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An unprecedented on its scale Ebola fever epidemic, caused by Zaire ebolavirus, has been registered in the territory of West Africa in 2014-2015. The virus quickly spread from the Republic of Guinea into the neighboring countries. Presented are the results of comparative analysis between three Zaire ebolavirus genomes, the complementary DNA of which was obtained from the samples from Ebola fever patients in the Republic of Guinea in 2014. The nucleotide sequences of the genomes received have allowed for identification of phylogenetic affinity to certain references, displayed in the database of NCBI GenBank. General phylogenetic analysis by means of representative sampling has revealed two trends of genome evolutionary development from one and the same ancestral form. The first branch of evolution is represented by a relatively small number of Zaire ebolavirus isolates, disseminated in Guinea. The second one, the most numerous trend, is generated by four variants of Zaire ebolavirus genome, which have been identified starting from May - early June, 2014 in Sierra-Leone, but within a short period of time they have won the whole territory of the country and the neighboring Guinea and Liberia.