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通过对模块单元的分析和研究，提出了模块尺寸的选型建议，并通过不同功能模块的组合，形成典型的模块化宿舍、住宅、办公、学校等建筑方案。基于此构建了模块化钢结构技术体系，并进行理论分析、试验研究、数值模拟，研发适用于模块单元间的拼接连接节点，提出了模块化建筑结构体系的标准化设计方法，并探究各类模块建筑抗侧体系在不同抗震设防烈度下的适用高度。通过系统研究模块单元的设计、制造、运输、安装等全过程，形成了模块化钢结构建筑产业化的成套技术，并以示范性生产基地、示范工程及系列化产品，加快推动模块化钢结构建筑的市场规模化应用。

近年来，轻度认知障碍(Mild cognitive impairment, MCI)作为阿尔茨海默病（Alzheimer’s disease,AD）的一个早期症状引发关注，对其进行早期干预具有积极意义。现有人群实验、动物实验及细胞实验多方面研究表明，多不饱和脂肪酸(PUFAs)中的ω-3多不饱和脂肪酸（ω-3 PUFAs）可以改善炎症反应，影响轻度认知障碍的发生发展。但ω-6多不饱和脂肪酸（ω-6 PUFAs）的相关代谢产物既包含抗炎物质，又有促炎物质，机制较为复杂，目前研究具有争议性。综述了两种多不饱和脂肪酸对轻度认知障碍作用的机制，探讨饮食营养对改善轻度认知障碍的意义，为多不饱和脂肪酸改善轻度认知障碍以及相关营养干预提供依据。In recent years, mild cognitive impairment (MCI) has attracted attention as an early symptom of Alzheimer’s disease (AD), and its early intervention is of positive significance. Existing studies in population, animal and cell experiments have shown that ω-3 polyunsaturated fatty acids (ω-3 PUFAs) in polyunsaturated fatty acids (PUFAs) can improve inflammation, and affect the ocurrance and development of MCI. However, the related metabolites of ω-6 polyunsaturated fatty acids (ω-6 PUFAs) contain both anti-inflammatory substances and pro-inflammatory substances, and the mechanism is relatively complicated, and current research is controversial. The mechanisms of the effects of two kinds of polyunsaturated fatty acids on MCI were reviewed, and the significance of dietary nutrition in improving MCI was explored, so as to provide a basis for polyunsaturated fatty acids to improve MCI and related nutritional interventions.

模块建筑作为一种新兴的建筑体系,具有较高的预制化和装配化程度,符合建筑工业化以及绿色建筑的发展要求,但国内的模块建筑大多只应用于低多层,探索多高层模块建筑结构体系的整体设计方法和适用性意义重大。针对应用于多高层的柱承重式钢模块建筑结构体系,首先根据抗侧力体系的不同,对典型的结构体系类型进行分类和简要介绍。考虑模块结构与传统结构的组成方式有所不同,对其特点及建模方法进行了论述。之后采用MIDAS/Gen有限元软件建立了大量模型进行分析,探究不同抗震设防烈度及建筑高度变化的情况下,各结构体系计算结果的变化规律,并与规范要求进行对比,从而得出各类抗侧体系的适用范围,最后提出针对多高层柱承重式模块建筑的设计建议。

模块建筑是一种新型的建筑结构体系,具有工业化程度高、施工绿色环保等优点,随着装配式建筑的大力发展,模块建筑得到了广泛的应用。一个完整的模块其四周墙体的蒙皮效应是不可忽略的,对某公寓实际工程中模块建筑的蒙皮效应进行研究,得出蒙皮效应在模块建筑中所发挥的刚度贡献,并采用等效的方式将其刚度贡献考虑在整体模型中进行分析,进而将钢模块-框架复合结构体系简化为纯模块体系。分析发现,模块建筑墙体的侧向刚度对结构有较大贡献,考虑蒙皮效应后,结构的总体位移和层间位移均有所减小,使结构用钢量得以降低并使结构得以简化。

高雄市立图书馆,地上结构以位于四角的巨型柱与第8层的巨型桁架层组成巨型框架作为主要抗侧力及竖向力系统,并利用钢材受拉最有效率的设计原则,采用高张力钢棒悬吊3楼至7楼的楼板,有效减小柱截面尺寸,实现了地面层的无柱开放空间。地下部分以经济性最好的钢筋混凝土梁柱构造加上筏式基础。该工程为悬吊式结构,故施工顺序是先完成巨柱及顶部桁架层,再自上而下建造,有别于传统建筑工法。该工程在完工后还针对整体结构及楼板作微震测量,以考察理论分析和实际建筑物的振动频率差异,及楼板振动的舒适性。

