9 results on '"Özdemir SA"'
Search Results
2. Optimization of polyphenol extraction, phenolic profile by LC-ESI-MS/MS, antioxidant, anti-enzymatic, and cytotoxic activities of Physalis acutifolia
- Author
-
Derbak Larbi, Bendif Hamdi, Ayad Radia, Bensouici Chawki, Yildiz İlyas, Demirtas Ibrahim, Rebbas Khellaf, Plavan Gabriel, Ben Hamadi Naoufel, Abu-Elsaoud Abdelghafar M., Alomran Maryam M., Özdemir Sadin, and Boufahja Fehmi
- Subjects
polyphenols ,physalis acutifolia ,flavonoids ,pharmacokinetics ,biological activity ,lc-esi-ms/ms ,Chemistry ,QD1-999 - Abstract
During the current study, the phenolic and flavonoid contents were measured in Physalis acutifolia extracts with Folin–Ciocalteu and AlCl3 methods, respectively. Various antioxidant assays, including 1,1-diphenyl-2-picrylhydrazyl, ABTS, reducing power, Fe2+-phenanthroline reduction, and silver nanoparticle assays, were also conducted, along with anti-enzymatic assays. The cytotoxicity of the ethanolic extract was assessed on cancer cell lines (i.e., CAPAN-1 and dld-1) and a healthy cell line (i.e., L929). Optimal parameters for polyphenol extraction were determined: extraction time of 72 h, solvent-to-plant ratio of 10 mL/1 g, and plant concentration of 90%. The n-butanol extract showed the highest phenolic and flavonoid contents (i.e., 263.84 mg GAE/g dw and 72.03 QE/g dw, respectively), along with superior antioxidant and anti-enzymatic activities with IC50 values of 49.77 and 187.12 µg/mL with acetylcholinesterase and butyrylcholinesterase assays, respectively. LC-ESI-MS/MS analysis revealed 12 components, with hesperidin being the most abundant (i.e., 1829.0001 µg/g). The ethanolic extract exhibited cytotoxic effects on cancer cell lines, with an IC50 value of 0.959 mg/mL for dld-1, but with no effect on healthy cells. The bioavailability scores of the identified components support the in vitro findings and confirm the different assessed therapeutic effects.
- Published
- 2024
- Full Text
- View/download PDF
3. The missing link between standing- and traveling-wave resonators
- Author
-
Zhong Qi, Zhao Haoqi, Feng Liang, Busch Kurt, Özdemir Şahin K., and El-Ganainy Ramy
- Subjects
integrated photonics ,optical resonators ,sensing ,Physics ,QC1-999 - Abstract
Optical resonators are structures that utilize wave interference and feedback to confine light in all three dimensions. Depending on the feedback mechanism, resonators can support either standing- or traveling-wave modes. Over the years, the distinction between these two different types of modes has become so prevalent that nowadays it is one of the main characteristics for classifying optical resonators. Here, we show that an intermediate link between these two rather different groups exists. In particular, we introduce a new class of photonic resonators that supports a hybrid optical mode, i.e. at one location along the resonator the electromagnetic fields associated with the mode feature a purely standing-wave pattern, while at a different location, the fields of the same mode represent a pure traveling wave. The proposed concept is general and can be implemented using chip-scale photonics as well as free-space optics. Moreover, it can be extended to other wave phenomena such as microwaves and acoustics.
