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Objective To investigate the effect of modified Morita therapy combined with motor imagery training on pulmonary rehabilitation of elderly patients with chronic obstructive pulmonary disease(COPD). Methods Totally 130 elderly COPD patients were selected and divided into two groups according to the random number table method, with 65 cases in each group. During the rehabilitation treatment, the control group received modified Morita therapy intervention, and the observation group received modified Morita therapy combined with motor imagery training. The changes of lung function, negative emotion and quality of life before and after intervention were compared between the two groups. Results After intervention, the value of forced expiratory volume in 1 s (FEV1), forced expiratory volume in one second/predicted value ratio(FEV1%pred), forced vital capacity (FVC), FEV1/FVC of the observation group were higher than those of the control group (P＜0. 05). Scores of Self-rating Anxiety Scale (SAS), Self-rating Depression Scale(SDS)in the observation group were lower than those in the control group (P＜0. 05). The total score of St George's Respiratory Questionnaire (SGRQ) and dimension scores of symptom, activity and impact in the observation group were lower than those in the control group (P＜0. 05). Conclusion Modified Morita therapy combined with motor imagery training can promote pulmonary function recovery, relieve negative emotion, and improve quality of life in COPD patients. (目的 观察改良森田疗法结合运动想象应用于老年慢性阻塞性肺疾病(COPD)患者肺康复中的效果。方法 选择2019年1月—2020年3月呼吸内科收治的老年COPD患者130例, 按随机数字表法分为对照组和观察组, 各65例。在常规治疗和护理的基础上, 对照组给予改良森田疗法干预, 观察组给予改良森田疗法结合运动想象干预。对比2组干预前后肺功能、不良情绪及生活质量变化情况。结果 干预后观察组第1秒用力呼气容积(FEV1)、第1秒用力呼气容积占预计值百分比(FEV1% pred)、用力肺活量(FVC)、第一秒用力呼气容积与用力肺活量比值(FEV1/FVC)指标均高于对照组(P＜0. 01)。干预后观察组焦虑自评量表(SAS)、抑郁自评量表(SDS)评分均低于对照组(P＜0. 01)。干预后观察组圣乔治呼吸问卷(SGRQ)症状部分、活动部分、疾病影响部分及总分低于对照组(P＜0. 01)。结论 改良森田疗法结合运动想象应用于老年COPD患者肺康复中, 可促进患者肺功能康复, 缓解不良情绪, 提升生活质量。)

Copyright of Science & Technology of Food Industry is the property of Science & Technology of Food Industry Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Computer Engineering & Applications is the property of Beijing Journal of Computer Engineering & Applications Journal Co Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Background and purpose: Invasive breast carcinoma is the most prevalent malignancy in women worldwide and has a poor prognosis. Tumor xenobiotics change the tumor microenvironment and participate in the regulation of tumor occurrence, development and metastasis, which provide new ideas for the diagnosis and treatment of tumors. DZNep can target and regulate the degradation of H3K27me3 histone methyltransferase and specifically induce tumor cell apoptosis, thereby inhibiting cell proliferation and migration in a variety of tumors. In this study, we investigated the effect of DZNep on invasive breast carcinoma exosomes and observed its effect on epithelial-mesenchymal transition (EMT) of breast cancer cells by regulating intercellular junctions. Methods: EZH2 expression in invasive breast carcinoma was analyzed using the The Cancer Genome Atlas (TCGA) database and the online analysis software GEPIA2, and the Tumor Immunity Estimation Resources (TIMER) was used to analyze the relationship between EZH2 and the expressions of tumor microenvironment cytokines and EMT-related proteins. Intervention of invasive breast carcinoma MDA-MB-231 with DZNep and extraction of exosomes using differential ultracentrifugation were performed. Exosome membrane-bound protein expression was identified by detecting the expressions of CD9, CD63 and TSG101 using Western blot. The Brownian motion of exosomes was tracked and analyzed by nanoparticle tracking analysis (NTA) technique, and the hydrodynamic diameter and concentration of exosome particles were calculated in combination with