【目的】体外实验探索使用Cool-tipTM射频消融电极进行离体心肌组织射频消融的适宜条件，以及消融灶范围内温度变化趋势，为制定解除梗阻性肥厚型心肌病（HOCM）左心室流出道梗阻，提供安全可靠的射频消融条件参考。【方法】采用针尖裸露端2 cm的Cool-tipTM射频消融电极对30枚新鲜离体猪心进行射频消融，能量输出功率分别采用20、30、40、60和80W，消融时间为2 min、4 min，观察不同消融条件造成的心肌组织凝固范围和形态。采用实时温度测量设备测量消融电极针尖处及距其5 mm、10 mm的热场温度变化。【结果】单次能量输出造成的心肌消融灶范围为横径（0.8～2.3）cm × 纵径（2.2～3.2）cm，横径变化范围更大；随输出功率及时间增加，心肌消融灶体积增大，为（0.8～8.1）cm3。消融过程中，各温度测量点温度均随时间增加而升高，针尖处温度迅速升高，最高温度可达（128.5 ± 0.3）℃；距针尖5 mm处最高温度可达（98.1 ± 0.4）℃，距针尖10 mm处最高温度可达（72.9 ± 0.2）℃。【结论】对离体心肌射频消融可得到随时间、功率改变而变化的消融灶，以射频电极为中心的向外部温度逐渐降低的热场分布，为临床采用超声引导下经皮室间隔射频消融技术治疗梗阻性肥厚型心肌病的参数条件选择提供基本依据。

【目的】研究人远端上游原件结合蛋白（FUBP1）在舌鳞状细胞癌（TSCC）组织及其癌旁正常组织中 的表达情况，探讨FUBP1在TSCC发生发展中的作用及其临床意义。【方法】采用免疫组化法检测FUBP1在收集 的90例TSCC组织及其癌旁正常组织中的表达；qRT-PCR及Western blot技术分别检测20对和8对TSCC组织及 其癌旁正常组织中FUBP1的表达，并分析其与患者临床病理参数、预后的关系。【结果】免疫组化、qRT-PCR和 Western blot结果均显示，TSCC组织中FUBP1的表达水平高于相应癌旁正常组织（P

摘要：【目的】初步探讨经食道三维超声心动图在房颤患者经皮左心耳封堵术中的应用价值。【方法】2015年10月至 2016年6月大连地区房颤患者7例，女性4例，男性3例，平均年龄（71.5 ± 3.6）岁。术前利用经食道三维超声心动图测量左 心耳开口最大直径、最小直径和最大深度，并观查左心耳开口形态和分叶数，选用美国波士顿WATCHMAN封堵器，判断封 堵器大小是否合适。术中在经食道超声引导下监测封堵过程，并于术后3个月复查。【结果】7例患者均封堵成功。术前经 食道三维超声心动图显示左心耳开口5 例呈椭圆形，2 例呈近圆形，分叶数（1.6 ± 0.8）个，测量左心耳口最大直径（23.1 ± 1.7）mm，最小直径（19.2 ± 2.1）mm，最大深度（27.6 ± 3.3）mm，最大直径与封堵器大小相关性良好（r = 0.944，P = 0.001）。术 中经食道三维超声心动图引导房间隔穿刺、输送鞘管放置、封堵器输送释放，释放后压缩比为（20.4 ± 2.7）%，6例无残余分 流，1例有少量残余分流。术后3个月复查封堵器位置形态良好。【结论】经食道三维超声心动图术前评估左心耳形态及大 小并选择合适封堵器、术中引导房间隔穿刺及封堵器输送和释放、术后即刻评价封堵器位置及残余分流，在经皮左心耳封 堵术中具有重要作用。

THz（太赫兹）通信在高速、超宽带的无线接入网中有着重要的应用。THz光开关是THz通信的关键器件之一,对其进行研究具有重要意义。文章设计了一种新型的基于复式晶格光子晶体的多波长THz光开关,它能够有效地实现四波长THz波的开、关控制。利用RSOFT软件中的FDTD（有限差分时域）方法进行了仿真,结果表明,该开关的消光比达40dB,插入损耗为0.109dB,开关速率为5.55GHz,在未来无线光通信方面有着重要的应用潜力。

针对武汉中心主塔楼智能型施工钢平台模架体系复杂,制作要求精度高和制作过程中的重点、难点等进行了分析总结。从下料、组装、焊接和制孔等工序流程,严格管理智能型施工钢平台钢框架体系的生产全过程,控制每道工序的质量。通过合理的制作工艺方案,反变形参数的设置、焊接后应力消除的处理和钻模钻孔技术的应用,有效地控制了焊接变形问题以及确保了高强度螺栓孔群的精度。通过在胎架上进行预拼装,及时对预拼装尺寸进行检查与纠偏,从而保证了构件的加工精度。

