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Background and purpose: Cough, hoarseness, and sore throat are complications of intubation. The aim of this study was to evaluate the effect of gargling with honey and lemon water on cough, sore throat, and hoarseness after extubation of endotracheal tube following surgery. Materials and methods: A clinical trial was carried out in 110 patients undergoing surgery in Neyshabur 22 Bahman Hospital, Iran 2020. They were selected using convenience sampling and randomly allocated to experimental or control group. In experimental group, 6 hours after surgery, 30 cc of honey lemon water was gargled, three times, every two hours and then swallowed. The control group received routine care. Postoperative sore throat, cough, and hoarseness were assessed before the intervention, and 12 and 24 hours after extubation of endotracheal tube. Data were analyzed by independent t-test and repeated measures analysis of variance. Results: Findings showed no significant difference between the two groups in cough and sore throat 12 hours after extubation, but the score for hoarseness was lower in experimental group (P= 0.05). Twenty-four hours after extubation, cough (P= 0.001), hoarseness (P= 0.006), and sore throat (P= 0.023) were significantly lower in experimental group. The passage of time was found to significantly affect all three variables (P<0.001). Conclusion: Considering the positive effects of gargling with honey and lemon water in reducing the complications of endotracheal tube and no side effects, it is recommended to be used after extubation. [ABSTRACT FROM AUTHOR]