- Published
- 2022
- Full Text
- View/download PDF
4. Agenesis of the left abdominal wall in a fetus yeanling
- Author
-
ÖZDEMİR SALCI ES and SEYREK İNTAŞ K
- Subjects
Veterinary medicine ,SF600-1100 - Published
- 2014
- Full Text
- View/download PDF
5. Evaluation of syringin's neuroprotective effect in a model of neonatal hypoxic-ischemic brain injury.
- Author
-
Ergon EY, Çelik A, Diniz G, Çolak R, Özdemir SA, Çalkavur Ş, and Yilmaz O
- Subjects
- Animals, Rats, Phenylpropionates pharmacology, Phenylpropionates therapeutic use, Glucosides pharmacology, Glucosides therapeutic use, Apoptosis drug effects, Interleukin-1beta metabolism, Neuroprotective Agents pharmacology, Hypoxia-Ischemia, Brain pathology, Hypoxia-Ischemia, Brain drug therapy, Rats, Wistar, Disease Models, Animal, Animals, Newborn
- Abstract
Background/aim: A significant cause of mortality and morbidity in the neonatal era is hypoxic-ischemic encephalopathy (HIE). This study examined the histopathological analysis and neuroprotective impact of syringin (SYR) in an experimental HIE rat model., Material and Methods: On the 7th postnatal day, 24 Wistar albino rats were evaluated in 3 groups using the HIE model under gas anesthesia. In the experiment, Group A received 10 mg/kg SYR plus dimethyl sulfoxide (DMSO), Group B received DMSO only, and Group C served as a sham group. Immunohistochemical techniques were used to assess apoptotic cell measurement and proinflammatory cytokines (TNF-α and IL-1β primary antibodies)., Results: Rats suffering from hypoxic-ischemic brain damage had their apoptosis assessed. The SYR and sham groups had statistically fewer cells undergoing apoptosis (p < 0.001). There was no difference between the groups in terms of IL-1β and TNF-α during immunohistochemical staining. Neuronal degeneration was significantly lower in the histological evaluation of the hippocampus in the SYR group (p = 0.01). A statistically significant difference (p = 0.01) was observed between the SYR and the control groups regarding pericellular and perivascular edema., Conclusion: SYR reduced apoptosis, perivascular and pericellular edema, and neuronal degeneration in rat cerebral tissue. These results raise the possibility that SYR may have a neuroprotective effect on the harm brought on by HIE. This is the first investigation of SYR's function within the HIE paradigm., Competing Interests: DisclaimerConflict of interest: None of the authors have a conflict of interest., (© TÜBİTAK.)
- Published
- 2023
- Full Text
- View/download PDF
6. Can surfactants affect mortality and morbidity in term infants with respiratory failure?
- Author
-
Özdemir SA, Yılman Ö, Çalkavur Ş, and Yıldırım TG
- Subjects
- Humans, Male, Female, Pregnancy, Infant, Newborn, Infant, Transient Tachypnea of the Newborn, Meconium Aspiration Syndrome, Treatment Outcome, Surface-Active Agents administration & dosage, Surface-Active Agents therapeutic use, Pulmonary Surfactants administration & dosage, Pulmonary Surfactants therapeutic use, Respiratory Distress Syndrome, Newborn drug therapy, Respiratory Insufficiency drug therapy
- Abstract
Background: We aimed to discuss term infants who are given surfactant due to respiratory disorder according to the underlying etiology, the dose of surfactant administration, and the need for repeated surfactant administration., Methods: In this retrospective study infants hospitalized in the 4th level neonatal intensive care unit during January 2019 and December 2021 and administered surfactant due to respiratory distress were included. Term infants given surfactant due to respiratory failure were included in the study through the data recording system. The number of surfactant doses, indications for administration, mortality, duration of hospitalization, intubation time, and inotrope use were recorded in the infants included in the study., Results: : During the two-year period, 1250 infants were hospitalized in our neonatal intensive care unit. Of those, 56 infants received surfactant replacement therapy for severe respiratory failure. There were 30 infants with pneumonia, 4 infants with meconium aspiration syndrome (MAS), and 22 infants with transient tachypnea of the newborn (TTN). It was seen that single-dose administration was higher in patients with TTN (p = 0.01), while multiple-dose surfactant administration was more common in patients with MAS, resulting in a statistical difference (p = 0.02). Mortality was lower, especially in cases given early surfactant administration and this situation was statistically significant (p < 0.001). Duration of intubation was 5.05 ± 4.7 days in early surfactant administration group and 8.0 ± 6.1 days in late surfactant administration group. This difference was statistically significant (p = 0.04). While early surfactant application was statistically higher in the TTN group (p = 0.007), late surfactant application was statistically higher in the pneumonia group (p = 0.001)., Discussion: Despite the difference on administration time and repeat dose interval due to etiology, surfactant treatment is improving the respiratory distress of term infants.
