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Aim: Inflammatory process plays a critical role in the progression of aortic valve sclerosis (AVS). This study aims to evaluate the haematological and biochemical inflammatory markers in AVS patients.Methods: A retrospective observational study was included consecutive 557 patients who underwent an echocardiogram between June 2021 and September 2021. The study population was divided into two groups according to the presence of AVS. The groups were compared in terms of C-reactive protein (CRP), Neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and monocyte-HDL cholesterol ratio (MHR).Results: The mean age was 63 ± 10 years. C-reactive protein (CRP), NLR, PLR and MHR were significantly higher in patients with AVS. The best cut-off values of the NLR were 1.4 (a sensitivity of 84%, a specificity of 74%), PLR was 116 (a sensitivity of 75%, a specificity of 54%), and MHR was 9.5 (a sensitivity of 78%, a specificity of 75%). CRP (OR: 1.246, 95% CI: 1.117 – 1.389; p < 0.001), NLR (OR: 2.10, 95% CI: 1.456 – 3.032; p < 0.001), and MHR (OR: 1.227, 95% CI: 1.125 – 1.339; p < 0.001) were independent predictors of the AVS when NLR and MHR analysed as a continuous variable. Using a cut off level of NLR > 1.4 (OR: 4.825, 95% CI: 2.430 – 9.583; p < 0.001) and MHR > 9.5 (OR: 13.937, 95% CI: 7.464 – 26.023; p < 0.001) were independent predictors of the AVS.Conclusion: Increased CRP levels, NLR and MHR were found to be independent predictors for AVS. Hematological inflammatory biomarkers are cost effective and helpful approach for prediction of AVS presence.

Objectives:Cardio-renal syndrome type 1 (CRS1) complicates 40% of patients hospitalized for acute decompensated heart failure (ADHF) and is associated with poor prognosis. Factors associated with the development and recovery of CRS1 have not been completely understood, and the value of cystatin C in this context has not been studied.Materials and Methods:We evaluated the predictive value of cystatin C levels at admission and 24thhour and deltacystatin C (cystatin C change in the first 24 hours of admission) in the development and reversibility of CRS1 in patients hospitalized for ADHF. One hundred ten consecutive patients hospitalized for ADHF were enrolled.Results:Admission cystatin C [odds ratio (OR): 30.97, confidence interval (CI): 9.28-139.60, pConclusion:This study demonstrated the potential value of cystatin C and delta-cystatin C in CRS1. Further studies are required to determine the clinical utility of these findings.

The rate of saphenous vein graft (SVG) occlusion within the first year of bypass graft surgery is 15%. The CHA2DS2-VASc score is used to predict the risk of thromboembolic events in patients with nonvalvular atrial fibrillation. We aimed to evaluate the predictive role of the CHA2DS2-VASc score in the estimation of intracoronary thrombus burden in patients with acute myocardial infarction (AMI) who underwent SVG-PCI. We retrospectively evaluated 221 patients who were admitted with AMI and underwent PCI of SVGs at the Department of Cardiology in the Turkiye Yuksek Ihtisas Education and Research Hospital between 2012 and 2018. The study population was divided into two groups according to their Thrombolysis in Myocardial Infarction (TIMI) thrombus grade: low thrombus burden (LTB; TIMI 0–3) and high thrombus burden (HTB; TIMI 4 and 5). The study included 221 patients with a mean age of 63.3 ± 6.7 years. The patients with HTB had significantly higher CHA2DS2-VASc scores (p 3 (OR: 3.876, 95% CI: 1.705–8.808, p = 0.001) were significantly associated with HTB. The ability of the CHA2DS2-VASc score to predict HTB burden was evaluated by receiver-operating characteristics analysis curve analysis. The optimum cut-off value of the CHA2DS2-VASc score for predicting HTB was 3 (with a sensitivity of 67.9% and a specificity of 69.3%) according to the Youden index. The CHA2DS2-VASc score can be used as an easy practical tool to predict HTB in AMI patients undergoing SVG-PCI.

Myocarditis contributes to the global burden of cardiovascular disease mainly through sudden death and chronic cardiomyopathy in young age groups. Monocyte/high-density lipoprotein cholesterol (HDL-C) ratio (MHR) has developed as a new inflammation biomarker. In this study has investigated that relationship between admission MHR levels and the reduced left ventricular systolic functions after acute myocarditis. The study included a total of 156 consecutive cases wanted by their doctors to undergo cardiovascular magnetic resonance imaging for acute myocarditis as the clinical diagnosis between 2009 and 2017 at our hospital. Study participants were split into two groups; group I patients (patients with LVEF [Med-Science 2021; 10(2.000): 304-9]

