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Cervical spondylosis is one of the common clinical diseases. At present, the main drugs used in the clinic are non-steroidal anti-inflammatory drugs (NSAIDs), neurotrophic drugs, skeletal muscle relaxation drugs, opioids, etc. , which can alleviate the clinical symptoms of patients to a certain extent, but cannot be eradicated. The theory of syndrome differentiation of the six channels in Treatises on Febrile Diseases has made the system of syndrome differentiation and treatment with both principles, methods, prescriptions and medicines perfect. Through the syndrome differentiation of the six channels, doctors can accurately locate the location and etiology of various clinical diseases, including cervical spondylosis, and provide more targeted programs for clinical diagnosis and treatment. This paper discusses the application of syndrome differentiation theory of six channels in the prevention and treatment of cervical spondylosis through literature search, in order to provide certain ideas and methods for clinical diagnosis and treatment. (颈椎病是临床常见病之一, 通过药物、功能康复等, 在一定程度上可缓解患者的临床症状。六经辨证是中医诊疗疾病的方法论, 是中医辨证施治整体观的具体体现, 通过六经辨证, 医者可以准确地定位包括颈椎病在内的临床各类疾病的位置和病因, 为临床诊疗提供更有针对性的方案。本文通过检索文献, 探讨六经辨证理论在颈椎病防治中的应用, 以期为临床诊疗提供一定的思路和方法。)

Objective To understand the current situation, hotspot and development trend of the research about mutuality in the past 20 years in China and abroad, so as to provide reference for the research about mutuality in China. Methods CiteSpace software and bibliometric online analysis platform were used to visually analyze the literature about mutuality research published between January 1, 2003 and March 1, 2023. Results A total of 11 Chinese literatures and 1374 English literatures were included. The number of annual publications is on the rise, and the countries with large research contributions were the United States, the UK and Canada. Foreign research institutions were mainly concentrated in colleges and universities, with close exchanges and cooperation, while domestic research institutions were few and dispersed, with less cooperation and exchange. The frontiers of mutuality research were “quality of life” and “caregivers” in China. Foreign study of mutuality mainly focused on impact and caregivers, and extended the scope of the study to nursing of cancer and chronic diseases, as wells as interplay of mental health between patients and their caregivers. Conclusion The study of mutuality has a wide scope. It has been used extensively in psychology, medicine and other fields in foreign countries. However, the study of dependency relationship has just been started in our country. Therefore, Chinese scholars should combine our national conditions and culture, draw lessons from mature research abroad, and innovate and deepen on this basis. (目的 了解国内外近20年相依关系研究的现状、热点和发展趋势, 为我国相依关系研究提供参考和借鉴。方法 使用CiteSpace软件和文献计量在线分析平台对国内外2003年1月1日至2023年3月1日相依关系研究文献进行可视化分析。结果 中文文献共纳入11篇, 英文文献共纳入1374篇。年度发文量呈上升趋势, 研究贡献较大的国家是美国、英国和加拿大; 国外研究机构主要集中于高校, 交流合作较紧密; 国内研究机构较少, 且分布相对分散, 合作交流较少。国内相依关系的护理研究前沿为“生活质量”和“照顾者”, 已在相关疾病领域, 国外集中于将相依关系应用于研究前沿为“impact”、“caregivers”, 并已延伸到癌症、慢性病等护理等领域, 对患者和照顾者心理健康问题的相互影响进行了深入了解。结论 相依关系研究范围较为广泛, 国外已将其大量应用于心理学、医学等多个领域, 而我国对于相依关系的研究才起步不久。国内学者应结合我国国情和文化, 借鉴国外成熟研究, 在此基础上创新和深入。)

Copyright of Practical Pharmacy & Clinical Remedies is the property of Editorial Department of Practical Pharmacy & Clinical Remedies and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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To circumvent the supervision of law, illicit manufacturers turn to produce drug related precursors. Among them, tert-butoxycarbonyl (t-Boc) substituted drug precursors are the most common type recently. The t-Boc moiety is a common protecting group in organic synthesis. It can prevent a chemical reaction at one specific group in a molecule, while other functional groups are transformed, and then can be easily chemically removed through a simple carbamate hydrolysis. Due to the lack of control, the readily availability from chemical suppliers, and easy conversion to an immediate, these t-Boc substituted precursors are attractive to illicit manufacturers. The identification of these newly emerging precursors has posed great challenges to forensic science laboratories worldwide. In this study, four types of t-Boc substituted drug precursors, including tert-butyl 4-(phenylamino)piperidine-1-carboxylate (t-Boc-4-AP),tert-butyl 4-((4-fluorophenyl)amino)piperidine1-carboxylate (t-Boc-4F-AP), tert-butyl 4-((4-bromophenyl)amino)piperidine-1-carboxylate (t-Boc4Br-AP), and tert-butyl (1-(2-chlorophenyl)-2-oxocyclohexyl)carbamate (t-Boc-norketamine), were analyzed by using gas chromatography-mass spectrometry (GC-MS) and ultra-high performance liquid chromatography-quadrupole time of flight-mass spectrometry (UPLC-QTOF MS). After analyzing the characteristic fragment ions under electron impact (EI) mode and electrospray ionization collision-induced dissociation (ESI-CID) mode, the possible fragmentation pathways of tBoc substituted drug precursors were deduced. The main product ions of t-Boc substituted drug precursors are tert butyl ion (C4H9 + ), and product ions of [M−C4H8 ] +, [M−C4H9O• ] +, and [M−C5H8O2 ] + under EI mode. Under ESI-CID mode, product ions are mainly formed by the loss of C4H8 and the further loss of CO2 . The study of the fragmentation pathways of t-Boc substituted drug precursors in mass spectrometry benefits the structure elucidation of unknown compounds, and provides reference for forensic science laboratories to identify such substances. [ABSTRACT FROM AUTHOR]

