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Objective: This study was conducted to present the long-term functional outcomes of injection laryngoplasty (IL) with hyaluronic acid/dextranomer (HA/D) in unilateral vocal fold paralysis (UVFP). Methods: A total of 40 patients who underwent HA/D injection for UVFP were enrolled. The acoustic analysis of the voice was evaluated with jitter percentage, shimmer percentage, maximum phonation time, harmonics-to-noise ratio, and fundamental frequency. The psychosocial effect of the voice was determined using the Voice Handicap Index-10. Fiberoptic endoscopic evaluation of swallowing was performed and 2 scales were used for quantification: a modified penetration-aspiration scale and a dysphagia score. All measurements were performed at preoperative day and postoperative months 1, 6, and 24. Results: A statistically significant improvement was observed for all of the evaluated parameters except the maximum phonation time for postoperative months 1, 6, and 24 (P <.05). In the evaluation of the maximum phonation time, although there was a significant improvement for the postoperative months 1 and 6, no significant difference was observed between the postoperative 24th month and the preoperative value. Conclusions: HA/D injection laryngoplasty is an effective method both in the short- and long-term to improve voice and swallowing functions in patients with UVFP. [ABSTRACT FROM AUTHOR]

Copyright of Praxis of Otorhinolaryngology / Kulak Burun Boğaz Uygulamaları is the property of Official Journal of ENT-HNS Society of Istanbul and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: Sinonasal inverted papillomas are benign neoplasms of the nasal cavity and paranasal sinuses. They have characteristic features such as a high risk of recurrence and possible malignant transformation. This study was conducted to investigate the relationship between sinonasal inverted papilloma and inflammatory blood markers. Patients and Methods: Sixty-five patients who were diagnosed histologically as having sinonasal inverted papilloma and 65 age- and sex-matched healthy controls were included in the study. Inflammatory blood markers such as neutrophil–lymphocyte ratio (NLR), platelet–lymphocyte ratio (PLR), red cell distribution width (RDW), mean platelet volume (MPV), and platelet distribution width (PDW) of the patient and control groups were compared. Results: There were no statistically significant differences between the patients and controls for white blood cell, platelet, hemoglobin, neutrophil, and lymphocyte counts (P >.05). No statistically significant difference was found between the patients and controls for NLR, PLR, RDW, MPV, and PDW (P >.05). In the logistic regression analysis model, which was created to investigate the effects of inflammatory blood markers in determining the patient group, the increase in the NLR and decrease in the PLR were found to be statistically significant factors (P =.008, P =.039). Conclusion: This is the first study in the literature to investigate the relationship between sinonasal inverted papilloma and inflammatory blood markers, and the results suggest that NLR and PLR may be used to distinguish patients with sinonasal inverted papilloma from controls. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Traditional Medical Complementary Therapies is the property of Turkiye Klinikleri and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: Adenotonsillar surgery remains the second most common surgical practice in pediatric otolaryngology. We aimed to evaluate whether a comorbid disease in children undergoing surgery has any impact on postoperative complication rate. Methods: This study was conducted at a tertiary otolaryngology department with 643 children. The study included children with symptoms of obstructive sleep-disordered breathing and recurrent infection who underwent adenotonsillar surgery. Patients with a comorbid disease constituted the study group and otherwise healthy children constituted the control group. The data were evaluated to find out any association among clinical variables such as gender, age, tonsil grade, type and extent of surgery, indication for surgery, body mass index percentile, comorbid diseases and postoperative complications. Results: There were 245 (38.1%) patients with a comorbid disease. The most common comorbidity was cardiovascular diseases (n=68) followed by neurological diseases (n=48). We performed adenoidectomy in 319, tonsillectomy in 44, tonsillotomy in nine, adenotonsillectomy (AT) in 190 and adenoidectomy with tonsillotomy (ATT) in 81 patients. The overall rate of postoperative late complication was 17/643 (2.6%) with post-tonsillectomy hemorrhage being the most common (n=10). There was no association between other clinical variables and the complication but older age (p=0.042) and type of surgery (p<0.001) revealed increased risk. The rates of complications in patients with or without comorbid disease were found 5/245 (2%) and 12/389 (3%), respectively, with no difference (p=0.621). Conclusion: The risk of postoperative complications was increased in older children and in patients undergoing AT and ATT, however, the presence of comorbid disease did not increase likelihood of postoperative complications. [ABSTRACT FROM AUTHOR]

Objective: Benign paroxysmal positional vertigo (BPPV) is the most common peripheral vestibular system disease causing dizziness. It occurs more in the 5th decade of life and affects the posterior canal in 90% of the patients. The most effective treatment method is canalith repositioning (CRP) maneuver. The aim of this study is to evaluate the effects of betahistine and dimenhydrinate therapies in addition to CRP maneuver on BPPV patients. Methods: The study included 64 patients who had complaints of dizziness and were diagnosed with BPPV by their history and provocation maneuvers. The patients were divided into two groups. In Group 1, only repositioning maneuver was performed. Group 2 was divided into two subgroups. In Group 2a, repositioning maneuver was performed and betahistine 24 mg twice daily was given for 10 days. In Group 2b, repositioning maneuver was performed and dimenhydrinate 50 mg once daily was given for five days. On the 10th day, all patients were reexamined, and provocation maneuver was performed. Dizziness handicap inventory (DHI) was completed and outcomes were reviewed for therapeutic efficacy. Results: Mean DHI scores in all patient groups statistically significantly decreased from a pre-treatment level of 52.16 (range, 20-100) to a post-treatment level of 17.84 (range, 0-78) (p<0.001). No statistically significant differences were found in terms of DHI scores between Group 1 (repositioning maneuver only) and Group 2 (repositioning maneuver plus betahistine or dimenhydrinate). Conclusion: The most effective treatment method of BPPV is repositioning maneuver. Addition of betahistine or dimenhydrinate pharmacotherapy to repositioning maneuver did not show superiority to treatment with repositioning maneuvers alone. [ABSTRACT FROM AUTHOR]

