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Objective: To investigate the clinical effect of octreotide-assisted duodenoscopy on the acute edematous biliary pancreatitis. Method: 100 patients with acute edematous biliary pancreatitis were selected and randomly divided into the study group and the control group with 50 cases in each group. Both groups of patients were given fasting, anti infection, nutritional support, enzyme inhibitor therapy, the control group was treated with duodenal endoscopy and the study group was treated with octreotide-assisted duodenoscopy at the same time. The abdominal pain relief time, white blood cells (WBC), temperature recovery time, hemodlastase and urine amylase, changes of serum CRP, IL-6, TNF-αlevels before treatment (T0), on the 3rd day after treatment (T1), on the 7th day after treatment(T2) were compared between the two groups. Results: ① The relief time of abdominal pain, WBC, body temperature returned to normal time of study group were all significantly shorter than those of the control group (P<0.05). ②The hemodlastase and urine amylase level at T1, T2 of both groups of patients were significantly lower than those at T0 and hemodlastase and urine amylase level at T2 lower than T1 (P＜0.05). The hemodlastase and urine amylase levels of study group were lower than those of the control group at T1, T2(P＜0.05). ③ The serum CRP, IL-6, TNF-αlevels in both groups at T1, T2 were significantly lower than at T0 with and T2 lower than T1 (P＜0.05), the serum CRP, IL-6, TNF-α levels of study group were lower than those of the control group at T1, T2 (P＜0.05). Conclusion: Octreotide- assisted duodenoscopy could effectively enhance the early clinical efficacy and relieve the inflammatory response of acute edematous biliary pancreatitis patients. [ABSTRACT FROM AUTHOR]