 23 surgeons anonymously completed two rounds of responses to a 29-item questionnaire with 110 possible answers. The consensus was assessed using the percentage of responders agreeing on each question. Results From the 29 questions, the study generated 27 recommendations based on 20 (69.0%) questions reaching consensus, one that was considered uncertain (3.4%), and six (20.7%) items that remained open questions. In two (6.9%) cases, no consensus was reached, and no recommendation could be made. Conclusions This study provides recommendations for the perioperative management of cholecystectomy in public hospitals in Mexico. As a guide for public institutions in low- and middle-income countries, the study identifies recommendations for perioperative tests and evaluations, perioperative decision making, postoperative interventions and institutional investment, that might ensure the safe practice of cholecystectomy and contribute to conserving resources.

Las neoplasias quisticas de pancreas (NQP) se originan a partir de los diversos componentes glandulares; son lesiones infrecuentes que se manifiestan como dolor abdominal cronico e inespecifico. Son subdiagnosticadas. Su conocimiento debe ser difundido con base en que cada estirpe histologica presenta comportamiento biologico distinto y puede progresar a carcinoma invasivo; su diagnostico y terapeutica en etapas tempranas es fundamental. En el Hospital General de Mexico se llevo a cabo un analisis retrospectivo de los pacientes con NQP tratados en la clinica de patologia hepatobiliar. Material y metodos: Se realizo un estudio retrospectivo, descriptivo y transversal de enero de 2004 a diciembre de 2014 en el que se analizaron las caracteristicas demograficas y clinicas de los pacientes con diagnostico de NQP que fueron tratados mediante reseccion quirurgica; los resultados fueron expresados mediante medidas de tendencia central y porcentajes. Resultados: Se incluyo un total de 18 casos, todos del sexo femenino, con una frecuencia de dos casos por ano y una edad promedio de 38 anos; la cirugia realizada con mayor frecuencia fue la pancreatectomia distal y en segundo lugar, la pancreatoduodenectomia, con una morbilidad del 39% y una mortalidad del 6%. Los diagnosticos histopatologicos fueron neoplasia quistica mucinosa (NQM) 33%, neoplasia solido quistica pseudopapilar mucinosa (NSQPM) 33%, neoplasia quistica serosa (NQS) 22%, carcinoma neuroendocrino con degeneracion quistica (CNQ) 6%, quiste linfoepitelial (QL) 6%. La supervivencia global a cinco anos fue del 83%. Discusion: Las NQP constituyen un reto diagnostico y terapeutico. En nuestro medio, el tratamiento quirurgico fue curativo en el 83% de los casos. El abordaje de los pacientes con NQP debe llevarse a cabo en unidades especializadas en patologia hepatobiliar, ya que favorece mejores resultados

Background and aim: Some patients with SARSCov-2 infection develop severe disease (SARS);however, the factors associated with severity are not yet fully understood. Some reports indicate that liver injury may be a poor prognostic factor. AIM: To identify the biochemical factors related to the development of SARS with mechanical ventilation (MV) requirement in patients with SARSCov-2 and COVID-19. Methods. Type of Study: Observational. Cohort study. Procedure: Data from COVID-19 patients were collected at admission time to a tertiary care center. Differential factors were identified between seriously ill SARS + MV patients versus stable patients without MV. Transformation to the natural logarithm of significant variables was performed and multiple linear regression was applied, then a predictive model of severity called AAD (Age-AST-D dimer) was constructed. Result(s): 166 patients were included, 114(68.7%) men, mean age 50.6 +/- 13.3 years-old, 27(16.3%) developed SARS + MV. In the comparative analysis between those with SARS + MV versus stable patients without MV we found significant raises of ALT (225.4 +/- 341.2 vs. 41.3 +/- 41.1;P = 0.003), AST 325.3 +/- 382.4 vs. 52.8 +/- 47.1;P = 0.001), LDH (764.6 +/- 401.9 vs. 461.0 +/- 185.6;P = 0.001), D dimer (7765 +/- 9109 vs. 1871 +/- 4146;P = 0.003), age (58.6 +/- 12.7 vs. 49.1 +/- 12.8;P = 0-001). The results of the regression are shown in the Table, where model 3 was the one that best explained the development of SARS + MV;with these variables was constructed the model called AAD, where: [AAD = 3.896 + ln(age)x-0.218 + ln(AST)x-0.185 + ln(DD)x0.070], where a value = 2.75 had sensitivity = 0.797 and 1-specificity = 0.391, AUROC = 0.74 (95%CI: 0.62-0.86;P 0.0001), to predict the risk of developing SARS + MV (OR = 5.8, 95%CI: 2.2-15.4;P = 0.001). Conclusion(s): Elevation of AST (probable marker of liver damage) is an important predictor of progression to SARS, together with elevation of D-dimer and age early (at admission) and efficiently predict which patients will potentially require MV. Conflicts of interest: The authors have no conflicts of interest to declare. [Formula presented] [Formula presented] Copyright © 2020

The patient was a 55-year-old woman with a 4-month history of pain in left flank that irradiated to the lumbar region. Computed tomography revealed a cystic tumor in the retroperitoneal region that compresses the ureter and left renal pelvis in contact with pancreatic body and tail. Surgery was performed and the definitive pathological report diagnosed nodular retroperitoneal fibrosis associated with IgG4; Ki67-positive in germinal centers (5%) and IgG4-positive (40 plasma cells in 3 fields of 40x) by immunohistochemistry. Retroperitoneal fibrosis is a rare disease, that develops gradually and has an excellent response to steroid management. Surgical treatment is reserved for cases that compromise adjacent structures. Thus, identifying it when studying a retroperitoneal tumor leads to better prognosis and survival.