the Stokes-Einstein equation. Transmission electron microscopy analysis of the size and shape of exosomes was carried out. The above methods were used to explore the changes of exogenous exosomes in breast cancer induced by DZNep. In addition, Western blot was used to detect the expressions of EZH2, intercellular junction proteins such as occludin, zonula occludens-1 (ZO-1), laminin, aquaporin 4 (AQP4), connexin 43, claudin5 and collagen Ⅵ, and EMT-related proteins such as E-cadherin and vimentin, respectively, to analyze the regulatory mechanism of DZNep on the tumor microenvironment. Results: EZH2 expression was higher in cancer tissues than in normal tissues. High EZH2 expression was positively correlated with the upregulation of both invasive breast carcinoma immune cells and stromal cells in Luminal A, positively correlated with E-cadherin, N-cadherin and vimentin expressions in invasive breast carcinoma, positively correlated with E-cadherin expression and negatively correlated with N-cadherin expression in BRCA-Luminal B, and positively correlated with N-cadherin and vimentin expressions in BRCA-Luminal A (P＜0.05). The expressions of CD9, CD63 and TSG101 showed that the exosomes of MDA-MB-231 cells were successfully extracted. After DZNep intervention, the particle size of the exosomes was significantly reduced and the number was decreased. The expressions of intercellular junction proteins including occludin, ZO-1, laminin, AQP4 and connexin 43 were decreased, and the expressions of collagen Ⅵ and claudin 5 (CLDN5) were increased. The expression of EMT-related protein E-cadherin was increased, while the expressions of vimentin was decreased. Conclusion: DZNep reduces the generation of exosomes in BRCA by inhibiting EZH2, which further alters the tumor cell microenvironment and thus affects the EMT phenomenon. [ABSTRACT FROM AUTHOR]

Objective: To observe the effects of dexmedetomidine combined with sevoflurane on cerebral oxygen metabolism and stress response in elderly patients undergoing laparoscopic gastrointestinal tumor resection. Methods: 100 elderly patients undergoing laparoscopic gastrointestinal tumor resection who were treated in our hospital from January 2020 to December 2020 were divided into control group （n=50, sevoflurane anesthesia） and study group （n=50, dexmedetomidine combined with sevoflurane anesthesia） by random number table method. Hemodynamics, stress response, cerebral oxygen metabolism, cognitive function and adverse reactions of two groups were observed. Results: 60 min （T1） to 30 min （T3） after operation, The heart rate （HR） of the two groups first decreased and then increased compared with the time point before induction of anesthesia （T0）, and the mean arterial pressure （MAP） first increased and then decreased （P<0.05）. HR at T1～T3 time points in the study group were lower than those in the control group （P<0.05）. The dopamine（DA）, epinephrine （AD） and norepinephrine （NE） levels in two groups at 3 d after operation were increased, but the study group was lower than the control group （P<0.05）. The difference of blood oxygen content （DajvO2） and cerebral oxygen uptake rate （CERO2） in both groups at 3d after operation decreased, but the study group was lower than the control group （P<0.05）. The scores of mini mental state examination scale （MMSE） in the study group at 6h, 1d and 3d after operation were higher than those in the control group （P<0.05）There was no significant difference in the incidence of adverse reactions between the two groups （P>0.05）. Conclusion: Sevoflurane combined with dexmedetomidine in elderly patients undergoing laparoscopic gastrointestinal tumor resection can effectively reduce the body’s stress response, reduce the damage of cognitive function, and maintain hemodynamic stability and cerebral oxygen metabolism. [ABSTRACT FROM AUTHOR]

