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Copyright of Journal of Acupuncture & Tuina Science is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Contemporary Pediatrics is the property of Xiangya Medical Periodical Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Contemporary Pediatrics is the property of Xiangya Medical Periodical Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Prevention & Treatment For Stomatological Diseases is the property of Journal of Prevention & Treatment For Stomatological Diseases Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

目的　探讨血清补体1q (C1q), 红细胞分布宽度 (RDW), 红细胞沉降率 (ESR) 水平与炎症性肠病 (IBD) 患 儿疾病活动度的关系. 方法　选择125例IBD患儿, 其中溃疡性结肠炎 (UC) 65例, 克罗恩病 (CD) 60例. 根据儿童 UC疾病活动指数 (PUCAI) 评分将UC患儿分为缓解期组 (<10分, 18例), 活动期组 (≥10分, 47例), 根据严重程度将 活动期UC患儿分为轻度组 (13例), 中度组 (22例) 和重度组 (12例) ；根据儿童CD疾病活动指数 (PCDAI) 评分将CD 患儿分为缓解期组 (<10分, 16例), 活动期组 (≥10分, 44例), 根据严重程度将活动期CD患儿分为轻度组 (12例), 中 度组 (19例) 和重度组 (13例) . 检测并比较各组血清 C1q, RDW, ESR 水平, 用 Pearson 相关法分析血清 C1q, RDW, ESR水平与PCDAI, PUCAI评分的相关性. 结果 UC, CD活动期组C1q水平低于缓解期组 (P<0. 05), RDW, ESR水 平及 PUCAI 评分高于缓解期组 (P 均<0. 05) . UC, CD 轻度组, 中度组, 重度组 C1q 水平依次降低 (P<0. 05), RDW, ESR水平及 PUCAI评分依次升高 (P均<0. 05) . 活动期 UC, CD患儿 C1q水平与 PUCAI评分呈负相关 (P均<0. 05), RDW, ESR水平与PUCAI呈正相关 (P均<0. 05) ；缓解期UC, CD患儿C1q, RDW, ESR水平与PUCAI评分无相关性 (P 均>0. 05) . 结论　低水平C1q和高水平RDW, ESR与IBD患儿疾病活动度加重有关. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Acupuncture & Tuina Science is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To analyze the short-term clinical efficacy and influencing factors of ustekinumab monoclonal antibody （UST） in the treatment of Crohn's disease （CD）. Methods Retrospective cohort study was used to collect the clinical data of CD patients treated with UST in the 10th People's Hospital affiliated to Tongji University from December 2020 to October 2022. The main analysis is the short-term clinical efficacy and influencing factors of UST treatment for CD at weeks 8 and 16, And analyze the endoscopic response rate of some patients. Results A total of 91 CD patients who first used UST were included. The 8-week clinical response rate of UST treatment for CD was 61.5%, and the clinical response rate was 45%; The clinical response rate at 16 weeks was 71.4%, and the clinical response rate was 54.9%. 56 cases underwent endoscopic re-examination in our hospital, and the endoscopic response rate at 16 weeks was 41.1%. Univariate analysis showed that fistula （including anal fistula, personal history of anal fistula, and intestinal skin fistula） is associated with clinical remission in Crohn's disease patients at 8/16 weeks. Further multivariate COX regression analysis showed that the presence of a history of anal fistula surgery was an independent protective factor affecting clinical remission in CD patients treated with UST at 8 weeks （HR = 0.04, 95% CI: 0.00 ~ 0.38; P = 0.005） and 16 weeks （HR = 0.04, 95% CI: 0.01 ~ 0.34; P = 0.003） compared to those without fistula; Narrow lesions are an independent risk factor for 16 week clinical remission in CD patients compared to non-narrow and non-penetrating lesions （HR = 1.75, 95% CI: 1.08 ~ 2.84; P = 0.023）. No patients were found to have stopped medication due to serious adverse reactions. Conclusions UST can improve the clinical remission and response of CD patients at 8/16 weeks, and has good short-term clinical efficacy. CD patients with a personal history of anal fistula are recommended to use UST monoclonal antibodies, while patients with stenotic lesions should be cautious in using UST monoclonal antibodies. Whether the patient has undergone surgical treatment in the past, as well as whether UST has been used on the first or non-first line, has no significant impact on clinical remission. [ABSTRACT FROM AUTHOR]

Copyright of Journal of China Medical University is the property of Journal of China Medical University Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Crohn's disease is a type of inflammatory bowel disease (IBD). Its symptom cluster can damage patients’ psychical and psychological health. It is required to enhance the symptom cluster management of patients with Crohn's disease. In this paper, the concept of symptom cluster, assessment tools of symptom cluster and intervention of symptom cluster were summarized to enlighten the future research direction and clinical nursing practice, aiming to provide reference for symptom cluster management and nursing of patients with Crohn's disease. (克罗恩病是一种常见的胃肠道慢性炎症性疾病, 克罗恩病症状群严重影响患者的身心健康和生活质量。因此, 加强克罗恩病患者症状群的管理是十分必要的。本研究就症状群的概念、克罗恩病症状群评估工具以及症状群干预等方面的现状进行总结和分析, 旨在为制定克罗恩病患者的症状群管理方案和护理工作提供参考。)

