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旨在为开发高附加值鸡油产品提供原料，以黄羽肉鸡腹脂为原料，利用二次干法分提技术提取富含不饱和脂肪酸的鸡液油。以鸡液油得率、碘值为评价指标，通过单因素试验和正交试验对一次干法分提和二次干法分提工艺条件进行优化，并对分提前后鸡油的脂肪酸组成进行分析。结果表明：一次干法分提最优工艺条件为冷却速率8 ℃/h、结晶温度24 ℃、养晶时间9 h，在此条件下鸡液油得率为77.71%，碘值(I)为75.89 g/100 g，不饱和脂肪酸含量由原料粗鸡油的63.87%提高至70.44%；二次干法分提最优工艺条件为结晶温度16 ℃、冷却速率2 ℃/h、养晶时间15 h，在此条件下鸡液油得率为78.85%，碘值(I)为81.52 g/100 g，不饱和脂肪酸含量为73.40%。综上，与原料粗鸡油相比，一次干法分提后鸡液油的不饱和脂肪酸含量有所提高,二次干法分提后鸡液油的不饱和脂肪酸含量进一步提高。In order to provide raw materials for developing high value-added chicken oil products, the chicken olein rich in unsaturated fatty acids was fractionated from yellow feather broiler belly fat by secondary dry fractionation technology. The extraction conditions of single and secondary dry fractionation were optimized by single factor test and orthogonal test with the yield and iodine value of the chicken olein as indexes. The fatty acid composition of chicken oil before and after fractionation was analyzed. The results showed that the optimal conditions for single dry fractionation were cooling rate 8 ℃/h, crystallization temperature 24 ℃, and crystallization time 9 h. Under these conditions, the yield of chicken olein was 77.71%, the iodine value was 75.89 gI/100 g, and the content of unsaturated fatty acids increased from 63.87% to 70.44%. Under the optimal conditions for secondary dry fractionation of cooling rate 2 ℃/h, crystallization temperature 16 ℃, and crystallization time 15 h, the yield of chicken olein was 78.85%, the iodine value was 81.52 gI/100 g, and the content of unsaturated fatty acids was 73.40%. In conclusion, compared with raw chicken oil, the content of unsaturated fatty acid of chicken olein increases after single dry fractionation, and the unsaturated fatty acid content of chicken olein can be further increased after the secondary dry fractionation.

为提高低温压榨菜籽饼的附加值和应用价值，采用石油醚对低温压榨菜籽饼进行脱脂，然后利用超声预处理分别辅助木瓜蛋白酶和碱性蛋白酶直接酶解制备菜籽肽，通过单因素试验探究超声功率、超声时间及酶添加量对菜籽肽得率的影响，通过响应面法优化超声辅助酶解工艺条件，并对所得菜籽肽的组成、物理特性以及结构进行分析。结果表明：碱性蛋白酶酶解的菜籽肽得率高于木瓜蛋白酶的；最佳超声辅助碱性蛋白酶酶解工艺条件为酶添加量12 289.79 U/g、超声时间21.82 min、超声功率306.56 W，该条件下菜籽肽得率为55.19%；最佳条件下所得菜籽肽的分子质量范围为88.02~1 290.00 Da，其中9840%的菜籽肽分子质量小于500 Da，相较于未超声辅助酶解，所制备的菜籽肽氨基酸含量增加，粒径变小，Zeta电位绝对值变大，二级结构中α-螺旋和β-折叠含量增加，β-转角含量减少，二级结构更有序、稳定。综上，超声辅助酶法不使用有机溶剂，环境友好，且产品品质较好，可以用于高效提取菜籽肽。 To enhance the added value and application potential of low temperature pressed rapeseed cake, the low temperature pressed rapeseed cake was defatted with petroleum ether, then ultrasound pretreatment was employed to assist in the direct enzymatic hydrolysis using both papain and alkaline protease to prepare rapeseed peptides. Single-factor experiments were conducted to investigate the effects of ultrasound power, ultrasound time, and enzyme addition amount on the yield of rapeseed peptides, followed by optimization of process conditions using response surface methodology. The composition, physical properties and structure of the obtained rapeseed peptides were analyzed.The results indicated that the yield of rapeseed peptides obtained by alkaline protease hydrolysis was higher than that of papain. The optimal process conditions were alkaline protease addition amount 12 289.79 U/g, ultrasound time 21.82 min, and ultrasound power 306.56 W. Under the optimal conditions, the yield of rapeseed peptide was 55.19%, and the molecular weight of rapeseed peptides ranged from 88.02 Da to 1 290.00 Da, with 98.40% of rapeseed peptides less than 500 Da. Compared with the product without ultrasound assisted enzymatic treatment, the content of amino acid of rapeseed peptides increased, the particle size decreased, the absolute value of Zeta potential increased, α-helix and β-folding in the secondary structure increased, β-angle decreased, and the secondary structure was more orderly and stable. In conclusion, ultrasound assisted enzymatic methods does not use solvent, is environmentally friendly and has good product quality, and can be used for the efficient and direct extraction of rapeseed peptides.