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Copyright of Application Research of Computers / Jisuanji Yingyong Yanjiu is the property of Application Research of Computers Edition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Objective: To evaluate the validity and reliability of the Chinese version of the Sensitivity to Punishment and Sensitivity to Reward Questionnaire-Revised and Clarified (SPSRQ-RC) in patients with eating disorders. Methods: Totally 111 patients with eating disorders meeting diagnostic criteria of DSM-5 were assessed with SPSRQ-RC, Barratt Impulsiveness Scale-11 (BIS-11), Trait Anxiety Inventory (TAI) and Eating Disorder Examination Questionnaire 6.0 (EDE-Q 6.0). Results: Three factors were extracted from the items by exploratory factor analysis with cumulative variance being 55.65%. The interclass correlation coefficient (ICC) of SR and BIS-11 was 0. 26, the ICC of SP and TAI was 0. 25, and the correlation coefficient of the SPSRQ-RC and EDE-Q 6.0 was 0. 35. The Cronbach's a coefficient of the SPSRQ-RC was 0.83, the test-retest reliability of the scale was 0. 82. Conclusion: The Chinese version of SPSRQ-RC shows good psychometric properties in patients with eating disorders. [ABSTRACT FROM AUTHOR]

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Copyright of Journal of Chongqing University of Technology (Natural Science) is the property of Chongqing University of Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To investigate the effect of humanistic care in nursing management of patients with liver disease under the under the regular epidemic prevention and control of COVID-19. Methods According to the sequence of hospital admission, totally 82 patients with liver disease were divided into two groups: 41 cases in control group and 41 cases in the observation group. Patients in both control and observation group received routine care during the treatment, and those in the observation group were given humanistic nursing interventions. The Patient acceptance of humanistic care and satisfaction with nursing service were measured. Results The satisfaction rate in the observation group was higher than that in the control group (P＜0. 01). The Self-rating Anxiety Scale (SAS) score decreased in both groups after intervention, and SAS score in the in the observation group was lower than that in the control group (P＜0. 01). Conclusion Under the regular epidemic prevention and control of COVID-19, implementation of humanistic nursing intervention based on the hospital infection management is potentially effective in relieve anxiety and improving satisfaction degree of patients with liver disease. (目的 探讨新型冠状病毒肺炎常态化疫情防控下肝病患者的人文关怀与护理管理策略, 为后疫情时期传染病医院住院管理提供参考。方法 82例肝病患者根据入院时间分为两组: 2020 年7月—11月收治的41例患者为对照组, 2020年12月—2021年4月收治的41例患者为观察组。住院治疗期间, 对照组采用常规护理模式, 观察组在常规护理的基础上实施人文关怀护理干预。评价两组患者对护理工作满意度和焦虑程度。结果 观察组患者满意度高于对照组, 差异有统计学意义(P＜0. 01)。干预后, 两组焦虑自评量表(SAS)评分均较干预前降低, 且观察组患者SAS评分低于对照组, 差异有统计学意义(P＜0. 01) 。结论 新型冠状病毒肺炎常态化疫情防控下, 在加强住院患者防控管理的基础上, 实施人文关怀护理有利于提高患者护理满意度, 改善患者不良情绪, 对提升治疗依从性有积极意义。)

我国是世界上雉科(Phasianidae)鸟类最多的国家,动物园在珍稀雉类迁地保护中发挥着重要作用。北京动物园通过多项措施来提高珍稀雉类繁育工作的成效:建造生态型饲养笼舍,丰富生活环境; 提供自然多样食物,满足营养需求; 开展行为训练,降低应激反应; 采用亲鸟抚育方式,提高雉类迁地保护成功率。近年来,对血雉(Ithaginis cruentus berezowskii)、暗腹雪鸡(Tetraogallus himalayensis)、红腹锦鸡(Chrysolophus pictus)、白鹇(Lophura nycthemera)、白冠长尾雉(Syrmaticus reevesii)、红腹角雉(Tragopan temminckii)、蓝马鸡(Crossoptilon auritum)和石鸡(Alectoris chukar)等雉类开展了亲鸟抚育试验,在圈养雉类保护性繁育方面进行了有益探索,取得了较好的试验效果,开展亲鸟抚育与未来再引入相结合,是今后动物园珍稀雉类饲养的主要发展方向。

