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INTRODUCTION: The increased risk of infection for patients caused by construction and renovation near hematology inpatient clinics is a major concern. The use of high-efficiency particulate absorption (HEPA) filters can reduce the risk of infection. However, there is no standard protocol indicating the use of HEPA filters for patients with hematological malignancies, except for those who have undergone allogeneic hematopoietic stem cell transplantation. This quasi-experimental study was designed to measure the efficacy of HEPA filters in preventing infections during construction. METHODS: Portable HEPA filters were placed in the rooms of patients undergoing treatment for hematological malignancies because of large-scale construction taking place near the hematology clinic. The rates of infection during the 6 months before and after the installation of the portable HEPA filters were compared. A total of 413 patients were treated during this 1-year period. RESULTS: There were no significant differences in the antifungal prophylaxis and treatment regimens between the groups. The rates of infections, clinically documented infections, and invasive fungal infections decreased in all of the patients following the installation of the HEPA filters. When analyzed separately, the rates of invasive fungal infections were similar before and after the installation of HEPA filters in patients who had no neutropenia or long neutropenia duration. HEPA filters were significantly protective against infection when installed in the rooms of patients with acute lymphocytic leukemia, patients who were undergoing consolidation treatment, and patients who were neutropenic for 1-14 days. DISCUSSION AND CONCLUSION: Despite the advent of construction and the summer season, during which environmental Aspergillus contamination is more prevalent, no patient or patient subgroup experienced an increase in fungal infections following the installation of HEPA filters. The protective effect of HEPA filters against infection was more pronounced in patients with acute lymphocytic leukemia, patients undergoing consolidation therapy, and patients with moderate neutropenia.

Introduction: In this study, it was aimed to evaluate factors associated with hepatitis B surface antigen (HBsAg) and anti-hepatitis C virus (HCV) positivity through the "Raising Public Awareness and Determining Epidemiological Changes in Hepatitis" project conducted by the Viral Hepatitis Society of Turkey. Materials and Methods: A total of 61,943 participants (mean age 35±14.1 years, 50.8% males) who volunteered to participate in the study were screened for HBsAg and anti-HCV by primary healthcare centers distributed throughout 78 cities in Turkey. A standard questionnaire form about sociodemographic features and transmission-related risk factors was completed via face-to-face interviews with each participant. A sub-population of 21,473 participants with complete data were analyzed for the presence of risk factors associated with HBsAg and anti-HCV seropositivity. Results: HBsAg and anti-HCV seropositivity were detected in 1,515 (2.5%) and 332 (0.6%) of the 61,943 study population, respectively. By univariate chi-square test, significant associations were found between hospitalization and anti-HCV and between dental treatment in the last five years and HBsAg and anti-HCV seropositivity. In multivariate logistic regression analysis, dental treatment was still associated with HBsAg and anti-HCV seropositivity, while hospitalization was associated with anti-HCV seropositivity. Conclusion: In conclusion, our findings indicate dialysis and history of hospitalization impose significant risks for hepatitis C transmission, and dental treatment is associated with transmission of both hepatitis B and hepatitis C.