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The data obtained from the breeding environment has defects such as blurring and occlusion, rendering poor detection of the farmed fish. To solve the above problem,the farmed fish detection model ESBYOLO( ECBAM-SPPF-BiFPN-YOLO),based on a non-channel-downscaling attention mechanism(ECBAM) and improved YOLOv5,is proposed. ECBAM is adopted to obtain more detailed features. To alleviate the slowdown of detection speed caused by adopting ECBAM,SPPF is used to replace SPP to reduce model computation,decrease model detection time,and improve detection speed. BiFPN is used to perform weighted feature fusion to enhance feature fusion by increasing the proportion of functional features and reducing feature loss. To verify the effectiveness of the proposed modified module for YOLOv5,ablation tests were designed. The test results show that the average precision of ESB-YOLO is improved by 2. 40% compared with YOLOv5 while maintaining a similar detection speed. To demonstrate the competitiveness of ESB-YOLO,comparison tests were designed. Compared with advanced underwater object detection models such as FERNet,SWIPENet,and SK-YOLOv5,the average precision of ESB-YOLO is 3. 10%,3. 90%,and 0. 70% higher,respectively. The study shows that the proposed model is more effective and capable of farmed fish detection. [ABSTRACT FROM AUTHOR]

An “off-on” fluorescence probe (4a) based on N，N- (dimethylamino) naphthalenyl flavone (3) is designed and synthesized for detection of butyrylcholinesterase (BChE) by using resorcinol as starting materials. The structure of the probe is identified by nuclear magnetic resonance spectroscopy (NMR) and high resolution mass spectrometry (HRMS) . The results show that probe 4a could react rapidly and specifically with BChE， and its fluorescence intensity increases obviously at 574 nm in PBS of pH 8. 0. Meanwhile， the color change of the solution can be seen by naked eyes. The response mechanism is explored through high performance liquid chromatography (HPLC) and HRMS. The results reveal that BChE catalyzes the cleavage of the ester bond， and strongly fluorescent flavone 3 is released. In addition， probe 4a could be used for fluorescence imaging of BChE in living human hepatocellular carcinoma (HepG2) cells. [ABSTRACT FROM AUTHOR]

Soil surface water content, which exists at the land air interface, is an important variable to simulate the global hydrological, energy and carbon cycles and their interactions, and is crucial for climate and earth system research. In order to evaluate the accuracy and applicability of the soil moisture products of FY-3B, FY-3C and AMSR2 in Xilingol grassland and different land cover types, authors applied time series correlation (R), root mean square error (RMSE), the average deviation (Bias) and unbiased root mean square error (ubRMSE) were to analyze the reliability on these three grid products. The results showed that: (1) on a daily scale, FY-3B and FY-3C soil moisture products overestimated the land surface water content, while AMSR2 underestimated the soil water content. Each evaluation index showed that the three soil water content products can capture the time change trend of surface soil water content in Xilingol grassland. (2) On a monthly scale, compared with AMSR2, the monthly distribution of FY-3B and FY-3C soil moisture products was more consistent with the measured soil moisture distribution. (3) In the growing season scale, the three satellite soil moisture products reflected the soil moisture status of each grassland subtype. FY-3B and FY-3C soil moisture products had good applicability in areas with high vegetation coverage, AMSR2 had good reliability in areas with low vegetation coverage, and the three products had complementary functions in monitoring soil moisture. FY-3B had the best consistency with the change trend of in-situ soil water content, FY-3B and FY-3C can better reflect the variation of soil moisture in the west and east of the study area, and AMSR2 can well capture the variation of soil moisture in the middle of the study area. [ABSTRACT FROM AUTHOR]

目的　总结黑斑息肉综合征（PJS）的有效诊断及治疗方法，为该病的临床诊治提供参考。方法　对 1例 PJS患者的临床资料进行回顾性分析。结果　该患者为16岁男性，因“腹痛伴黏液血便2 d”入院。患者有典型口唇 及鼻周黑斑，以肠套叠为主要首诊症状，接受急诊剖腹探查术并切除病变段结肠，病理提示错构瘤性息肉，基因检测 证实存在丝/苏氨酸蛋白激酶（STK11）突变，本例患者排除阳性家族史。结论　皮肤黏膜黑斑、胃肠道多发性息肉 及家族遗传史可诊断为 PJS，定期内镜监测胃肠道息肉状况有助于减少该类患者急腹症的发生及降低息肉癌变风 险，内镜下息肉切除和（或）外科手术切除为其有效治疗方法。 [ABSTRACT FROM AUTHOR]

Osteoarthritis (OA) is a common clinical chronic degenerative disease caused by the degeneration and loss of articular cartilage, which brings a heavy medical burden to patients and the country. The in-depth study of its mechanism is conducive to strengthen the treatment of OA. Recent studies have found that wingless type MMTV integration site family member 5A (Wnt5a) gene plays an important role in the pathogenesis and progress of OA. It can affect the independent pathogenesis of OA, such as aging, metabolic obesity, and trauma, and can participate in it through classical and non-classical Wnt signaling pathways. This paper reviews the role and mechanism of Wnt5a gene in OA, so as to provide benefit for related research. [ABSTRACT FROM AUTHOR]

Osteoarthritis (OA) is a chronic degenerative disease caused by aging, obesity, trauma, heredity and other factors, which is a difficult disease faced by orthopedic doctors in clinic, and brings a heavy burden to patients and families. Resveratrol is a natural compound with anti-inflammatory and antioxidant effects. It can affect cartilage aging, cartilage matrix metabolism, and cartilage injury in participate in the process of OA, which might be related to NF-KB, TLR4 and ERK signaling pathway. This paper reviews the research progress of resveratrol in the process of OA and its possible mechanism, so as to facilitate relevant research. [ABSTRACT FROM AUTHOR]

Cartilage injury is caused by inflammation, trauma, and tumor. Due to the anatomical factors of articular cartilage, its healing ability is poor. The preparation of tissue engineering materials to promote the repair of cartilage injury has attracted much attention. Magnesium and magnesium materials have attracted extensive attention because of their good biosafety, biocompatibility, degradability, and availability. They play an important role in the repair of cartilage injury such as osteoarthritis. This paper reviews the role and mechanism of magnesium and magnesium materials in the repair of articular cartilage injury. [ABSTRACT FROM AUTHOR]