本研究主要探讨挫屈束制消能斜撑构架中梁柱效应及斜撑轴力效应对接合板耐震行为影响,利用一层楼挫屈束制消能斜撑构架试验及非线性有限元素分析,研究接合板在斜撑构架下的受力行为。本研究考虑接合板在同时承受构架效应（梁及柱剪力效应）及斜撑轴力下的影响,提出等效支撑概念计算接合板在受构架开合（梁及柱剪力）下的力量,如此将接合板的受力分为由构架及斜撑分别提供,再由有限元素分析观察的梁与接合板及柱与接合板界面应力分布,计算接合板端部应力值,以设计接合板及加劲板尺寸。藉由试验及有限元素分析所量测的梁、柱及斜撑力量,配合本研究提出的理论计算接合板在受梁柱开合效应下及斜撑力量下的受力模式,比对试验与分析下接合板端部的应力极值,验证此理论准确性,并建议设计准则,以确保接合板在达到设计层间侧位移角时无破坏产生。

文章采用全矢量有效折射法深入分析了光子晶体光纤结构参数及比例系数对波导色散、总色散的作用,总结了光子晶体光纤色散特性的调整方法,探索出特定色散特性光子晶体光纤的设计方法,并且设计了在800nm处具有近零平坦色散的光子晶体光纤,该光纤对于研究飞秒激光的传输特性和应用具有一定的价值。

在光通信系统中,光纤对系统性能影响较大。为了减小多模光纤的色散对光正交频分复用（OOFDM）系统性能的影响,阐述了一种新的基于恒定吞吐量的自适应调制算法,改进的算法与原始的恒定吞吐量的自适应调制算法相比,在系统误码率变化不大的情况下,算法的复杂度降低了,仿真结果证明改进算法是正确可行的。

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Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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BACKGROUND: Early postural adjustments serve as preparatory measures for forthcoming actions or potential disruptions in posture, thereby facilitating improved movement execution and mitigating destabilizing effects caused by posture interference. OBJECTIVE: To investigate the characteristics of temporal and intensity parameters of key lower limb muscles during early postural adjustment phase when stroke patients with varying levels of balance initiate walking at a self-selected comfortable pace. METHODS: The characteristics of early postural adjustments in 16 stroke patients were observed. Sixteen patients were divided into a non-fall group (n=8) and a fall group (n=8) based on the history of falls and Berg Balance Scale scores. Noraxon inertial sensors and Noraxon Ultium EMG wireless surface electromyography were utilized to collect body kinematic data and surface electromyography data during gait initiation. Muscle activation time and activation sequence of six key muscles in the lower limbs (tibialis anterior, medial and lateral gastrocnemius, rectus femoris, lateral femoris and biceps femoris muscles) during the early postural adjustment phase, as well as normalized electromyography integral values for the four time windows (each 150 ms) before gait initiation, were analyzed. RESULTS AND CONCLUSION: Stroke patients with a history of falls exhibited earlier activation times for the six key muscles in the lower limbs during gait initiation compared with those in the non-fall group. The fall group demonstrated significantly earlier activation times for tibialis anterior, lateral head of gastrocnemius, and vastus lateralis (P < 0.01, P < 0.05). In contrast, the non-fall group displayed a consistent pattern of activating extensor muscles before flexor muscles, with thigh muscle activation preceding calf muscle activation. However, in the fall group, calf extensor muscle activation occurred prior to thigh extensor muscle activation, and the vastus lateralis was activated even earlier. The tibialis anterior was the last activated muscle in both groups. Specifically during T3 (> -300 to -150 ms), the tibialis anterior exhibited significantly higher activity in the fall group compared with the non-fall group (P < 0.05), while the lateral head of gastrocnemius demonstrated significant inhibition during T3 (P < 0.05) and the medial head of gastrocnemius showed significant inhibition during both T3 and T4 (> -150 to 0 ms) stages compared with the non-fall group (P < 0.01, P < 0.05). To conclude, stroke patients with varying balance abilities employ distinct early postural adjustment strategies prior to stepping, as evidenced by differences in muscle activation timing, recruitment order, and muscle activity amplitude. Patients at a high risk of falling exhibit prolonged duration of early postural adjustment and delayed initiation of gait, indicating earlier activation of the tibialis anterior muscle and inhibition of gastrocnemius muscle activity. These delays in gait initiation and variations in muscle recruitment strategies may contribute to unstable posture and an increased susceptibility to falls. [ABSTRACT FROM AUTHOR]