Copyright of Food Research & Development is the property of Food Research & Development Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

BACKGROUND: In recent years, increasing studies have shown that low-intensity pulsed ultrasound can promote the healing of acute tendon injuries, but the specific mechanism is still unclear. OBJECTIVE: To observe the effect of low-intensity pulsed ultrasound on early angiogenesis after acute tendon injury, and to detect the regulatory relationship of low-intensity pulsed ultrasound with vascular endothelial growth factor-related signaling pathways, so as to reveal its potential mechanism of action. METHODS: Animal models of acute Achilles tendon injury were established using local injection of type I collagenase for 3 days in SPF male Sprague-Dawley rats aged 8-12 weeks, and were then randomly divided into ultrasound group and control group. In the ultrasound group, low-intensity pulsed ultrasound was treated daily with a small ultrasonic probe with an effective radiation area of 1 cm2 perpendicular to the Achilles tendon. No intervention was performed in the control group. Ultrasound imaging examination was performed 2 weeks later to observe the early healing of the tendon. Hematoxylin-eosin staining and CD31 immunohistochemical staining were performed to observe the changes in the number of blood vessels in the tissues after 1 and 2 weeks of treatment. The expression of vascular endothelial growth factor-related signaling pathway molecules in Achilles tendon tissues was detected by western blot or qRT-PCR. RESULTS AND CONCLUSION: Compared with the control group, the Achilles tendon in the ultrasound group was more continuous, the echo intensity was lower and more uniform, and the tendon thickness was significantly reduced (P < 0.05). Hematoxylin-eosin staining and CD31 immunohistochemical staining results showed that after 2 weeks of treatment, the number of new vessels in the ultrasound group was significantly increased compared with the control group (P < 0.05). Western blot and qRT-PCR results showed that after 2 weeks of continuous ultrasound intervention, the protein or mRNA expressions of vascular endothelial growth factor, Yes-associated protein, angiopoietin-2 and cysteine-rich angiogenic inducer 61 in the Achilles tendon of the ultrasound group were significantly higher than those of the control group (P < 0.05). These finding indicate that low-intensity pulsed ultrasound significantly increases the number of blood vessels in the early stage of acute tendon injury and accelerate tendon healing by up-regulating vascular endothelial growth factor expression. [ABSTRACT FROM AUTHOR]

Objective: To investigate the relationship between triggering receptor expressed on myeloid cells-1 (TREM-1) and monocyte chemoattractant protein-1 (MCP-1) in cerebrospinal fluid and the outcome of surgical treatment in patients with aneurysmal subarachnoid hemorrhage (aSAH). Methods: 294 patients with aSAH were selected, the levels of TREM-1 and MCP-1 in cerebrospinal fluid were detected before operation. 3 months after discharge, patient outcomes were assessed using the modified Rankin scale (mRS), and patients were divided into poor outcome group (103 cases) and good outcome group (191 cases) according to this. The factors affecting the poor outcome after aSAH were analyzed by multivariate logistic regression analysis. Results: The levels of TREM-1 and MCP-1 in cerebrospinal fluid in poor outcome group were higher than those in good outcome group (P<0.05). Hunt-Hess grade III-IV, delayed cerebral ischemia, increased TREM-1 and MCP-1 were risk factors for poor outcome after aSAH (P<0.05). Conclusion: The increase of serum TREM-1 and MCP-1 levels in patients with poor outcome after aSAH are risk factor for poor outcome after aSAH. [ABSTRACT FROM AUTHOR]

In off-chain payments, multi-path payments show a significant gap in both success rates and transaction latency compared to single-path payments. Although the Spear scheme significantly enhanced the performance of multi-path payments through over-collateralization, excessive locking of collateral funds may have a significant impact on network liquidity. To address this issue, this paper proposed an improved over-collateralized high-throughput multi-path payment scheme, optimizing path selection and fund allocation for large payments using maximum flow algorithm and technique for order preference by similarity to ideal solution. Experimental results show that compared to four other classic multi-path payment schemes, the proposed scheme reduces over-collateralized funds by 8%-16% under similar performance, effectively reducing collateral fund requirements and enhancing network liquidity. [ABSTRACT FROM AUTHOR]

Protein-based plant immune inducers are special compounds that can induce plant defense responses. They are mainly derived from pathogenic microorganisms, biocontrol microorganisms, host plants, and host-pathogen interaction processes. Protein elicitors improve plant resistance by triggering plant pathogen-associated molecular patterns to trigger immunity and effectors to trigger immune responses that frequently involve reactive oxygen species, Ca2+, salicylic acid, jasmonic acid, gibberellin, and ethylene cascade signaling pathways. They can bolster plant resistance against bacterial, fungal, and viral diseases, as well as environmental stress. Here we summarize the sources, mechanisms of action, and current applications of protein-based elicitors, identify existing problems, and outline future development trends. We propose that future research should focus on improving the persistence and stability of these elicitors, exploring the combined use of multiple elicitors or their combination with other agents, and their application in plant breeding., aiming for developing green biopesticides using protein-based elicitors. [ABSTRACT FROM AUTHOR]

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