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215 results on '"ŞAHİN, Nurhan"'

5. Histopathological Findings and Differential Diagnosis of Endolymphatic Sac Tumor: A Rare Case.

Author

Çoban, Ganime, Şahin, Nurhan, Hatiboglu, Mustafa Aziz, and Aralaşmak, Ayşe

Subjects
ENDOLYMPHATIC sac, TUMOR diagnosis, IMMUNOHISTOCHEMISTRY, PAIN management, RENAL cell carcinoma
Abstract

Copyright of Osmangazi Journal of Medicine / Osmangazi Tip Dergisi is the property of Eskisehir Osmangazi University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024
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9. Anticancer Properties of Lycopene

Author

Sahin, Kazim, Orhan, Cemal, Sahin, Nurhan, Kucuk, Omer, Mérillon, Jean-Michel, Series Editor, Ramawat, Kishan Gopal, Series Editor, Pavlov, Atanas I., Editorial Board Member, Ekiert, Halina Maria, Editorial Board Member, Aggarwal, Bharat B., Editorial Board Member, Jha, Sumita, Editorial Board Member, Wink, Michael, Editorial Board Member, Waffo-Téguo, Pierre, Editorial Board Member, and Riviere, Céline, Editorial Board Member

Published
2019
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20. PREVALENCE, DISTRIBUTION, AND PROGNOSTIC SIGNIFICANCE OF MORPHOLOGICAL VARIANTS OF NEUROENDOCRINE TUMORS OF THE GASTROINTESTINAL TRACT - A MULTICENTER STUDY.

Author

AKAY, EBRU, ORDU, MELIKE, ÇOBAN, GANIME, DARAKCI, SEHER, TOPALOĞLU, NAHIT, TAŞTEKIN, FILIZ MERAL, EKINCI, BÜŞRA, ŞAHIN, NURHAN, GUCIN, ZUHAL, and KARAMAN, HATICE

Abstract

The incidence and prevalence of neuroendocrine neoplasms (NENs) in many organs are increasing. Although such NENs have similar grades, they may exhibit quite different behaviors. In this multicenter study, we aimed to investigate the prevalence and distribution of different morphological NEN variants in the non-pancreatic gastrointestinal (GI) tract and determine whether they can guide prognosis prediction. Two hundred and fifty-six patients diagnosed with NENs originating from the GI tract from 7 different centers were included in the study. In 89 (36.6%) cases, different morphological variants were detected. When the variants were grouped according to their aggressiveness as described in the literature, a statistically significant relationship between aggressiveness and the variables organ and age was found (p < 0.05). The oncocytic variant was found to metastasize more than the other aggressive types (42.9%). The paraganglioma-like variant was found to have a smaller size, lower proliferation index, and a more benign clinical course. This study demonstrated that well-differentiated GI neuroendocrine tumors (GI-NETs) have considerable morphological diversity. Generally, case reports of rare morphological variants of GI-NETs are available in the literature. We believe that our study contributes to a better understanding of the prevalence, localization, and significance of morphological variations in GI-NETs. [ABSTRACT FROM AUTHOR]

Published
2024
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30. Significance of CD47 expression in endometrial carcinoma

Author

Kılıc, Gökhan, Şahin, Nurhan, Arıcı, Dilek S., Toluk, Özlem, Çoban, Ganime, Ünver, Nurcan, Tıp Fakültesi, TOLUK, ÖZLEM, KILIC, GÖKHAN, ÇOBAN, GANİME, and ŞAHİN, NURHAN

Subjects
Monoclonal Antibody, Şahin N., Çoban G., Ünver N., Arıcı D. S. , Kılıc G., Toluk Ö., -Significance of CD47 expression in endometrial carcinoma-, INDIAN JOURNAL OF PATHOLOGY AND MICROBIOLOGY, cilt.0, ss.1-4, 2022, Immunotherapy, CD47, Endometrial Carcinoma
Abstract

Objectives: CD47 is a membrane protein that belongs to the immunoglobulin superfamily and regulates macrophage phagocytosis negatively. As CD47 expression at the cancer cell membrane would inhibit the phagocytic activity of immune cells, it is connected to an unfavorable prognosis in leukemia and malignancies of various solid organs. Materials and. Methods: In this study, retrospectively evaluated 72 patients who had been diagnosed with endometrial carcinoma at Pathology Department and had undergone total abdominal hysterectomy and bilateral salpingo-oophorectomy (TAH + BSO) and/or lymphadenectomy. CD47 expression was evaluated in tumorous and nontumor areas in all patients considering cytoplasmic and membranous brown staining in cells. The proportion of expression was evaluated as well as the intensity and an "h score" was obtained. This score was compared with known prognostic parameters. Results: CD47 expressions showed a statistically significant correlation with tumor grade (P < 0.05); however, no significant relationship was observed with myometrial invasion depth and lymph vascular invasion status (P = 0.923 and P = 0.754, respectively). Conclusions: As with other tumors, anti-CD47 antibody may be an alternative treatment option in patients with high-grade endometrial carcinoma.

Published
2022

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