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Rakija od voća je jako alkoholno piće proizvedeno isključivo alkoholnom fermentacijom i destilacijom mesnatih plodova voća ili mošta od voća, bobica ili zelenih dijelova, destilirano na manje od 86 % vol. alkohola tako da ima miris i okus destilirane sirovine. Rakija od voća mora sadržavati količinu hlapivih tvari od najmanje 200 grama po hektolitru preračunato na 100 % vol. alkohola. Na temelju dobivenih fizikalnih i kemijskih parametara, koji u potpunosti zadovoljavju kriterije Pravilnika o jakim alkoholnim pićima, zaključuje se da je za proizvodnju destilata korištena kvalitetna sirovina u odgovarajućem stadiju zrelosti, te da je proces ukomljavanja, fermentacije i destilacije pravilno vođen. Odležavanjem rakije od jabuka kroz šest mjeseci došlo je do smanjenja udjela metanola i etil-acetata, dok je udio ostalih hlapive komponenata rastao, što je u konačnici utjecalo i na veći udio ukupnih hlapivih komponenti u finalnom proizvodu. Nadalje, praćenjem utjecaja šestomjesečnog dozrijevanja rakije u hrastovoj bačvi te na temelju analiza, zaključujemo da se odležavanjem dobiva kvalitetan finalni proizvod. Fruit brandy is a strong alcoholic drink produced exclusively by alcoholic fermentation and distillation of fleshy fruits or most of fruit, berry or green parts, distillled to less than 86 % alcohol by volume so that it has the smell and taste of the distilled raw material. Fruit brandy must contain a quantity of volatile substances of at least 200 grams per hectoliter converted to 100 % alcohol by volume.Based on the obtained physical and chemical parameters, wich fully meet the criteria of the Ordinance on strong alcoholic beverages, it is concluded that high-quality raw material at the appropriate stage of maturity were used for the production of distillate, and that the process of chopping and storing fruit, fermentation and distillation was properly managed. Ageing the apple brandy for six months resulted in a decrease in the proportion of methanol and ethyl acetate, while the proportion of other volatile components increased, which ultimately had an effect on the higher proportion of total volatile components in the final product. Furthermore, by monitoring the influence of the six-month maturation of brandy in an oak barrel and based on analyses, we conclude that ageing results in a high-quality final product.

Rakija od voća je jako alkoholno piće proizvedeno isključivo alkoholnom fermentacijom i destilacijom mesnatih plodova voća ili mošta od voća, bobica ili zelenih dijelova, destilirano na manje od 86 % vol. alkohola tako da ima miris i okus destilirane sirovine. Rakija od voća mora sadržavati količinu hlapivih tvari od najmanje 200 grama po hektolitru preračunato na 100 % vol. alkohola. Na temelju dobivenih fizikalnih i kemijskih parametara, koji u potpunosti zadovoljavju kriterije Pravilnika o jakim alkoholnim pićima, zaključuje se da je za proizvodnju destilata korištena kvalitetna sirovina u odgovarajućem stadiju zrelosti, te da je proces ukomljavanja, fermentacije i destilacije pravilno vođen. Odležavanjem rakije od jabuka kroz šest mjeseci došlo je do smanjenja udjela metanola i etil-acetata, dok je udio ostalih hlapive komponenata rastao, što je u konačnici utjecalo i na veću udio ukupnih hlapivih komponenti u finalnom proizvodu. Nadalje, praćenjem utjecaja šestomjesečnog dozrijevanja rakije u hrastovoj bačvi te na temelju analiza, zaključujemo da se odležavanjem dobiva kvalitetan finalni proizvod.

A beneficial effect of acetylsalicylic acid (ASA) on vein graft patency has been described, but some patients experience adverse cardiac events despite appropriate ASA treatment. Study aim was to define ASA resistance using Multiple electrode aggregometry (MEA) preoperatively in group of patients undergoing coronary artery bypass grafting (CABG). Prospective observational trial at University Hospital Center Zagreb enrolled 131 patients scheduled for CABG, and divided them into 4 groups with respect to preoperative antiplatelet therapy (APT). Group 1 received 100 mg ASA per day, Group 2 100 mg ASA + 75 mg clopidogrel per day, Group 3 75 mg clopidogrel per day, and Group 4 did not receive any APT. MEA with ASPI test (sensitive to ASA) and ADP test (sensitive to clopidogrel) was performed prior to surgery. In Group 1, patients were characterized as ASA resistant if their ASPI test value exceeded the 75th percentile distribution. Study enrolled 131 patients. Significant differences both in the ASPI (p < 0.001) and the ADP test (p = 0.038) were observed between patients in different APT groups. In Group (1) ASPI test value of 30 AUC presented 75th percentile of distribution, thus indicating ASA resistance. Group 2 patients had slightly lower ADP test values, but no significant difference occurred (mean 60.05 vs. 63.32 AUC, p = 0.469). In Group 1 and 2, significant correlations between the ADP test and both, platelet count (r = 0.347, p < 0.001) and fibrinogen level (r = 0.364, p < 0.001) were observed. Association between low response to ASA and post-CABG major adverse ischemic events risk increase has been described thus indicating need for ASA resistant patients detection. In patients with preoperative ASPI test exceeding 30 AUC postoperative, ASA dose adjustment or clopidogrel addition according to MEA results should be considered.

