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Two manipulator Jacobian matrix estimators for constrained planar snake robots are developed and tested, which enables the implementation of Jacobian-based obstacle-aided locomotion (OAL) control schemes. These schemes use obstacles in the robot’s vicinity to obtain propulsion. The devised estimators infer manipulator Jacobians for constrained planar snake robots in situations where the positions and number of surrounding obstacle constraints might change or are not precisely known. The first proposed estimator is an adaptation of contemporary research in soft robots and builds on convex optimization. The second estimator builds on the unscented Kalman filter. By simulations, we evaluate and compare the two devised algorithms in terms of their statistical performance, execution times, and robustness to measurement noise. We find that both algorithms lead to Jacobian matrix estimates that are similarly useful to predict end-effector movements. However, the unscented filter approach requires significantly lower computing resources and is not poised by convergence issues displayed by the convex optimization-based method. We foresee that the estimators may have use in other fields of research, such as soft robotics and visual servoing. The estimators may also be adapted for use in general non-planar snake robots.

Abstract Background The analysis of abdominal sounds can help to diagnose gastro-intestinal diseases. Sounds originating from the stomach and the intestine, the so-called bowel sounds, occur in various forms. They are described as loose successions or clusters of rather sudden bursts. Realistic recordings of abdominal sounds are contaminated with noise and artifacts from which the bowel sounds must be differentiated. Methods The proposed intrinsic mode function-fractal dimension (IMF-FD) filtering utilizes the property of the multivariate empirical mode decomposition (MEMD) to behave as a series of band pass filters. The MEMD decomposes the abdominal signal into its different frequency components. The resulting intrinsic mode functions (IMFs) are modulated in amplitude and frequency where transient sonic events occur. Based on the complexity of the IMFs, measured by their fractal dimension (FD) in sliding windows, the information-carrying IMFs are selected. The filtered signal is formed as the superposition of all selected IMFs. The IMF-FD filter not only enhances the non-linear components of the original signal but also segments them from the rest. Another important aspect of this work is that typical artifacts that occur in the same frequency range as bowel sounds can be subsequently eliminated by heuristic rules. Conclusions The method is tested on a realistic, contaminated data set with promising performance: close to 100% of the manually labeled bowel sounds are identified.

In a previous study we have shown that patients with long standing non-specific neck-pain display more rigid neck movement behavior than controls in response to unpredictable perturbations. In the present study we investigated head/neck motor control in patients with neck-pain during a course of physiotherapy intervention and the associations with pain, neck disability and kinesiophobia. In this longitudinal observational study, 72 patients with non-specific neck-pain were exposed to unpredictable horizontal rotations by means of an actuated chair in three conditions; with a visual reference, and without vision with and without a cognitive task before first consultation with physiotherapist, after 2 weeks and 2 months of intervention. The neck movements were analyzed in the frequency domain to cover voluntarily and reflex controlled responses. Questionnaires encompassed Neck Disability Index, Tampa Scale of Kinesiophobia, and the Numerical Rating Scale for current pain. The results showed that the response pattern for the amplitudes of movement between head and trunk across frequencies did not change over time, whereas some changes in timing were found for some frequencies. Pain, neck disability, and kinesiophobia improved after intervention, but were not significantly associated with neck movement responses to perturbations across time or condition. Although physiotherapy intervention improved self-reported function, the rigid responses to unpredictable perturbations remained unchanged. This indicates altered function in reflex mediated control mechanisms, i.e., the vestibulocollic and the cervicocollic reflex systems that control the head in space and on the trunk. Future research should further investigate pain related changes in reflex systems and whether alterations in these systems are modifiable.

Rapid, accurate and robust glucose measurements are needed to make a safe artificial pancreas for the treatment of diabetes mellitus type 1 and 2. The present gold standard of continuous glucose sensing, subcutaneous (SC) glucose sensing, has been claimed to have slow response and poor robustness towards local tissue changes such as mechanical pressure, temperature changes, etc. The present study aimed at quantifying glucose dynamics from central circulation to intraperitoneal (IP) sensor sites, as an alternative to the SC location. Intraarterial (IA) and IP sensors were tested in three anaesthetized non-diabetic pigs during experiments with intravenous infusion of glucose boluses, enforcing rapid glucose level excursions in the range 70--360 mg/dL (approximately 3.8--20 mmol/L). Optical interferometric sensors were used for IA and IP measurements. A first-order dynamic model with time delay was fitted to the data after compensating for sensor dynamics. Additionally, off-the-shelf Medtronic Enlite sensors were used for illustration of SC glucose sensing. The time delay in glucose excursions from central circulation (IA) to IP sensor location was found to be in the range 0--26 s (median: 8.5 s, mean: 9.7 s, SD 9.5 s), and the time constant was found to be 0.5--10.2 min (median: 4.8 min, mean: 4.7 min, SD 2.9 min). IP glucose sensing sites have a substantially faster and more distinctive response than SC sites when sensor dynamics is ignored, and the peritoneal fluid reacts even faster to changes in intravascular glucose levels than reported in previous animal studies. This study may provide a benchmark for future, rapid IP glucose sensors.

