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Background and Objective: All organisms for managing behaviors require to use of cognitive patterns of the central and peripheral nervous system. This study was done to compare the metacognitive beliefs and tolerance of ambiguity in depressed, anxious and normal people. Methods: This descriptive-analytic study was done on 120 depressed, anxious and normal people depressed, anxious and normal people in psychiatric clinic of Zare hospital in Sari city north of Iran during 2017. To measure ambiguity in depressed, anxious and normal people the tolerance for ambiguity scale of lane, wells metacognitive scale, Beck anxiety inventory (BDI) and Beck depression inventory (BDI) were used in this study. Results: Tolerance of ambiguity significantly increased in depressed and anxious groups in comparison with controls (P<0.05). Positive worry beliefs significantly reduced in depressed group in comparison with controls (P<0.05). Negative meta-cognitive beliefs about the thoughts and metacognitive beliefs significantly reduced in depressed group in compared to control group (P<0.05). Conclusion: This study emphasized the extent of anxiety and depression disorders in relation to ineffective metacognitive problems. These ineffective beliefs can cause a decrease in psychological tolerance. [ABSTRACT FROM AUTHOR]