Entity relation extraction is a fundamental task to detect a list of triplets, including two entities and the semantic relations between them. An overlapping relationship has caused the low performance of standard entity relation extraction in fishery in recent years. In this study, a novel entity relation extraction was proposed in fishery using the dual attention mechanism. First, a sentence classification and labeling strategy were selected to solve the difficulty in labeling overlapping relations in fishery standard texts. Second, an extraction model of standard entity relationship was established using a combination of dual attention, and Bidirectional Encoder Representations from Transformers-Bi-directional Long Short-Term Memory-Conditional Random Field (BERT-BiLSTM-CRF). Five components were included from the bottom to top: BERT layer, BiLSTM layer, word attention mechanism, sentence attention, and CRF output layer. In the pre-trained BERT model, the dual-layer two-way conversion and decoding were used to automatically learn sentence features for the vector representation. In the BiLSTM model, the context feature of the target entity was learned from the BERT output. The word and sentence level attention was utilized to optimize the weight of target words and sentences in the paragraph, including the noise removal, and the accuracy of relationship extraction. The CRF decoder was used to represent the output of the attention layer in the form of sequence tags. Finally, a comparative experiment was designed to verify the effectiveness of the model. The results show that better overall performance was achieved in the entity relationship extraction using the dual attention on the fishery standard interaction (DLOU-FSI) dataset, where the accuracy, recall, and F1 value were 92.67%, 92.31%, and 92.49%, respectively. The overlapping relations were effectively solved in the extraction of fishery standard relations. In addition, the recognition accuracy rates in the seven relation categories were all higher than others. The accuracy rate, recall rate, and F1 value were greatly improved by more than 90% in the quotation relationship, regulation, release, proposal, drafting, and centralization. Nevertheless, the recall rate of the improved model was dropped slightly in the comparison test. The reason was that there was a sparse distribution of sentence samples in the related category of comparative relations. In the DLOU-FSI corpus, each standard text of fishery contained only 0-3 comparison relation triples, less than 1% of the total number of all relational triples. As such, the comprehensive relationship features were necessary to learn for the higher recognition in the relationship extraction task. In addition, the quality of corpus was determined on the extraction of fishery standard text relations. The higher quality and the more accurate recognition of the model were achieved, as the deep learning model was trained to learn more data. There was also a critical value, after which the model cannot be greatly improved. In the case of a model adaptation, the test data can be effectively expanded to increase the number and diversity of samples for a better overall effect of relationship extraction. This finding can lay a significant foundation for the construction of fishery standard knowledge graphs. [ABSTRACT FROM AUTHOR]

Fishery information service is a vital component to realize data analysis, feature extraction, and fishing forecasting, particularly for a high comprehensive production capacity and modernized management in fishery. The commonly-used keyword matching without standard contents cannot meet the high demand for accurate service in the current information system of fishery. The standard quantitative indicators in fishery have become one of the most important tasks in the information service. Therefore, it is very necessary to accurately identify the effective standard quantitative indicators for the automatic extraction of fishery. Combining the attention mechanism and the BERT+BiLSTM+CRF (Bidirectional Encoder Representations from Transformers + Bi-directional Long Short-Term Memory + Conditional Random Field) model, this study aims to propose a highly accurate recognition method of standard quantitative indicators in fishery, further to replace the commonly-used entity recognition. The quantitative indicators were firstly divided into four types of entities: the indicator name, indicator value, unit, and qualified words for identification. This operation effectively dealt with the difficult identification of fishery standard quantitative indicator entities. It was found that the location information behaved a significant impact on the recognition of indicator names and other entities. Vector data was also utilized to improve the recognition of indicator names. Secondly, the BiLSTM model was used to learn the semantic features of long sequences in the fishery standard text quantitative indicators. The attention mechanism was then integrated to treat the long-sequence semantic dilution. Finally, all sequence tags were obtained through the CRF layer. The test results showed that the accuracy rate was 94.51%, the recall rate was 96.37%, and the F1 value was 95.43% for the fusion attention mechanism and the BERT+BiLSTM+CRF model. Compared with the fusion attention + BiLSTM + CRF (named entity recognition model), the accuracy, recall rate, and F1 value increased by 2.78, 6.73, and 4.65 percentage points, respectively. The word vectors, position vectors, and sentence features were combined for better recognition in the model. The self-attention mechanism of the BERT model was pre-trained, where a bidirectional encoder was used for the transformer layer in the BERT model, indicating a better performance on the text context memory. Compared with the BERT+BiLSTM+CRF model, the accuracy, recall, and F1 value increased by 1.62, 0.25, and 0.97 percentage points, respectively, indicating that the attention mechanism contributed to the greater weight of the target entity in the long- and short-term memory network. The features were then weighted to make the model more accurately identify quantitative indicators. The proposed model can be expected to more accurately identify the fishery standard quantitative indicators, especially the indicator names, indicator values, units, qualifiers. This investigation can provide promising data support to accurate information using standard content services. The effective fishery standard quantitative index can also offer new ideas for the identification of quantitative indicator named entities in agricultural, medical, and biological fields [ABSTRACT FROM AUTHOR]

Objective To investigate the pathology, clinical features, population features, and etiology of non - viral hepatitis - related abnormal liver function in the elderly. Methods A retrospective analysis was performed for 50 elderly patients, with abnormal liver function as disease onset for the first time, who were hospitalized and treated in Beijing YouAn Hospital, Capital Medical University, from January 2017 to September 2019. Abnormal liver function was defined as elevated alanine aminotransferase (≥2 x upper limit of normal), with or without the increases in the serum levels of aspartate aminotransferase, total bilirubin, alkaline phosphatase, and gamma - glutamyl transpeptidase, and there was no limit for the duration of abnormal liver function. According to the method for obtaining pathological specimens, the patients were divided into percutaneous liver biopsy group and transjugular liver biopsy group. The etiology of abnormal liver function was analyzed, and clinical features and laboratory markers were summarized. The t - test was used for comparison of normally distributed continuous data between two groups, and the Mann - Whitney U test was used for comparison of non - normally distributed continuous data between two groups; the chi - square test was used for comparison of categorical data between two groups. Results A total of 50 patients were enrolled, with a mean age of 64. 7 ±3. 7 years, and there were 19 male patients and 31 female patients. Of all patients, 21 underwent transjugular liver biopsy and 29 underwent percutaneous liver biopsy . Pathological examination showed that 20 patients (40.0%) were diagnosed with drug - induced liver injury, among whom 3 had autoimmune phenomena, 1 had liver failure, and 4 had hepatic veno - occlusive disease/ hepatic sinusoidal obstruction syndrome; 5 patients (10. 0%) were diagnosed with autoimmune liver disease, among whom 3 had primary biliary cholangitis and 2 had autoimmune hepatitis (1 patient already had liver cirrhosis); 4 patients (8. 0%) were diagnosed with nonalcoholic fatty liver disease. The etiology was not determined for 16 patients (32. 0%), among whom 8 had liver cirrhosis, 6 had hepatitis, and 2 had bile duct disease. In addition, there were 2 patients with non - cirrhotic portal hypertension (4. 0%), 1 patient with amyloidosis (2. 0%), and 2 patients with liver failure (4.0%). Conclusion Drug - induced liver injury has the highest incidence rate among non - viral hepatitis - related abnormal liver function in the elderly, which is often associated with the use of drugs for chronic diseases and Chinese patent drugs. Transjugular liver biopsy may help to determine the etiology of severe liver diseases. [ABSTRACT FROM AUTHOR]