Objective To develop a nomogram for predicting the risks of early anastomotic recurrence (EAR) after primary bowel resection in patients with Crohn′s disease (CD). Methods The patients with CD undergoing preoperative magnetic resonance enterography (MRE) and primary bowel resection were enrolled in this retrospective study and divided into an EAR group (18 patients) and EAR-free group (12 patients). The EAR group included the patients having an endoscopic Rutgeerts score of ≥ I2 month or the need for anastomotic resection within 12 months after surgery. All the 38 indexes including preoperative demographic characteristics, laboratory examinations, multi-parameter MRE features of the resected intestine and its adjacent mesentery, histological findings, and postoperative pharmacotherapy were analyzed. Least absolute shrinkage and selection operator (LASSO) regression and multivariate binary logistic regression analysis were performed to identify independent risk factors to be incorporated into the nomogram for predicting the risks of early anastomotic recurrence and the prediction performance was evaluated. Results Mesenteric creeping fat index on MRE and comb sign were independent risks of EAR, with a concordance index of 0.882 (95%CI: 0.764~1). The calibration plot revealed a strong relationship between actual observation and predicted probability of EAR. Conclusions The preoperative MRE-based nomogram may be a potential tool for predicting EAR following surgery in patients with CD, which is beneficial to individual management in those patients. It provides reference for the formulation of early postoperative individualized drug adjuvant therapy in patients at high risk of EAR. [ABSTRACT FROM AUTHOR]

目的 分析克罗恩病（CD）患者住院费用变化情况及其影响因素，为减轻患者经济负担、完善DIP政策提供参考意见。方法 对2018-2020年广州市某三甲医院657例CD患者的住院费用进行描述性分析、单因素分析和多因素logistic回归分析。结果 2018-2020年例均分值、CMI值逐年上升; 2020年住院费用构成以药费占比最大，平均药费逐年剧增，2020年达6 035.4（4 028.3,6 418.3）元，差异有统计学意义（P＜0.05）。人均检验检查费和材料费的占比分别于2020年降至27.5%和2.9%;手术病例数逐年增加，＞2倍费用偏差病例中44.4%为综合病种; 2020年和接受手术治疗均为住院费用高负担的危险因素（P＜0.05）。结论 积极倡导分级诊疗，优化病种结构，探寻日间手术可行性，重视构建医院-社区-家庭健康管理模式，规范医疗服务行为，完善综合病种分组管理等举措，可有效减轻患者疾病经济负担。 [ABSTRACT FROM AUTHOR]