Copyright of Food & Machinery is the property of Food & Machinery Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Nursing of Integrated Traditional Chinese & Western Medicine is the property of Journal of Clinical Nursing in Practice (Editorial Board, Shanghai Jiao Tong University Press) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Nursing of Integrated Traditional Chinese & Western Medicine is the property of Journal of Clinical Nursing in Practice (Editorial Board, Shanghai Jiao Tong University Press) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Systems Engineering & Electronics is the property of Journal of Systems Engineering & Electronics Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To investigate the influence of analgesic effect and hemodynamics of different doses of oxycodone hydrochloride combine dexmedetomidine in patients with abdominal surgery. Methods: 100 patients who underwent abdominal surgery in our hospital from March 2015 to March 2017 were selected in the study. According to the random number table method, the patients were divided into group A(application of 1.0 mg/kg oxycodone and 2.5 μg/kg dexmedetomidine), group B(application of 0.75 mg/kg oxycodone and 2.5 μg/kg dexmedetomidine), group C(application of 0.5 mg/kg oxycodone and 2.5 μg/kg dexmedetomidine), and group D(application of 1.0 mg/kg oxycodone), each group contained 25 cases. The satisfaction degree of analgesia effect in each group and hemodynamics indexes before anesthesia induction(T0), immediate intubation(T1), and 5 min after intubation(T2) were compared, and the adverse reactions of each group were statistically analyzed. Results: The satisfaction degree of analgesia effect in group A, B and C were significantly higher than those in group D, and the differences were statistically significant(all P<0.05), there was no significant difference in the satisfaction degree of analgesia effect between the three groups of A, B and C(P>0.05). The systolic blood pressure(SBP),diastolic blood pressure(DBP), mean arterial pressure(MAP) and heart rate(HR) levels in group A and B at T1 were higher than those in group C and D respectively, the differences were statistically significant(P<0.05). There was no statistically significant difference between SBP, DBP, MAP and HR at T0 and T2 in each groups(P>0.05). The levels of SBP, DBP, MAP and HR at T1 increased significantly compared with those at T0, but decreased significantly at T2, the differences were statistically significant(P<0.05). The total incidence of adverse reactions in group B was 12.00%, which was significantly lower than 36.00% in group A, 44.00% in group C and40.00% in group D, and the differences were statistically significant(all P<0.05). Conclusion: Different doses of oxycodone hydrochloride combine dexmedetomidine have better anesthesia on the analgesic effect of abdominal surgery patients, it has some influence on the hemodynamic level of the patients, but as time goes on, it gradually decreases. The treatment with 2.5 μg/kg dexmedetomidine and 0.75mg/kg oxycodone hydrochloride compound anesthesia of the higher safety, which is worthy of clinical application. [ABSTRACT FROM AUTHOR]

目的 在精神科医院内感染管理中应用风险管理,探索一种系统、科学、有效和实用的医院内感染预防控制措施。方法 选取2013-2017自贡市精神卫生中心精神科4个男病区和2个女病区,随机抽取2个男病区和1个女病区作为研究组,余下的2个男病区和1个女病区作为对照组。研究组应用风险管理医院内感染预防控制措施,对照组采取常规医院内感染预防控制措施,对比分析医院内感染预防控制效果。结果 研究组医院内感染率为1.44%,显著低于对照组的2.65%,差异有统计学意义(P<0.05);且观察组病区餐室、活动室和病室物表与患者手样、水杯细菌菌落数均低于对照组,差异均有统计学意义(P<0.05);两组仅病区治疗室物表和病区空气细菌菌落数差异无统计学意义(P>0.05)。在研究期内,研究组未发生医院内感染暴发,对照组发生1次36例流感和1次68例流感。结论 在医院内感染管理中应用风险管理,制定预防控制措施,能够很好地实现系统性、科学性、有效性和实用性的有机结合,能有效减少医院内感染的发生,在防止精神科医院内感染暴发上有显著效果。 [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Osteoporosis is the property of Chinese Journal of Osteoporosis and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Research & Exploration in Laboratory is the property of Research & Exploration in Laboratory and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)