Objective: To test the protection effect of PEA and to explore the possible mechanism. Methods: The male SD rats were divided into three groups: sham operation group, model group and treatment group.The models of middle cerebral artery occlusion were established with the suture method. The rats of treatment group were received PEA (10 mg/kg i.p.) 30 min and 4h after ischemia. 24 h after the reperfusion, neurological deficit was scored, and then removed their brains. TTC staining was applied to quantify infarction volume. Xanthine oxidase method was usedto test the activity of SOD and the malondialdehyde (MDA) content were measured by the method of thiobarbituric acid reaction (TBA). The protein of Bcl-2 and Bax were tested by Western Blot analysis. Results: In our study, neurological function score of treatment group was 1.33± 0.49. and model group's was 2.20± 0.41. And we also measured the infarct volume of model group(243.40± 14.19 mm3) and treatment group(l 14.00± 8.63 mm3). So cmpared with model group, the neurological deficit scores and infarction volume of treatment group were significantly decreased (P<0.05). The MDA content of treatment group was 3.85± 0.29 nmol/mg prof, and model group's was 4.85± 0.30nmol/mg prot. The SOD activity of treatment group was 13.95± 0.71 U/mg prof, and model group's was 12.44± 0.40 U/mg prot. So compared with model group, the activity of SOD of treatment group increased significantly and the content of MDA decreased (P<0.05). hi the treatment group, the ratio of Bcl-2 protein content to (3-action protein content was 0.53± 0.013 %, and the ratio of Bax protein content to (3-action protein content was 0.54± 0.012 %. In the model group, the ratio of Bcl-2 protein content to (3-action protein content was 0.40± 0.012 %.and the ratio of Bax protein content to (3-action protein content was 0.80± 0.012 %. Compared with model group, the content of bcl-2 in treatment group increased significantly and the content of Bax was decreased significantly (P<0.05). Conclusion: The cerebral ischemia reperfiision injury was significantly reduced by PEA administration. PEA had the protect effect on cerebral ischemia reperfiision from antioxidant and anti-apoptosis. [ABSTRACT FROM AUTHOR]

Objective: To investigate the effect of Atorvastatin Calcium Tablets combined with probucol treatment on the stability of carotid artery plaque and the change of blood flow change in arteriosclerosis rabbits. Methods: 40 male Japanese big ear rabbits were selected, and randomly divided into normal group, model group, experimental group, and control group, 10 rats in each group. The rabbits were replicated the model of carotid atherosclerosis. When the model was established successfully, the control group were treated with atorvastatin calcium 10 mg/(kg · d) dose for rabbits, according to the different weight to different doses of drugs, diluted with saline to 5 m L by gavage, and the rabbits of the experimental group was based on the use of control group, added with Probucol Tablets 0.25g/(kg · d) together diluted with saline to 5 mL gavage. The rabbits in the model group and normal group were given 5 m L saline gavage. The intervention lasted for 4 weeks. Ultrasound of carotid artery were performed on rabbits with animal ultrasound imaging system,degree, color Doppler flow imaging and vascular imaging to detect the stenosis of carotid artery, the blood flow velocity, and the changes of hemodynamics. Results: After the treatment, Atorvastatin Calcium Tablets combined with probucol treatment in the experimental group could improve the carotid intima-media thickness, and plaque area, and increase the number of stable plaque, and the difference was statistically significant compared with that of model group(P< 0.05). The carotid artery was normal in normal group, and after treatment, the stenosis of carotid artery in the experimental group was significantly reduced, and the blood flow velocity was close to the normal, and the stenosis of control group was also improved, but the carotid artery stenosis was the heaviest in model group, the blood flow speed and hemodynamic was changed, the instability of plaque was increased, and the difference was statistically significant(P<0.05). Conclusions: Atorvastatin Calcium Tablets combined with probucol treatment can effectively increase the stability of the rabbit carotid atherosclerotic plaque, improve carotid artery stenosis, and make the blood flow close to normal level. [ABSTRACT FROM AUTHOR]

Objective: To explore the clinical effect of r-tpa combined mannitol in treatment of cerebral infarction caused by vascular diseases. Methods: The patients with acute cerebral infarction (ACI) within 6 hours were randomly divided into treatment group and control group with 60 cases in each group. The patients in treatment group accepted r-tpa combined mannitol, and the patients in control group accepted ligustrazine injection. The clinical efficacy and recovery of neurological function were measured after 15 days treatment. Results: The clinical effect of treatment group was 93.33 %, which was obviously higher than 78.33 % of control group with statistically significance (P<0.05). The CSS scores of two groups after treatment were obviously lower than before, and the treatment group was much lower than control group (P<0.05). The ADL scores of two groups after treatment were obviously higher than before, and the treatment group was much higher than control group (P<0.05). Conclusions: Using r-tpa combined mannitol has good effect in treatment of cerebral infarction caused by vascular diseases, which is safe and good at symptom improvement of later stage. [ABSTRACT FROM AUTHOR]

Objective: To investigate the effects of immune enhanced enteral nutrition on nutritional status, lung function and humoral immunity in elderly patients with severe pneumonia（SP). Methods: 104 elderly SP patients in our hospital from January 2021 to January 2023 were selected as research objects, and were randomly divided into control group and observation group with 52 cases in each group according to random drawing method. The control group received conventional enteral nutrition support, and the observation group received immune enhanced enteral nutrition support. The recovery time of symptoms and signs, severity of disease, pneumonia severity index, lung function, nutritional status, humoral immunity index before and after treatment were compared between the two groups. Results: The disappearance time of fever, cough, lung rales and X-ray shadow in observation group was shorter than that in control group（P＜0.05). After treatment, the Acute Physiology and Chronic Health Evaluation Ⅱ（APACHEⅡ） scores of the observation group were lower than those of the control group（P＜0.05); After treatment, the risk grade of pneumonia in observation group was better than that in control group（P＜0.05). After treatment, the levels of total protein（TP), prealbumin（PA), albumin（ALB） and transferrin（TRF） in observation group were higher than those in control group（P＜0.05); After treatment, the dynamic lung compliance（Cdyn） of observation group was higher than that of control group, and airway resistance（R） was lower than that of control group（P＜0.05). After treatment, the levels of immunoglobulin A（Ig A), immunoglobulin M（Ig M), immunoglobulin G（Ig G), complement C3 and complement C4 in observation group were higher than those in control group（P＜0.05). Conclusion: Immune enhanced enteral nutrition support can accelerate the relief of clinical symptoms and signs in elderly SP patients, improve their condition, pneumonia severity and lung function, and enhance their immune capacity and nutritional level, which has certain clinical application value. [ABSTRACT FROM AUTHOR]

Objective To investigate the immunohistochemical expression of glucose transporter 2 (GLUT2) in patients with hepatogenous diabetes and its significance. Methods A total of 40 liver tissue samples were collected from patients who were treated in Department of Severe Liver Disease and Department of Hepatobiliary Surgery in Beijing YouAn Hospital, Capital Medical University, from June 2012 to July 2014. Immunohistochemistry was used to measure the expression of GLUT2 in liver tissue in all four groups (normal group, chronic hepatitis B group, liver cirrhosis group, and hepatogenous diabetes group). A one-way analysis of variance was used for the comparison of continuous data between groups, and the least significant difference t-test was used for further comparison between any two groups; the Fisher′s exact test was used for the comparison of categorical data between groups. Results There were significant differences in fasting blood glucose, glycosylated hemoglobin, glycosylated serum albumin, body mass index, and proportion of liver tissue with steatosis between the hepatogenous diabetes group and the other three groups (all P＜0.05). Immunohistochemistry showed that GLUT2 was mainly expressed in the liver cell membrane, especially the cell membrane near the sinus cavity. In the patients with normal liver tissue, chronic hepatitis B, or liver cirrhosis, the expression of GLUT2 in liver tissue tended to gradually decrease from the central vein to the portal area, and one patient with liver cirrhosis had enhanced expression of GLUT2 in the regenerative nodules of hepatocytes. In the 10 patients with hepatogenous diabetes, 6 had significant steatosis of the liver tissue and strongly positive and relatively even expression of GLUT2 at the site of steatosis, as well as the cytoplasm around steatotic hepatocytes, with no significant difference from the expression of GLUT2 in the sinus cavity. Conclusion Patients with hepatogenous diabetes tend to have steatosis in the liver tissue and a significant increase in the expression of GLUT2, which may be the pathogenesis of abnormal glucose metabolism. [ABSTRACT FROM AUTHOR]