To investigate the correlation of serum zonulin. monocyte chemotactic protein-1 (MCP-1). hypoxia-inducible factor-1α (HIF-1α) with disease activity and intestinal microflora in patients with Crohn's disease (CD), and to analyze the value of zonulin. MCP-1 and HIF-1α in the identification of severe CD. 162 patients with CD who were admitted to The First Affiliated Hospital of Hunan University of Chinese Medicinel from January 2019 to January 2022 were selected. According to Crohn's disease activity index (CDAI). patients with CD were divided into severe group. moderate group and mild group. with 42. 69. and 51 cases. respectively. another 151 physical examination volunteers during the same period were selected as the control group. The levels of serum zonulin. MCP-1 and HIF-1α in the patients with CD and control group were detected. Pearson correlation analysis was performed to analyze the correlation between zonulin. MCP-1 and HIF-1α with CDAI score and the relative abundance of intestinal flora. Receiver operating characteristic curve (ROC) was used to analyze the value of zonulin. MCP-1 and HIF-1α in identifying severe CD. The levels of serum zonulin. MCP-1 and HIF-1α in the severe group. moderate group and mild group were higher than those in the control group (P<0.05). The levels of serum zonulin. MCP-1. HIF-1α. and the relative abundance of Escherichia coli. Choleosinophilus wardeni. and Atopobium parvulum in the severe group were higher than those in the moderate group and mild group. and the moderate group was higher than the mild group (P<0.05). and the relative abundance of Clostridium pratense in the mild group was higher than that in the moderate group. and moderate group was higher than the severe group (P<0.05). The levels of serum zonulin. MCP-1 and HIF-1α inpatients with CD were positively correlated with CDAI score. the relative abundance of Escherichia coli. Choleosinophilus wardeni and Atopobium parvulum. and negatively correlated with the relative abundance of Clostridium pratense (P<0.05). The area under curve (AUC) of zonulin. MCP-1 and HIF-1α in the identification of severe CD was 0.856. which was higher than 0.706. 0.693 and 0.747 ofzonulin. MCP-1 and HIF-1α alone. The levels of serum zonulin. MCP-1 and HIF-1α are increased in patients with CD. and are associated with increased CD disease activity and intestinal microbiota disorder. which may be a potential biomarker for the diagnosis of severe CD. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Acupuncture & Tuina Science is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective·To investigate the effect of ceria nanoparticles-polyethylene glycol (CeNP-PEG) on scavenging reactive oxygen species (ROS) and alleviating disease activity in dextran sulphate sodium (DSS)-induced colitis mice. Methods·CeNP was synthesized with the hydrates of cerium acetate, oleamine, and xylene, which was modified with polyethylene glycol-stearyl phosphatidylethanolamine (mPEG-DPSE) to obtain CeNP-PEG. Then CeNP-PEG was purified. The particle size and zeta potential of CeNP-PEG were measured by using transmission electron microscopy (TEM) and dynamic light scattering (DLS). Mouse macrophages (Raw264.7) were cultured in vitro and induced to a pro-inflammatory phenotype (M1 phenotype). M1 macrophages were treated with 0.5 μg/mL and 1.0 μg/mL CeNP-PEG, respectively, and then Western blotting was used to detect the expression changes of the proteins related with nuclear factor-κB (NF-κB) signaling pathway. DSS-induced colitis mice models were constructed, and CeNP-PEG (1.0 mg/mL) was intravenously administrated for 3 times via tail vein during the modeling period. Meanwhile, the body weight, fecal characteristics, and frequency of rectal bleeding in mice were monitored in the normal control group (Normal group), the model group (DSS group), and the CeNP-PEG treatment group. The disease activity index (DAI) was calculated to evaluate the intestinal inflammation. The level of ROS in mouse intestinal tissues was detected by dihydroethidine (DHE) staining and the mRNA expression levels of inflammatory cytokines interferon-γ (Ifn-γ), interleukin-6 (Il-6), Il-1β and tumor necrosis factor-α (Tnf-α) were detected by real-time quantitative PCR (RT-qPCR). Results·The hydrated particle size of synthesized CeNP-PEG was (6.96±0.27) nm, and the average zeta potential was (-6.02±1.31) mV. Western blotting results showed that the expression of p-P65 increased in the pro-inflammatory macrophages compared with the control group. The expression of NF-κB inhibitor-α (IκB-α) decreased, and their expressions tended to recover after the intervention of different concentrations of CeNPPEG. In the DSS-induced colitis models, mice in the CeNP-PEG treatment group lost less weight than those in the DSS group (P= 0.000) and had lower DAI scores (P=0.000). The RT-qPCR results of intestinal tissues showed that the mRNA levels of Ifn-γ, Il-1β, Il-6 and Tnf-α in the DSS group were significantly up-regulated compared with those in the Normal group (P=0.000), and all of them significantly decreased in the CeNP-PEG treatment group. The results of DHE staining showed that the fluorescence intensity of intestinal tissues in the DSS group was significantly enhanced than that in the Normal group, and the fluorescence intensity decreased in the CeNP-PEG treatment group. Conclusion·CeNP-PEG can inhibit the expression of intestinal inflammatory factors and the activation of NF-κB-related inflammatory pathway of pro-inflammatory macrophages, eliminate intestinal ROS, improve the intestinal inflammatory microenvironment, and alleviate the disease activity of DSS-induced colitis in mice. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Contemporary Pediatrics is the property of Xiangya Medical Periodical Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

克罗恩病（CD）是一种进展性、破坏性、复发缓解性的慢性炎症性肠病，随着疾病进展会导致不可逆性的肠道结构改变和功能损害，造成肠腔狭窄、瘘管形成和肛周病变，严重影响患者的生活质量。目前已有多项临床研究证实乌帕替尼可改善CD患者的预后。本综述从乌帕替尼治疗CD的作用机制、临床应用、药物安全性等方面总结其相关研究进展，乌帕替尼可提高CD患者的临床缓解率及内镜反应率，对改善CD患者的长期结局具有重要意义，为CD患者的生物制剂治疗提供新的思路。