Objective: The aim of this study was to investigate the expression of toll-like receptor 2,3,4 genes in larynx cancers, one of the cancers with no increase in survival rates despite the recent advancements, and to demonstrate their clinicopathologic correlation with the disease. Methods: The study was retrospectively conducted on 50 patients who underwent an open total or partial laryngectomy procedure for squamous cell carcinoma of the larynx in the years 2016-2018. Toll-like receptor 2,3,4 expression levels were measured by real-time Polymerase Chain Reaction in the normal tissue and the tumor tissue samples of patients. Toll-like receptor gene expression levels were compared with the demographic (age, gender, alcohol and tobacco consumption), clinical and histopathologic characteristics of patients. Gene expressions were examined based on the cartilaginous, vascular, lymphatic and perineural invasion conditions of the tumors. Further, toll-like receptor expression levels were compared between the larynx tumor materials and the normal tissues of the same patients. Results: The ages of the patients ranged from 34 to 84 with a mean of 60.56±9.67 years. Of the 50 patients 47 (94%) were male and 3 (6%) were female. Examination of the cases of the 50 patients found a 2...ΔΔCT level of 1 in normal tissue and 0.1±0.1 in tumor tissue for TLR-2; of 1 in normal tissue and 0 in tumor tissue for TLR-3; and of 1 in normal tissue and 1±1 in tumor tissue for TLR-4. There was reduced expression in tumor tissues compared to normal tissues for all three genes and the difference was statistically significant (p<0.001). No statistically significant correlations were found in terms of the clinicopathological characteristics of patients between the groups that showed unchanged or increased expression for TLR-2, TLR-3, TLR-4 and the group that showed decreased expression. Conclusion: According to the data obtained in our study, TLR 2, 3, 4 expressions decrease in squamous cell cancers of the larynx. Targeting this gene in future studies can provide beneficial results in the diagnosis and treatment of the disease. [ABSTRACT FROM AUTHOR]

Abstract: Inverted papillomas are predominantly seen in the sinonasal region. Extra-sinonasal lesions are considered to be heterotopic. We present a case of primary laryngeal inverted papilloma with an unusual subglottic localization. An 84-year-old female patient presented with dyspnea on exertion. In the endoscopic examination, a subglottic vegetative lesion was observed. Radiological examination revealed a well-circumscribed, solid mass involving the anterior commissure and extending to the subglottic region. Total excision of the mass was performed with the CO2 laser surgery. Histopathologic examination revealed endophytic growth of round-oval nests of transitional hyperplastic epithelium. The patient was diagnosed with primary laryngeal inverted papilloma. Primary laryngeal inverted papillomas are extremely rare. This is the fifth case and the only the second with a subglottic localization. Due to its rarity, it is difficult to predict the underlying cause and clinical course. However, cases with an atypical localization must be followed up like those in the sinonasal region., (Copyright © 2023 Indian Journal of Pathology and Microbiology | Published by Wolters Kluwer – Medknow.)

Objective: Sinonasal inverted papillomas are benign neoplasms of the nasal cavity and paranasal sinuses. They have characteristic features such as a high risk of recurrence and possible malignant transformation. This study was conducted to investigate the relationship between sinonasal inverted papilloma and inflammatory blood markers., Patients and Methods: Sixty-five patients who were diagnosed histologically as having sinonasal inverted papilloma and 65 age- and sex-matched healthy controls were included in the study. Inflammatory blood markers such as neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), red cell distribution width (RDW), mean platelet volume (MPV), and platelet distribution width (PDW) of the patient and control groups were compared., Results: There were no statistically significant differences between the patients and controls for white blood cell, platelet, hemoglobin, neutrophil, and lymphocyte counts ( P > .05). No statistically significant difference was found between the patients and controls for NLR, PLR, RDW, MPV, and PDW ( P > .05). In the logistic regression analysis model, which was created to investigate the effects of inflammatory blood markers in determining the patient group, the increase in the NLR and decrease in the PLR were found to be statistically significant factors ( P = .008, P = .039)., Conclusion: This is the first study in the literature to investigate the relationship between sinonasal inverted papilloma and inflammatory blood markers, and the results suggest that NLR and PLR may be used to distinguish patients with sinonasal inverted papilloma from controls.

Middle ear myiasis and factors determining the types of flies. To the laboratory in saline with 10% formaldehyde and sent them larvae stereo-microscope (Olympus 10×) were examined. Adult by making one portion of the surviving larvae instar larvae and adults are defined utilizing state properties. The larvae and live larvae of the fly Sarcophaga sp. rendered adults were determined. In both patients, the middle ear causing myiasis flies species Sarcophaga sp. was determined to be.