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目的探讨糖代谢异常的Ⅰ期子宫内膜样腺癌（EA）患者预后差异及其影响因素。方法选取2015年1月至2019年12月期间在中山大学孙逸仙纪念医院妇科肿瘤专科行手术治疗的Ⅰ期EA患者共387例，根据糖代谢是否正常分为糖代谢异常（IGM）组和糖耐量正常（NGT）组。其中IGM组分三个亚组，即糖尿病（DM）组、糖耐量异常（IGT）组、空腹血糖受损（IFG）组。回顾性分析各组临床病理指标及预后，探讨糖代谢异常对Ⅰ期子宫内膜样腺癌患者预后的影响及影响预后的相关因素。结果IGM组患者的5年生存率及5年无进展生存率均低于NGT组（P＜0.05）。DM组中血糖控制不达标者（糖化血红蛋白≥7.0%）5年生存率及5年无进展生存率均低于血糖控制达标者（P＜0.05）。多因素COX回归分析提示，CA125水平（≥ 35 U/mL）、淋巴脉管间隙浸润（LVSI）阳性是5年生存率的独立危险因素；脂代谢异常、LVSI阳性、深肌层浸润是5年无进展生存率的独立危险因素。结论Ⅰ期子宫内膜样腺癌患者中合并糖代谢异常者较糖耐量正常者预后差，血糖控制良好可改善合并糖尿病的早期子宫内膜样腺癌患者预后，CA125水平、LVSI阳性、脂代谢异常和深肌层浸润等因素可能影响Ⅰ期子宫内膜样腺癌患者的预后。

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Copyright of West China Journal of Stomatology is the property of Sichuan University, West China College of Stomatology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To evaluate the feasibility of using the Chinese version of Addenbrooke's cognitive examination version Ⅲ (ACE-Ⅲ) on cognitive assessment in patients with cerebellar infarction. Method: Forty patients with isolated cerebellar infarction were collected in the department of neurology, Beijing Tiantan Hospital, along with 40 healthy controls were recruited matched by age and education. The clinical demographics was collected and the severity of ataxia and balance dysfunction was assessed. ACE-Ⅲ was used to evaluate cognitive function. The Cronbach's alpha and receiver operating characteristic (ROC) curve were used to assess the reliability and validity of ACE-Ⅲ respectively. Furthermore, the correlation of ACE-Ⅲ total score with age and education was examined by spearman analysis. Result: The total score of ACE-Ⅲ in patients' group and healthy controls was 88.3±6.0 and 93.1±3.0 respectively, showing a significant different (P<0.001). Compared with healthy group, patients with cerebellar infarction had lower performance in attention (P<0.001), language fluency (P<0.001) and visuo-spatial function (P=0.001). The overall Cronbach's alpha of ACE-Ⅲ was 0.58, and the area under curve was 0.79±0.05 (95% confidence interval: 0.69—0.89). According to Youden index, the optimal cut- off for ACE-Ⅲ was 88. Furthermore, spearman analysis showed cognitive function was significant negative associated with age in patients' group (r=-0.52, P<0.0001) and healthy controls (r=-0.67, P<0.001), and was significant positive associated with education in patients' group (r=0.74, P<0.01) and healthy controls (r=0.72, P<0.0001) Conclusion: ACE-Ⅲ scale is a good tool to detect cognitive dysfunction in patients with isolated cerebellar infarction. The total score of ACE-Ⅲ is associated with age and educational attainment. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Ordnance Equipment Engineering is the property of Chongqing University of Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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糖尿病脑病(DE)是糖尿病最常见的慢性并发症之一, 其发病机制目前尚未完全阐明, DE作为中枢神经系统的严重并发症正逐渐成为国内外研究的热点之一。近年来, 随着学者们对DE 的研究进展,DE的发病机制也愈渐明确, 且针对不同的发病机制研究了多种治疗方法。该文就目前 对DE的发病机制和治疗已有的文献及新进展进行综述, 以期为DE的早期防治提供参考. [ABSTRACT FROM AUTHOR]

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Copyright of Journal of Chongqing University of Technology (Natural Science) is the property of Chongqing University of Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of Science Technology & Engineering is the property of Chinese Society of Technology Economics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

