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Copyright of Guangdong Medical Journal is the property of Guangdong Medical Journal Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of China Rural Water & Hydropower is the property of China Rural Water & Hydropower Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

糖尿病足是糖尿病最严重的并发症之一，治疗费用高，预后较差。近年来，以肠促胰素 为基础的降糖药物已成为2型糖尿病的重要治疗策略。既往研究表明，肠促胰素类药物具有抗炎、抗 氧化、促进血管生成和增强组织重塑的作用，这表明其对糖尿病创面愈合有潜在的益处。同时，部分 肠促胰素类药物已被证明具有抗动脉粥样硬化和神经保护作用，故肠促胰素类药物可能成为难治性 糖尿病足溃疡新的辅助治疗策略。该文对肠促胰素类药物在糖尿病足创面愈合中的潜在作用及机制 进行综述。 [ABSTRACT FROM AUTHOR]

Objective To investigate the effect and mechanism of microRNA-125a-5p (miR-125a) on the prolifera⁃ tion of nasopharyngeal carcinoma cell line HK-1. Methods Human nasopharyngeal carcinoma cells (HK-1 cells) and human embryonic kidney immortalized cells (293T cells) were cultured routinely. HK-1 cells were randomly divided into the control group 1, miR-125a overexpression group (transfected with miR-125a mimics), and miR-125a silencing group (transfected with miR-125a inhibitor). Some cells were further divided into the control group 2, miR-125a overexpression group (transfected with miR-125a mimics), and rescue group (transfected with miR-125a mimics and TAZ overexpression simultaneously). The transfection efficiency was verified by detecting miR-125a expression at 48 h after transfection. RTqPCR was used to detect the expression levels of miR-125a-5p and TAZ mRNA, while Western blotting was used to detect TAZ protein expression. Cell proliferation capacity was assessed using the CCK-8 assay and colony formation assay. Tar⁃ getScan and miRDB prediction websites were used to predict the binding site of miR-125a and TAZ. The 293T cells were divided into four groups： WT+miR-ctrl group (co-transfected with TAZ wild-type and miR-ctrl), Mut+miR-ctrl group (cotransfected with TAZ mutant and miR-ctrl), WT+miR-125a group (co-transfected with TAZ-WT and miR-125a mimic), and Mut+miR-125a group (co-transfected with TAZ-MUT and miR-125a). Dual-luciferase reporter gene experiments were conducted to further validate the downstream target of miR-125a. Results There were significant differences in the rela⁃ tive expression levels of miR-125a among the control group 1, the miR-125a overexpression group, and the miR-125a si⁃ lencing group (all P<0. 05). Statistically significant differences were found in the proliferation activity (OD450 values) on the 2nd, 3rd, 4th, 5th, and 6th days after transfection and colony formation numbers in the control group 1, miR-125a overexpression group, and miR-125a silencing group (all P<0. 05). There was significant difference in the relative expres⁃ sion level of TAZ protein among the control group 1, miR-125a overexpression group, and miR-125a silencing group (all P <0. 05). Website prediction indicated the existence of binding sites between miR-125a and TAZ, and mutated sequences (TAZ-3’UTR MT) were designed. MiR-125a directly targeted TAZ in the non-coding region. The relative fluorescence in⁃ tensity of the WT+miR-125a group was lower than those of the WT+miR-ctrl group and the Mut+miR-ctrl group (both P< 0. 05), while there was no significant difference in relative fluorescence intensity among the WT+miR-125a group, WT+ miR-ctrl group and the Mut+miR-ctrl group (all P>0. 05). Statistically significant differences were found in proliferation activity on the 2nd, 3rd, 4th, 5th, and 6th days after transfection and colony formation numbers between the control group 2, miR-125a mimics group, and miR-125a mimics+TAZ group (all P<0. 05). Conclusion MiR-125a can inhibit the proliferation of nasopharyngeal carcinoma cells, and its mechanism of action is related to the inhibition of its downstream target TAZ expression. [ABSTRACT FROM AUTHOR]

