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The article presents simulation modeling as a mathematical basis for the study of logistic systems. The object is pharmaceutical logistics - logistics chains of pharmaceutical companies. Attention is focused on the problems of functioning of domestic pharmaceutical logistics in the conditions of military realities. The expediency of using simulation modeling technologies to reproduce the changing, force majeure conditions of functioning of the supply channels of finished pharmaceutical products is substantiated. Models of one-level and two-level sales channels for pharmaceutical products, built using the discrete-event simulation paradigm on the software platform of the AnyLogic system, are presented. The results of the simulation are illustrated by fragments of simulation experiments based on the materials of the pharmaceutical company FARMAK. [ABSTRACT FROM AUTHOR]