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25. Genetically modified foods in the opinion of the second-year students of biology, biotechnology and tourism and recreation of the Jan Kochanowski University in Kielce – a preliminary study

Author

Chmielewski Jarosław, Ochwanowska Ewa, Czarny-Działak Małgorzata, and Łuszczki Jarogniew J.

Subjects
students, genetically modified food, gmo, knowledge, students’ attitude, Environmental technology. Sanitary engineering, TD1-1066
Abstract

The aim of this work was to assess knowledge of and to identify awareness in second-year students of biology, biotechnology and tourism and recreation, regarding the use of genetically modified organisms (GMO) in food. The analysis of obtained results shows that about 98% of respondents know the concept of GMO and highly appreciate their knowledge of this topic. The main source of knowledge about GMO for the students is the Internet and the University. It is worth noting that 59% of respondents are aware of the use of GMO in food, while more than half do not know how the GMO in food should be labeled. In particular, students of biotechnology showed a distinctive knowledge about GMO. Over half of students of the Jan Kochanowski University in the fields of biology, biotechnology, and tourism and recreation (55%) recognized that the use of GMO poses a threat to human health.

Published
2017
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42. Effect of Linker Elongation on the VGSC Affinity and Anticonvulsant Activity among 4-Alkyl-5-aryl-1,2,4-triazole-3-thione Derivatives.

Author

Paruch, Kinga, Kaproń, Barbara, Łuszczki, Jarogniew J., Paneth, Agata, and Plech, Tomasz

Subjects
PILOCARPINE, SODIUM channels, RADIOLIGAND assay, SODIUM channel blockers, ANTICONVULSANTS, HYDROPHOBIC interactions, BINDING sites, PHENOBARBITAL
Abstract

The main aim of the current project was to investigate the effect of the linker size in 4-alkyl-5-aryl-1,2,4-triazole-3-thione derivatives, known as a group of antiepileptic drug candidates, on their affinity towards voltage-gated sodium channels (VGSCs). The rationale of the study was based both on the SAR observations and docking simulations of the interactions between the designed ligands and the binding site of human VGSC. HYDE docking scores, which describe hydrogen bonding, desolvation, and hydrophobic effects, obtained for 5-[(3-chlorophenyl)ethyl]-4-butyl/hexyl-1,2,4-triazole-3-thiones, justified their beneficial sodium channel blocking activity. The results of docking simulations were verified using a radioligand binding assay with [3H]batrachotoxin. Unexpectedly, although the investigated triazole-based compounds acted as VGSC ligands, their affinities were lower than those of the respective analogs containing shorter alkyl linkers. Since numerous sodium channel blockers are recognized as antiepileptic agents, the obtained 1,2,4-triazole derivatives were examined for antiepileptic potential using an experimental model of tonic–clonic seizures in mice. Median effective doses (ED50) of the compounds examined in MES test reached 96.6 ± 14.8 mg/kg, while their median toxic doses (TD50), obtained in the rotarod test, were even as high as 710.5 ± 47.4 mg/kg. [ABSTRACT FROM AUTHOR]

Published
2023
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