With the increased aging of the population, muscle and bone synergy degeneration diseases such as sarcopenia-osteoporosis is increasing, which seriously affects the health of the elderly and brings enormous burden to the social medical treatment. In order to deeply study the pathological mechanism of sarcopenia-osteoporosis and develop effective clinical drugs, it is very important to construct an effective experimental animal model of sarcopenia-osteoporosis. This paper reviews the research progress of five sarcopenia-osteoporosis models, namely aging sarcopenia-osteoporosis model, castrated sarcopenia-osteoporosis model, chemically induced sarcopenia-osteoporosis model, disused sarcopenia-osteoporosis model, and gene sarcopenia-osteoporosis model. This paper deeply explores the research progress, characteristics, and application scope of different models, and briefly describes the evaluation methods of models, so as to provide a reasonable animal model for the study of pathological mechanism and clinical drugs of late sarcopenia-osteoporosis. [ABSTRACT FROM AUTHOR]

Disease diagnosis and treatment have been an important support for aquatic animal health in aquaculture. A knowledge graph can be an effective way to express and apply the knowledge on the aquatic animal disease diagnosis and treatment. Among them, the named entity recognition has been the key component to construct the knowledge graph of aquatic animal diseases, particularly on the polysemy and entity nesting. However, the low recognition accuracy of named entities has posed a great challenge to the diagnosis and treatment of aquatic animal diseases. In this study, a diagnosis and treatment of aquatic animal diseases named entity recognition was proposed using BERT+CaBiLSTM+CRF (Bidirectional Encoder Representations from Transformers+Cascade-Bi-directional Long Short-Term Memory+Conditional Random Field). Firstly, the feature of the BERT model contained the position vector information. The polysemy was effectively improved to distinguish the different meanings that were expressed by entities in different contexts. Secondly, the CaBiLSTM model was designed for the nested named entity recognition using “hierarchical thinking”. The reason was that the inner entity in the nested entity of aquatic medicine greatly contributed to the recognition of the outer entity. First of all, the BiLSTM+CRF model was used to identify the inner entities that appeared frequently, and then the dimension reduction of the identified inner entity feature matrix was connected outer entity feature matrix to retain the complete inner entity feature information. After that, the BiLSTM+CRF model was used for the outer entity recognition to improve the discrimination of outer entities for the accurate recognition of outer entities. Finally, a comparative experiment was designed to verify the effectiveness of the proposed recognition. The test results show that the accuracy, recall, and F1 value of the named entity recognition task in the aquatic medicine using the BERT+CaBiLSTM+CRF model reached 93.07%, 92.85%, and 92.96%, respectively. The entity structure features were outstanding in terms of specific entity categories, due to the five types of non-nested entities, such as aquatic animal names, drug names, disease names, disease sites, and pathogens. For example, most aquatic animal names contained the radicals, such as “worm” and “fish”. The radicalsand drug names were mostly composed of chemical elements, while the disease names were mostly ended with the word “disease”, indicating a higher recognition accuracy than that in the nested entities. But in view of the outstanding nested structure of entities, the model performed better to identify the nested named entities, such as the clinical symptoms using the named entity recognition model integrating the BERT and CaBiLSTM designed by the “hierarchical idea”. Higher recognition was achieved than before. The recognition accuracy, recall, and F1 value increased by 12.31, 12.76, and 12.53 percentage points, respectively. Therefore, the model can be expected to effectively improve the accuracy of entity recognition caused by ambiguity and entity nesting in the task of diagnosis and treatment of aquatic animal diseases named entity recognition. The finding can provide the potential support to construct the fisheries field knowledge graph, further promote the healthy aquaculture projects. [ABSTRACT FROM AUTHOR]

Objective To observe the effects of circLMNB1 expression on the proliferation，apoptosis，and cell cy⁃ cle of colorectal cancer cells，and to explore the mechanism. Methods Colorectal cancer cell line HCT116 was cultured and divided into the experimental group，the control group and the blank group. The cells in the blank group were cultured normally，and the cells in the experimental group and control group were transfected with circLMNB1siRNA and NC siR⁃ NA，respectively，and the interference effect of circLMNB1 siRNA was verified by qPCR. The ability of cell proliferation was detected by CCK-8 assay，the apoptotic cells and the distribution of cell cycle were detected by flow cytometry，and the apoptosis-related proteins Caspase-3 and Bax were detected by Western blotting. The expression of miR-143 was de⁃ tected by qPCR. The interaction between circLMNB1 and miR-143 was verified by double luciferase assay. Results The proliferation ability and the proportion of cells in the S phase of the experimental group were higher than those in the control group，while the apoptosis level，the relative expression of Bax protein，Caspase-3 protein and the proportion of cells in the G1 phase of the experimental group were lower than those in the control group（all P<0. 05）. The results of dou⁃ ble luciferase assay showed that circLMNB1 could interact with miR-143 directly. Conclusions Down-regulation of cir⁃ cLMNB1 expression can inhibit the proliferation，promote apoptosis and block the cell cycle of colorectal cancer cells， which may be achieved by interacting with miR-143. [ABSTRACT FROM AUTHOR]