Objective To investigate the effect of Tuina combined with auricular acupoint pressing therapy in the treatment of post-stroke constipation. Methods Totally 100 bedridden patients with post-stroke constipation were randomly divided in the observation group and control group, with 50 cases in each group. All patients received comprehensive treatment and routine nursing interventions, and those in the observation group were given Tuina combined with aricular acupoint pressing therapy. The intervention effect was evaluated and compared between two groups. Results The total effective rate was 94. 00%(47/50) in the observation, which was higher than 66. 00%(33/50) in the control group(P＜0. 05). Conclusion Tuina combined with aricular acupoint pressing therapy is effective to relive the symptoms of constipation in bedridden patients with post-stroke constipation. (目的 探讨便秘推拿联合耳穴压豆治疗中风后恢复期便秘的效果。方法 将100例卧床的中风后恢复期便秘患者随机分为观察组及对照组, 各50例。对照组实施常规护理干预, 观察组在对照组基础上增加便秘推拿联合耳穴压豆。评价两组干预效果。结果 观察组总有效率94. 00%(47/50), 高于对照组的66. 00%(33/50), 差异有统计学意义(P＜0. 05)。结论 对中风后恢复期患者采用便秘推拿配合耳穴压豆, 能进一步缓解便秘症状。)

Objective To understand the current status of humanistic care in clinical nursing teaching, and analyze its influencing factors. Methods Using the convenient sampling method, a total of 170 clinical nursing teachers were selected. Caring Ability Inventory and the general information questionnaire were used to investigate clinical nursing teachers. Results A total of 170 questionnaires were distributed, and 164 were effectively recovered, with an effective recovery rate of 96. 47%. The humanistic care behavior score of clinical nursing teacher was (100. 90±12. 97). Univariate analysis revealed that the dimension of respectful and connectedness was influenced by marital status, professional titles, years of working and years of clinical teaching(P＜0. 01), dimension of knowledge and skill was influenced by education level and whether having children(P＜0. 01), and dimension of assurance was influenced by marital status and whether having children(P＜0. 01). Multiple linear regression analysis showed that education level and whether having children were influencing factors of teachers’ knowledge and skill in humanistic care practice, which explained 4. 80% of the variation. Conclusion The level of humanistic care behavior in clinical nursing teacher is at a medium level, which is related to marital status. The level of humanistic care behavior in clinical nursing teacher is associated with whether having children, years of working, years of clinical teaching, professional titles, education level and other factors. Nursing managers should take targeted measures to strengthen the cultivation of humanistic care ability in clinical nursing teachers. (目的 了解临床护理带教人文关怀行为现状, 探究影响因素, 为提升临床护理人文关怀水平提供参考。方法 采用方便抽样法, 随机抽取170名临床护理带教老师为调查对象, 使用护理人文关怀量表、一般资料调查表等工具进行问卷调查。结果 共发放170份问卷, 有效回收164份, 有效回收率96. 47%, 临床护理带教人文关怀行为评分为(100. 90±12. 97)分。单因素分析显示, 尊重和联系维度与护士婚姻状况、职称、工作时长、参加带教工作时长有关(P＜0. 01), 知识和技能维度与护士文化水平、有无子女有关(P＜0. 01), 支持和保证维度与护士婚姻状况、有无子女有关(P＜0. 01)。多重线性回归分析显示, 文化水平及有无子女对护理人文关怀能力的知识和技能维度有显著影响, 可解释人文关怀能力知识和技能维度变异的4. 80%。结论 临床护理带教人文关怀行为水平处于中等水平, 与婚姻状况、有无子女、工作时长、带教时长、职称、文化水平等因素相关, 护理管理者应采取针对性的措施加强临床护理带教的人文关怀能力的培养。)