The correlation between serum visfatin and peroxiredoxin 1 (PRDX1) levels and activity indexes and intestinal flora in patients with Crohn's disease (CD) was analyzed. 146 CD patients who were admitted to the 910th Hospital of the Joint Logistics Support Force from April 2019 to December 2022 were selected, all CD patients were divided into mild moderate to severe activity group (n=36), activity group (n=49), remission group (n=61) according to the simplified Crohn's disease activity index (CDAI). Serum Visfatin, PRDX1, CRP levels, ESR, and intestinal flora were compared among three groups. The correlation between serum Visfatin, PRDX1 and CDAI, C-reactive protein (CRP), Erythrocyte sedimentation rate (ESR) and intestinal flora were analyzed by Pearson correlation analysis. The levels of serum visfatin and PRDX1 in moderate to severe activity group and mild activity group were higher than those in remission group, and the levels of serum Visfatin and PRDX1 in moderate to severe activity group were higher than those in mild activity group (P<0.05). The CRP and ESR in moderate to severe activity group and mild activity group were higher than those in remission group, and the CRP and ESR in moderate to severe activity group were higher than those in mild activity group(P<0.05). The enterococcus and escherichia coli in moderate to severe activity group and mild activity group were higher than those in remission group, and the enterococcus and escherichia coli in moderate to severe activity group were higher than those in mild activity group (P<0.05), the bacillus bifidus and bacteroides in moderate to severe activity group and mild activity group were lower than those in remission group, and the bacillus bifidus and bacteroides in moderate to severe activity group were lower than those in mild activity group (P<0.05). Pearson correlation analysis showed that, serum Visfatin, PRDX1 and CRP levels were positively correlated with the number of enterococcus and escherichia coli flora, CDAI and ESR, but negatively correlated with the number of bacillus bifidus and bac原 teroides flora (P<0.05). The levels of serum Visfatin and PRDX1 in CD patients are increase, which can lead to disease progression and aggravation of intestinal flora disorder [ABSTRACT FROM AUTHOR]

Copyright of Journal of Clinical Nursing in Practice is the property of Journal of Clinical Nursing in Practice (Editorial Board, Shanghai Jiao Tong University Press) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

AIM: To investigate the effect and possible mechanism of sakuranetin(SK)on 2,4,6-trinitroben-zenesulfonic acid (TNBS) -induced Crohn disease (CD) -like colitis in mice. METHODS: A total of 24 C57BL/6J mice were randomly divided into a control, model (TNBS), and SK (20 mg-kg'-d"1) treatment groups(TNBS+SK), with eight mice in each group. Colitis symptoms were evaluated using the disease activity index(DA1) and body weight change. The colon injury was evaluated based on colon length, histological inflammation score, and levels of intestinal mucosal inflammatory mediators(TNF-ot, IL-6, 1L-17A, and IL-1 p). The intestinal barrier function was assessed by measuring the levels of fluorescein isothiocyanate-dextran 4 kD(FD4)and intestinal fatty acid binding protein (1-FABP)in the peripheral blood, colonic transcpitliclial electric resistance (TEER), and intestinal bacterial translocation rate. (tCiic Ontology ((;O)and Kyoto Encyclopedia of Genes and Genomes(KEG(;) cnrichmciit analyses were performed to predict the potential pathways and SK mechanisms, followed by validation through animal experiments. RESULTS: The DAI score and body weight loss in the l -BS+SK group were significantly lower than those in the group hut higher than those in the control group (P<0. 05). The TMJS+SK group showed a significant reduction in colonic shortening, histological iiiflammatory scores, and levels of colonic mucosal inflammatoiy mediators compared to the TABS group, hut higher than those in the control group (P<0. 05). The levels of FD4 and 1-1ABP in the peripheral blood of the TMiS+SK group were significantly lower than those of the TJSBS group, hut higher than those of the control group(P

Copyright of Chinese Journal of Contemporary Pediatrics is the property of Xiangya Medical Periodical Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To determine whether Fusobacterium nucleatum (Fn) infection will aggravate the condition of patients with inflammatory bowel disease (IBD) and make it more difficult to treat them by meta analysis. Methods PubMed, MEDLINE, EMBASE, Web of Science, Wanfang database and China National Knowledge Infrastructure and other databases were searched by computer, the time limit was from January 1988 to June 2022. The inclusion and exclusion criteria were used to screen literatures and extract data. Meta analysis was performed by stata 12. 0 software. Results A total of six case-control studies were included. Compared with the uninfected patients, the clinical inflammatory activity of IBD patients with Fn infection was significantly increased, and the number of patients required surgical treatment was also significantly increased, with statistical significance [odds ratio (OR) = 4. 13, 3. 90, 95% confidence interval (95% CI): 2.08-8.23, 1.22-12.45]. Compared with uninfected patients, there were no significant differences in age, gender, inflammatory site, clinical progress and refractory of IBD patients with Fn infection (OR=0. 76, 1. 51, 1. 59, 1.94, 1.80; 95%CI: 0.39-1. 50,0.86-2. 64,0. 90-2. 80,0. 41-9. 09,0.07-49. 84). One by one exclusion method was used for sensitivity analysis, and the OR value of clinical activity was stable. Conclusion Fn infection may aggravate the condition of patients with IBD, and increase the risk of surgical treatment obviously. The IBD patients with Fn infection may need antibiotic treatment. These results need to be further confirmed by more prospective studies. [ABSTRACT FROM AUTHOR]