Objective To investigate the expression features of glucocorticoid receptor（ GR） and its subtypes α and β in patients with early-or middle-stage hepatitis B virus-related acute/subacute-on-chronic liver failure（ HBV-ACLF） treated by glucocorticoid（ GC） and their association with sensitivity to glucocorticoid therapy. Methods A prospective non-randomized controlled trial was performed for 33 patients with early-or middle-stage HBV-ACLF who were hospitalized and treated in Beijing YouAn Hospital from September 2015 to June2018,and among these patients,18 received intravenous infusion of methylprednisolone for 7 days in addition to comprehensive medical treatment. Flow cytometry and RT-PCR were used to measure the mRNA expression of GR,GR-α,and GR-β,and the expression of GR,GR-α,and GR-β was observed at baseline and on day 8.According to the response to GC on day 10,the hormone group was further divided into hormone-sensitive group with 13 patients and hormone-insensitive group with 5 patients. The two-independent-samples t test was used for comparison of continuous data between two groups,and the paired t-test was used for comparison within one group before and after treatment; the Fisher’s exact test was used for comparison of categorical data between groups. The Kaplan-Meier survival curve was used to analyze 28-day survival,and the log-rank test was used for comparison between groups. Results The hormone group had a significant reduction in the mRNA expression of GR-α on day 8 after hormone administration [（ 0.99 ± 0.48） × 10-2vs（ 1.96 ±0.50） × 10-2,t = 6.586,P< 0.001]There was a significant difference in the mRNA expression of GR-α between the hormone group and the non-hormone group on day 8 [0.99 ± 0.48) × 10-2vs（ 1.70 ± 0.66） × 10-2,t =-3.518,P = 0.001]On day 8,the hormone-sensitive group had significantly higher mRNA expression of GR-α than the hormone-insensitive group [1.21 ± 0.34) × 10-2vs（ 0.43 ± 0.31） × 10-2,t = 4.456,P< 0.001]and the hormone-sensitive group had a significantly greater reduction in the mRNA expression of GR-α compared with the hormone-insensitive group（ t =-2.904,P = 0.01）. There was no significant difference in the mRNA expression of GR-β on day 8 between the hormone-sensitive group and the hormone-insensitive group [0.14 ± 0.08) × 10-2vs（ 0.10 ±0.04） × 10-2,t = 1.092,P = 0.291]For the hormone group,the mean ratio of reduction in GR-α mRNA expression to baseline value was46% on day 8,and according to this,the patients were divided into ≤46% group with 10 patients and > 46% group with 8 patients. There was a significant difference in the ratio of reduction in GR-α mRNA expression to baseline value between the two groups（ 26.99% ± 25.09% vs 70.09% ± 16.08%,t =-4.203,P = 0.001）. On day 10,there were significant differences between the ≤46% group and the >46% group in the ratio of reduction in total bilirubin（ TBil） to baseline value（ P = 0.021） and the ratio of increase in prothrombin time activity（ PTA） to baseline value（ P = 0.048）. Conclusion In patients with early-or middle-stage HBV-ACLF,there is a significant reduction in the mRNA expression of GR-α after GC treatment. Patients sensitive to hormone have a relatively low degree of reduction in the mRNA expression of GR-α,with better improvements in TBil and PTA on day 28 than those insensitive to hormone. Dynamic change of GR-α mRNA has a certain reference value in predicting the outcome of hormone therapy. [ABSTRACT FROM AUTHOR]

Objective To investigate the efficacy and safety of regional citrate anticoagulation（RCA） in patients with severe liver diseasesand acute kidney injury（AKI） receiving continuous renal replacement therapy（CRRT）.Methods A retrospective analysis was performedfor the medical records and first-time CRRT data of 175 liver disease patients with AKI（liver disease group） and 285 non-liver diseasepatients with AKI（non-liver disease group） who underwent RCA-CRRT in Beijing You’ an Hospital and Beijing Friendship Hospital,Capital Medical University, from January 2016 to March 2019. The two groups were compared in terms of the changes in hepatic and renalfunction markers, blood gas parameters, lactic acid, ionized calcium(iCa2+), and total calcium(tCa2+) after treatment, as well as themean operation life of filter and adverse reactions. The pairedt-test or the independent samplest-test was used for comparison of normallydistributed continuous data between two groups, and the Mann-WhitneyUtest was used for comparison of non-normally distributed contin-uous data between two groups; the chi-square test was used for comparison of categorical data between two groups. The Kaplan-Meier sur-vival curve was used to analyze the operation life of filter in the two groups, and the log-rank test was used for comparison.Results BeforeCRRT, the level of ALT、AST、TBil、BUN in liver disease group were significantly higher than those in non-liver disease group（allP<0. 05）. After treatment, iCa2+, tCa2+, pH value, and base excess basically returned to normal, and there were significant differences inthe same group before and after treatment（allP<0.05）. Compared with the non-liver disease group, the liver disease group had a signifi-cantly higher incidence rate of citrate accumulation(tCa2+/iCa2+> 2.5) during treatment（12% vs 2.2%,χ2 =18.65,P<0.001）.There was no significant difference in the mean operation life of filter between the liver disease group and the non-liver disease group（32.20 ± 24.99 h vs 32.96 ± 18.93 h,t =0.346,P>0.05） and there was also no significant difference in the 48-hour survival rate withfilter between the two groups（28.1% vs 26.9%,χ2 =1.356,P=0.381）. No adverse reaction associated with citrate accumulation wasobserved.Conclusion In patients with severe liver diseases, although RCA used in CRRT may induce a high incidence rate of citrate accu-mulation, it can achieve a satisfactory anticoagulant effect and is relatively safe. [ABSTRACT FROM AUTHOR]

Objective: To investigate the expression of long non-coding RNA PVT1 (lncRNA-PVT1) in the hepatocellular carcinoma and its clinical significance in the diagnosis and treatment of hepatocellular carcinoma (HCC). Methods: The expression level of lncRNA-PVT1 in the hepatocellular carcinoma tissue and adjacent hepatic tissue were detected by qRT-PCR. x2 test was used to analyze the correlation between lncRNA-PVT1 expression level and clinicopathological parameters of HCC patients. The postoperative survival curve was drawn by Kaplan-meier method and the comparison of survival rates was performed by Log-rank test. Univariate and multivariate analysis was carried out to assess the independent risk factors affecting the prognosis of HCC patients. Results: The expression level of lncRNA-PVT1 in hepatocellular carcinoma tissues was significantly higher than that of the adjacent hepatic tissue(P< 0.05). High level of expression of lncRNA-PVT1 was associated with the Edmondson grading, TNM staging, degree of differentiation and vascular metastasis, and it showed no significant correlation with the age, sex, level of serum AFP, tumor diameter, the number of tumors and the history of hepatitis. The postoperative survival rate of patients with high expression of lncRNA-PVT1 was significantly lower than that in the patients with low expression of lncRNA-PVT1. High expression level of lncRNA-PVT1, Edmondson grading, TNM staging, the degree of differentiation and vascular metastasis are independent risk factors affecting the prognosis of HCC patients. Conclusions: LncRNA-PVT1 is highly expressed in hepatocellular carcinoma, and high expression level of lncRNA-PVT1 is closely related to the poor clinical prognosis of HCC patients, which is expected to be a new target for the treatment of hepatocellular carcinoma in the future. [ABSTRACT FROM AUTHOR]

Objective: To investigate the morphological characteristics of gallstones and the relationship between plasma lipopolysaccharide (LPS) level and acute biliary pancreatitis (ABP) in patients with gallstones. Methods: 164 patients with cholecystolithiasis who were admitted to Renmin Hospital of Wuhan University from October 2015 to September 2018 were selected as the study subjects. The morphological characteristics of gallstones and whether ABP was concurrent in all subjects were recorded. The relationship between the morphological characteristics of gallstones and the concurrent ABP was analyzed. Logistic regression analysis was used to analyze the high risk factors of incidence of ABP. All patients were divided into low LPS group (n=65, <10 pg/mL) and high LPS group (n=99, >10 pg/mL) according to the level of LPS. The effect of plasma LPS level on concurrent ABP in patients with different stone sizes and different levels of total cholesterol (TG) were analyzed. Results: The incidence of concurrent ABP in patients with multiple gallstones, spherical gallstones, <3 mm gallstones and soft-crushed gallstones was significantly higher than that in patients with single gallstone, irregular gallstones or sandy gallstones, 3-10 mm gallstones or >10 mm gallstones, hard gallstones or gelatinous gallstones (P<0.05). Logistic regression analysis showed that multiple cholecystolithiasis, spherical gallstones, <3 mm gallstones and soft crushed gallstones were all high risk factors for ABP (P<0.05). When patients were in high TG, the incidence of concurrent ABP in high LPS group was higher than that in low LPS group (P<0.05). When patients in small gallstones, the incidence of concurrent ABP in high LPS group was higher than that in low LPS group (P<0.05). Conclusions: According to the morphological characteristics of gallstones, the possibility of concurrent ABP complication in patients with gallstones can be early judged. At the same time, the elevated plasma LPS level is one of the important factors for concurrent ABP in patients with high TG and small gallstones. [ABSTRACT FROM AUTHOR]