Background Approximately 48,960 people in the USA will be diagnosed with pancreatic cancer in 2015 and 40,560 will die for this reason; in Mexico, the new cases of pancreatic cancer in 2012 were 4274, with 4133 deaths; survival rate at 5 years goes from 1% to 15%. Less than 20% of cases were considered resectable at the time of diagnosis. The Whipple procedure is currently the only curative treatment option for periampullary cancers since the first communication by Whipple in 1935, and up until now is a common procedure in several reference centres around the world. In 1994, Gagner reported the first totally laparoscopic pancreaticoduodenectomy. Some groups have currently demonstrated the safety and efficacy of this technique. Objective To report our initial experience with totally laparoscopic pancreaticoduodenectomy in the Hospital General de Mexico. Clinical case The case concerns a 58 year-old women with jaundice and loss of weight of 3 months onset. Her biopsy reported adenocarcinoma of Vater's ampulla, and as it was considered resectable, she underwent a laparoscopic pancreaticoduodenectomy. Conclusions This procedure must be performed in centres with experience in open pancreatic surgery and training in advanced laparoscopic surgery. The main advantages are lower blood loss and shorter hospital stay.

Introduction: Iatrogenic bile duct injuries (IBDI) with loss of confluence are understood as those where right and left hepatic ducts lose continuity with the common biliary tree. These represent 4% of all IBDI and are considered a very demanding surgical challenge. Study design: This is a series of case in a reference center during an eight-year period (2008 – 2016), where all patients with IBDI and loss of confluence submitted to any bilioenteric derivation procedure were included. Results: From a total of 11 cases, 10 of them (90.1%) were treated with double bilioenteric derivation and 1 (9%) with a neo-confluence. In 90.9% (n=10) of the patients a percutaneous catheter of biliary drainage was placed before the surgical procedure. Within a 34.5 months follow-up, the initial approach was successful in 54.5% (n=6), meanwhile accumulated achievement was 81.8% (n=9) considering dilatation and remodeling procedures. From this, 18.2% (n=2) are still with stenosis of derivation in a dilatation protocol with percutaneous catheter. Conclusions: Double hepatojejunostomy with transanastomotic stents and management of eventual stenosis with percutaneous dilatation as a first therapeutic intention results in a standardized practice that leads to reasonable results compared with other high volume centers.

ResumenAntecedentesSe estima que en el 2015 en Estados Unidos de Norteamérica 48,960 personas serán diagnosticadas con cáncer de páncreas y 40,560 morirán por esta causa; en México, el número de nuevos casos en 2012 fue de 4,274, mientras que se presentaron 4,133 defunciones; la sobrevida a 5 años va del 1 al 15%. Menos del 20% de los casos son considerados resecables al momento del diagnóstico. La cirugía de Whipple continúa siendo hoy en día la única opción de tratamiento con intento curativo para la enfermedad tumoral periampular, desde la primera publicación por Whipple en 1935 hasta nuestros días, en que se realiza con frecuencia en centros de referencia. En 1994, Gagner reportó la primera pancreatoduodenectomía realizada completamente por vía laparoscópica. Diversos grupos han demostrado la seguridad y eficacia del empleo de este abordaje.ObjetivoComunicar nuestra experiencia inicial con la pancreatoduodenectomía totalmente laparoscópica en el Hospital General de México.Caso clínicoSe reporta el caso de una mujer de 58 años con ictericia obstructiva y pérdida de peso de 3 meses de evolución, a quién se diagnostica adenocarcinoma de ámpula de Váter, se consideró resecable por estudios de imagen y se realizó cirugía de Whipple, por vía laparoscópica.ConclusiónEste tipo de procedimiento debe ser realizado en centros con experiencia en cirugía pancreática abierta, con adiestramiento en cirugía laparoscópica avanzada. La ventaja de este abordaje se centra, principalmente, en un menor sangrado transoperatorio y menor estancia hospitalaria.AbstractBackgroundApproximately 48,960 people in the USA will be diagnosed with pancreatic cancer in 2015 and 40,560 will die for this reason; in México, the new cases of pancreatic cancer in 2012 were 4,274, with 4,133 deaths presented; survival rate in 5 years goes from 1 to15%. Less than 20% of the cases are considered resectable at the time of diagnosis. The Whipple procedure is currently the only curative treatment option for periampullary cancers since the first communication by Whipple in 1935, and up until now is a common procedure in several reference centres around the world. In 1994, Gagner reported the first totally laparoscopic pancreaticoduodenectomy, for which currently some groups have currently demonstrated the safety and efficacy of this technique.ObjectiveTo report our initial experience with totally laparoscopic pancreaticoduodenectomy in the Hospital General de México.Clinical caseThe case concerns a 58 year-old women with jaundice and loss of weight of 3 months onset. Her biopsy reported adenocarcinoma of the Váter's ampulla, and as it was considered resectable, she underwent a laparoscopic pancreaticoduodenectomy.ConclusionsThis procedure must be performed in centres with experience in open pancreatic surgery and training in advanced laparoscopic surgery. The main advantages are lower blood loss and shorter hospital stay.