Objective To establish a risk prediction model for frailty in patients with inflammatory bowel disease and verify its prediction effect. Methods A classic sampling method was used to collect samples from 360 patients with inflammatory bowel disease who were hospitalized in the Department of Gastroenterology of Peking Union Medical College Hospital from July 2021 to November 2021. According to the evaluation results of the FRAIL Scale (FS), patients were divided into two group: frail group and non-frail group. The differences of demographic factors and disease related factors between the two categories of patients were compared. Randomized number method was used to divide the model group and verification group at a ratio of 8∶2. Logistic regression analysis was used to establish a risk prediction model. Hosmer-Lemeshow χ² was used to test the prediction model fitting effect, and receiver operator characteristic curve (ROC curve) was drawn. Area under ROC curve (AUC) and Youden index were calculated to evaluate the differentiation ability of the prediction model. Results The incidence of frailty in patients with inflammatory bowel disease was 16.6%. Age (OR=1.041), emaciation (OR=10.135), several times of exercise per month (OR=0.345), ulcerative colitis (OR=2.952), quality of life (OR=0.979), family care index (OR=1.629), depression (OR=1.194) and sleep disorders (OR=1.158) were independent influencing factors (P<0.05). The results of Hosmer-Lemeshow test showed that χ²=1.594, P=0.991, AUC=0.934 (95% confidence interval, 95% CI: 0.901~0.966), the maximum Youden index was 0.728, the optimal critical value was 0.128, the sensitivity was 92.0%, and the specificity was 81.8%. The validation results show that the sensitivity of the model is 88.9%, the specificity is 72.6%, and the accuracy is 91.55%. Conclusions The prediction effect of the risk prediction model is good, which can provide a reference for clinical evaluation of the frail risk of patients with inflammatory bowel disease. [ABSTRACT FROM AUTHOR]

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Copyright of Imaging Science & Photochemistry is the property of Imaging Science & Photochemistry Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Contemporary Pediatrics is the property of Xiangya Medical Periodical Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

炎症性肠病是肠道的慢性非特异性炎症性疾病，其根本病因及发病机制尚不明确，目前认为遗传、环境、 免疫因素间复杂的相互作用可能是炎症性肠病发病的主要原因。Wnt/β-连环蛋白信号通路能调节肠道干细胞的 增殖和分化进程，维持肠上皮细胞的有序结构和肠道内稳态，其功能紊乱与炎症性肠病密切相关. [ABSTRACT FROM AUTHOR]

Objective To comprehensively evaluate the efficacy and safety of enteral nutrition in the treatment of inflammatory bowel disease (IBD) and the improvement of patients′ nutritional status. Methods The databases of CNKI, Wanfang database, VIP database, PubMed, Embase, Cochrane Library, Web of Science were retrieved. The retrieval time limit was from the establishment of the database to November 2021.The randomized controlled trials and cohort studies on the treatment of IBD with conventional drugs combined with enteral nutrition (the experimental group) and simple conventional drugs (the control group) were retrieved, and the RevMan 5.3 software was used for meta-analysis. Results A total of 33 literatures involving 2,466 patients were included. The clinical effective rate of the experimental group was higher than that of the control group, and the difference was statistically significant (RR=1.25,95%CI:1.17-1.34,Z=6.37,P<0.000 01). There was no significant difference in the incidence of adverse reactions between the two groups (RR=0.98,95%CI:0.64-1.48,Z=0.11,P=0.91). After treatment, the body mass index, hemoglobin and albumin levels of the experimental group were significantly better than those of the control group, and the difference was statistically significant (P<0.000 01). Conclusion Drugs combined with enteral nutrition have better clinical efficacy than conventional drugs alone in the treatment of IBD (including ulcerative colitis and Crohn′s disease), can better improve the nutritional status of patients, and has good safety. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Contemporary Pediatrics is the property of Xiangya Medical Periodical Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Fibrosis is a progressive process induced by tissue damage or inflammation that can lead to various organ failure. 30% of patients with Crohn’s disease（CD） develop fibrotic intestinal strictures. There are no effective drugs to prevent or reverse the progression of fibrosis-induced stricture. The intestinal stricture is usually treated by endoscopic dilatation and surgery with high rates of recurrence. With early diagnosis and intervention, fibrosis may be reversed resulting in inhibition of intestinal stricture. Because of varying degrees of inflammation and fibrosis in the damaged bowel segment, it is very important to differentiate fibrosis from inflammation for treatment planning. Magnetic resonance enterography（MRE）, computed tomography enterography（CTE）, and bowel ultrasound（US）have been performed to assess small bowel and CD-related complications such as strictures. We review diffusion-weighted and magnetization transfer MR imaging, strain elastography, shear-wave imaging, and positron emission tomography for treatment planning in CD patients with intestinal fibrosis and stricture. [ABSTRACT FROM AUTHOR]