Ｏｂｊｅｃｔｉｖｅ Ｔｏ ｓｙｓｔｅｍａｔｉｃａｌｌｙ ｒｅｖｉｅｗ ｔｈｅ ｃｌｉｎｉｃａｌ ｅｆｆｅｃｔ ｏｆ ｇｌｕｃｏｃｏｒｔｉｃｏｉｄｓ ｕｓｅｄ ａｌｏｎｅ ｏｒ ｉｎ ｃｏｍｂｉｎａｔｉｏｎ ｗｉｔｈ ｐｅｎｔｏｘｉｆｙｌｌｉｎｅ ｉｎ ｐａ ｔｉｅｎｔｓ ｗｉｔｈ ｓｅｖｅｒｅ ａｌｃｏｈｏｌｉｃ ｌｉｖｅｒ ｄｉｓｅａｓｅ． Ｍｅｔｈｏｄｓ ＰｕｂＭｅｄ，Ｅｍｂａｓｅ，Ｃｈｉｎｅｓｅ Ｓｃｉｅｎｔｉｆｉｃ Ｊｏｕｒｎａｌ Ｆｕｌｌ － Ｔｅｘｔ Ｄａｔａｂａｓｅ，ＣＢＭ，Ｃｈｉｎａ Ｓｃｉ ｅｎｔｉｆｉｃ Ｊｏｕｒｎａｌ Ｄａｔａｂａｓｅ，ａｎｄ Ｃｈｉｎｅｓｅ Ｍｅｄｉｃａｌ Ａｓｓｏｃｉａｔｉｏｎ Ｄｉｇｉｔａｌ Ｊｏｕｒｎａｌ Ｄａｔａｂａｓｅ ｗｅｒｅ ｓｅａｒｃｈｅｄ ｆｏｒ ｒｅｌａｔｅｄ ａｒｔｉｃｌｅｓ ｐｕｂｌｉｓｈｅｄ ｕｐ ｔｏ Ｎｏｖｅｍ ｂｅｒ ２０１８，ａｎｄ ｒｅｌａｔｅｄ ｊｏｕｒｎａｌｓ ａｎｄ ｃｏｌｌｅｃｔｅｄ ｐａｐｅｒｓ ｆｒｏｍ ｃｏｎｆｅｒｅｎｃｅｓ ｗｅｒｅ ｓｅａｒｃｈｅｄ ｍａｎｕａｌｌｙ． Ｔｈｅ ｃｌｉｎｉｃａｌ ｅｆｆｅｃｔ ｏｆ ｇｌｕｃｏｃｏｒｔｉｃｏｉｄｓ ｖｅｒｓｕｓ ｐｌａｃｅｂｏ，ｇｌｕｃｏｃｏｒｔｉｃｏｉｄｓ ｖｅｒｓｕｓ ｐｅｎｔｏｘｉｆｙｌｌｉｎｅ，ａｎｄ ｇｌｕｃｏｃｏｒｔｉｃｏｉｄｓ ｃｏｍｂｉｎｅｄ ｗｉｔｈ ｇｌｕｃｏｃｏｒｔｉｃｏｉｄｓ ｖｅｒｓｕｓ ｇｌｕｃｏｃｏｒｔｉｃｏｉｄｓ ａｌｏｎｅ ｗａｓ ａｎａｌｙｚｅｄ． Ｔｈｅ ｅｆｆｅｃｔ ｏｆ ｇｌｕｃｏｃｏｒｔｉｃｏｉｄｓ ａｎｄ ｐｅｎｔｏｘｉｆｙｌｌｉｎｅ ｕｓｅｄ ａｌｏｎｅ ｏｒ ｉｎ ｃｏｍｂｉｎａｔｉｏｎ ｏｎ ２８ － ｄａｙ ｓｕｒｖｉｖａｌ ｒａｔｅ ａｎｄ ｈｅｐａｔｏｒｅｎａｌ ｓｙｎｄｒｏｍｅ ｉｎ ｐａｔｉｅｎｔｓ ｗｉｔｈ ｓｅｖｅｒｅ ａｌｃｏｈｏｌｉｃ ｌｉｖｅｒ ｄｉｓｅａｓｅ ｗａｓ ａｓｓｅｓｓｅｄ． Ｏｄｄｓ ｒａｔｉｏ （ＯＲ）ａｎｄ ９５％ ｃｏｎｆｉｄｅｎｃｅ ｉｎｔｅｒｖａｌ （ＣＩ）ｗｅｒｅ ｕｓｅｄ ｔｏ ｅｖａｌｕａｔｅ ｏｕｔｃｏｍｅ ｉｎｄｉｃａ ｔｏｒｓ． ＲｅｖＭａｎ ５． ３ ｓｏｆｔｗａｒｅ ｗａｓ ｕｓｅｄ ｆｏｒ ｄａｔａ ａｎａｌｙｓｉｓ． Ｒｅｓｕｌｔｓ Ａ ｔｏｔａｌ ｏｆ ２２ ｓｔｕｄｉｅｓ ｗｅｒｅ ｉｎｃｌｕｄｅｄ，ｗｉｔｈ １９５６ ｐａｔｉｅｎｔｓ ｉｎ ｔｏｔａｌ． Ｔｈｅ ｇｌｕ ｃｏｃｏｒｔｉｃｏｉｄ ｇｒｏｕｐ ｈａｄ ａ ｓｉｇｎｉｆｉｃａｎｔｌｙ ｌｏｗｅｒ ２８ － ｄａｙ ｍｏｒｔａｌｉｔｙ ｒａｔｅ ｔｈａｎ ｔｈｅ ｃｏｎｔｒｏｌ ｇｒｏｕｐ （２５． １２％ ｖｓ ３０． ６７％ ，ＯＲ ＝０． ７１，９５％ ＣＩ：０． ５５ － ０． ９３，Ｐ ＝ ０． ０１）． Ｓｕｂｇｒｏｕｐ ａｎａｌｙｓｉｓ ｓｈｏｗｅｄ ｔｈａｔ ｔｈｅｒｅ ｗａｓ ａ ｓｉｇｎｉｆｉｃａｎｔ ｄｉｆｆｅｒｅｎｃｅ ｉｎ ２８ － ｄａｙ ｍｏｒｔａｌｉｔｙ ｒａｔｅ ｂｅｔｗｅｅｎ ｔｈｅ ｇｌｕｃｏｃｏｒｔｉｃｏｉｄ ｇｒｏｕｐ ａｎｄ ｔｈｅ ｐｅｎｔｏｘｉｆｙｌｌｉｎｅ ｇｒｏｕｐ （ＯＲ ＝０． ６８，９５％ ＣＩ：０． ４８ － ０． ９７，Ｐ ＝ ０． ０３），ｗｈｉｌｅ ｔｈｅｒｅ ｗａｓ ｎｏ ｓｉｇｎｉｆｉｃａｎｔ ｄｉｆｆｅｒｅｎｃｅ ｂｅｔｗｅｅｎ ｔｈｅ ｇｌｕｃｏｃｏｒｔｉｃｏｉｄ ＋ ｐｅｎｔｏｘｉｆｙｌｌｉｎｅ ｇｒｏｕｐ ａｎｄ ｔｈｅ ｇｌｕｃｏｃｏｒｔｉｃｏｉｄ ｇｒｏｕｐ （ＯＲ ＝０． ９２，９５％ ＣＩ：０． ６６ －１． ２９，Ｐ ＝０． ６４）． Ｃｏｍｐａｒｅｄ ｗｉｔｈ ｔｈｅ ｇｌｕ ｃｏｃｏｒｔｉｃｏｉｄ ｇｒｏｕｐ，ｔｈｅ ｇｌｕｃｏｃｏｒｔｉｃｏｉｄ ＋ ｐｅｎｔｏｘｉｆｙｌｌｉｎｅ ｇｒｏｕｐ ｈａｄ ａ ｓｉｇｎｉｆｉｃａｎｔｌｙ ｌｏｗｅｒ ｉｎｃｉｄｅｎｃｅ ｒａｔｅ ｏｆ ｈｅｐａｔｏｒｅｎａｌ ｓｙｎｄｒｏｍｅ （３． ９４％ ｖｓ ８ ０３％ ，ＯＲ ＝０． ４５，９５％ ＣＩ：０． ２４ －０． ８３，Ｐ ＝０． ０１）． Ｆｕｎｎｅｌ ｐｌｏｔｓ ｓｈｏｗｅｄ ｎｏ ｐｕｂｌｉｃａｔｉｏｎ ｂｉａｓ． Ｃｏｎｃｌｕｓｉｏｎ Ｇｌｕｃｏｃｏｒｔｉｃｏｉｄｓ ｃｏｍｂｉｎｅｄ ｗｉｔｈ ｐｅｎｔｏｘｉｆｙｌｌｉｎｅ ｃａｎ ｒｅｄｕｃｅ ｔｈｅ ｉｎｃｉｄｅｎｃｅ ｒａｔｅ ｏｆ ｈｅｐａｔｏｒｅｎａｌ ｓｙｎｄｒｏｍｅ ｉｎ ｐａｔｉｅｎｔｓ ｗｉｔｈ ｓｅｖｅｒｅ ａｌｃｏｈｏｌｉｃ ｌｉｖｅｒ ｄｉｓｅａｓｅ． [ABSTRACT FROM AUTHOR]