BACKGROUND:In diabetes research, the development of the artificial pancreas has been a major topic since continuous glucose monitoring became available in the early 2000's. A prerequisite for an artificial pancreas is fast and reliable glucose sensing. However, subcutaneous continuous glucose monitoring carries the disadvantage of slow dynamics. As an alternative, we explored continuous glucose sensing in the peritoneal space, and investigated potential spatial differences in glucose dynamics within the peritoneal cavity. As a secondary outcome, we compared the glucose dynamics in the peritoneal space to the subcutaneous tissue. MATERIAL AND METHODS:Eight-hour experiments were conducted on 12 anesthetised non-diabetic pigs. Four commercially available amperometric glucose sensors (FreeStyle Libre, Abbott Diabetes Care Ltd., Witney, UK) were inserted in four different locations of the peritoneal cavity and two sensors were inserted in the subcutaneous tissue. Meals were simulated by intravenous infusions of glucose, and frequent arterial blood and intraperitoneal fluid samples were collected for glucose reference. RESULTS:No significant differences were discovered in glucose dynamics between the four quadrants of the peritoneal cavity. The intraperitoneal sensors responded faster to the glucose excursions than the subcutaneous sensors, and the time delay was significantly smaller for the intraperitoneal sensors, but we did not find significant results when comparing the other dynamic parameters.

The design of a prosthetic wrist is the result of compromises between the function and the practicality of the device. Conventional prosthetic wrists use a single degree of freedom to produce pro/supination of the hand. It has not been demonstrated that this is the most functional alignment for a single axis. Previous work by the authors suggests that if the wrist must have only one rotatory axis then a more oblique orientation would be more functional. To test this idea, a compact wrist with a single axis and spherical design has been made that will allow any axis of rotation to be selected and the functional performance of the resulting arm be tested.

Freestyle Libre (FL) is a factory calibrated Flash Glucose Monitor (FGM). We investigated Mean Absolute Relative Difference (MARD) between Self Monitoring of Blood Glucose (SMBG) and FL measurements in the first day of sensor wear in 39 subjects with Type 1 diabetes. The overall MARD was 12.3%, while the individual MARDs ranged from 4% to 25%. Five participants had a MARD ≥ 20%. We estimated bias and lag between the FL and SMBG measurements. The estimated biases range from −1.8 mmol / L to 1.4 mmol / L , and lags range from 2 min to 24 min . Bias is identified as a main cause of poor individual MARDs. The biases seem to persist in days 2–7 of sensor usage. All cases of MARD ≥ 20% in the first day are eliminated by bias correction, and overall MARD is reduced from 12.3% to 9.2%, indicating that adding support for voluntary user-supplied bias correction in the FL could improve its performance.

This paper gives a treatment of various aspects related to snake locomotion. A mathematical model and a physical implementation of a modular snake robot are presented. A control strategy is also developed, yielding a general expression for different gait patterns. Two forms of locomotion have been simulated with the mathematical model, and experiments with the physical snake robot have been conducted. The simulation results revealed the parameter through which directional control may be achieved for each gait pattern. Experiments with the physical snake robot gave a crude qualitative verification of these findings.

Rotational data in the form of measured three-dimensional rotations or orientations arise naturally in many fields of science, including biomechanics, orthopaedics and robotics. The cyclic topology of rotation spaces calls for special care and considerations when performing statistical analysis of rotational data. Relevant theory has been developed during the last three decades, and has become a standard tool in some areas. In relation to the study of human kinematics and motion however, these concepts have hardly been put to use. This paper gives an introduction to the intricacies of three-dimensional rotations, and provides a thorough geometric interpretation of several approaches to averaging rotational data A set of novel, simple operators is presented. Simulations and a prosthetics-related real-world example involving wrist kinematics illuminate important aspects of the results. Finally generalizations and related subjects for further research are suggested.

In nature, snakes can gracefully traverse a wide range of different and complex environments. Snake robots that can mimic this behaviour could be fitted with sensors and transport tools to hazardous or confined areas that other robots and humans are unable to access. In order to carry out such tasks, snake robots must have a high degree of awareness of their surroundings (i.e., perception-driven locomotion) and be capable of efficient obstacle exploitation (i.e., obstacle-aided locomotion) to gain propulsion. These aspects are pivotal in order to realise the large variety of possible snake robot applications in real-life operations such as fire-fighting, industrial inspection, search-and-rescue, and more. In this paper, we survey and discuss the state of the art, challenges, and possibilities of perception-driven obstacle-aided locomotion for snake robots. To this end, different levels of autonomy are identified for snake robots and categorised into environmental complexity, mission complexity, and external system independence. From this perspective, we present a step-wise approach on how to increment snake robot abilities within guidance, navigation, and control in order to target the different levels of autonomy. Pertinent to snake robots, we focus on current strategies for snake robot locomotion in the presence of obstacles. Moreover, we put obstacle-aided locomotion into the context of perception and mapping. Finally, we present an overview of relevant key technologies and methods within environment perception, mapping, and representation that constitute important aspects of perception-driven obstacle-aided locomotion.