Objectives:Myocarditis is an inflammatory disease of the heart muscle. Inflammation and oxidative stress are known to play an important role in myocarditis pathogenesis. The aim of this study is to evaluate the relationship between clinical endpoints and monocyte/high-density lipoprotein (HDL) ratio in acute myocarditis patients.Materials and Methods:Between March 2009 and March 2017, 156 consecutive patients who underwent cardiac magnetic resonance with the diagnosis of acute myocarditis were included in the study. The patients were divided into two groups according to clinical endpoints. The clinical endpoint was defined as malignant arrhythmia, cardiovascular death during follow-up, and new-onset heart failure.Results:High C-reactive protein level, low high density lipoprotein cholesterol and glucose levels, and low ejection fraction were found in patients with clinical endpoints. (p

Objectives:We investigated the effects of different revascularization methods on soluble ST2 (sST2) levels and echocardiographic parameters of left ventricular systole and diastolic in patients admitted with acute myocardial infarction (AMI).Materials and Methods:A total of 30 patients were included in the study. The study population was divided into two groups. Patients who underwent primary percutaneous intervention (PCI) or fibrinolytic therapy admitted with AMI were formed the study groups. sST2 and echocardiography parameters were compared during 3-month follow-up of patients.Results:There was no difference between sST2 levels in both groups. Left ventricular ejection fraction (LVEF) was higher in the PCI group.Conclusion:Consequently, the sST2 level did not change in AMI patients regardless of the revascularization method. LVEF was significantly higher in the PCI group compared to the fibrinolytic group.

The rate of saphenous vein graft (SVG) occlusion within the first year of bypass graft surgery is 15%. The CHAWe retrospectively evaluated 221 patients who were admitted with AMI and underwent PCI of SVGs at the Department of Cardiology in the Turkiye Yuksek Ihtisas Education and Research Hospital between 2012 and 2018. The study population was divided into two groups according to their Thrombolysis in Myocardial Infarction (TIMI) thrombus grade: low thrombus burden (LTB; TIMI 0-3) and high thrombus burden (HTB; TIMI 4 and 5).The study included 221 patients with a mean age of 63.3 ± 6.7 years. The patients with HTB had significantly higher CHAThe CHAHINTERGRUND: Die Verschlussrate für V.-saphena-Transplantate (SVG) innerhalb des ersten Jahres nach der Bypass-Operation liegt bei 15%. Zur Vorhersage des Risikos thromboembolischer Ereignisse bei Patienten mit nichtvalvulärem Vorhofflimmern wird der CHARetrospektiv wurden 221 Patienten untersucht, die wegen AMI stationär aufgenommen wurden und bei denen zwischen 2012 und 2018 am Department of Cardiology im Turkiye Yuksek Ihtisas Education and Research Hospital eine SVG-PCI durchgeführt wurde. Die Studienpopulation wurde entsprechend ihrem Thrombusgrad gemäß Thrombolysis in Myocardial Infarction (TIMI) in 2 Gruppen unterteilt: niedrige Thrombuslast (LTB; TIMI 0–3) und hohe Thrombuslast (HTB; TIMI 4 und 5).In die Studie wurden 221 Patienten mit einem Durchschnittsalter von 63,3 ± 6,7 Jahren aufgenommen. Patienten mit HTB wiesen signifikant höhere CHADer CHA

Objectives: The relationship between sex hormones such as estrogen, testosteron and coronary artery disease (CAD) has been found to be controversial in various studies. Moreover, recent studies revealed an association between CAD and dehydroepiandrosterone sulphate (DHEA-S) which is an endogenous steroid hormone and the precursor of sex hormones. We aimed to investigate the relationship between serum testosterone, estrogen, DHEA levels and CAD.

Kalp yetersizligi, insan yasam omrunun uzamasi, kullanilan ilac ve ilac disi tedaviler ve ilerleyen tetkik ve tani yontemleri nedeniyle klinik hayatimizda karsimiza daha fazla cikmaktadir. Bu kitapta kalp yetersizligi tanisini, baska hastaliklar ile iliskisini, tedavisinde kullanilan ilac, cihaz ve cerrahi yontemleri pratik bilgiler de sunarak anlatmaya calistik. Kardiyoloji, Ic Hastaliklari ve Aile Hekimligi uzmanlari basta olmak uzere kalp yetersizligi ile ilgilenen tum hekim arkadaslarin ilgiyle okuyacaklarini dusunmekteyiz.Bu sebeple son yayin ve kilavuzlar isiginda kalp yetersizligi ile iliskili guncel verileri iceren “Kalp Yetersizliginde Pratik Bilgiler” isimli kitabimizi siz okuyucularimiza kazandirmaktan gurur duyuyoruz.Kalp yetersizligi ile ilgilenen hekim arkadaslarimiza faydali olacagini umdugumuz kitabin bolumlerin yazilmasinda emegi gecen tum degerli meslektaslarimiza tesekkur ederiz.