1. 国产注射用伏立康唑与果糖注射液的配伍稳定性研究.
- Author
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卢彦芳, 林萍萍, 王川平, 亢泽坤, and 任进民
- Abstract
OBJECTIVE ： To investigate the compatible stability of homebred voriconazole injection and fructose injection with the ingredients of hydroxypropyl-p-cyclodextrin. METHODS ： To observe the changes of characters of solution, the number of insoluble particle and pH within 5 h in voriconazole injection that was diluted by fructose injection, and the internal standard method of high performance liquid chromatography was established to determine its content. RESULTS ： After the compatibility of voriconazole injection and fructose injection, there were no obvious changes in the characters of solution, pH within 5 h and voriconazole content, and the number of insoluble particle had met the specification of Pharmacopoeia of the Peopled Republic. CONCLUSIONS： The compatibility of homebred voriconazole injection and fructose injection is stable within 5 h. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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