Objective: To analyze the treatment of a case of antiphospholipid syndrome and Crohn s disease complicated with deep venous thrombosis, and also to evaluate the rationality of antithrombotic drug selection, so as to provide reference for rational use of drugs. Methods: Depending on the disease characteristics of the patient and obtained laboratory data, clinical pharmacists assisted physicians to assess risks of thrombosis and hemorrhage, and develop optimal individualized anticoagulant profile. Results and Conclusion: The initial anticoagulant drug for the patient was rivaroxaban. With the help of evidence-based medical evidence, clinical pharmacists recommended to use warfarin for anticoagulant therapy and offered proposals on the intensity and course of anticoagulant therapy. Active involement of clinical pharmacists in clinical drug treatment facilitates comprehensive pharmaceutical care of patients, and they could play a positive role in the efficacy and safety of clinical medication. [ABSTRACT FROM AUTHOR]

Objective To investigate the factors affecting loss of response (LOR) to infliximab (IFX) in treatment of Crohn's disease (CD) . Methods A retrospective analysis on the clinical data of 63 CD patients treated with IFX was conducted, including age, gender, disease duration, Montreal classification (age at diagnosis, CD location, and CD behavior), concomitant immunosuppressant, concomitant enteral nutrition, combined fistula, combined perianal disease, combined extraintestinal manifestations, CDAI score, BMI, CRP, CRP reduction rate, erythrocyte sedimentation rate (ESR), Hb, and ALB. According to the CDAI score after three administrations, patients were divided into the primary non-response (PNR) group and response group, and those in the response group were then divided into secondary LOR and continuous response groups by assessment. We compared the above clinical data between the PNR and response groups, and between the LOR and continuous response groups. Logistic regression was used to analyze the factors affecting the failure of IFX treatment for CD patients. Results A total of 22 (34. 9%) of 63 CD patients experienced IFX treatment failure. PNR occurred in 8 patients (12. 7%) and LOR in 14 patients (22. 2%) . We noted there were statistically differences in BMI, disease behavior, and concomitant enteral nutrition between the PNR group and response group (all P< 0. 05) . No independent predictors of PNR were found. Univariate analysis revealed the gender, CDAI score, and Hb were related to LOR (all P<0. 05) . Multivariate analysis showed that CDAI score > 220 was an independent predictor for LOR (P<0. 05) . Conclusions LOR to IFX treatment in CD patients is inevitable. Disease behavior, BMI, and concomitant enteral nutrition of CD patients possibly influence PNR. CDAI score >220 is an independent predictor for LOR, and gender, CDAI score and Hb are associated with LOR. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Modern Laboratory Medicine is the property of Journal of Modern Laboratory Medicine Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of CT Theory & Applications is the property of Editorial Department of CT Theory & Applications and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shipin Kexue/ Food Science is the property of Food Science Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Acupuncture & Tuina Science is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

尿酸具有抗氧化与促氧化的双重作用, 研究显示其与心血管疾病, 代谢性疾病, 呼吸系统疾病, 肿瘤, 帕金 森病等多种疾病相关。IBD 的发病机制主要是遗传易感性和环境对菌群相互作用的结果, 通过削弱肠道屏障导致 肠道免疫的过度激活。目前研究发现大多 IBD 患者存在尿酸代谢异常, 同时肠道菌群, 氧化应激均参与了尿酸代 谢。IBD 患者合并有尿酸水平异常, 其可能是潜在的提示疾病活动性和严重程度的血清标志物, 在临床诊治中具有 重要意义。 [ABSTRACT FROM AUTHOR]

克罗恩病（CD）是炎症性肠病的一种，是多因素共同作用所致的肠道免疫失衡疾病。间充质干细胞 （MSCs）可通过极化和归巢发挥其生物学功能。MSCs极化可分为促炎型MSC1与抗炎型MSC2，MSC1可抑制肿瘤细 胞的增殖，MSC2在发挥抗炎作用的同时，促进肿瘤细胞的增殖、生长。MSCs的归巢可影响肿瘤细胞的增殖、凋亡及 迁移。MSCs治疗CD的作用机制可能与免疫调节、极化、归巢、TLRs受体激活、组织修复与免疫原性低下等因素有 关。目前用于CD治疗的MSCs主要来源于脂肪组织、骨髓及脐带血。MSCs适用于糖皮质激素、免疫抑制剂与生物 制剂等治疗效果有限时的重症CD或合并肛瘘患者，尤其是对于复杂难治性肛瘘CD患者，MSCs 治疗是一种很有前 景的方法。应用前应判断CD疾病状态，排除腹腔、盆腔脓肿或其他感染。临床对MSCs治疗CD的剂量与疗程尚没 有统一标准，MSCs给予方法有静脉输注、局部注射、肠系膜上动脉注射、股动脉注射等。MSCs治疗CD疗效及安全 性均较好。 [ABSTRACT FROM AUTHOR]