为了科学指导坚果选购和膳食合理搭配，以福建地区5个获全国农产品地理标志的花生品种（“赖坊”“衙口小琉球”“朱口小籽”“文亨红衣”“洋后”）为研究对象，以七大类营养素、必需脂肪酸、必需氨基酸和部分功能性营养因子共50种营养素为评价指标，依次计算花生仁中营养素的多样度、匹配度和平衡度。在此基础上，计算综合评价指标偏离指数，获得5种花生仁营养价值的综合排序。结果表明：5种花生仁营养素的多样度一致，均含有46种营养素，但匹配度差异较大，“洋后”“赖坊”“朱口小籽”“衙口小琉球”“文亨红衣”的匹配度分别为0.933、0.671、0.449、0.440和0.367；5种花生仁营养素的平衡度比较接近，介于0.353~0.375之间；5种花生仁营养素的偏离指数从低至高排序为“洋后”“赖坊”“朱口小籽”“衙口小琉球”“文亨红衣”。因此，5种花生中营养价值最高的为“洋后”，最低的为“文亨红衣”。In order to scientifically guide the selection of nuts and dietary rationing, five peanut varieties of Lai Fang (LF), Yakou Xiaoliuqiu (YK), Zhukou Xiaozi (ZK), Wenheng Hongyi (WH) and Yang Hou (YH) with national geographical indications of agricultural products in Fujian were selected as the research objects, a total of 50 nutrients including seven types of nutrients, essential fatty acids, essential amino acids and some functional nutrition factors were used as evaluation indexes, and the degree of diversity (DD), degree of match(DM) and degree of balance(DB) of nutrients in peanut kernels were calculated. On this basis, the deviation index of the comprehensive evaluation index was calculated to obtain the comprehensive ranking of the nutritional value of five varieties of peanut kernels. The results showed that the DD of the five varieties of peanut kernels were the same, all containing 46 nutrients, but the MD were different. The MD of YH, LF, ZK, YK and WH were 0.933, 0.671, 0.449, 0.440 and 0.367, respectively. The DB of five varieties of peanut kernel nutrients were close, ranging from 0353 to 0.375. The deviation index (DI) of five varieties of peanut kernels was ranked from low to high as YH, LF, ZK, YK and WH. Therefore, among the five peanut varieties, the highest nutritional value is YH, and the lowest is WH.