Objective To investigate the Clinical effect of infusion of albumin versus artificial colloidal fluid after ascites drainage in patients with liver cirrhosis and ascites. Methods Cochrane Library ( from 1993 to February 2018) PubMed (from 1966 to February 2018 ), Em-ban (from 1990 to February 2018 ). Chinese Scientific Journal Full -Text Database ( from 1994 to February 2018), CBM ( from 1978 to February 2018), China Science and Technology Journal Database (from 1989 to February 2018) . Chinese Medical Association Digital Peri­odical Database (from 1997 to February 2018 ), and related periodicals and conference proceedings were searched for randomized controlled trials ( KCTs) on infusion of albumin and artificial colloidal fluid after ascites drainage in patients with liver cirrhosis and ascites. The modi­fied JADAD method and Cochrane systematic review were used for data extraction and literature quality assessment, and a statistical analysis was performed. KevMan 5. 3 was used for the Meta - analysis. Results A total of 7 KCTs with 696 patients were included, with 299 pa­tients in the human serum albumin group and 397 in the artificial colloidal fluid group. The human serum albumin group had a significantly lower incidence rate of hyponatremia than the artificial colloidal fluid group ( 11.04% vs 20.4%, risk ratio KK =0.58, 95% confidence in­terval [CI J ; 0.411 -0. 84, P =0.004). There were no significant differences between the two groups in the incidence rates of kidney injury (7.02% vs7.81%. KK =0.93. 95%CI: 0.53 - 1.65, P=0.82), hepatic encephalopathy (6.77% vs7.45%, KK =0.87. 95%C1: 0.48 -1.55. P=i). 63) . gastrointestinal bleeding (3.91% vs3.65%. KK=0.97. 95% d; 0.43-2.22. />=0.95). abdominal infection (5.22% vs4. 56% . KK =1.07. 95%d: 0.52 -2. 18. P =0. 86) . and hospital death ( 12.78% vs 14.59%. RR =0.70. 95%CI: 0. 47 - 1. 02. P = 0. 06 ). Conclusion Human albumin has an advantage over artificial colloidal fluid in reducing hyponatremia after ascites drainage in patients with cirrhotic ascites. [ABSTRACT FROM AUTHOR]

目的：总结腹腔妊娠的诊治经验。方法回顾性分析1例经剖腹取胎术治疗的腹腔妊娠患者临床资料，并复习相关文献。结果患者停经后超声提示宫内早孕，行清宫术＋宫内节育器放置术后出现不规则阴道流血、发热伴下腹痛。查血人绒毛膜促性腺激素（HCG）97871 mIU／mL，超声提示腹腔内妊娠囊，确诊为腹腔妊娠。行剖腹取胎术，刺破妊娠囊取出胎儿后，胎盘附着处大量出血，腹腔留置纱布压迫止血。3天后，行二次手术取出腹腔纱布，术中见胎盘附着于结肠系膜，血运丰富，故未处理胎盘。术后患者血HCG进行性下降，3个月后出现下腹部疼痛，给予第3次剖腹手术，取出胎盘。术后血HCG 0．12 mIU／mL，患者恢复正常。结论腹腔妊娠无特异性临床表现，需结合实验室检查进行确诊，临床误诊率较高；其治疗以剖腹取胎术为主，术中根据胎盘附着部位给予针对性处理。 [ABSTRACT FROM AUTHOR]

With the wide spread of drip irrigation, low-pressure subsurface drip system has come into notice as it can reduce the operation cost and improve water and fertilizer use efficiency, and it has become an emerging trend in drip technology development. A field experiment was carried out in Xinjiang to investigate the variation law of hydraulic performance and irrigation uniformity in subsurface drip system under low pressure. We chose lateral capillary from the head and end of the main branch to be the representatives, as well as the middle ones. The inlet pressure of branch pipe was set between 1.40 and 6.55 m; then we compared subsurface drip system with surface drip system under the same conditions in relation to flow rate, working pressure, and total head loss. The results indicate that: 1) The operation status of laterals can be monitored by working pressure and flow rate in the drip irrigation system. 2) When the emitter outflow is driven by the soil matric potential, the flowrate of underground laterals is larger than that of the surface laterals, and the coefficient of flow variation is increasing by 0.12 to 0.9, and it keeps increasing with the decrease of working pressure. 3) When comparing the working pressure of subsurface drip system with that of the surface drip system, 90% of subsurface drip laterals are less than that in the surface drip irrigation system, and the variation coefficient of working pressure is from ?10% to 0 with the probability of 70%. 4) The increasing coefficient considering local head loss of laterals (ICCLHLL) is calculated by using the total head loss, the Blasius formula, and the flow from multiple outlets, and the value of surface drip system is within the range of 1.32-5.94, while range between 1.37 and 2.18 for subsurface drip system, and the ICCLHLL increases with the decrease of working pressure. The flow rate of subsurface laterals keeps increasing under the influence of the soil matric potential, which leads to the decrease of ICCLHLL in surface drip laterals. 5) When decreasing working pressure, the irrigation uniformity of surface drip system will also decline. The soil matrix potential improves the irrigation uniformity of subsurface drip system. The deviation rates of working pressure and flow rate in the subsurface drip system are 0.62%-3.44% and 8.15%-22.4% lower than those in the surface drip system, respectively. The research can provide a scientific basis for design and management of low-pressure subsurface drip irrigation. [ABSTRACT FROM AUTHOR]