Tvrtka Welplast utemeljena je 1983. godine i trenutno je vodeća tvrtka u završnoj preradi polimernih materijala (polietilen PE i polipropilen PP) na prostoru BIH i Republike Hrvatske odnosno na prostorima jugoistočne Europe.

Early post coronary artery bypass hyperactivity, assessed by whole blood impedance aggregometry, indicates dual antiplatelet therapy.

Acute aortic dissection bears all the stigmata of a true clinical emergency. The natural history of this acute aortic syndrome warrants prompt surgical intervention, with only a few absolute contraindications to this line of treatment. We present a 74-year-old man with documented metastatic prostate cancer who underwent emergent surgery for acute Stanford A aortic dissection. Having acknowledged the relatively favorable evolution of our patient's malignant disease, we were not deterred by its presence from pursuing surgical treatment of his aortic dissection.

Beside multiple clinical benefits, cardiac resynchronization therapy (CRT) is linked to 30% of non-responders, due to the underlying disease not being influenced by the electrical therapy, or suboptimal therapy delivery. In case of inadequate coronary veins anatomy or failed coronary sinus lead placement, mini-thoracotomy is advocated as an alternative approach. It is known that CRT induces acute changes in haemodynamics and that lead placement can influence the amount of response. While TEE is regularly used during valve surgery, little attention is paid to using echo guided CRT implantation and monitoring acute response of differential LV lead positioning. 10 patents (3F/7M, 54±14 years) referred for surgical CRT implantation via a mini-thoracotomy were analyzed. Intraoperative TEE including Doppler myocardial imaging data were acquired pre- and post-CRT device activation. The right atrial and ventricular leads were placed transvenously, the LV screw-in lead was positioned epicardially on the lateral wall via an anterolateral mini-thoracotomy. Selective LV lead pacing was performed on 4 sites (basal and apical anterior/posterior wall), analysing acute changes in LV dimensions, mechanics and haemodynamics. Optimisation criteria included the septal flash reduction, the decrease in end-systolic volume (LVESV) and the increase in dP/dt and EF. The septal flash was defined as an early inward and outward ventricular septal motion within the isovolumic contraction period, imaged by gray-scale or Tissue Doppler colour (anatomical) M-mode. dP/dt was measured from the mitral regurgitation CW Doppler traces. Reverse remodelling was defined as a reduction of LVESV ≥10%. Assessing the acute response to CRT was feasible in all patients. The LV pacing site with optimal response was the basal anterior wall (50% of pts), followed by the basal posterior (30% of pts), apical anterior and apical posterior wall (10% of pts each). Such LV lead positioning lead to a significant LVESV reduction (172±91 ml vs.136±75 ml, p=0.0003) and EF increase (22±9% vs. 32±8%, p=0.0001) immediately following pacemaker activation, with reverse LV remodelling and septal flash resolution occurring in all patients. A significant increase of post-implantation dP/dt was also noted in all patients (333.5±64.4 mmHg/s vs. 633.6±196.9 mmHg/s, p=0.001). Conclusion: Intraoperative echocardiography is a feasible tool which can be used to assess acute response to CRT and to guide optimal LV lead placement based on septal flash reduction and increase in dP/dt, leading to immediate LV reverse remodelling.

Early post coronary artery bypass grafting platelet hyperactivity, assessed by whole blood imnpedance aggregometry, indicates dual antiplatelet therapy

Na ovom posteru je prikazan rezultat implantacije CRT uređaja navođenjem implantacije elektrode za lijevi ventrikul pomoću transezofagijske ehokardiografije.

Effect of Oseogenetic Protein-1 (OP-1) on Survival Rate and Glomerular Filtration Rate in Rats With Chronic Renal failure.

U otkrivanju nastalih deformacija, pukotina, lomova kao i u procjeni preostalog vijeka trajanja dijelova energetske opreme, osim nerazornih važna su i ispitivanja uz razaranje materijala. Analize mikrostrukture cijevi peći za pirolizu pokazuju da tijekom rada na visokim temperaturama dolazi do bitnih promjena u strukturi i svojstvima materijala. Nekontrolirani procesi pougljičavanja dovode do taloženja koksa na stijenke cijevi što dovodi toplinskih naprezanja. Zbog toga i pojave puzanja materijala nastaju radijalne mikronapukline i pukotine. Napukline napreduju po granicama zrna gdje su lančasto izlučeni karbidi. Polazno austenitna struktura mjestimično je promjenila karakteristike - pojava delta ferita i sigma faze, koji zajedno sa karbidima unutar i po granicama zrna smanjuju duktilnost materijala. Ispitivanjem mehaničkih svojstava cijevi koje su bile u radu 5 i 7 godina utvrđen je bitan pad istezljivosti što je posljedica strukturnih promjena. U radu se predlaže primjena vatrootpornih ljevova boljih svojstava od postojećeg.