波纹钢板剪力墙（Corrugated Steel Plate Shear Walls， 简称CSPSW）作为一种新型抗侧力构件，其几何构造在一定程度上起到了加劲肋作用，避免了板面加劲肋的焊接问题。两边连接横向CSPSW通过合理设计可实现先屈服后屈曲，具有两阶段受力特征，可获得较高的初始抗侧刚度和残余水平承载力。采用有限元软件ABAQUS对两边连接横向CSPSW的滞回性能进行系统的参数研究，提出了具有较优残余水平承载力的板型推荐建议。通过对影响CSPSW力学性能的高厚比（H/t）、跨高比（L/H）、波长（Cl）、波形比（Ca/Cl）和波纹角（θ）等几何参数进行了分析，发现高厚比和跨高比对CSPSW抗侧性能影响最大，波纹钢板高厚比应在450~900之间，跨高比建议控制在0.7~1.0之间，可获得良好的滞回耗能和延性；波纹钢板的波形比及波纹角是影响两边连接横向CSPSW残余水平承载力和耗能能力的重要因素，波纹钢板的波形比控制在0.5~1.0之间且波形角控制在90°~120°之间，两边连接横向CSPSW可获得足够的残余水平承载力。

目的探讨估计葡萄糖处置率（eGDR）与冠心病（CAD）严重程度的关联。方法采用以医院为基础的横断面研究设计，纳入因疑似冠心病而接受冠状动脉造影检查的患者共1 258人（平均年龄：62（53~68）岁；男性占53.9%）。按照eGDR公式计算胰岛素抵抗水平（IR）：eGDR =21.158 - ［0.09×腰围（WC， cm）］ - ［3.407×高血压（hypertension， 是/否）］ - ［0.551×糖化血红蛋白（HbA1c， %）］。根据eGDR三分位数对研究对象进行分组。冠心病的严重程度由狭窄血管的数量决定： 无明显CAD组（所有冠脉狭窄均n=704），单支血管CAD组（只有一条受累的主要冠脉狭窄≥50%，n=205），多支血管CAD组 （两条或两条以上受累的主要冠脉存在狭窄≥50%，n=349）；以无明显CAD作参照，采用多因素logistic回归模型分析eGDR与CAD严重程度之间的关联。采用限制性立方样条分析eGDR和CAD在整个eGDR范围内的线性关联。采用亚组分析评估不同糖尿病状态下eGDR和CAD严重程度之间的关联。受试者工作特征（ROC）曲线分析eGDR对提高CAD筛查模型的价值。结果eGDR降低与CAD严重程度的风险增加显著相关。（OR：2.79；95%CI：1.72~4.55；PPP-linearityPPP>0.05）。ROC曲线分析，eGDR加入到CAD传统筛查模型中时，AUC、IDI、NRI的结果显示，模型对CAD和多支血管CAD的筛查有显著改善。结论eGDR与CAD及CAD严重程度呈负相关。eGDR作为一种无创且易于获取的非胰岛素测量指标，具有筛查大规模人群中CAD严重程度的潜在价值。

目的对比应用解剖型锁定钛板与髓内钉治疗胫骨远端骨折的临床疗效与并发症情况。方法自2019年9月至2021年9月，于中山大学孙逸仙纪念医院诊断为胫骨远端AO-A型骨折的手术患者纳入本研究，共32例。其中15例采用钛板螺钉治疗，17例采用髓内钉治疗。比较两组一般手术指标、骨折愈合时间、术后并发症发生情况、手术前后VAS评分及术后踝关节功能。结果患者均获得随访，随访时间10～20个月，平均12个月。髓内钉组手术时间、术中透视次数均长于钛板螺钉组，但术前等待时间、住院天数少于钛板螺钉组，统计学差异显著（P＜0.05）；两组骨折愈合时间相比，差异无统计学意义（P＞0.05）；术后6周，两组VAS评分均低于术前，统计学差异显著（P＜0.05）；髓内钉组与钛板螺钉组相比，手术前后VAS评分差异无统计学意义（P＞0.05）；术后6月AOFAS评分、术后1年踝关节活动度、并发症发生率髓内钉组优于钛板螺钉组，统计学差异显著（P＜0.05）；术后1年AOFAS评分两组差异无统计学意义（P＞0.05）。结论钛板螺钉与髓内钉均是治疗胫骨远端AO-A型骨折的有效术式，远期临床疗效无明显差异。髓内钉的软组织并发症较少，对踝关节活动度影响更小，康复更快，安全性更高，而钛板螺钉发生术后软组织感染的概率较大。我们建议在临床工作中，应该做好患者的术前评估，在把握适应症的前提下，髓内钉并发症更少，有一定优势。