克罗恩病、肠结核及原发性肠道淋巴瘤是3类可以导致肠道溃疡的疾病,临床上鉴别诊断相当困难。过去,因临 床医师经验不足,实验室检验、检查设备限制,病理活检取材不足等原因,误诊误治的病例不在少数,因而延误了患者治疗的最佳时期,增加了医患矛盾、纠纷。随着指南的不断更新、进展,内镜技术、病理活检水平的日益提升,加之患者依从性的提高,临床医师对这3类疾病的认识也上升至了新的台阶,鉴别诊断水平与日俱进。目前,就3种疾病的两两鉴别已层出不穷,就三者之间的某项诊断措施的鉴别比较也日渐增多。但围绕三者之间的系统性的全面鉴别仍匮乏,故该文将根据克罗恩病、肠结核及原发性肠道淋巴瘤的定义、临床特征、实验室检查、影像学检查、内镜及病理特点、治疗及预后等进行综述。 [ABSTRACT FROM AUTHOR]

Copyright of Journal of Acupuncture & Tuina Science is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To explore the difference of small bowel CT and double-balloon enteroscopy in the diagnosis of Crohn's disease. Method: Choose 60 patients with Crohn's disease who were treated in our hospital from April 2017 to March 2019, and perform small bowel CT and double-balloon enteroscopy respectively, and compare the two detection methods to accurately diagnose Crohn's disease patients Rate and detection difference of lesion range, lesion location, mobility and complications. Results: The accuracy rate of CT in detecting Crohn's disease was 96.67%, and the accuracy of detecting Crohn's disease by double-balloon enteroscopy was 93.33%, and the difference was not statistically significant (P>0.05). Small bowel CT mainly showed 50 cases of intestinal stenosis (83.33%), 52 cases of intestinal wall thickening (86.67%), 46 cases of extraintestinal lymph nodes (76.67%), 21 cases of mesenteric edema and vascular changes (35.00%), extraintestinal Inflammation in 10 cases (16.67%), fistula in 3 cases (5.00%), fistula in 1 case (1.67%); double balloon enteroscopy showed ring ulcers, irregular ulcers, ring ulcers, etc., a total of 46 cases (76.67%), 22 cases (36.67%) of aphthous ulcers, 26 cases (43.33%) of mucosal hyperemia and edema, 6 cases (10.00%) of nodular hyperplasia, 16 cases (26.67%) of intestinal segmental stenosis of the small intestine, pseudo 9 cases of polyps (15.00%); pathological examination showed inflammatory infiltration of lymphocytes, neutrophils, eosinophils, and hyperplasia of lymphoid tissues and granulation tissues. CT showed extraintestinal inflammation, fistulas, fistulas, etc. There were 14 cases in total, and no complications were found with double balloon enteroscopy. Conclusion: Compared with double-balloon enteroscopy, small bowel CT can more accurately determine whether patients with Crohn’s disease are in an inflammatory state, and can more effectively detect the presence of extraintestinal complications, but small bowel CT and double-balloon enteroscopy are combined The application monitoring effect is better. [ABSTRACT FROM AUTHOR]

肠腔纤维性狭窄是克罗恩病（CD）常见及严重的并发症之一,其发生、发展在CD患者中有明显的不均质性。本文主要就CD肠腔纤维性狭窄的临床预测、基因预测、血清学预测、病理预测及影像学评估的研究现状予以综述。 [ABSTRACT FROM AUTHOR]

Copyright of Nursing of Integrated Traditional Chinese & Western Medicine is the property of Journal of Clinical Nursing in Practice (Editorial Board, Shanghai Jiao Tong University Press) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of CT Theory & Applications is the property of Editorial Department of CT Theory & Applications and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To observe the expression changes of plasma 25-hydroxyvitamin D [ 25 ( OH) VitD ], hepcidin ( Hepc) and hemoglobin ( Hb) in children with inflammatory bowel disease ( IBO ) and to explore their clinical significance. Methods Totally 187 children with IBO were selected, including 131 cases of ulcerative colitis ( UC group) and 56 cases of Crohn's disease ( CD group). Forty healthy children were taken as the control group. The levels of plasma 25 ( OH) VitD, Hepc, and Hb were detected by enzyme-linked immunosorbent assay ( ELISA ) . The expression differences and correlation between the indexes were analyzed statistically. Results: Compared with the control group, the levels of plasma 25 ( OH) VitD and Hb in the UC group and CD group decreased, while the level of plasma Hepc increased ( all P < 0. 05 ). The levels of plasma 25 ( OH) VitD, Hepc and Hb in the UC group and CD group were not related to the sex, age, disease type or lesion range ( all P > 0. 05 ). Compared with children in remission of UC and CD, children with active UC and CD had lower levels of plasma 25 ( OH) VitD and Hb, while had higher Hepc level ( all P < 0. 05 ). The level of plasma 25 ( OH) VitD was negatively correlated with Hepc (r = - 0. 634, - 0. 620, both P < 0. 05 ), and was positively correlated with Hb (r = 0. 61 1, 0. 589, both P < 0. 05 ). Conclusions Plasma 25 ( OH) VitD and Hb levels decrease in children with IBD, while Hepc level increases. These three indexes are related to IBD disease activity. The detection of plasma 25 ( OH) D, Hepc, and Hb is helpful to the diagnosis of IBD patients. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Contemporary Pediatrics is the property of Xiangya Medical Periodical Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