- Published
- 2022
- Full Text
- View/download PDF
7. A rare vascular lesion of newborn: cutis marmorata telangiectatica congenital.
- Author
-
Ergon EY, Çelik K, Çolak R, Özdemir SA, Olukman Ö, Kundak S, and Çalkavur Ş
- Abstract
Cutis marmorata telangiectatica congenita is a rare, benign, sporadic and cutaneous vascular disease. A newborn female baby whose mother was aged 29 years and used propylthiouracil during pregnancy was hospitalized because of varicose lesions on the skin of the lower extremity and on the back, which were present at birth. It was observed that the lesions did not disappear, although appropriate room temperature was provided. The patient was diagnosed as having cutis marmorata telangiectatica congenita and screened for additional anomalies. She had no additional anomalies, and she was discharged and monitored. At the postnatal sixth month, the cutaneous vascular lesions disappeared spontaneously. Cutis marmorata telangiectatica congenita, which is a rare condition, should be kept in mind in the differential diagnosis of physiologic cutis marmoratus, which occurs frequently in the neonatal period., Competing Interests: Conflict of Interest: No conflict of interest was declared by the authors.
- Published
- 2019
- Full Text
- View/download PDF
8. Kyphectomy in neonates with meningomyelocele.
- Author
-
Özdemir N, Özdemir SA, and Özer EA
- Subjects
- Female, Humans, Infant, Newborn, Kyphosis complications, Male, Meningomyelocele complications, Orthopedic Procedures methods, Treatment Outcome, Kyphosis surgery, Lumbar Vertebrae surgery, Meningomyelocele surgery
- Abstract
Purpose: Kyphosis is the most severe spinal deformity associated with meningomyelocele (MMC) and is seen in approximately 15% of neonates. Our purpose is to present our clinical experience, to discuss the technique and deformity correction in kyphectomy in neonates with MMC, and to assess its long-term outcomes., Method: In this prospective study, the authors reviewed eight cases submitted to surgery between 2013 and 2015. We evaluated clinical characteristics that were analyzed, as were the operative technique employed, and angle range of the kyphosis deformity postcorrection follow-up., Results: Neonatal kyphectomy was performed of six females and two males. The mean birth weight was 2780 g, and the mean age at the time of surgery was 5.6 days. There were S-shaped type deformity in lumbar region in all neonates. In the correction of the kyphotic deformity, a total vertebrae were removed from four patient, whereas a partial vertebrectomy was done in four. The mean operative time was 116 min. No patients did not require the blood transfusion. There were no serious complications, and wound closure was successful in all patients. The mean follow-up period was 4 years and 3 months (range 36-61 months), except one patient who died 1 week after discharge. The mean preoperative kyphosis of 75.6° (range, 50°-90°) improved at last follow-up to 35° (range 15°-55°). All patients had surgical procedures for hydrocephalus. Three patients had surgery for Chiari type II malformation. The mean hospital stay was 27.7 days., Conclusion: Kyphectomy performed at the time of dural sac closure in the neonate is a safe procedure with excellent correction.
- Published
- 2019
- Full Text
- View/download PDF
9. Congenital Complete Tracheal Ring in a Neonate: A Case Report.
- Author
-
Özer EA, Cumurcu S, Bayol Ü, Özdemir SA, Ilhan Ö, and Sütçüoğlu S
- Subjects
- Humans, Infant, Newborn, Anal Canal abnormalities, Esophagus abnormalities, Heart Defects, Congenital, Kidney abnormalities, Limb Deformities, Congenital, Spine abnormalities, Trachea abnormalities
- Abstract
Abnormalities of the upper airway tract lead to congenital high airway obstruction and may complicate neonatal airway management in the delivery room. Congenital complete tracheal rings are a rare and unusual tracheal anomaly, usually presenting in the neonate or infant as respiratory distress. The clinical presentation can vary from almost asymptomatic patients to near-fatal airway obstruction. It may exist as an isolated entity, or in association with other congenital malformations, in particular, cardiac anomalies along with vascular rings and pulmonary slings. Other associated anomalies have also been reported, for example, chromosomal anomalies, malformation of other parts of the respiratory tract, esophagus and skeletal systems. Here, we report an extreme case of VACTERL/TACRD association presented with congenital complete tracheal ring, encephalocele, bilateral radial agenesis with absent thumbs, equinovalgus deformity on right foot, low-set ears and micrognathia.
- Published
- 2017
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.