目的诺卡氏菌是一种病原体，可引起人体的机会性感染，呈全球性分布。近年来发现诺卡氏菌对常用药物已产生耐药性，因此，挖掘新抗诺卡氏菌药物靶点、开发新药物具有迫切需求。方法取GenBank数据库中31株诺卡氏菌的全基因组序列，利用BPGA进行泛基因组学分析，利用消减蛋白组学筛选药物靶点。在此基础上，同源建模预测靶点蛋白的3D结构，采用DrugBank对靶点蛋白进行潜在药物的预测，并使用分子对接技术验证药物与靶点的结合活性。结果31株诺卡氏菌的泛基因组中有1 421个核心蛋白，消减蛋白组学分析获得15个候选药物靶点蛋白。其中，OG1493蛋白的理化性质（氨基酸数目、分子量、等电点、总平均亲水性、脂肪指数和不稳定性指数Ⅱ等）最符合作为靶点蛋白的理化性质。运用DrugBank数据库筛选出Adenosine-5'-Rp-Alpha-Thio-Triphosphate、 alpha，beta-Methyleneadenosine 5'-triphosphate、 Phosphoaminophosphonic Acid-Adenylate Ester 、Radicicol、2-Hydroxyestradiol、p-Coumaric acid、Ethylmercurithiosalicylic acid等7个化合物可能会针对该靶点蛋白发挥抗诺卡氏菌作用，分子对接结果显示靶点与化合物结合力良好。经实验验证发现根赤壳霉素可能是针对该靶点的抗诺卡氏菌药物。结论泛基因组学和消减蛋白质组学可应用于挖掘新型抗诺卡氏菌药物靶点 。

目的比较程控硬膜外间歇脉冲注入技术（PIEB）与持续硬膜外输注（CEI）在剖宫产术后快速康复中的效果。方法择期行剖宫产术患者120例，年龄18～45岁，单胎，足月妊娠（≥37周），ASA分级Ⅱ或Ⅲ级。采用随机数字表法分为程控硬膜外间歇脉冲注入组（PIEB组）与持续硬膜外输注组（CEI组），每组60例。术毕两组患者通过硬膜外导管给予相同镇痛首剂后实施硬膜外镇痛。PIEB组在首次剂量注入30分钟后，开始PIEB模式，6 mL·h-1；CEI组首次剂量注入后立即开始CEI模式，6 mL·h-1。镇痛泵中均使用0.1％罗哌卡因。于术后2、6、12、24和36 h采用VAS评分评估患者的整体疼痛情况，采用Bromage score评分评估双侧下肢的运动阻滞程度；记录术后首次肛门排气的时间、首次下床活动的时间和麻醉满意度评分。结果PIEB组术后12、24和36 h VAS评分及术后6、12和24 h下肢Bromage评分均低于CEI组，差异有统计学意义（PP=0.002）。PIEB组首次肛门排气时间和下床活动时间短于CEI组，麻醉满意度高于CEI组，差异有统计学意义（PP＞0.05）。结论与CEI相比，PIEB可为剖宫产患者提供更好的术后镇痛、降低术后运动阻滞评分、减少硬膜外镇痛用药量、缩短术后首次排气时间和首次下床活动的时间，并提高患者的满意度，更有利于患者术后早期的康复。