BACKGROUND: In recent years, the incidence of inflammatory bowel disease is yearly increasing, and there are no effective treatment plans. Mesenchymal stem cells have achieved good outcomes in the treatment of immune-related diseases such as systemic lupus erythematosus, myocardial infarction and graft-versus-host disease. Numerous studies have shown that mesenchymal stem cells have their unique advantages in the treatment of inflammatory bowel disease. Therefore, increasing concern has been placed on the treatment of inflammatory bowel disease by mesenchymal stem cells. OBJECTIVE: To summarize the existing research on the treatment of inflammatory bowel disease by mesenchymal stem cells, and to discuss its application and safety. METHODS: “Mesenchymal stem cells, inflammatory bowel disease, pathogenesis, treatment” were used as keywords to search CNKI, WanFang and PubMed databases for relevant literatures in the past 20 years both in Chinese and English. Finally, 62 papers were selected for review. RESULTS AND CONCLUSION: Mesenchymal stem cells have the abilities of self-renewal, tissue migration and pluripotency, as well as strong immunomodulatory effects. They not only show satisfying therapeutic effects in systemic lupus erythematosus, myocardial infarction, graft-versus-host disease and other immune-related diseases, but also have promising prospects in inflammatory bowel disease. However, little is reported in clinical studies, and there are still many problems, such as safety, encountered in the treatment of inflammatory bowel disease with mesenchymal stem cells. [ABSTRACT FROM AUTHOR]

【目的】探讨磁化传递成像（MTI）预测克罗恩病（CD）患者肠瘘发生风险的应用价值。【方法】分析12例CD手术患者的术前MTI资料，在磁化传递率（MTR）图像上测量并计算病变肠壁的标准化MTR（标准化MTR=肠壁MTR/肌肉MTR）。采用MTI图像和手术切除肠道区域对区域定位的方法，切取对应位置的肠壁组织行Masson染色以评估纤维化程度。采用Wilcoxon秩和检验比较有肠瘘和无肠瘘肠壁的标准化MTR，绘制ROC曲线分析标准化MTR预测CD肠瘘发生的效能。【结果】12例患者手术切除15个病变肠段，共获取35个肠壁标本，其中发生肠瘘的肠段有5段共12个标本，无发生肠瘘的肠段有10段共23个标本。有肠瘘的肠壁标准化MTR高于无肠瘘者（P=0.045）。ROC曲线分析显示标准化MTR预测病变肠壁发生肠瘘风险的曲线下面积为0.674（95%置信区间：0.537-0.811）；以标准化MTR=0.768为诊断阈值时，诊断可能发生肠瘘的敏感度和特异度分别为93.3%、51.1%。有肠瘘的肠壁的纤维化评分高于无肠瘘者（P=0.012）。肠壁标准化MTR与纤维化评分呈正相关（r=0.708，P

Objective To explore the relative efficacy and safety of infliximab combined with azathio prine(IFX + AZA) and infliximab combined with enteral nutrition(IFX + E N) in the treatment of Crohn's disease. Methods PubMed, Cochrane Library, Embase, Medline, VIP, Wanfang, CN KI and China Biomedical Document Service System (CBM) were retrievaled by two independent reviewers, the prospective randomized controlled clinical trial(RCT), cohort study, or meta analysis of comparison of enteral nutrition combined with infliximab vs. azathioprine combined with infliximab or infliximab combined with azathioprine vs. infliximab or infliximab combined with enteral nutrition vs. infliximab is selected for this study, selecting efficacy and adverse event rates as end points of the study, comparing the relative efficacy and safety between infliximab combined with azathioprine and infliximab combined with enteral nutrition through indirect comparisons. Results A total of 8 studies were included, including 5 RCT and 2 retrospective studies comparing IFX+ AZA with IFX, 1 meta analysis of IFX+EN and IFX, and 1 461 Crohn's disease patients was in eluded. Infliximab combined with azathioprine and infliximab in combination with enteral nutrition had a better efficacy in the treatment of moderate severe Crohn' s disease and no significant difference in safety when comparing with infliximab. Conclusion IFX + AZA and IFX + EN in the treatment of Crohn' s disease have equal efficacy and safety. [ABSTRACT FROM AUTHOR]

Copyright of CT Theory & Applications is the property of Editorial Department of CT Theory & Applications and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Practical Pharmacy & Clinical Remedies is the property of Editorial Department of Practical Pharmacy & Clinical Remedies and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)