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Objective: To explore the pathogenesis mechanism of schizophrenia induced by MK-801 in order to provide reference for clinical research and treatment. Methods: Mice were divided into 3 groups, control group, low dose group and high dose group (n=20). The schizophrenia mice model was established by injecting MK-801, and the expression of c-Fos and NADPH oxidase units was detected by Western blot. Results: The activity distance and stereotyped behavior were enhanced in the low dose and high dose of MK-801 group (P<0.01), and the expression of c-fos, and the NADPH oxidase units, p22 and p47 were upregulated greatly compared with control group (P<0.01). But high dose of MK-801 indicated toxic role for myodynamia disorder of legs. Conclusion: c-Fos overexpression and oxidative stress participated in the pathogenesis of schizophrenia in mice induced by MK-801. [ABSTRACT FROM AUTHOR]