Siqi Tiaoshen Dalun is an important part of Traditional Chinese Medicine (TCM) healthcare thought, discussing the physiological and psychological changes of the human and its relationship with seasonal changes. Theoretical principle and practical application of health preservation in four seasons were demonstrated in Siqi Tiaoshen Dalun, which plays an important role in guiding the prevention of diseases and keeping physical fitness in modern life. (《素问·四气调神大论》从四季论述了人与自然相对应的生理及心理变化, 讲述了四季不同的养生原则, 对中医养生及现代疾病预防、强身健体的发展起到了重要的指导作用。)

To explore the causes and nursing strategies of peripherally inserted central catheters (PICC) removal difficulty in senior elderly patients. A senior elderly patient with PICC difficulty for removing was analyzed comprehensively. The main reasons for the difficulty of removal were the adhesion of the catheter tip to the wall of superior vena cava, the change of anatomical structure of the vein and the loss of elasticity of the catheter after repeated pulling. The senior elderly group has some characteristics different from the general patient group, such as long-term bed rest, limb loss, long-term intravenous parenteral nutrition and so on, During the use of PICC, attention should be paid to abnormal changes of catheter, consult with specialist nurses in time, and solve problems with multidisciplinary consultation when necessary, so as to avoid difficulties in removal caused by improper maintenance and improper removal operation and serious complications caused by removal failure. (探讨老年高龄患者经外周静脉穿刺置入中心静脉导管(PICC)拔管困难的原因和护理对策。对1例老年高龄患者PICC拔管困难进行综合分析。导管头端黏附于上腔静脉壁、静脉解剖结构改变、反复牵拉导管至导管失去弹性是此患者拔管困难的主要原因。老年高龄群体有一些不同于普通患者群体的特点, 如长期卧床、肢体失功、长期静脉高营养等特点, PICC使用期间应关注导管异常变化, 及时请专科护士会诊, 必要时联合多学科会诊解决问题, 以避免因维护不当以及拔管操作不当导致的拔管困难以及因拔管失败造成的严重并发症。)

This paper summarized the nursing management for a long-term bedridden elderly patient with nasal feeding diet complicated with various diseases. During the daily oral care, the patient swallowed the mouth care straw tip (silicone foreign body) accidentally. Given the old age and poor gastrointestinal function of the patient, targeted intervention was implemented followed by precisely locating foreign body. Comprehensive nursing measures including biochemical index monitoring, medication care and prevention of complications were carried out to ensure the successful removal of the foreign body (本文总结1例高龄、合并多种疾病且长期卧床的鼻饲饮食患者发生异物吞食事件的护理体会。老年人群胃肠功能减弱, 通过检查定位异物位置, 针对性采取消化道异物处理方式, 同时注意生化指标监测、用药以及并发症预防等细节护理, 以促进异物顺利排出体外。)

随着新能源接入电网比例的不断提高，新能源送端电网常规电源调峰能力不足造成的风电消纳受阻问题凸显，急需挖掘负荷的可调节潜力以增加对风电的消纳能力。蓄热电锅炉负荷具有可调节特性，通过合理的市场交易方法激励蓄热电锅炉企业参与调节成为消纳受阻风电的新途径。为此，提出了一种蓄热电锅炉负荷参与消纳受阻风电的主从博弈交易决策方法。首先分析了蓄热电锅炉负荷参与调控对消纳受阻风电的作用机理；其次对蓄热电锅炉负荷参与消纳风电的荷源双边收益以及主从博弈关系进行了研究；基于此，提出了蓄热电锅炉负荷参与消纳受阻风电的主从博弈交易决策方法；最后，采用某新能源送端电网荷源实际运行数据进行仿真分析，验证了所提决策方法可充分调动蓄热电锅炉企业参与消纳风电的积极性，从而有效提升风电消纳能力。