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Landslide disaster has the characteristics of suddenness and high destructiveness. It is of great significance to identify landslide quickly and accurately for emergency rescue and disaster assessment in affected areas. Unmanned aerial vehicle (UAV) has the advantages of flexible operation, high timeliness and high resolution, which can provide powerful technical support for landslide data acquisition in specific areas. Lvchun County of Yunnan Province was taken as the research area, and UAV visible light image was used as the data source. Firstly, the digital orthophoto map (DOM) of the study area is constructed, and multi-scale segmentation is carried out. Then, the spectrum, shape, texture and other multi-feature information are integrated to calculate the sample separation degree and optimize the feature space. Finally, the landslide identification and accuracy analysis are carried out based on object-oriented Bayes classification method. The results show that the overall accuracy (OA) of landslide identification obtained by Bayes method is 92.49%, and the Kappa coefficient is 0.888. The producer accuracy (PA) and user accuracy (UA) of landslide are 89.84% and 83.17%, respectively. In addition, compared with the landslide identification results of decision tree (DT), random forest (RF) and support vector machine (SVM), the OA of Bayes method is 3.26%~5.86% higher than that of other classification methods, and the Kappa coefficient is 0.048~0.092 higher. This method has high accuracy for landslide identification in complex and fractured mountains, and can meet the application requirements of landslide fine identification based on high-resolution UAV images. [ABSTRACT FROM AUTHOR]

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Copyright of Food Research & Development is the property of Food Research & Development Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The utilization of implicit representation for visual data (such as images, videos, and 3D models) had recently gained significant attention in computer vision research. A novel model steganography scheme with implicit neural representation was proposed. In this scheme, the message sender leveraged neural radiance fields (NeRF) and its viewpoint synthesis capabilities by introducing a viewpoint as a key. The NeRF model generated a secret viewpoint image, which served as a backdoor. Subsequently, a message extractor was trained using overfitting to establish a one-to-one mapping between the secret message and the secret viewpoint image. To transmit the secret message, the sender sent both the trained NeRF model and the message extractor to the receiver through an open communication channel. The receiver employed the shared key to obtain the rendered image from the NeRF model in the secret viewpoint. Consequently, the secret message was extracted by the message extractor. The inherent complexity of the viewpoint information prevented attackers from stealing the secret message accurately. Experimental results demonstrate that the message extractor trained achieves high-capacity steganography with fast performance, achieving a 100% message embedding. Furthermore, the extensive viewpoint key space of NeRF ensures the security of the steganography scheme. [ABSTRACT FROM AUTHOR]

Objective: To explore the mechanism of hepatitis B virus (HBV) inhibiting M1 macrophages to promote immune escape, and to provide targets and strategies for antiviral therapy. Methods: The human monocyte cell line THP-1 was induced into M1 macrophages with PMA+LPS+IFN-γ. Cell morphological changes and the expressions of CD68, CD86, HLA-DR and functional molecules IL-1β, IL-6, TNF-α in M1 macrophages were detected by flow cytometry and RT-qPCR to identify M1 macrophages. HBV stable replication cell line HepG2.2.15 were co-cultured with M1 macrophages, and the expression of HBV-DNA was detected by qPCR. The expression of CD68, CD86 and HLA-DR were detected by flow cytometry. The expressions of functional molecules TLR4, NLRP3, Caspase-1, pro-caspase-1, caspase-1 p20, IL-1β and IL-18 in M1 macrophages were determined by RT-qPCR and Western blot. Apoptosis rate was detected by flow cytometry, and the expression of apoptosis related protein cleaved-caspase-3 was determined by Western blot. Results: THP-1 was successfully induced to differentiate into M1 macrophages. M1 macrophages inhibited HBV replication (P<0.05). HBV inhibited the expressions of CD68, CD86 and HLA-DR in M1 macrophages（P<0.01). HBV inhibited the expressions of TLR4, NLRP3, Caspase-1, caspase-1 p20, IL-1β and IL-18 in M1 macrophages (P<0.01). HBV induced M1 macrophage apoptosis (P<0.05). Conclusion: HBV inhibits M1 macrophages and their functional molecules TLR4, NLRP3 and downstream factors, reduces the synthesis and secretion of inflammatory factors, induces apoptosis, and then promotes immune escape, resulting in the persistence and replication of HBV in the body. [ABSTRACT FROM AUTHOR]

Copyright of China Journal of Oral & Maxillofacial Surgery is the property of Shanghai Jiao Tong University, College of Stomatology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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