Head deviation ratio is a key technical indicator for length optimization in drip irrigation laterals. The deviation ratio in sub-surface drip irrigation is different from that in surface drip irrigation because the laterals are embedded and compressed in soil, and influenced by the submerged discharging. This study aimed to investigate head deviation property of subsurface drip irrigation laterals and its relationship with soil moisture uniformity. This experiment including 3 large pipe networks of subsurface drip irrigation in cotton field was carried out in Xinjiang. The drip irrigation pipe was buried in 28-33 cm below the soil surface. The length was 100 m. The spacing of pipes was 0.5 m in 2002, and 1 m after tye year of 2004. A total of 3 pairs of laterals were chosen out of upstream, medium-stream and downstream of the branch pipe. For each pipe network, more than 6 laterals were selected for the experiment. Among the laterals, some were ring network and some were tree network. The precision pressure gauge was used to measure the water pressure in the head and tail of laterals, and water meter to measure water volume at the beginning of laterals. During the experiment, the designed working pressure was 10 m. The soil moisture at depths of 30 cm along the laterals was determined by a soil moisture measuring instrument. The head deviation ratio and soil moisture uniformity was calculated based on soil moisture. The relationship between the laterals' head deviation ratio and soil moisture uniformity coefficient in 30 cm depths along the laterals was analyzed. The results showed that the head deviation ratio of the laterals were from 0.58% to 12.80%, meeting the requirement of Chinese microirrigation standard (smaller than or equal to 20%). Overall, the head deviation ratio in each lateral were different in a same pipe network with the value fluctuated in a certain range, whereas the changing trend was stable between tree-like laterals and ring-like laterals in a same branch pipe. The analysis on outliers of measured head deviation ratio showed that the deviation ratio may be affected by thickness of lateral wall. The lateral with thick wall had more stable hydraulic performance than that of the thin wall. During the entrance pressure of 7.32-11.75 m, the entrance pressure had no significant influence on head deviation ratio (P>0.05). The head deviation ratio was extremely negatively correlated with soil moisture uniformity coefficient (P<0.001). According to theoretical analysis, a model was established with soil moisture uniformity coefficient as response variable and head deviation ratio as independent variable. By comparing the calculated values and model-established values of soil moisture uniformity coefficient, we found the model was reliable in predicting oil moisture uniformity coefficient with the absolute error from -6.0% to 5.3% and 85% of laterals had the absolute error smaller than 5%. This study can provide valuable information for the length optimization of laterals, evaluation of working conditions, and management of operation in subsurface drip irrigation system. [ABSTRACT FROM AUTHOR]

Objective: To explore the application of serum heart type fatty acid binding protein(H-FABP) and S-100 B protein(S-100B) in the early diagnosis and condition assessment in patients with acute cerebral infarction(ACI). Methods: A total of 91 patients with ACI, who were admitted to Cangzhou Central Hospital from September 2012 to March 2015, were chosen as observation group, divided into subgroups according to the Adama classification method, the degree of nerve defect and different invasion time. Meanwhile, 73 healthy people were selected as control group.The blood of all the participants was collected to detect the levels of serum H-FABP and S-100 B by enzyme-linked immunosorbent method. The correlation of the above indexes with ACI was analyzed.Results: The levels of serum H-FABP and S-100 B in the observation group 1 h, 3 h, 12 h after invasion were significantly higher than those in the control group(P<0.05). Level of serum H-FABP in the observation group began to increase 1 h after invasion, and kept to the highest level 3 h after invasion, then it gradually declined; the change trend of S-100 B was the same, but the highest level appeared 12 h after invasion, then it gradually declined.The greater lesions diameter, the higher levels of serum H-FABP and S-100 B, the differences were statistically significant(P<0.05). The levels of serum H-FABP and S-100 B in the patients with severe nerve defect were obviously higher than those in the patients with moderate and mild nerve defect, and the levels of serum H-FABP and S-100 B in the patients with moderate nerve defect were significantly higher than those in the patients with mild nerve defect(P<0.05). The levels of serum H-FABP and S-100 B in the patients with ACI were positively correlated with the lesion diameter and the degree of nerve defect(P<0.05).Conclusions: The levels of serum H-FABP and S-100 B can be used as one of early diagnosis standards for patients with ACI; they can accurately assess the illness development and have a great significance in the clinical detection and diagnosis, which is worthy of clinical application. [ABSTRACT FROM AUTHOR]

OBJECTIVE: To effectively strengthen the management of high-alert medications， so as to ensure the medication safety for patients. METHODS: To establish management system of high-alert medications and develop list of high-alert medications and design specific warning sign. RESULTS： Through taking a series of effective management strategies of high-alert medications，the safety of the clinical application of high-alert medications was improved, and the level of medical treatment and pharmaceutical care was increased. CONCLUSIONS： The high-alert medications are a special class of drugs，therefore，hospitals need to pay close attention to them and strengthen the management，so as to ensure the medication safety for patients. [ABSTRACT FROM AUTHOR]

NDV (Newcastle disease virus) is paramyxovirus, due to the safety in the treatment of process, attracted many researchers attention since its discovery. After years of development, Newcastle disease virus can suppress human hepatoma, malignant pleural mesothelioma, fibrosarcoma, and head and neck cancer and the anti-tumor effect of NDV had been proven. The effects and mechanisms in inhibiting tumor of Newcastle disease virus is not completely understood, possible mechanism of action is inducing apoptosis of tumor and enhancing immune cellular activity and suppressing chemotherapy-resistant cells. NDV can exert anti-tumor effect steady in hypoxic conditions, and virulent strain of NDV can exert highly efficient anti-tumor effects. This article reviews the recent progress of the anti-tumor effect of Newcastle disease virus. [ABSTRACT FROM AUTHOR]

OBJECTIVE: To explore the management measures of effective period of medications in outpatient pharmacy. METHODS: According to the work experience and the relevant regulations of drug administration，the management measures of effective period of medications in outpatient pharmacy were summarized. RESULTS： Through scientific management of effective period，the medications were used in the effective period，so as to ensure the medication safety for patients. CONCLUSIONS： The management of effective period of medications in outpatient pharmacy is essential for ensuring the medication safety and reducing the wastage. [ABSTRACT FROM AUTHOR]