Copyright of Pearl River is the property of Pearl River Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Urban Architecture & Development is the property of Omniscient Pte. Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of China Rural Water & Hydropower is the property of China Rural Water & Hydropower Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of China Rural Water & Hydropower is the property of China Rural Water & Hydropower Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Wool Textile Journal is the property of National Wool Textile Science & Technology Information Center and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Northwest A & F University - Natural Science Edition is the property of Editorial Department of Journal of Northwest A&F University (Natural Science Edition) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Wind turbines have been widely applied to convert the kinetic energy of wind into electrical energy. Among them, the yaw system of wind turbine is the one of the most important components to rotate the rotor optimally into the wind direction. However, the load fluctuation has posed a great challenge on the safety and reliability of yaw system. This study aims to clarify the influence of the low-level jet (LLJ) on the structural loads of the wind turbine. The harmonic superposition was firstly used to generate the atmospheric turbulence using the LLJ wind speed spectrum and a jet model. Then, the power and thrust were calculated for a 15 MW wind turbine using the blade element momentum (BEM) and geometrically exact beam theory (GEBT). The numerical accuracy was also validated against the theoretical values. It was found that the overall numerical error was less than 10%, where the numerical error below the rated wind speed was less than 5%. A systematic analysis was made to determine the power performance, rotor yaw moment, rotor pitch moment, and tower foundation moment in the 15 MW wind turbine under different LLJ conditions. The results showed that two coupling effects of the jet and strong shear were identified in the height range of the wind turbine. Specifically, the dominant type was changed with the jet height. Once the jet height was lower than the hub height, the dominant type was the jet; when the jet height was higher than the hub height, the dominant type was the strong shear. Correspondingly, the rotor power, rotor pitching moment, and rotor yaw moment of the LLJ increased by about 40%, 50%, and 1.5 times than before, respectively. The fluctuation intensity of the yaw moment for the tower base also increased by 60% of the loads in the condition of the LLJ spectrum. Therefore, the regions with the frequent LLJ streams needed to be considered for the design of the yaw bearings, tower foundations, and components of wind turbine. At the same time, the power spectrum characteristics of the rotor yaw and pitch moment were distributed in a double-staircase type, which was mainly divided into a decreasing and a secondary increasing stage. Among them, the secondary increasing stage was caused by the coupled response of multi-scale frequency in the atmospheric turbulence and the rotational frequency of wind turbine. When the jet height was lower than the hub height of wind turbine, the pitching moment of the rotor caused the wind turbine to tilt downward. There was the risk of the wind turbine blades hitting the tower. A full consideration was also made to determine the impact of the LLJs on the structural load characteristics, when installing the high-rise structures, such as the wind turbines in the areas with the frequent LLJs. Finally, there was the anisotropic Reynolds stress in the incoming flow. A strong response of the tower base moment was then observed at different frequencies in the corresponding time period. The larger moment fluctuation was posed a threat to the yaw direction of the tower base. Specifically, the maximum moment fluctuation was about 60% higher than that in the Kaimal spectrum. Therefore, controlling the fluctuation characteristics of tower load in the yaw direction can greatly contribute to the less impact on the fatigue characteristics of wind turbines in the regions with the frequent LLJs. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Northwest A & F University - Natural Science Edition is the property of Editorial Department of Journal of Northwest A&F University (Natural Science Edition) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Forest Engineering is the property of Forest Engineering Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Diabetes Mellitus is the property of Chinese Journal of Diabetes Mellitus and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Acta Prataculturae Sinica is the property of Acta Prataculturae Sinica Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Agricultural Science & Technology (1008-0864) is the property of Journal of Agricultural Science & Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Evaluation & Analysis of Drug-Use in Hospitals of China is the property of Evaluation & Analysis of Drug-Use in Hospitals of China Editorial Board and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Yellow River is the property of Editorial Board of Yellow River and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Southern Yangtze University: Humanities & Social Sciences Edition is the property of Jiangnan Daxue and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of International Reproductive Health/Family Planning is the property of Editorial Board of the Journal of International Reproductive Health/Family Planning and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Applied Ecology / Yingyong Shengtai Xuebao is the property of Chinese Journal of Applied Ecology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

营养不良是慢性阻塞性肺疾病（ＣＯＰＤ）患者常见的临床症状之一，是影响预后的一个独立危险因素。 ＣＯＰＤ营养不良与年龄、性别、婚姻状况以及缺氧、胃肠道功能下降、能量消耗增加、体液因子改变等多种因素有关，且ＣＯＰＤ与营养不良相互影响，严重者形成恶性循环。正确评价ＣＯＰＤ患者的营养状况，并给予科学合理的营养支持，可以改善患者的呼吸肌肌力、肺功能、免疫防御功能等，提高患者的生活质量，改善预后。 [ABSTRACT FROM AUTHOR]