In order to improve the position estimation accuracy of ORB-SLAM2 system and solve the problem that only generate sparse maps, proposing position estimation strategy integrating the ICP(iterative closest point) algorithm and the Manhattan world hypothesis and adding dense-map building thread on the system. Firstly, extracting point, line and surface features by ORB(oriented fast and rotated brief) feature point method, LSD( least-significantdifference) algorithm and AHC( agglomerative hierarchical clustering) method, in which matching the point and line features with previous frame and matching the surface features in the global map. Then the image was divided into non-planar and planar raegions using surfel-based dense-map building strategy, the non-plane uses the ICP algorithm to compute pose, and the plane determines Manhattan world through the orthogonal relationship between plane and plane to use different estimation strategies. The Manhattan world scene realizes the drift-free rotation estimation based on the observation of the Manhattan frame through position decoupling, the translation of the scene and the pose of the non-Manhattan world scene were estimated and optimized by the traced points, lines and surface features. Finally, according to the key frame and the corresponding pose to realize the dense-map. The TUM(technische universität münchen) dataset was used to verify the map method, comparing with ORBSLAM2 algorithm, RMSE(root mean squared error) decreased by 0. 24 cm and the average positioning accuracy increased by 7. 17%, which verify the feasibility and effectiveness of the proposed method for the dense map. [ABSTRACT FROM AUTHOR]

Heavy metal pollution is one of the most serious risks to sustainable agriculture in China. Among them, mercury (Hg) and lead (Pb) are two of the most hazardous heavy metals. Typically, Hg2+ and Pb2+ are believed to threaten the growth of crops and the quality of agricultural products, when entering the farmland via atmospheric sedimentation and irrigation. As a result, it is urgent to develop efficient devices for the accurate, rapid and on-site detection of Hg2+ and Pb2+ in farmland. In this work, a functional nucleic acid (FNA)-based ratiometric and electrochemical device was developed to couple the microcontroller unit (MCU) voltage application and laser-induced graphene (LIG) electrode array. A series of experiments were carried out to verify the feasibility of this device for the Hg2+ and Pb2+ detection in farmland. The electric field was designed to improve the analytical performance. Briefly, the 3.0V electric field was applied to push the Hg2+ and Pb2+ approaching FNA, while retaining the orientation of FNA at the surface of the LIG electrode; The 2.5 V electric field was also used to collect the signals, where the FNA orientation was remained to provide a constant current as a reference signal. The single-chip microcomputer (AT89S52) was selected as the main control chip on the applied voltage, while the DAC0832 was the output port of voltage. The electric field generator was developed to control the output voltage using a single-chip microcomputer. The programmable output of voltage was realized to verify the stability of voltage signal output by oscilloscope. The electric field was utilized to enhance the preconcentration of heavy metals. The output voltage and time were directly displayed on the LCM display. LIG electrode array was applied to fabricate the FNA-based biosensor. The CO2 laser direct writing was utilized to prepare the LIG electrode. One step free of any treatment was realized to prepare the working, reference, and counter electrodes. The large surface area and high conductivity of graphene allowed for the high performance of the as-prepared sensor. The epoxy resin transfer was also developed to efficiently fabricate the LIG electrode array. The LIGbased reference electrode showed higher stability and reliability, compared with the commercial Ag/AgCl ones. The ferrocene (Fc)-labeled FNA for Hg2+, and methylene blue (MB)-labeled FNA for Pb2+ were bound to the anthraquinone-2-carboxylic acid (AQ)-labeled complementary DNA (cDNA), in order to assemble the sensing interface at the LIG electrode array. Doublestranded DNA (dsDNA) was obtained to assemble on the LIG electrode array. Then, the MCU voltage module and LIG electrode array were combined to assemble the detection device. And the currents of MB (IMB), Fc (IFc), and AQ (IAQ) were recorded by the electrochemical workstation. The ratios of IAQ/IFc and IAQ/IMB increased at the higher concentration of Hg2+ and Pb2+, thus representing the response signal for the detection of Hg2+ and Pb2+, respectively. Consequently, the higher limits of detection were achieved in 8.5×10-12 mol/L (4.25×10-11 mg/L) and 4.6×10-13 mol/L (2.22×10-12 mg/L) (S/N=3) for Hg2+ and Pb2+, respectively. The linear ranges of this device were 1.0×10-11 -1.0×10-8 mol/L (5×10-11 -5×10-8 mg/L), 1.0×10-12 -1.0×10-9 mol/L (4.8×10-12 -4.8×10-9 mg/L) for the detection of Hg2+ and Pb2+, respectively. Moreover, the high selectivity was realized in the field of accurate detection of Hg2+ and Pb2+. This device was successfully used to analyze the water for agricultural irrigation. At last, the reliability of the detection was also validated by the gold standard of inductively coupled plasma mass spectrometry (ICP-MS). The findings can offer scientific information to monitor and remediate heavy metal pollution. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Aesthetic & Plastic Surgery is the property of Chinese Journal of Aesthetic & Plastic Surgery Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of Food & Fermentation Industries is the property of Food & Fermentation Industries and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Sixteen Male Sprague-Dawley rats were divided into control and acute silicosis model groups, and instilled intratracheally with 1 mL of normal saline and 50 g/L silica suspension, respectively. After 7 d, the rats were sacrificed for collection of lung tissue and serum. The serum levels of interleukin-1β （IL-1β）, IL-18 and tumor necrosis factor-α （TNF-α） were measured by using ELISA. The protein expression levels of nucleotide-binding oligomerization domain-like receptor protein 3（ NLRP3） and gasdermin D（ GSDMD） were measured by immunohistochemistry. Bacterial DNA was extracted from the lung tissue for 16S ribosomal RNA gene sequencing to characterize changes in the composition of lung flora. The differences in the structure of bacterial flora between control and model groups were analyzed by bioinformatic analyses. RESULTS: Immunohistochemical analysis showed that the protein expression levels of NLRP3 and GSDMD were higher in the lungs of the rats in model group. In addition, serum cytokine profiling showed that IL-1β, IL-18 and TNF-α levels were significantly higher in model group. The most abundant bacterial genera in the lung flora of the rats in model group were Bifidobacterium, Clostridium sensu stricto 1, and Parasutterella. The NLRP3 and GSDMD levels in the lung tissue and IL-1β and TNF-α levels in serum were positively correlated with the abundance of Parasutterella. CONCLUSION: The alterations in lung flora structure and increased inflammation levels may be the actual biological mechanisms underlying silica-induced acute lung injury. The modulation of lung flora may provide a basis for the prevention and treatment of silica-induced acute lung injury. [ABSTRACT FROM AUTHOR]