装配式轻型钢结构中的冷弯薄壁型钢构件常采用自攻螺钉连接，国内外学者针对连接板件厚度小于2 mm的自攻螺钉抗剪承载力进行了大量研究，并给出了设计建议，但实际工程中仍存在采用自攻螺钉连接较厚钢板的情况。为评估厚度大于2 mm连接钢板中自攻螺钉的抗剪性能，完成了8组16个较厚钢板连接的单颗自攻螺钉抗剪试验，重点考虑了钢板厚度、自攻螺钉直径、自攻螺钉钉头与钢板接触情况等相关参数的影响，获得了用于厚板连接自攻螺钉的破坏模式、极限抗剪承载力、剪切刚度等性能。采用多国规范中的设计公式计算了单颗自攻螺钉的抗剪承载力，并进行了对比分析。试验结果表明，ST4.8自攻螺钉均发生剪断破坏，滑移变形略小；ST6.3自攻螺钉在发生剪断的同时，钉孔内壁出现了明显的挤压变形和豁孔现象。在连接钢板厚度大于2 mm的情况下，钢板厚度、自攻螺钉钉头接触情况对其抗剪承载力影响不明显；随着自攻螺钉直径的增加，其抗剪承载力呈增大趋势。根据各国规范计算得到的单颗自攻螺钉抗剪承载力与试验值差别较大，存在高估的现象，偏不安全；基于自攻螺钉剪断破坏模式所给出的建议公式可保守地确定厚板连接自攻螺钉抗剪承载力，具有一定的安全储备。

为合理开发利用四川省凉山州德昌县的核桃资源，对该产地采摘的10种核桃及其油脂品质进行对比分析，检测了核桃横径、平均果质量、出仁率，核桃仁水分含量、粗脂肪含量、出油率，核桃油酸值、过氧化值和脂肪酸组成。结果表明：10种核桃的平均果质量为7.76~17.03 g，横径为29.60~48.17 mm，出仁率为40.76%~57.39%；核桃仁水分含量均低于5%，粗脂肪含量为57.54%~6926%；核桃油过氧化值与酸值均符合国标要求，脂肪酸组成以不饱和脂肪酸为主，棕榈酸、硬脂酸、油酸、亚油酸和α-亚麻酸含量分别为5.25%~5.93%、2.17%~3.85%、27.32%~4450%、42.22%~57.13%和4.43%~6.44%。综合考虑各项因素，德昌37号、德昌7号和德昌11号更适合用于加工生产核桃油。 For the rational development and utilization of walnut resources in Dechang county, Liangshan prefecture, Sichuan province, 10 walnuts and their oil quality in Dechang county were compared and analyzed. The horizontal diameter, average fruit weight and kernel rate of walnut, moisture content and crude fat content, and oil yield of walnut kernel, acid value, peroxide value and fatty acid composition of walnut oil were determined. The results showed that the average fruit weight, horizontal diameter and kernel rate of 10 walnuts was 7.76-17.03 g, 29.60-48.17 mm and 40.76%-57.39% respectively; the moisture content of walnut kernel was all less than 5%; the crude fat content of walnut kernel was 5754%-69.26%; the peroxide value and acid value met the requirements of the national standard; the fatty acid composition was mostly unsaturated fatty acid, and the contents of palmitic acid, stearic acid, oleic acid, linoleic acid and α-linolenic acid were 5.25%-5.93%, 2.17%-3.85%, 27.32%-44.50%, 42.22%-57.13% and 443%-6.44% respectively. Considering all factors, Dechang 37, Dechang 7 and Dechang 11 are more suitable for processing and producing walnut oil.

