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BACKGROUND: Multiple clinical observational studies have suggested a close relationship of serum trace elements and nutrients with osteonecrosis, but it remains unclear whether there is a genetic causal effect between serum trace elements and nutrients on osteonecrosis. OBJECTIVE: To investigate the causal effects of serum trace elements and nutrients on osteonecrosis using the Mendelian randomization approach. METHODS: The exposure factors of serum trace elements and vitamins with mononucleotide polymorphisms were obtained from the published UK Biobank database and publicly available databases of genome-wide association studies. The outcome event of osteonecrosis was derived from the FinnGen Biobank database. Mendelian randomization methods were employed to explore the causal relationship between seven trace elements and three nutrients with osteonecrosis. Causal inference was conducted using inverse variance weighting, MR-Egger, and weighted median methods. F-statistic was calculated to ensure the robustness of instrumental variables. Cochran's Q test and leave-one-out method were used for heterogeneity testing. MR-Egger regression and MR-PRESSO were employed for horizontal pleiotropy testing. PhenoScanner database was utilized to remove mononucleotide polymorphisms with horizontal pleiotropy to ensure the reliability of the results. RESULTS AND CONCLUSION: Causal relationships were found between serum selenium, phosphate, vitamin C, vitamin E, and osteonecrosis through Mendelian randomization analysis. Serum selenium, vitamin C, and vitamin E were found to have a protective effect on osteonecrosis, while excessive intake of phosphate increased the risk of osteonecrosis. No heterogeneity or horizontal pleiotropy was observed during the study, and Mendelian randomization statistical power (Power value > 80%) indicated the reliability of the aforementioned four results. These findings have important clinical implications for the development of targeted preventive and therapeutic measures for osteonecrosis. [ABSTRACT FROM AUTHOR]

Copyright of Research of Soil & Water Conservation is the property of Institute of Soil & Water Conservation, Chinese Academy of Sciences & Ministry of Water Resources and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To investigated vascular characteristics and clinical follow-up results of gestational trophoblastic neoplasia (GTN) with uterine arteriovenous malformation (UAVM) using contrast-enhanced magnetic resonance angiography (CE-MRA). Methods Patients clinically suspected of GTN at Obstetrics and Gynecology Hospital, Fudan University from Dec 2015 to Dec 2020 were selected. Imaging characteristics of conventional magnetic resonance imaging and CE-MRA before treatment. The International Federation of Gynecology and Obstetrics (FIGO)2000 clinical staging and prognosis scoring system was used to evaluate the severity of the condition and related risk factors, the treatment methods (chemotherapy, surgical treatment, and arterial embolization) and prognosis determined during follow-up were recorded. Results A total of 44 cases were included, including 5 cases of placental site trophoblastic tumor (PSTT) and 39 cases of the other GTN. There were 3 cases of PSTT combined with UAVM and 23 cases of the other GTN combined with UAVM. Thirty-nine cases of the other GTN were divided into two groups according to the presence or absence of UAVM. Data regarding the β -human chorionic gonadotropin (β -hCG ) value (<10 000 mIU/mL and ≥10 000 mIU/mL) were evaluated using Chi-square test, and the difference was statistically significant (P=0.001). The average FIGO scores of the two groups were 4.19±3.69 and 6.70±3.39, and the difference was statistically significant (P=0.035). Conclusion When β -hCG value≥10 000 mIU/mL, the probability of UAVM occurrence increases. The higher the prognosis score is, the more possibility of formation of UAVM. The use of CE-MRA technology helps to better diagnose UAVM. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Cryptologic Research (2097-4116) is the property of Editorial Board of Journal of Cryptologic Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Oncology is the property of Chinese Journal of Oncology / Zhonghua Zhongliu Zazhi and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Hydrogeology & Engineering Geology / Shuiwendizhi Gongchengdizhi is the property of Hydrogeology & Engineering Geology Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Laser Technology is the property of Gai Kan Bian Wei Hui and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

To investigate the effect of glucose addition on the dynamic process of soil CO2 emission and the mechanisms involved, subtropical evergreen broad-leaf forest soil was used as the research object. The incubation experiments were conducted at a constant incubation temperature of 20 ℃ and a soil field water holding capacity of 60% by inputting different concentrations of glucose with a carbon content of 0, 50, 150, and 450 μg·g-1, labeled as CK, C1, C2, and C3 treatments, respectively. The results showed that soil CO2 emission rate and soil CO2 cumulative emission significantly increased following the C2 and C3 treatments（P＜0.05). The soil CO2 emission rate and soil CO2 cumulative emission significantly increased（P＜0.01) with increasing incubation time after 28 h for the C2 and C3 treatments. After more than 65 h of incubation time, the soil CO2 emission rate of the C1 treatment showed a significant decreasing trend with increasing incubation time（P＜0.01). Compared to CK soil C/N, the DOC content significantly increased with C3 treatment（P＜0.05). The soil CO2 emission rate was significantly and positively correlated with C/N and DOC content（P＜0.05). The effects of different concentrations of glucose additions on soil CO2 emissions were found to be different. In subtropical evergreen broad-leaf forest soils, increased addition of glucose from root exudation may alter soil C and N content and increase CO2 emissions, thereby further accelerating soil carbon loss. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Food Safety & Quality is the property of Journal of Food Safety & Quality Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Architecture & Civil Engineering is the property of Chang'an Daxue Zazhishe and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Liquid Crystal & Displays is the property of Chinese Journal of Liquid Crystal & Displays and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shipin Kexue/ Food Science is the property of Food Science Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Polymer Materials Science & Engineering is the property of Sichuan University, Polymer Research Institute and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Applied Ecology / Yingyong Shengtai Xuebao is the property of Chinese Journal of Applied Ecology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

BACKGROUND: Pigmented villonodular synovitis is a rare synovial inflammatory disease. There is no relevant biomarker for early diagnosis. Messenger RNA (mRNA) has been confirmed to be involved in the occurrence and development of the disease, but its mechanism is not clear. OBJECTIVE: To identify the potential biomarkers and pathogenesis of pigmented villonodular synovitis by bioinformatics and related transcriptome analysis for differential diagnosis of the disease. METHODS: The microarray data set of synovial tissue associated with pigmented villonodular synovitis was searched by GEO database, and the differentially expressed genes were identified by NetworkAnalyst analysis (P < 0.05). The genes related to pigmented villonodular synovitis were searched in the disease database, and the differentially expressed genes were obtained by overlap with differentially expressed mRNAs. Tissue/organ localization of specific genes was carried out by BioGPS. The protein-protein interaction network was constructed by STRING database. The differentially expressed genes were enriched and analyzed by KOBAS3.0 and GSEA4.1.0, and the hub genes were identified by multiple computing methods. Cytoscape was used to build competitive endogenous RNA network. GEO dataset validated the biomarkers with high diagnostic value. In addition, the concentrations of 64 kinds of immune cells and stromal cells were analyzed by Xcell website, and the abundance fraction was calculated. RESULTS AND CONCLUSION: A total of 2 546 differentially expressed genes were identified in the GSE175626 dataset, including 2 317 differentially expressed mRNA and 229 differentially expressed lncRNA. After intersection with the related genes in the disease database, 70 differentially expressed genes were obtained, 60 of which were identified by BioGPS. Compared with patients with osteoarthritis, GO and KEGG enrichment analysis showed that differentially expressed genes in patients with pigmented villonodular synovitis were mainly involved in inflammation, cell proliferation, angiogenesis, and immune response. Fifteen hub genes were determined by CytoHubba and four gene cluster modules were identified by MCODE. Twelve heterosexual hub genes were verified by GEO dataset. Immune and stromal cell deconvolution analysis showed that 12 hub genes were closely related to some immune cells. Overall, IL-6, TNF, CD163, KRAS, FN1, HMOX1, GAPDH, IL1B, PTPRC, MAPK1, CCR2, and NFKBIA may be potential biomarkers for the diagnosis of pigmented villonodular synovitis. SNHG14-hsa-miR-206-FN1 and XIST-hsa-miR-107-HMOX1/CD163 may be potential RNA pathways to regulate the progression of pigmented villonodular synovitis. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Jilin University (Medicine Edition) is the property of Jilin University Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

BACKGROUND: Hypoxic training is a training method that utilizes the dual stimulation of hypoxia and exercise to mobilize the potential of athletes and improve athletic performance. Oxygen sensing is the ability of cells to sense oxygen and adapt to oxygen, which is regulated by many key factors in cells, such as hypoxia-inducible factors, which in turn form an oxygen sensing pathway. This pathway plays an important role in hypoxic training. OBJECTIVE: From the perspective of how the body cells perceive oxygen and adapt to hypoxia during hypoxic training, to explore the physiological mechanism by which hypoxic training promotes exercise health and improves exercise performance. METHODS: A literature search of CNKI and PubMed was conducted using the keywords of “oxygen-sensing, hypoxic training, hypoxia inducible factor” in Chinese and English, respectively. After title, abstract and main text reading, 50 articles were finally included for review. RESULTS AND CONCLUSION: Hypoxia-inducible factors are important regulators in the oxygen sensing pathway. Hypoxic training can significantly upregulate the expression of hypoxia-inducible factor-1, enhance glucose metabolism, oxygen transport and angiogenesis in tissues, providing theoretical support for hypoxic training to prevent and alleviate hypoxia-induced cardiovascular diseases through the oxygen sensing pathway. The hypoxia-inducible factor signaling pathway may play its value as a new therapeutic target to improve human tissue function in the future and the elucidation of the mechanism by which hypoxiainducible factors act on cellular sensing and response to oxygen levels opens up new fields for biology and medicine. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Food Safety & Quality is the property of Journal of Food Safety & Quality Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Xi'an Jiaotong University (Medical Sciences) is the property of Xian Jiaotong University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shipin Kexue/ Food Science is the property of Food Science Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in the world, with the features of insidious onset, low surgical resection rate, and frequent early metastasis and recurrence. With the development of new molecular biology technology in recent years, a liquid biopsy technology, circulating tumor DNA (ctDNA) detection, has achieved encouraging results. This article reviews the current research status and future prospects of ctDN A as a key component of liquid biopsy in patients with HCC, in order to provide new ideas for the clinical treatment of HCC. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Food Safety & Quality is the property of Journal of Food Safety & Quality Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Applied Chemistry is the property of Chinese Journal of Applied Chemistry and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shipin Kexue/ Food Science is the property of Food Science Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shipin Kexue/ Food Science is the property of Food Science Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Materials Engineering / Cailiao Gongcheng is the property of Journal of Materials Engineering Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Transportation Science & Technolgy is the property of Transportation Science & Technology Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Clinical Pediatric Surgery is the property of Journal of Clinical Pediatric Surgery Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Irrigation & Drainage is the property of Journal of Irrigation & Drainage Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Agro-Environment Science is the property of Journal of Agro-Environment Science Editorial Board and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Systems Engineering & Electronics is the property of Journal of Systems Engineering & Electronics Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Northeastern University (Natural Science) is the property of Dongbei Daxue Xuebao and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of China Brewing is the property of China Brewing Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of International Obstetrics & Gynecology is the property of TianJin Medical Information Center and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Transactions of China Pulp & Paper is the property of China Pulp & Paper Magazines Publisher and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shipin Kexue/ Food Science is the property of Food Science Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To observe the effect of Xinyue capsule combined with tirofiban on cardiac function and cardiovascular adverse events in patients with acute myocardial infarction (AMI) undergoing percutaneous coronary intervention (PCI). Methods: 120 patients with AMI undergoing PCI were randomly divided into control group (60 cases treated with tirofiban) and study group (60 cases treated with Xinyue capsule combined with tirofiban). The curative effect, improvement of clinical symptoms, cardiac troponin I (cTnI), left ventricular end diastolic diameter (LVEDD), left ventricular end systolic diameter (LVESD), left ventricular ejection fraction (LVEF), creatine kinase isoenzyme (CK-MB), brain natriuretic peptide (BNP), adverse reactions, incidence of cardiovascular adverse events and prognosis were compared between the two groups. The clinical total effective rates of the control group and the study group were 75.00%(45/60) and 90.00% (54/60), respectively. Results: The clinical total effective rate of the study group was higher than that of the control group(P<0.05). The remission rate of chest pain, chest tightness, nausea, vomiting and sweating in the study group was higher than that in the control group (P<0.05), but there was no difference in palpitation, shortness of breath, fatigue, syncope, fecal incontinence between the two groups(P>0.05). After treatment, LVEDD and LVESD of study group were(49.38± 6.73) mm and(38.14± 4.35) mm, which were lower than those of control group (55.27± 5.24) mm, (43.73± 5.24) mm, LVEF was (57.09± 4.34)%, higher than (52.63± 5.33)% (P<0.05). After treatment, CK-MB, cTnI and BNP in the study group were (13.46± 2.34) ng/mL, (0.29± 0.08) μg/L and (363.44± 29.66) pg/mL in the study group, which were lower than those in the control group [(24.75± 2.63) ng/mL, (0.41± 0.12) μg/L, (548.12± 57.61) pg/mL] (P<0.05). The incidence rate of adverse reactions in the control group and the study group were 8.33% (5/60) and 11.67% (7/60), respectively. There was no difference in the incidence of adverse reactions between the two groups(P>0.05). The incidence rate of cardiovascular adverse events in the control group and the study group were 5.00% (3/60) and 16.67% (10/60), respectively. The incidence rate of cardiovascular adverse events in the study group was lower than that in the control group(P<0.05). Conclusion: Xinyue capsule combined with tirofiban can protect the cardiac function of AMI patients undergoing PCI, reduce the incidence of cardiovascular adverse events, and the medication is safe and reliable with definite curative effect. [ABSTRACT FROM AUTHOR]