On December 23-24, 2023, the 2023 Annual Conference on Information Behavior Research was held at Peking University, with more than 200 participants from over 70 universities across China. The theme of this year's conference is "Research on Information Behaviors from the AI Empowerment perspective". The agenda of the conference include keynote speeches, panel discussions, poster presentations, sub- forum oral presentation of full papers, and a workshop on eyetracking method, to conduct in-depth discussions on theoretical innovation, method application, situational expansion, humanistic care, social development, and other aspects of information behavior research in the new wave of artificial intelligence (AI) technology. The article summarizes the academic achievements and main viewpoints of the participants, providing theoretical enlightenment and research guidance for the exploration and innovation of information behavior research. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Clinical Nursing in Practice is the property of Journal of Clinical Nursing in Practice (Editorial Board, Shanghai Jiao Tong University Press) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of Journal of Clinical Pediatric Surgery is the property of Journal of Clinical Pediatric Surgery Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To understand the screening of 296 106 newborns with intrahepatic cholestasis caused by citrin protein deficiency born in Heze area from May 2015 to December 2021. Methods The heel blood samples of 296 106 newborns born in Heze area from May 2015 to December 2021 were collected to screen for intrahepatic cholestasis caused by the deficiency of citrin protein. The primary screening method was liquid chromatography-tandem mass spec‑ trometry (LC-MS/MS) analysis. In addition to LC-MS/MS analysis, alpha-fetoprotein (AFP), SLC25A13 gene detection, and gas chromatgraphy-mass spectrometrometry (GC-MS) were performed during follow-up. Results Sixteen cases of in‑ trahepatic cholestasis were confirmed, the prevalence rate was 16/296 106, the detection rate was 13/16. Among them, 8 cases were diagnosed with the increase of specific citrulline value in the primary screening, 5 cases were diagnosed with re‑ screening of abnormal non-specific index value, and 3 cases were diagnosed with rescreening after onset. Compared with the primary screening, the results of MS/MS were significantly different, and the results of urine gas chromatography, blood AFP, SLC25A13 gene were obviously abnormal. A total of 11 SLC25A13 gene mutations were found, and c. 852_ 855del was the most common mutation, accounting for 50%, followed by IVS16ins3kb, accounting for 33%. Conclusions Most cases of intrahepatic cholestasis caused by citlin protein deficiency can be primarily screened by MS/MS, and rescreening should be combined with urine gas chromatography, blood AFP, SLC25A13 gene detection to improve the detection rate of this disease. [ABSTRACT FROM AUTHOR]