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Objective: We aimed to determine the efficacy of fosfomycin and ciprofloxacin combination on infectious complications in transrectal ultrasound-guided prostate biopsy (TRUGPB) prophylaxis. Methods: Patients who underwent TRUGPB between January 2018 and January 2023 were retrospectively analyzed, and 1109 patients were included in the study. Patients were divided into 2 groups according to the antibiotic prophylaxis used before the procedure: group-1, oral ciprofloxacin 500 mg (2 x 1) 5 days starting 24 hours before biopsy and group-2, oral ciprofloxacin 500 mg (2 x 1) 5 days starting 24 hours before biopsy and oral fosfomycin 3 g single dose the night before biopsy. Results: Evaluation of the antibiotic prophylaxis used by the patients before the biopsy revealed that 323 (29.1%) patients received ciprofloxacin (group 1), and 786 (70.9%) patients received fosfomycin + ciprofloxacin (group 2) prophylaxis. When infectious complications after biopsy were analyzed, 15 patients (1.4%) developed fever, 9 patients (0.8%) developed febrile urinary tract infection (UTI), 9 patients (0.8%) developed afebrile UTI, and4 patients (0.5%) developed sepsis. When infectious complications were compared according to the antibiotic prophylaxis, febrile UTI and sepsis were statistically significantly more common in group 1 (P = .003 and P = .027). Conclusion: In conclusion, adding fosfomycin to ciprofloxacin in TRUGPB prophylaxis effectively prevents post-biopsy infective complications compared to ciprofloxacin prophylaxis alone. [ABSTRACT FROM AUTHOR] more...

Copyright of Turkish Journal of Trauma & Emergency Surgery / Ulusal Travma ve Acil Cerrahi Dergisi is the property of KARE Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) more...

Copyright of Journal of Inonu University Health Services Vocational School / İnönü Üniversitesi Sağlık Hizmetleri Meslek Yüksek Okulu Dergisi is the property of Inonu Universitesi Saglik Hizmetleri Meslek Yuksekokulu and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) more...

Metabolic syndrome (MS) is composed of obesity, hyperglycemia-insulin resistance, hypertension and dyslipidemia. As a result of lifestyle changes, the incidence of MS has increased especially in Western countries. MS has become an important public health problem. For many years this disorder's cardiovascular and endocrinological relations were emphasized. But in recent years MS is found to be related with the pathogenesis of benign prostate hyperplasia/lower urinary tract symptoms, prostate cancer, erectile dysfunction, male infertility, urinary system stone disease, urinary incontinence. In this review, the role of MS in the pathogenesis of urologic disorders and the importance in urology were summarized in the light of current literature. [ABSTRACT FROM AUTHOR] more...

Copyright of Journal of Turgut Ozal Medical Center is the property of Annals of Medical Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) more...

Background: In this study, we aimed to determine the most appropriate antimicrobial agents for prophylactic antibiotic use during emergency and elective transurethral procedures., Methods: The study was conducted in five hospitals located in five different geographical regions of Türkiye. The microorganism cultured in urine before emergency and elective transurethral procedures in these centers between March 2021 and March 2022 were reviewed retrospectively from the hospital records. Demographic data (age and gender) of the patients, comorbid disorders, previous urological procedures, anomalies of the urogenital tract, use of urethral catheters (permanent or clean intermittent catheterization), cultured microorganisms, and antibiotic susceptibilities were noted. The patients hospitalized or had antibiotics for any reason in the previous 1 month were excluded from the study., Results: A total of 1450 patients, 742 men (51.2%) and 708 women (48.8%), were included in the study. The mean age of the patients was 55.3±19.36 (1-98) years. Diabetes mellitus was evident in 271 (18.7%) patients. The five most common microorgan-isms cultured in urine, in order of frequency, were: ESBL (-) Escherichia coli in 418 (28.8%), ESBL (+) E. coli in 309 (21.3%), Klebsiella pneumonia in 183 (12.6%), Enterococcus faecalis in 124 (8.6%), and Pseudomonas aeruginosa in 89 (6.1%). The susceptibility rates to antimicrobial agents recommended for prophylaxis by the American Urology Association and the European Association of Urology guidelines were found as follows: cefepime 87.1%, ampicillin+sulbactam 84%, TMP-SMX 71.6%, amoxicillin+clavulanate 63.5%, cefoxitin 59%, ceftazidime 58.6%, cefuroxime 43.5%, ceftriaxone 43%, and cefixime 38.4%., Conclusion: We found that currently recommended antimicrobials provide poor coverage for the most common pathogens isolated. Urologists should consider patient-based antibiotic prophylaxis in endoscopic urethral procedures, follow appropriate proto-cols, and consider local antibiotic resistance. more...