目的 探讨小鼠脑缺血损伤后阿司匹林和氯吡格雷联合应用21 d对骨髓中性粒细胞炎症因子及脑内小胶质细胞极化的影响。 方法 雄性C57BL/6小鼠随机分为对照组、阿司匹林联合氯吡格雷组（双抗组）2组，每组10只。通过结扎大脑中动脉远端制作脑缺血再灌注模型（缺血60 min，解开结扎实现再灌注），再灌注即刻通过灌胃给予饮用水100 μL（对照组）和阿司匹林（剂量12 mg/kg，每只实际用量0.3 mg）与氯吡格雷（剂量12 mg/kg，每只实际用量0.3 mg）混悬液100 μL（双抗组），每日1次，连续21 d。21 d后处死小鼠，分离骨髓中性粒细胞，通过实时荧光定量PCR检测骨髓中性粒细胞相关炎症因子，包括IL-1β、IL-6、IL-10、诱导型一氧化氮合酶（inducible nitric-oxide synthase，iNOS）、TNFα、精氨酸酶1（arginase1，Arg1）、转化生长因子β（transforming growth factor β，TGFβ）、CD206、CD32、几丁质酶样蛋白（chitinase-like3，Chil3/YM1）的表达情况。脑组织行冰冻切片，免疫荧光染色标记离子化钙结合适配分子1（ionizedcalcium binding adapter molecule 1，Iba1）、CD16和CD206，观察小胶质细胞数量、形态变化与极化状态。 结果 与对照组相比，治疗21 d后双抗组小鼠骨髓中性粒细胞IL-1β的相对表达下降（0.703±0.124vs. 1.000±0.203，P =0.019）；YM1（2.173±0.968 vs. 1.000±0.282，P =0.019）和CD206（1.361±0.203vs. 1.000±0.260，P =0.048）的相对表达上调。治疗21 d后双抗组与对照组梗死周边区的小胶质细胞数量差异无统计学意义，但双抗组CD16阳性（M1型）小胶质细胞数量降低（119.4±37.43个/平方毫米vs. 220.2±63.07个/平方毫米，P

Objective To observe the curative effect of massage technique and acupoint application in treating constipation after stroke. Methods Totally 78 patients with acute constipation after cerebral infarction were selected, divided into control group, acupoint application group (Acupoint application group) and massage treatment group (massage group), among which 22 patients in control group, 31 patients in application group and 25 patients in massage group. The control group patients received integrative medicine treatment and nursing. On this basis, the massage group patients received acupoint massage technique; the Acupoint application group patients were given Traditional Chinese Medicine Shenque acupoint application. The defecation situation of the three groups was observed daily for 2 weeks, and the defecation frequency of the three groups was compared with the 7th and 14th day of treatment. Barthel Index was used to evaluate the activity of daily living of patients before discharge from hospital. Results In the first week of treatment, the defecation frequency was higher in the massage group than that in the massage group and control group (P

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Topologically nontrivial Fe-based superconductors attract extensive attentions due to their ability of hosting Majorana zero modes (MZMs) which could be used for topological quantum computation. Topological defects such as vortex lines are required to generate MZMs. Here, we observe the robust edge states along the surface steps of CaKFe4As4. Remarkably, the tunneling spectra show a sharp zero-bias peak (ZBP) with multiple integer-quantized states at the step edge under zero magnetic field. We propose that the increasing hole doping around step edges may drive the local superconductivity into a state with possible spontaneous time-reversal symmetry breaking. Consequently, the ZBP can be interpreted as an MZM in an effective vortex in the superconducting topological surface state by proximity to the center of a tri-junction with different superconducting order parameters. Our results provide new insights into the interplay between topology and unconventional superconductivity, and pave a new path to generate MZMs without magnetic field. [ABSTRACT FROM AUTHOR]

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Dermatophytosis is distributed worldwide, with a global prevalence of 20%-25%, while allergic diseases have a high prevalence of 10%-45% in the global population. In recent years, research on the correlation between dermatophytosis and allergic diseases such as allergic rhinitis, atopic dermatitis, and asthma has been reported successively, highlighting a previously overlooked relationship between dermatophytes and allergic diseases. This review summarizes the research progress on fungal allergens, the correlation between dermatophytosis and allergic diseases, as well as the mechanisms of interaction, aiming to provide insights for the clinical diagnosis and treatment of dermatophytosis and allergic diseases. [ABSTRACT FROM AUTHOR]

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